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Strain Name:

B6C3Fe a/a-Col1a2oim/J

Stock Number:

001815

Availability:

Repository- Live

Price and Supply Information

General Terms and Conditions

Former Name      B6C3Fe-a/a-Col1a2oim/+    (Changed: 15-DEC-04 )
Genes & Alleles   Col1a2;   Col1a2oim;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Mating SystemOutcross-Intercross         (Female x Male)
TJL Breeding Summary: homozygote x B6C3Fe a/a F1 or B6C3Fe a/a F1 x homozygote then heterozygote x heterozygote
Specieslaboratory mouse
GenerationN40 (23-JAN-08)

Appearance
black, skeletal defects
Related Genotype: a/a Col1a2oim/Col1a2oim

black, normal outward appearance
Related Genotype: a/a +/? or a/a Col1a2oim/+

Strain Development
The mutation to osteogenesis imperfecta (oim) arose spontaneously in 1985 in the F2 generation of a C57BL/6J male bred with a C3H/HeJ-din ovarian transplant host which was itself a B6C3Fe-a/a F1 hybrid. In this F2 generation a pair of mice showing the abnormal leg development were mated and an affected offspring was outcrossed to a B6C3FeF1/J-a/a hybrid. The strain was subsequently maintained by cross-intercross, crossing a homozygote to a B6C3FeF1/J-a/a hybrid to maintain hybrid vigor then intercrossing the heterozygous offspring to produce affected homozygotes for the next cross to the F1 hybrid. In 1991 B6C3FeF1/J-a/a hybrid females were bred with N13 males homozygous for oim to generate embryos for cryopreservation.

Related Disease (OMIM) Terms

Osteogenesis Imperfecta, Type III
Mammalian Phenotype Terms assigned by genotype

Col1a2oim/Col1a2+

        B6C3Fe a/a-Col1a2oim/J
  • skeleton phenotype
  • abnormal cortical bone morphology (MGI Ref ID J:38013)
    • cortical bone consists of areas of normal lamellar bone intermixed with hypercellular, highly vascularized bone, however cortical thickness is normal
  • decreased bone strength (MGI Ref ID J:38013)
    • although heterozygotes do not exhibit fractures, they show reduced bone mechanical strength
    • male and female femurs have a 21% and 18% reduction in maximum load, respectively
    • male and female femurs have a 32% and 39% reduction in energy to failure, respectively, compared to wild type

Col1a2oim/Col1a2oim

        involves: C3H/HeJ * C57BL/6JLe
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:4348)
  • skeleton phenotype
  • abnormal bone mineralization (MGI Ref ID J:31692)
    • mineral crystals within cortical bone are thinner and less well aligned, probably contributing to the brittleness of bones
    • decreased bone density (MGI Ref ID J:4348)
      • generalized osteopenia
  • abnormal cancellous bone morphology (MGI Ref ID J:4348)
    • femurs at 7 months of age show fewer medullary trabeculae
  • abnormal cortical bone morphology (MGI Ref ID J:4348)
    • lack of normal lamellar organization of the cortical bone
    • decreased cortical bone thickness (MGI Ref ID J:31692)
      • femurs at 7 months of age show cortical thinning and an increase in the number or density of cortical osteocytes
  • abnormal joint morphology (MGI Ref ID J:4348)
    • joint subluxation
    • sclerosis around the knee joints
  • abnormal osteocyte morphology (MGI Ref ID J:4348)
    • increase in the number or density of cortical osteocytes
  • abnormal skeleton extremities morphology (MGI Ref ID J:4348)
    • drooping wrist appearance due to subluxation on one or both forepaws
    • abnormal caudal vertebrae morphology (MGI Ref ID J:4348)
      • periodically noticeable breaks in the tail vertebrae
    • abnormal long bone morphology (MGI Ref ID J:31692)
      • exhibit visible breaks in the long bones of the legs and bowing of the long bones
  • fragile skeleton (MGI Ref ID J:31692)
    • homozygotes are born with bone fractures or develop them at an early age and mutants often show evidence of healed fractures
  • kyphosis (MGI Ref ID J:4348)
    • older mice develop dorsal kyphosis
  • scoliosis (MGI Ref ID J:4348)
    • in older mice
  • behavior/neurological phenotype
  • abnormal gait (MGI Ref ID J:4348)
    • older animals develop an abnormal gait
  • cardiovascular system phenotype
  • hemorrhage (MGI Ref ID J:4348)
    • hemorrhage into the joint cavities, sides of the body, or around the scapulas
  • limbs/digits/tail phenotype
  • abnormal skeleton extremities morphology (MGI Ref ID J:4348)
    • drooping wrist appearance due to subluxation on one or both forepaws
    • abnormal caudal vertebrae morphology (MGI Ref ID J:4348)
      • periodically noticeable breaks in the tail vertebrae
    • abnormal long bone morphology (MGI Ref ID J:31692)
      • exhibit visible breaks in the long bones of the legs and bowing of the long bones
  • skin/coat/nails phenotype
  • abnormal skin morphology (MGI Ref ID J:4348)
    • fibroblasts in the skin contain greatly dilated cisternae of the rough endoplasmic reticulum
    • abnormal dermal layer morphology (MGI Ref ID J:4348)
      • dermal fibroblasts exhibit a rounded morphology instead of the typical elongated shape
  • muscle phenotype
  • decreased tendon stiffness (MGI Ref ID J:41509)
    • tendon collagen is less resistant to tensile stress than wild type collagen indicating that tendons are weaker

