Strain Name: |
B6EiC3Sn a/A-Ts(417)2Lws Tim/J |
|---|---|
Stock Number: |
001923 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
B6EiC3Sn-a/A-T2Lws Tim (Changed: 15-DEC-04
) |
| Genes & Alleles | A; Tim; a; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type Trisomy Additional information on Mice with Chromosomal Aberrations. Species laboratory mouse Generation N65 (07-DEC-07) Appearance
agouti
Related Genotype: A/a
black
Related Genotype: a/aStrain Description
The Tim mutation (translocation induced circling mutation) was induced by ethylene oxide in a mutagenesis experiment. The mutation was induced simultaneously with a reciprocal translocation between Chrs 4 and 17. Because the mutation has so far been inseparable from the translocation, it may be that one of the translocation breakpoints has disrupted a gene on Chr 4 or 17. Heterozygotes exhibit circling, head tossing, poor limb coordination, and corneal clouding. The affected mice are usually smaller than wildtype littermates. Inner ear studies have not been done. The mutants swim poorly but can orient themselves in the water. One mutated copy of the gene is dominant over two normal alleles because segmentally trisomic mice with two normal Chrs 4 and 17 and the small 417 translocation product have the behavioral abnormalitites. Breeding is generally poor.
Gene & Allele Details
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Allele Symbol | Tim | ||
| Allele Name | translocation induced circling mutation | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | ||
| General Note | The Tim mutation was induced by ethylene oxide in a mutagenesis experiment. The mutation was induced simultaneously with a reciprocal translocation between Chrs 4 and 17. Because the mutation has so far been inseparable from the translocation, it may be that one of the translocation breakpoints has disrupted a gene on Chr 4 or 17. Heterozygotes exhibit circling, head tossing, poor limb coordination, and corneal clouding. Inner ear studies have not been done. The mutants swim poorly but can orient themselves in the water. One mutated copy of the gene is dominant over two normal alleles because segmentally trisomic mice with two normal Chrs 4 and 17 and the small 417 translocation product have the behavioral abnormalities. Breeding is poor. Homozygotes have not yet been identified but insufficient studies have been done to determine whether the mutation is homozygous lethal (J:10392). | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
Related Strains
Trisomies
001924 B6EiC3Sn a/A-Ts(1716)65Dn 004861 B6EiC3Sn-Ts(16C-tel)1Cje View Trisomies (2 strains)
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/J 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/J 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J
Animal Health Reports
Room Number A2A
Research Applications
This mouse can be used to support research in many areas including:Tim related
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Cataracts
Vestibular and Hearing Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6EiC3Sn a/A-Ts(417)2Lws Tim/J |
| Stock Number: | 001923 |
Price Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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