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- Description
- Phenotype
- Genes & alleles
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Description
Strain Information
Former Names (Rb(6.16)24Lub x Rb(16.17)7Bnr)F1 (Changed: 27-DEC-07 ) [Rb(6.16)24Lub x Rb(16.17)7Bnr]F1 (Changed: 15-DEC-04 ) Type Chromosome Aberration; Robertsonian; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Parentals STOCK Rb(6.16)24Lub (000885) Female x STOCK Rb(16.17)7Bnr (000615) Male Appearance
dark agouti
Related Genotype: Mc1rE-tob/Mc1rE-tobDescription
This F1 hybrid is produced by crossing a female of strain STOCK Rb(6.16)24Lub (Stock No. 000885) with a male of strain STOCK Rb(16.17)7Bnr (Stock No. 000615). The maternal parental strain (Stock No. 000885) is homozygous for the Robertsonian chromosome Rb(6.16)24Lub. The paternal parental strain (Stock No. 000615) is homozygous for the Robertsonian chromosome Rb(6.16)24Lub. The F1 hybrid is heterozygous for each of these Robertsonian chromosomes. This F1 hybrid is used to produce Chromosome 16 trisomy (Ts16) embryos, which have many of the fetal developmental features of Down Syndrome, by mating to usually C57BL/6J mice. Mice heterozygous for two Robertsonian chromosomes with a chromosome in common (monobrachial homology), when mated to mice with a normal 40 acrocentric karyotype, produce a higher than background frequency of trisomy selectively for the chromosome that the Robertsonians have in common.Please see [Rb (6.16)24Lub X Rb(16.17)7Bnr]F1 at the Cytogenetics Models Resource for more information on this strain.
Phenotype
Phenotype Information
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Developmental Biology Research
Embryonic Lethality (Trisomic)
Internal/Organ Defects (heart)
Neurodevelopmental Defects
Neurobiology Research
Behavioral and Learning Defects (Down syndrome)
Research Tools
Genetics Research (Chromosome Specific Trisomy Production, Trisomy 16)
Genes & Alleles
Gene & Allele Information
| Gene Symbol and Name | Rb(6.16)24Lub, Robertsonian translocation, Chr 6 and 16, Lubeck 24 | ||
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| Chromosome | 16 | ||
| Gene Common Name(s) | Rb(6.16)24Lubx; Rb24Lub; | ||
| Gene Symbol and Name | Rb(16.17)7Bnr, Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | Rb7Bnr; | ||
| Gene Symbol and Name | Rb(6.16)24Lub, Robertsonian translocation, Chr 6 and 16, Lubeck 24 | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | Rb(6.16)24Lubx; Rb24Lub; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
This strain is currently Under Development for Cryo.
To register your interest in this strain go to the Strain Interest Form.
Estimated Available for Sale Date:
Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.
View All Strains Under Development and On Hold
Supply Details
| Standard Supply | Under Development for Cryopreservation Repository |
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| Supply Notes |
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| Request Form |
Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire. |
General Terms and Conditions
See Terms of Use
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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