Col1a2oim/Col1a2oim

        B6C3Fe a/a-Col1a2oim/J
  • skeleton phenotype
  • abnormal compact bone morphology (MGI Ref ID J:38013)
    • exhibit very little lamellar bone
    • abnormal cortical bone morphology (MGI Ref ID J:38013)
      • cortical bone appears disorganized, very cellular, and highly vascularized
  • decreased bone strength (MGI Ref ID J:38013)
    • femurs have reduced biomechanical properties in bending
    • male and female femurs have a 67% and 60% reduction in maximum load, respectively
    • both male and female femurs have a 79% reduction in energy to failure compared to wild type
    • male and female femurs have a 64% and 40% reduction in stiffness, respectively

Gene & Allele Details

Allele Symbol Col1a2oim
Allele Name osteogenesis imperfecta
Common Name(s) oim;
Strain of Origin(C3H/HeJ x C57BL/6JLe)F2
Gene Symbol and Name Col1a2, collagen, type I, alpha 2
Chromosome 6
Gene Common Name(s) AA960264; AI325291; Col1a-2; Cola-2; Cola2; OI4; expressed sequence AA960264; expressed sequence AI325291; oim; osteogenesis imperfecta; procollagen type I, alpha 2;
General Note Heterozygotes exhibit phenotypic similarity to human syndrome: mild form of osteogenesis imperfecta (J:38013).
Molecular Note A deletion of a single G residue at position 3983 is predicted to result in a frameshift mutation and an alteration of the last 48 amino acids in the encoded protein. [MGI Ref ID J:17202] [MGI Ref ID J:41994] [MGI Ref ID J:4348]
 
Allele Symbol a
Allele Name nonagouti

Control Information

  Allele   Control
 Col1a2oim  Untyped from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (67 strains)

Animal Health Reports

Room Number           FGB29

Research Applications

This mouse can be used to support research in many areas including:

Col1a2oim related

Developmental Biology Research
Defects in Extracellular Matrix Molecules
Skeletal Defects

Mouse/Human Gene Homologs
osteogenesis imperfecta congenita, Ehlers-Danlos syndrome, type VII, autosomal dominant

References

Additional References

Price and Supply Information

Strain Name: B6C3Fe a/a-Col1a2oim/J
Stock Number: 001815

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)Genotype(s) Provided
Individual Mouse Price $261.50Homozygous for Col1a2oim
Pair $330.00Heterozygous for Col1a2oim x Heterozygous for Col1a2oim

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.
Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.
View Control Pricing Information for JAX® Strains.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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