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Former Names B6EiC3Sn a/A-Ts(417)2Lws Tim/J (Changed: 13-NOV-09 ) B6EiC3Sn-a/A-T2Lws Tim (Changed: 15-DEC-04 ) Type Chromosome Aberration; Trisomy; Additional information on Mice with Chromosomal Aberrations. Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N69 (30-OCT-09) Appearance
agouti
Related Genotype: A/a
black
Related Genotype: a/aDescription
The Tim mutation (translocation induced circling mutation) was induced by ethylene oxide in a mutagenesis experiment. The mutation was induced simultaneously with a reciprocal translocation between Chrs 4 and 17. Because the mutation has so far been inseparable from the translocation, it may be that one of the translocation breakpoints has disrupted a gene on Chr 4 or 17. Heterozygotes exhibit circling, head tossing, poor limb coordination, and corneal clouding. The affected mice are usually smaller than wildtype littermates. Inner ear studies have not been done. The mutants swim poorly but can orient themselves in the water. One mutated copy of the gene is dominant over two normal alleles because segmentally trisomic mice with two normal Chrs 4 and 17 and the small 417 translocation product have the behavioral abnormalitites. Breeding is generally poor.
Trisomies
001924 B6EiC3Sn a/A-Ts(1716)65Dn 004861 B6EiC3Sn-Ts(16C-tel)1Cje View Trisomies (2 strains)
Strains carrying A allele
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/GrsrJ 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J View Strains carrying A (17 strains)
Strains carrying a allele
View Strains carrying a (104 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (67 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
TimT(4;17)3Lws/Tim+
involves: C57BL/6J * DBA/2J
- behavior/neurological phenotype
- abnormal motor capabilities/coordination/movement (MGI Ref ID J:10392)
- mice that are heterozygous for the translocation or have a karyotype of 41 chromosomes including Chr4, Chr17, and the small reciprocal translocation product 417 are affected
- circling (MGI Ref ID J:10392)
- head tossing (MGI Ref ID J:10392)
- becomes more pronounced as mice age
- hyperactivity (MGI Ref ID J:10392)
- impaired limb coordination (MGI Ref ID J:10392)
- disability is progressive
- impaired swimming (MGI Ref ID J:10392)
- mice are able to orient themselves in water, but exhibit rolling and poor limb coordination and must be rescued
- older mice appear better able to keep their heads above water
- hearing/vestibular/ear phenotype
- circling (MGI Ref ID J:10392)
- head tossing (MGI Ref ID J:10392)
- becomes more pronounced as mice age
- impaired hearing (MGI Ref ID J:10392)
- some mice do not respond to clicking
- lethality-postnatal
- *normal* lethality-postnatal (MGI Ref ID J:10392)
- mice appear to live a normal lifespan
- reproductive system phenotype
- decreased litter size (MGI Ref ID J:10392)
- heterozygote x wild-type matings produce small litters
- average litter size produced by a male heterozygote x wild-type mating is 1.8 pups
- average litter size produced by a female heterozygote x wild-type mating is 3-5 pups
- male infertility (MGI Ref ID J:10392)
- many males are sterile
- reduced fertility (MGI Ref ID J:10392)
- observed in both males and females
- vision/eye phenotype
- corneal opacity (MGI Ref ID J:10392)
- younger animals exhibit a slight bilateral clouding which progresses to a white/opaque cornea by several months of age
Ts(417)2Lws/0
involves: C3H/HeSnJ * C57BL/6J * C57BL/6JEiJ * DBA2/J
- reproductive system phenotype
- abnormal male germ cell morphology (MGI Ref ID J:117029)
- significantly more sperm with head abnormalities
- abnormal sperm motility (MGI Ref ID J:117029)
- significantly reduced frequencies of sperm with progressive motility
- arrest of male meiosis (MGI Ref ID J:117029)
- spermatogenesis was arrested at meiosis (prophase or metaphase I) in many tubules
- decreased testis weight (MGI Ref ID J:117029)
- significantly smaller testes than controls
- male infertility (MGI Ref ID J:117029)
- produced no progeny
- fail to produce a vaginal plug
- endocrine/exocrine gland phenotype
- decreased testis weight (MGI Ref ID J:117029)
- significantly smaller testes than controls
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:TimT(4;17)3Lws related
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Cataracts
Vestibular and Hearing Defects
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type agouti | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | dark-bellied agouti; | ||
| Allele Symbol | TimT(4;17)3Lws | ||
| Allele Name | translocation induced circling mutation 3 Lewis | ||
| Allele Type | Chemically induced (other) | ||
| Common Name(s) | Tim; | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | ||
| Gene Symbol and Name | Tim, translocation induced circling mutation | ||
| Chromosome | 4 | ||
| Molecular Note | The translocation breakpoint in Chr4 produced this allele. | ||
| Allele Symbol | Ts(417)2Lws | ||
| Allele Name | trisomy 17, Chr 17 translocation to Chr 4, Lewis 2 | ||
| Allele Type | Chemically induced (other) | ||
| Common Name(s) | T2Lws; | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | ||
| Gene Symbol and Name | Ts(417)2Lws, trisomy 17, Chr 17 translocation to Chr4, Lewis 2 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | T2Lws; | ||
| Molecular Note | Breakpoints for chromosome 17 span from E4 to the telomere where induced by treatment with ethylene oxide. This sequence was fused to chromosome 4, demonstrating breakpoints spanning from the centromere to 4A4. [MGI Ref ID J:10392] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Lewis SE; Barnett LB; Akeson EC; Davisson MT. 1990. A new dominant neurological mutant induced in the mouse by ethylene oxide. Mutat Res 229(2):135-9. [PubMed: 2320026] [MGI Ref ID J:10392]
Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550] [MGI Ref ID J:117029]
Ts(417)2Lws relatedDavisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550] [MGI Ref ID J:117029]
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $131.70 Female or Male Trisomic
Pairs /Price (US dollars $) Pair Genotype $225.80 B6EiC3Sn a/A-Ts(417)2Lws Tim/J x B6EiC3SnF1/J (001875)
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $171.30 Female or Male Trisomic
Pairs /Price (US dollars $) Pair Genotype $293.60 B6EiC3Sn a/A-Ts(417)2Lws Tim/J x B6EiC3SnF1/J (001875)
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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