Strain Name: |
SJL/Bm |
|---|---|
Stock Number: |
001902 |
Availability: | Research Strain |
General Terms and Conditions |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Species laboratory mouse H2 Haplotype s Generation F153 (16-NOV-05) Appearance
albino
Related Genotype: Tyrc/TyrcStrain Description
SJL mice were developed by James Lambert at The Jackson Laboratory in 1955 from three different sources of Swiss Webster mice. Mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin's disease around one year of age. Sarcomas first appear in the Peyer's patches and mesenteric lymph nodes and later in the spleen, liver, thymus and other lymph nodes Most of the tumors are mixed-cell types classified as type B reticulum cell neoplasms, but a few are type A histiocytomas. This strain is also characterized by extreme agression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research. SJL mice fail to develop atherosclerotic aortic lesions following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat).Strain Development
This sub-line of SJL was separated from the original SJL strain very early in inbreeding (at approximately F16) and thus may differ significantly from SJL/J (000686).
Related Strains
SJL Strains
000686 SJL/J View SJL Strains (1 strain)
Phenotypic Data
Mouse Phenome Database
Festing Inbred Strain Characteristics: SJL
Research Applications
This mouse can be used to support research in many areas including:
Cancer Research
Increased Tumor Incidence (Other Tissues/Organs: reticulum cell sarcomas, Hodgkin's disease)
Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
References
Additional ReferencesPrice and Supply Information
| Strain Name: | SJL/Bm |
| Stock Number: | 001902 |
Price Details
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Supply Details
| Standard Supply | Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain. |
|---|---|
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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