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| In this congenic strain, the wild type Pde6b allele from C57BL/LiA was introgressed onto the C3Hf/HeA background. Retinal degeneration 1 (Pde6brd1) is a spontaneous mutation that is present in multiple inbred strains, including the C3H substrains. Strains that carry rd1 lack rod cells. This strain provides a sighted C3H mouse for use in research studies that require normal vision. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain C3H/HeA Donor Strain C57BL/LiA Appearance
agouti
Related Genotype: A/ADescription
In this congenic strain, the wild type Pde6b allele from C57BL/LiA was introgressed onto the C3Hf/HeA background. Retinal degeneration 1 (Pde6brd1) is a spontaneous mutation that is present in multiple inbred strains, including the C3H substrains. Strains that carry rd1 lack rod cells. This strain provides a sighted C3H mouse for use in research studies that require normal vision.Development
This strain was developed in the laboratory of Willem J. de Grip at Erasmus Universiteit, Rotterdam, the Netherlands. An initial cross of C3Hf/HeA with C57BL/LiA was followed by 8 generations of backcrossing to C3Hf/HeA to introgress the wild type Pde6b allele of C57BL/LiA onto the C3Hf/HeA background. The heterozygous progeny of the last backcross were intercrossed to produce homozygous wild type (Pde6b+/Pdeb+) mice, after which the strain was maintained by sib inbreeding. The strain had exceeded 30 generations of sibling mating when it was sent to The Jackson Laboratory in 1991. (Schalken et al., 1990 and TJL documentation)Additional backgrounds available: using this strain as the donor, the wild type allele of Pde6b was backcrossed for 10 generations to C3H/HeSnJ. This was done for the purpose of generating a hardier control/background strain for use in studies of additional retinal degeneration mutations. The product of this backcross, C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648), is now maintained by sib mating.
Control Information
| Control | ||
|---|---|---|
| See control note: | This strain can be used as a normal, sighted control for C3A Pde6brd1.O20-RdsRd2 (001957) and for C3A.BLiA-+Pde6b.O20-RdsRd2 (001979). For applications related to Pde6brd1, this strain serves as a control for C3H/HeJ (000659). | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6b+ allele
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.Cg-Pde6b+ Prph2Rd2/J 003648 C3Sn.BLiA-Pde6b+/DnJ 004624 FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (8 strains)
Phenotype
Phenotype Information
Currently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:Pde6b+ related
Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype
Sensorineural Research
Retinal Degeneration
wild-type
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Pde6b+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
References
References provided by MGI
Selected Reference(s)
Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9. [PubMed: 2137350] [MGI Ref ID J:109932]
Additional References
Pde6b+ relatedDobkin C; Rabe A; Dumas R; El Idrissi A; Haubenstock H; Brown WT. 2000. Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100(2):423-9. [PubMed: 11008180] [MGI Ref ID J:119166]
Ivanco TL; Greenough WT. 2002. Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice. Hippocampus 12(1):47-54. [PubMed: 11918288] [MGI Ref ID J:113177]
Sakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587] [MGI Ref ID J:142108]
Zhao MG; Toyoda H; Ko SW; Ding HK; Wu LJ; Zhuo M. 2005. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci 25(32):7385-92. [PubMed: 16093389] [MGI Ref ID J:100197]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Breeding & Husbandry Malocclusion occurs occasionally in this strain. Mating System Sibling x Sibling (Female x Male) 01-MAR-06
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $109.30 Female or Male Homozygous for Pde6b+ Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $142.10 Female or Male Homozygous for Pde6b+ Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
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Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
General Supply Notes
- This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| See control note: | This strain can be used as a normal, sighted control for C3A Pde6brd1.O20-RdsRd2 (001957) and for C3A.BLiA-+Pde6b.O20-RdsRd2 (001979). For applications related to Pde6brd1, this strain serves as a control for C3H/HeJ (000659). | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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