| |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6EiC3Sn a/A-Ts(417)2Lws Tim/J (Changed: 13-NOV-09 ) B6EiC3Sn-a/A-T2Lws Tim (Changed: 15-DEC-04 ) Type Chromosome Aberration; Trisomy; Additional information on Mice with Chromosomal Aberrations. Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N69 (30-OCT-09) Appearance
agouti
Related Genotype: A/a
black
Related Genotype: a/aDescription
The Tim mutation (translocation induced circling mutation) was induced by ethylene oxide in a mutagenesis experiment. The mutation was induced simultaneously with a reciprocal translocation between Chrs 4 and 17. Because the mutation has so far been inseparable from the translocation, it may be that one of the translocation breakpoints has disrupted a gene on Chr 4 or 17. Heterozygotes exhibit circling, head tossing, poor limb coordination, and corneal clouding. The affected mice are usually smaller than wildtype littermates. Inner ear studies have not been done. The mutants swim poorly but can orient themselves in the water. One mutated copy of the gene is dominant over two normal alleles because segmentally trisomic mice with two normal Chrs 4 and 17 and the small 417 translocation product have the behavioral abnormalitites. Breeding is generally poor.
Related Strains
Trisomies
001924 B6EiC3Sn a/A-Ts(1716)65Dn 004861 B6EiC3Sn-Ts(16C-tel)1Cje View Trisomies (2 strains)
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/GrsrJ 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
TimT(4;17)3Lws/Tim+
involves: C57BL/6J * DBA/2J
- behavior/neurological phenotype
- abnormal motor capabilities/coordination/movement (MGI Ref ID J:10392)
- mice that are heterozygous for the translocation or have a karyotype of 41 chromosomes including Chr4, Chr17, and the small reciprocal translocation product 417 are affected
- circling (MGI Ref ID J:10392)
- head tossing (MGI Ref ID J:10392)
- becomes more pronounced as mice age
- hyperactivity (MGI Ref ID J:10392)
- impaired limb coordination (MGI Ref ID J:10392)
- disability is progressive
- impaired swimming (MGI Ref ID J:10392)
- mice are able to orient themselves in water, but exhibit rolling and poor limb coordination and must be rescued
- older mice appear better able to keep their heads above water
- hearing/vestibular/ear phenotype
- circling (MGI Ref ID J:10392)
- head tossing (MGI Ref ID J:10392)
- becomes more pronounced as mice age
- impaired hearing (MGI Ref ID J:10392)
- some mice do not respond to clicking
- lethality-postnatal
- *normal* lethality-postnatal (MGI Ref ID J:10392)
- mice appear to live a normal lifespan
- reproductive system phenotype
- decreased litter size (MGI Ref ID J:10392)
- heterozygote x wild-type matings produce small litters
- average litter size produced by a male heterozygote x wild-type mating is 1.8 pups
- average litter size produced by a female heterozygote x wild-type mating is 3-5 pups
- male infertility (MGI Ref ID J:10392)
- many males are sterile
- reduced fertility (MGI Ref ID J:10392)
- observed in both males and females
- vision/eye phenotype
- corneal opacity (MGI Ref ID J:10392)
- younger animals exhibit a slight bilateral clouding which progresses to a white/opaque cornea by several months of age
Ts(417)2Lws/0
involves: C3H/HeSnJ * C57BL/6J * C57BL/6JEiJ * DBA2/J
- reproductive system phenotype
- abnormal male germ cell morphology (MGI Ref ID J:117029)
- significantly more sperm with head abnormalities
- abnormal sperm motility (MGI Ref ID J:117029)
- significantly reduced frequencies of sperm with progressive motility
- arrest of male meiosis (MGI Ref ID J:117029)
- spermatogenesis was arrested at meiosis (prophase or metaphase I) in many tubules
- decreased testis weight (MGI Ref ID J:117029)
- significantly smaller testes than controls
- male infertility (MGI Ref ID J:117029)
- produced no progeny
- fail to produce a vaginal plug
- endocrine/exocrine gland phenotype
- decreased testis weight (MGI Ref ID J:117029)
- significantly smaller testes than controls
This mouse can be used to support research in many areas including:TimT(4;17)3Lws related
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Cataracts
Vestibular and Hearing Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type agouti | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | dark-bellied agouti; | ||
| Allele Symbol | TimT(4;17)3Lws | ||
| Allele Name | translocation induced circling mutation 3 Lewis | ||
| Allele Type | Chemically induced (other) | ||
| Common Name(s) | Tim; | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | ||
| Gene Symbol and Name | Tim, translocation induced circling mutation | ||
| Chromosome | 4 | ||
| Molecular Note | The translocation breakpoint in Chr4 produced this allele. | ||
| Allele Symbol | Ts(417)2Lws | ||
| Allele Name | trisomy 17, Chr 17 translocation to Chr 4, Lewis 2 | ||
| Allele Type | Chemically induced (other) | ||
| Common Name(s) | T2Lws; | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | ||
| Gene Symbol and Name | Ts(417)2Lws, trisomy 17, Chr 17 translocation to Chr4, Lewis 2 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | T2Lws; | ||
| Molecular Note | Breakpoints for chromosome 17 span from E4 to the telomere where induced by treatment with ethylene oxide. This sequence was fused to chromosome 4, demonstrating breakpoints spanning from the centromere to 4A4. [MGI Ref ID J:10392] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Lewis SE; Barnett LB; Akeson EC; Davisson MT. 1990. A new dominant neurological mutant induced in the mouse by ethylene oxide. Mutat Res 229(2):135-9. [PubMed: 2320026] [MGI Ref ID J:10392]
Additional References
Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550] [MGI Ref ID J:117029]
Ts(417)2Lws relatedDavisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550] [MGI Ref ID J:117029]
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $131.70 Female or Male Trisomic
Pairs /Price (US dollars $) Pair Genotype $225.80 B6EiC3Sn a/A-Ts(417)2Lws Tim/J x B6EiC3SnF1/J (001875)
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $171.30 Female or Male Trisomic
Pairs /Price (US dollars $) Pair Genotype $293.60 B6EiC3Sn a/A-Ts(417)2Lws Tim/J x B6EiC3SnF1/J (001875)
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
|---|---|
| Supply Notes |
|
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.