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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain C3H/HeA Donor Strain C57BL/LiA Appearance
agouti
Related Genotype: A/ADevelopment
This strain was developed in the laboratory of Willem J. de Grip at Erasmus Universiteit, Rotterdam, the Netherlands. An initial cross of C3Hf/HeA with C57BL/LiA was followed by 8 generations of backcrossing to C3Hf/HeA to introgress the wild type Pde6b allele of C57BL/LiA onto the C3Hf/HeA background. The heterozygous progeny of the last backcross were intercrossed to produce homozygous wild type (Pde6b+/Pdeb+) mice, after which the strain was maintained by sib inbreeding. The strain had exceeded 30 generations of sibling mating when it was sent to The Jackson Laboratory in 1991. (Schalken et al., 1990 and TJL documentation)Additional backgrounds available: using this strain as the donor, the wild type allele of Pde6b was backcrossed for 10 generations to C3H/HeSnJ. This was done for the purpose of generating a hardier control/background strain for use in studies of additional retinal degeneration mutations. The product of this backcross, C3Sn.BLiA-Pde6b+/Dn (Stock No. 003648), is now maintained by sib mating.
Control Information
| This strain can be used as a normal, sighted control for C3A Pde6brd1.O20-RdsRd2 (001957) and for C3A.BLiA-+Pde6b.O20-RdsRd2 (001979). For applications related to Pde6brd1, this strain serves as a control for C3H/HeJ (000659). | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6b+ allele
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 003648 C3Sn.BLiA-Pde6b+/Dn 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (7 strains)
Phenotype
Phenotype Information
Currently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:Pde6b+ related
Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype
Sensorineural Research
Retinal Degeneration
wild-type
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Pde6b+ | ||
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| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9. [PubMed: 2137350] [MGI Ref ID J:109932]
Additional References
Pde6b+ relatedSakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587] [MGI Ref ID J:142108]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Breeding & Husbandry Malocclusion occurs occasionally in this strain. Mating System Sibling x Sibling (Female x Male) 01-MAR-06
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $91.30 Female or Male Homozygous for Pde6b+
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $118.70 Female or Male Homozygous for Pde6b+
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| This strain can be used as a normal, sighted control for C3A Pde6brd1.O20-RdsRd2 (001957) and for C3A.BLiA-+Pde6b.O20-RdsRd2 (001979). For applications related to Pde6brd1, this strain serves as a control for C3H/HeJ (000659). | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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