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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C3Ga.Cg-Cas1b (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Radiation Induced Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain C3HfB/Ga Donor Strain (C3H/HeH x 101/H)F1 Generation N8F13+F44+3 Donating Investigator Allen Gates, University of Rochester Appearance
agouti
Related Genotype: A/AImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Development
The Catb allele arose in the randomly mated progeny of a male that had been exposed to X-irradiation at Oak Ridge National Laboratory. The male was an F1 from a cross between 101 and C3H. He was bred to a female from a recessive test stock that was homozygous for the following seven alleles: a, Tyrp1b, Tyr c-ch, p, Myo5ad, Bmp5se, and Ednrbs. This test stock was derived from the breeding of NB stock, which contained the first six alleles, with a non-inbred stock that was homozygous for Ednrbs and three of the other six alleles (Russell, WL, 1951. Cold Spring Symp. Quant. Biol. 16, 327-336). A female was identified with a blood catalase level of 40 PU/ml. She was bred to a wild type male and the offspring also had lower than normal blood catalase activity. One of these F1 males was backcrossed to its mother and a strain described as acatalasemic derived from this. While the history of this strain began at Oak Ridge National Laboratory, it moved to RN Feinstein at The Argonne National Laboratory and was backcrossed to C3HfB/Anl for 8 generations, reaching N8 in approximately 1968, and was then inbred. It was transferred from RN Feinstein to Allen H. Gates at The University of Rochester in 1975 when it was at N8F13. In 1986 this strain was at N8F13+30. The N8F13+44 generation of this strain was received by The Jackson Laboratory in July, 1991 from Allen H. Gates. It was sibling mated and frozen as embryos at N8 F13+44+2. (Gates, AH, Mouse News Lett. 1987. 79:17)
Control Information
| Control | ||
|---|---|---|
| 000658 C3HeB/FeJ | (approximate) | |
| 001908 C3HfB/BiJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Phenotype
Phenotype Information
Catalase; CAT - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
assigned by genotype
Catb/Catb
C3.Cg-Catb/Anl
- homeostasis/metabolism phenotype
- decreased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:5971)
- when maintained on a diet containing 1% 3-amino-1H-1,2,4-triazole, homozygotes congenic on a C3H background carrying MMTV have delayed onset of mammary tumors compared with C3H controls carrying MMTV
- homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole
- life span-post-weaning/aging
- decreased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:5971)
- when maintained on a diet containing 1% 3-amino-1H-1,2,4-triazole, homozygotes congenic on a C3H background carrying MMTV have delayed onset of mammary tumors compared with C3H controls carrying MMTV
- homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole
- tumorigenesis
- abnormal tumor incidence (MGI Ref ID J:5971)
- a larger percentage of homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole develop liver tumors and these have earlier onset
- fewer homozygotes fed a diet containing 1% 3-amino-1H-1,2,4-triazole developed tumors of the hardarian gland or ovaries subsequent to exposure to radiation
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Catb/Cat+
Background Not Specified
- homeostasis/metabolism phenotype
- abnormal enzyme/coenzyme activity (MGI Ref ID J:5015)
- blood catalase activity in heterozygotes is generally between 40 and 100 perborate units per ml of whole blood
Catb/Catb
Background Not Specified
- homeostasis/metabolism phenotype
- abnormal enzyme/coenzyme activity (MGI Ref ID J:105024)
- very low catalase activity in blood (1.1.-2.4 PU/ml) as compared to wildtype Cata mice (144-155 PU/ml)
- catalase activity in liver (21-28 PU/gm), kidney (6.0-8.7PU/gm), lung (12-17 PU/gm), and intestine (18-19 PU/gm) is lower than wild-type Cata mice
- catalase activity in stomach (26 PU/gm) and brain (37-40 PU/gm) is higher than wild-type Cata mice
- catalase activity in liver and kidney exhibits increased sensitivity to the inhibitory agents guanidine, urea , and aminotriazole relative to wild-type
- catalase activity in liver and kidney exhibits decreased sensitivity to the inhibitory agent azide relative to wild-type
- blood catalase activity in homozygotes is generally below 10 perborate units per ml of whole blood
- decreased circulating cholesterol level (MGI Ref ID J:5351)
- average serum cholesterol is approximately 94 mg/kg instead of 111.6 mg/kg in control mice
- decreased circulating triglyceride level (MGI Ref ID J:5351)
- serum triglyceride levels are much lower than normal
- cellular phenotype
- abnormal redox activity (MGI Ref ID J:105024)
Catb/Catb
B6.Cg-Catb/Anl
- homeostasis/metabolism phenotype
- decreased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:5971)
- homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole
- life span-post-weaning/aging
- decreased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:5971)
- homozygotes survive longer than controls on a diet containing 1% 3-amino-1H-1,2,4-triazole
