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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names T50H (Changed: 15-DEC-04 ) Type Chromosome Aberration; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Appearance
black
Related Genotype: a/a
Related Strains
Reciprocal Translocations
View Reciprocal Translocations (46 strains)
000601 B6 x STOCK a/a T(7;18)50H/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
T(7;18)50H/+
involves: 101/H * C3H/HeH * C57BL/6J
- endocrine/exocrine gland phenotype
- decreased testis weight (MGI Ref ID J:23104)
- mean testis weights were significantly reduced compared to wild-type males in the presence of C57BL/6 compared to CBA/H alleles
- lowered weight is associated with decreased sperm count
- growth/size phenotype
- decreased body weight (MGI Ref ID J:23104)
- body-weights are slightly reduced in translocation carriers compared to wild-type siblings
- reproductive system phenotype
- abnormal sperm head morphology (MGI Ref ID J:23104)
- frequency of sperm-head abnormalities is doubled compared to wild-type; difference was significant only in presence of CBA/H alleles
- abnormal sperm number (MGI Ref ID J:23104)
- lowered sperm count is not signficant enough to be the reason for decreased fertility
- lowered sperm count is associated with reduction in testis weight
- mean sperm counts for heterozygous males are significantly lower than for wild-type males; substituting CBA/H for C57BL/6J in the background normalizes the sperm count
- oligozoospermia (MGI Ref ID J:23104)
- decreased litter size (MGI Ref ID J:23104)
- decreased testis weight (MGI Ref ID J:23104)
- mean testis weights were significantly reduced compared to wild-type males in the presence of C57BL/6 compared to CBA/H alleles
- lowered weight is associated with decreased sperm count
- multivalent meiotic configurations (MGI Ref ID J:23104)
- resolve to chromosomally unbalanced gametes and reduced fertility
- decreased frequency of ring configurations are seen compared to mice inheriting strain CBA/H alleles
- reduced female fertility (MGI Ref ID J:23104)
- reduced male fertility (MGI Ref ID J:23104)
T(7;18)50H/T(7;18)50H
involves: 101/H * C3H/HeH
- reproductive system phenotype
- multivalent meiotic configurations (MGI Ref ID J:23104)
- chromosomal breakpoints in this reciprocal translocation results in 47% RIV, 47% CIV, and 6% CIII+I
Genes & Alleles
Gene & Allele Information
| Allele Symbol | T(7;18)50H | ||
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| Allele Name | reciprocal translocation, Chr 7 and 18, Harwell 50 | ||
| Allele Type | Radiation induced | ||
| Strain of Origin | (C3H/HeH x 101/H)F1 | ||
| Gene Symbol and Name | T(7;18)50H, reciprocal translocation, Chr 7 and 18, Harwell 50 | ||
| Chromosome | 18 | ||
| Gene Common Name(s) | T50H; | ||
| Molecular Note | The chromosomal breakpoints for this reciprocal translocation are at 7E2 and 18B2. [MGI Ref ID J:148604] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Searle AG; Beechey CV. 1978. Complementation studies with mouse translocations. Cytogenet Cell Genet 20(1-6):282-303. [PubMed: 648183] [MGI Ref ID J:5977]
Additional References
T(7;18)50H relatedBeechey CV. 1994. List of Chromosome Anomalies Mouse Genome 92:336-47. [MGI Ref ID J:23392]
Cattanach BM; Barr JA; Evans EP; Burtenshaw M; Beechey CV; Leff SE; Brannan CI; Copeland NG; Jenkins NA; Jones J. 1992. A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nat Genet 2(4):270-4. [PubMed: 1303278] [MGI Ref ID J:3618]
Evans EP. 1991. T(7;18)50H refinement of breakpoints Mouse Genome 89(3):551. [MGI Ref ID J:148604]
Lane PW; Searle AG; Beechey CV; Eicher E. 1981. Chromosome 18 of the house mouse. J Hered 72(6):409-12. [PubMed: 6949984] [MGI Ref ID J:6710]
Lyon MF; Phillips RJS; Searle AG. 1964. The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice. Genet Res 5:448-467. [MGI Ref ID J:12947]
Searle AG; Beechey CV. 1990. Genome imprinting phenomena on mouse chromosome 7. Genet Res 56(2-3):237-44. [PubMed: 2272514] [MGI Ref ID J:10945]
Searle AG; Whitehill KJ. 1991. Spermatogenic effects of male-fertile translocations in the mouse. Mutat Res 249(2):331-7. [PubMed: 2072976] [MGI Ref ID J:23104]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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