Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Species laboratory mouse H2 Haplotype q Generation F188 (06-OCT-08)

Appearance
albino
Related Genotype: Tyr^c/Tyr^c

Description
SWR/Bm is a substrain of SWR and characteristics are very similar to SWR/J (Stock No. 000689). SWR/J mice are used widely in research as a general purpose strain. Aging mice exhibit a high incidence of lung and mammary gland tumors. They also develop extreme polydipsia and polyuria (nephrogenic diabetes insipidus) with increasing age. SWR/J mice are highly susceptible to experimental allergic encephalomyelitis (EAE). They are resistant to collagen-induced arthritis. SWR/J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions (1670 to 1690 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). SWR/J mice have been recommended for generation and propogation of transgenic mice because they are high responders to exogenous hormones, have large and prominant pronuclei with good resistance to lysis following microinjection, and are genetically well-defined. SWR/J mice may also be used as controls for comparison to the autoimmune diabetic NOD/LtJ mice (Stock No. 001976), especially for experiements examining the abberant immune functions of NOD/LtJ mice. Both NOD and SWR/J mice are derived from swiss mice. SWR/J are in some cases more suitable than random bred swiss ICR mice because of their genetic uniformity. Unlike, NOD/LtJ mice they are not immunocompromised but they are genetically very different from NOD.

Development
The SWR inbred strain was developed by Clara J Lynch at The Rockefeller Institute obtained swiss mice from A. de Coulon of Lausanne, Switzerland and began inbreeding around 1926. This strain was transferred to Raymond Parker at the University of Toronto who supplied them to The Jackson Laboratory in 1947 at F28+. The SWR/Bm substrain is maintained by Dr. Wes Beamer at The Jackson Laboratory.

Related Strains

SWR Strains

000689

SWR/J

View SWR Strains     (1 strain)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Festing Inbred Strain Characteristics: SWR

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))

Genes & Alleles

Gene & Allele Information

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Kutscher CL; Miller M; Schmalbach NL. 1975. Renal deficiency associated with diabetes insipidus in the SWR/J mouse. Physiol Behav 14(6):815-8. [PubMed: 1187837]  [MGI Ref ID J:25303]

Kutscher CL; Schmalbach NL. 1975. Effects of water deprivation, NaCl injection, and seven aversive taste stimuli on drinking in two normal mouse strains and one with diabetes insipidus. Physiol Behav 15(6):659-67. [PubMed: 1226406]  [MGI Ref ID J:25302]

Levine S; Sowinski R. 1973. Experimental allergic encephalomyelitis in inbred and outbred mice. J Immunol 110(1):139-43. [PubMed: 4631068]  [MGI Ref ID J:24660]

Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7. [PubMed: 8753860]  [MGI Ref ID J:35147]

Lynch CJ. 1969. The so-called Swiss mouse. Lab Anim Care 19(2):214-20. [PubMed: 4240230]  [MGI Ref ID J:24849]

Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588]  [MGI Ref ID J:13267]

Ortman RA; Holderbaum D; Qu XM; Banerjee S; Haqqi TM. 1994. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis. J Immunol 152(8):4175-82. [PubMed: 8144978]  [MGI Ref ID J:17601]

Osman GE; Jacobson DP; Li SW; Hood LE; Liggitt HD; Ladiges WC. 1997. SWR: an inbred strain suitable for generating transgenic mice. Lab Anim Sci 47(2):167-71. [PubMed: 9150496]  [MGI Ref ID J:40533]

Serreze DV; Leiter EH. 1988. Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies. J Immunol 140(11):3801-7. [PubMed: 2897395]  [MGI Ref ID J:27617]

Tennent BJ; Shultz KL; Beamer WG. 1993. Genetic susceptibility for C19 androgen induction of ovarian granulosa cell tumorigenesis in SWXJ strains of mice. Cancer Res 53(5):1059-63. [PubMed: 8439952]  [MGI Ref ID J:4202]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
Supply Notes	Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

General Terms and Conditions

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