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Strain Name:

(STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J

Stock Number:

001887

Availability:

Under Development for Cryopreservation Repository

To register your interest in this strain go to the Strain Interest Form.
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General Terms and Conditions

Former Name      (Rb(6.16)24Lub x Rb(16.17)7Bnr)F1    (Changed: 27-DEC-07 )
      [Rb(6.16)24Lub x Rb(16.17)7Bnr]F1    (Changed: 15-DEC-04 )
Genes & Alleles   Rb(16.17)7Bnr;   Rb(6.16)24Lub;   ;

Product Information

Strain Details

Type Chromosome Aberration
Additional information on Mice with Chromosomal Aberrations.
Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Type Robertsonian
Additional information on Mice with Chromosomal Aberrations.
Specieslaboratory mouse
Parentals STOCK Rb(6.16)24Lub (000885) Female x STOCK Rb(16.17)7Bnr (000615) Male

Appearance
dark agouti
Related Genotype: Mc1rE-tob/Mc1rE-tob

Strain Description
This F1 hybrid is produced by crossing a female of strain STOCK Rb(6.16)24Lub (Stock No. 000885) with a male of strain STOCK Rb(16.17)7Bnr (Stock No. 000615). The maternal parental strain (Stock No. 000885) is homozygous for the Robertsonian chromosome Rb(6.16)24Lub. The paternal parental strain (Stock No. 000615) is homozygous for the Robertsonian chromosome Rb(6.16)24Lub. The F1 hybrid is heterozygous for each of these Robertsonian chromosomes. This F1 hybrid is used to produce Chromosome 16 trisomy (Ts16) embryos, which have many of the fetal developmental features of Down Syndrome, by mating to usually C57BL/6J mice. Mice heterozygous for two Robertsonian chromosomes with a chromosome in common (monobrachial homology), when mated to mice with a normal 40 acrocentric karyotype, produce a higher than background frequency of trisomy selectively for the chromosome that the Robertsonians have in common.

Please see [Rb (6.16)24Lub X Rb(16.17)7Bnr]F1 at the Cytogenetics Models Resource for more information on this strain.

Gene & Allele Details

Gene Symbol and Name Rb(6.16)24Lub, Robertsonian translocation, Chr 6 and 16, Lubeck 24
Chromosome 16
Gene Common Name(s) Rb(6.16)24Lubx; Rb24Lub;
Gene Symbol and Name Rb(16.17)7Bnr, Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7
Chromosome 16
Gene Common Name(s) Rb7Bnr;
Gene Symbol and Name Rb(6.16)24Lub, Robertsonian translocation, Chr 6 and 16, Lubeck 24
Chromosome 6
Gene Common Name(s) Rb(6.16)24Lubx; Rb24Lub;

Research Applications

This mouse can be used to support research in many areas including:

Developmental Biology Research
Embryonic Lethality (Trisomic)
Internal/Organ Defects (heart)
Neurodevelopmental Defects

Neurobiology Research
Behavioral and Learning Defects (Down syndrome)

Research Tools
Genetics Research (Chromosome Specific Trisomy Production, Trisomy 16)

Price and Supply Information

Strain Name: (STOCK Rb(6.16)24Lub x STOCK Rb(16.17)7Bnr)F1/J
Stock Number: 001887
 

This strain is currently Under Development for Cryopreservation Repository.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard SupplyUnder Development for Cryopreservation Repository
Supply Notes This strain is included in the Cytogenetic Resource collection.
Request Form Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire.
LicensingSee General Terms and Conditions below  

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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