Strain Name: |
STOCK Gusbmps Tg(GUSB)4Sly/BirJ |
|---|---|
Stock Number: |
001880 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
STOCK Tg(mpsGUSB)13Bir/J (Changed: 06-JUN-08
) |
| Genes & Alleles | GUSB; Gusb; Gusbmps; Tg(GUSB)4Sly; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Type JAX® GEMM® Strain - Transgenic Species laboratory mouse
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Gusbmps | ||
|---|---|---|---|
| Allele Name | beta glucuronidase, mucopolysaccharidosis VII | ||
| Common Name(s) | Gus-b; asd; gusmps; | ||
| Mutation Made By | Brian Soper, The Jackson Laboratory | ||
| Strain of Origin | C57BL/6By | ||
| Gene Symbol and Name | Gusb, glucuronidase, beta | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | AI747421; Ac2-223; FLJ39445; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut; MPS7; adipose storage deficiency; asd; beta-glucuronidase regulator; beta-glucuronidase structural; beta-glucuronidase systemic regulator; beta-glucuronidase temporal; expressed sequence AI747421; g; | ||
| Molecular Note | A 1-bp deletion creates a frameshift mutation within exon 10, which introduces a premature stop codon at codon 497. [MGI Ref ID J:13207] | ||
| Allele Symbol | Tg(GUSB)4Sly | ||
| Allele Name | transgene insertion 4, William S Sly | ||
| Common Name(s) | TgGUSB; | ||
| Strain of Origin | C57BL/6J | ||
| Expressed Gene | Gusb, glucuronidase, beta, mouse, laboratory | ||
| Promoter | GUSB, glucuronidase, beta, human | ||
| Molecular Note | The entire human beta-glucuronidase gene with 1.6kb of 5'-flanking sequence and 3.8kb of 3'-flanking sequence was microinjected into C57BL/6J zygotes. Founder line 4 was subsequently propagated. Mice that are homozygous for this transgene and the Gusbmps allele have approximately 20-fold higher beta-glucuronidase enzyme activity than wildtype controls. Distribution of human enzyme activity throughout various tissues mimics the endogenous mouse enzyme activity pattern. [MGI Ref ID J:21256] | ||
Related Strains
Strains carrying Gusbmps allele
006564 B6(C)-KitW-41J Gusbmps/BrkJ 006559 B6.C-H2bm1/ByBir-Gusbmps/BrkJ 000256 B6.C-H2bm1/ByBir-Gusbmps/J 006562 B6.CBy(Cg)-Gusbmps Gpi1a-m1J/BrkJ 006407 B6.Cg-Gusbmps/BrkJ 002086 B6.Cg-Gusbmps Tg(Gussx)1Wat/J 005053 NOD.Cg-Prkdcscid Gusbmps/SndsJ View Strains carrying Gusbmps (7 strains)
006558 B6.Cg-H2bm1 Tg(GUSB)4Sly/SndsJ
005643 B6.129X-Gusbtm1Sly/J 005644 B6.129X-Gusbtm3Sly/J 006557 B6.C3-Gusbmps-2J/BrkJ 003525 C3H/HeOuJ-Gusbmps-2J/BrkJ 005322 C57BL/6J-Gusbmps-3J/J
Research Applications
This mouse can be used to support research in many areas including:Gusbmps related
Developmental Biology Research
Growth Defects Growth Defects (homozygous)
Skeletal Defects
Metabolism Research
Mouse/Human Gene Homologs
mucopolysaccharidosis type VII, GUSB deficiency
Neurobiology Research
Behavioral and Learning Defects
Sensorineural Research
References
Selected Reference(s)
Additional ReferencesKyle JW; Birkenmeier EH; Gwynn B; Vogler C; Hoppe PC; Hoffmann JW; Sly WS. 1990. Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene. Proc Natl Acad Sci U S A 87(10):3914-8. [PubMed: 2111021] [MGI Ref ID J:21256]
Price and Supply Information
| Strain Name: | STOCK Gusbmps Tg(GUSB)4Sly/BirJ |
| Stock Number: | 001880 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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