Strain Name: |
B6.MRL-Cacng2stg-wag/J |
|---|---|
Stock Number: |
001883 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
C57BL/6J-Cacng2stg-wag/J (Changed: 15-DEC-04
) |
| Genes & Alleles | Cacng2; Cacng2stg-wag; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation N7 Strain Development
The waggler mutation arose spontaneously on the MRL/MpJ-Tnfrsf6lpr background in the laboratory of Dr. Charles Sidman in 1988. This mutation was backcrossed to C57BL/6J via backcross-intercross and the lpr mutation was removed from the strain. Ovary transplantation from homozygous females was used when it became necessary. In 1991 N6 heterozygotes were bred together to generate embryos for cryopreservation.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Cacng2stg-wag | ||
|---|---|---|---|
| Allele Name | waggler | ||
| Common Name(s) | wag; | ||
| Strain of Origin | MRL/MpJ-Faslpr/J | ||
| Gene Symbol and Name | Cacng2, calcium channel, voltage-dependent, gamma subunit 2 | ||
| Chromosome | 15 | ||
| Gene Common Name(s) | AW060990; B230105C07Rik; B930041E13Rik; Ipr328; MGC138502; MGC138504; RIKEN cDNA B230105C07 gene; RIKEN cDNA B930041E13 gene; TARP gamma 2; expressed sequence AW060990; stargazer; stargazin; stg; wag; waggler; | ||
| General Note | Waggler is a second recessive mutation at the Cacng2 locus that arose in 1988 in the MRL/MpJ-Tnfrsf6 colony maintained at The Jackson Laboratory by Dr. Charles Sidman. Mutant homozygotes are characterized by whole body tremor, an unstable gait, and growth retardation. Hydrocephaly occurs occasionally. Hearing tests by Dr. Lawrence Erway of the University of Cinncinnati showed that the mutant was not deaf. Both sexes breed; no gross neuroanatomical or histopathologic lesions have been found (J:14313). | ||
| Molecular Note | The phenotype of the waggler is associated with aberrant splicing residing in the first intron. Like the stargazer allele, a RT-PCR analysis demonstrated that in addition to aberrant transcripts, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. [MGI Ref ID J:48966] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Cacng2stg-wag | Untyped from the colony | |
| Cacng2stg-wag | 000664 C57BL/6J | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Cacng2
001756 B6C3Fe a/a-Cacng2stg/J View Strains carrying other alleles of Cacng2 (1 strain)
Additional Web Information
Congenic Nomenclature
JAX® NOTES, Spring 2005, 497. Supression of Absence Epilepsy Seizures Dependent on Complex Balance of Proteins.
Research Applications
This mouse can be used to support research in many areas including:Cacng2stg-wag related
Cell Biology Research
Channel and Transporter Defects (calcium)
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Channel and Transporter Defects (calcium)
Epilepsy
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.MRL-Cacng2stg-wag/J |
| Stock Number: | 001883 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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