Strain Name: |
C3Ga.Cg-Catb/J |
|---|---|
Stock Number: |
001906 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
C3Ga.Cg-Cas1b (Changed: 15-DEC-04
) |
| Genes & Alleles | Cat; Catb; Pde6b; Pde6brd1; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Radiation Induced Mutation Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain C3HfB/Ga Donor Strain (C3H/HeH x 101/H)F1 Generation N8F13+F44+3 Appearance
agouti
Related Genotype: A/AImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1Strain Development
The Catb allele arose in the randomly mated progeny of a male that had been exposed to X-irradiation at Oak Ridge National Laboratory. The male was an F1 from a cross between 101 and C3H. He was bred to a female from a recessive test stock that was homozygous for the following seven alleles: a, Tyrp1b, Tyr c-ch, p, Myo5ad, Bmp5se, and Ednrbs. This test stock was derived from the breeding of NB stock, which contained the first six alleles, with a non-inbred stock that was homozygous for Ednrbs and three of the other six alleles (Russell, WL, 1951. Cold Spring Symp. Quant. Biol. 16, 327-336). A female was identified with a blood catalase level of 40 PU/ml. She was bred to a wild type male and the offspring also had lower than normal blood catalase activity. One of these F1 males was backcrossed to its mother and a strain described as acatalasemic derived from this. While the history of this strain began at Oak Ridge National Laboratory, it moved to RN Feinstein at The Argonne National Laboratory and was backcrossed to C3HfB/Anl for 8 generations, reaching N8 in approximately 1968, and was then inbred. It was transferred from RN Feinstein to Allen H. Gates at The University of Rochester in 1975 when it was at N8F13. In 1986 this strain was at N8F13+30. TheN8 F13+44 generation of this strain was received by The Jackson Laboratory in July, 1991 from Allen H. Gates. It was sibling mated and frozen as embryos at N8 F13+44+2. (Gates, AH, Mouse News Lett. 1987. 79:17)
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Catb | ||
|---|---|---|---|
| Allele Name | acatalasemia | ||
| Common Name(s) | Csb; M1; | ||
| Strain of Origin | (101 x C3H)F1 | ||
| Gene Symbol and Name | Cat, catalase | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | CS1; Cas-1; Cas1; Cs-1; MGC138422; MGC138424; RATCAT01; RATCATL; catalase 1; | ||
| Molecular Note | This allele corresponds to a mutation located in the first alpha helix in the amino terminal arm of the catalase subunit. The substitution of G to T results in an amino acid substitution that replaces glutamine with histidine at position 11. [MGI Ref ID J:10926] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
Control Information
| Control | ||
|---|---|---|
| 000658 C3HeB/FeJ | (approximate) | |
| 001908 C3HfB/BiJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
004297 B6.CXB1-Pde6brd10/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Catb related
Pde6brd1 relatedMetabolism Research
Sensorineural Research
Retinal Degeneration
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
References
Additional ReferencesPrice and Supply Information
| Strain Name: | C3Ga.Cg-Catb/J |
| Stock Number: | 001906 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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