This mouse can be used to support research in many areas including:Catb related
Pde6brd1 relatedMetabolism Research
Sensorineural Research
Retinal Degeneration
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Catb | ||
|---|---|---|---|
| Allele Name | acatalasemia | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | Csb; M1; | ||
| Strain of Origin | (101 x C3H)F1 | ||
| Gene Symbol and Name | Cat, catalase | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | CS1; Cas-1; Cas1; Cs-1; MGC138422; MGC138424; RATCAT01; RATCATL; catalase 1; | ||
| Molecular Note | This allele corresponds to a mutation located in the first alpha helix in the amino terminal arm of the catalase subunit. The substitution of G to T results in an amino acid substitution that replaces glutamine with histidine at position 11. [MGI Ref ID J:10926] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Gates AH. 1987. Report by Allen Gates Mouse News Lett 79:17. [MGI Ref ID J:154291]
Additional References
Feinstein RN; Braun JT; Howard JB. 1967. Acatalasemic and hypocathalasemic mouse mutants. II. Mutational variations in blood and solid tissue catalases. Arch Biochem Biophys 120(1):165-9. [PubMed: 6058079] [MGI Ref ID J:105024]
Feinstein RN; Fry RJ; Staffeldt EF. 1978. Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice. J Natl Cancer Inst 60(5):1113-6. [PubMed: 642030] [MGI Ref ID J:5971]
Feinstein RN; Howard JB; Braun JT; Seaholm JE. 1966. Acatalasemic and hypocatalasemic mouse mutants. Genetics 53(5):923-33. [PubMed: 5929246] [MGI Ref ID J:5015]
Shaffer JB; Preston KE. 1990. Molecular analysis of an acatalasemic mouse mutant. Biochem Biophys Res Commun 173(3):1043-50. [PubMed: 2268310] [MGI Ref ID J:10926]
Shaffer JB; Sutton RB; Bewley GC. 1987. Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem 262(27):12908-11. [PubMed: 3654595] [MGI Ref ID J:20302]
Catb relatedAikoh H; Ogata M. 1988. Levels of metallic mercury and mercuric ion in the venous and arterial bloods of normal and acatalasemic mice following exposure to mercury vapor. Physiol Chem Phys Med NMR 20(3):177-81. [PubMed: 3244799] [MGI Ref ID J:27660]
Cuadrado RR; Bricker LA. 1973. An abnormality of hepatic lipogenesis in a mutant strain of acatalasemic mice. Biochim Biophys Acta 306(2):168-72. [PubMed: 4713148] [MGI Ref ID J:5351]
Feinstein RN; Braun JT; Howard JB. 1967. Acatalasemic and hypocathalasemic mouse mutants. II. Mutational variations in blood and solid tissue catalases. Arch Biochem Biophys 120(1):165-9. [PubMed: 6058079] [MGI Ref ID J:105024]
Feinstein RN; Fry RJ; Staffeldt EF. 1978. Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice. J Natl Cancer Inst 60(5):1113-6. [PubMed: 642030] [MGI Ref ID J:5971]
Feinstein RN; Howard JB; Braun JT; Seaholm JE. 1966. Acatalasemic and hypocatalasemic mouse mutants. Genetics 53(5):923-33. [PubMed: 5929246] [MGI Ref ID J:5015]
Feinstein RN; Jaroslow BN; Howard JB. 1972. Molecular location of the genetic lesion in the acatalasemic mouse. Biochem Genet 6(4):263-73. [PubMed: 4666756] [MGI Ref ID J:5376]
Feinstein RN; Suter H; Jaroslow BN. 1968. Blood catalsase polymorphism: some immunological aspects. Science 159(815):638-40. [PubMed: 4975476] [MGI Ref ID J:5103]
Goldfischer S; Roheim PS; Edelstein D; Essner E. 1971. Hypolipidemia in a mutant strain of acatalasemic mice. Science 173(991):65-6. [PubMed: 5087482] [MGI Ref ID J:5205]
Kobayashi M; Sugiyama H; Wang DH; Toda N; Maeshima Y; Yamasaki Y; Masuoka N; Yamada M; Kira S; Makino H. 2005. Catalase deficiency renders remnant kidneys more susceptible to oxidant tissue injury and renal fibrosis in mice. Kidney Int 68(3):1018-31. [PubMed: 16105032] [MGI Ref ID J:114312]
Shaffer JB; Preston KE. 1990. Molecular analysis of an acatalasemic mouse mutant. Biochem Biophys Res Commun 173(3):1043-50. [PubMed: 2268310] [MGI Ref ID J:10926]
Shaffer JB; Sutton RB; Bewley GC. 1987. Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem 262(27):12908-11. [PubMed: 3654595] [MGI Ref ID J:20302]
Sunami R; Sugiyama H; Wang DH; Kobayashi M; Maeshima Y; Yamasaki Y; Masuoka N; Ogawa N; Kira S; Makino H. 2004. Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction. Am J Physiol Renal Physiol 286(6):F1030-8. [PubMed: 14722014] [MGI Ref ID J:113602]
Wang DH; Tsutsui K; Sano K; Masuoka N; Kira S. 2001. cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant. Biochim Biophys Acta 1522(3):217-20. [PubMed: 11779637] [MGI Ref ID J:76951]
Yamada K; Ito A; Watanabe H; Takahashi T; Basaran NH; Gotoh T. 1997. High sensitivity to hepato-tumorigenesis in hypocatalasemic C3H/C(s)b/Gen mice exposed to low doses of 252Cf fission neutrons and 60Co gamma-rays. Anticancer Res 17(3C):2041-7. [PubMed: 9216662] [MGI Ref ID J:41873]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
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| Important Note | |
| This strain is homozygous for the retinal degeneration allele Pde6brd1. | |
Control Information
| Control | ||
|---|---|---|
| 000658 C3HeB/FeJ | (approximate) | |
| 001908 C3HfB/BiJ | (approximate) | |
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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