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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
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Description
Strain Information
Type Chromosome Aberration; Trisomy; Additional information on Mice with Chromosomal Aberrations. Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N?+N6 (08-OCT-08) Important Note
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.Description
Segmentally trisomic Ts(1716)65Dn mice provide a postnatal model for Down syndrome. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are homologues of human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation. Neural cognitive deficits and behavioral abnormalities have been noted in Ts65Dn mice. They have spatial learning and memory defects as assessed in the Morris water maze and the radial arm maze, show developmental delay in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior. They perform similar to controls in visual placing, balance, prehensile reflex and traction on a horizontal bar, motor coordination, swimming ability, olfaction orienting. They also show altered noradrenergic transmission in the hippocampus and cerebral cortex and degeneration of basal forebrain cholinergic neurons by 6 months of age. Trisomic females have smaller and fewer litters than euploid females while trisomic males are effectively sterile with hypospermia.Please see Ts(1716)65Dn at the Cytogenetics Models Resource for more information on this strain.
Control Information
| Control | ||
|---|---|---|
| Wild-type littermate | ||
| Considerations for Choosing Controls | ||
Related Strains
Trisomies
001923 B6EiC3Sn a/A-Ts(417)2Lws Tim/J 004861 B6EiC3Sn-Ts(16C-tel)1Cje View Trisomies (2 strains)
Additional Web Information
JAX® NOTES, Spring 2005, 497. Down Syndrome Model Distribution Expanded.
JAX® NOTES, Winter 2008; 508. JAX® Mice Strain May Hold Key to Treating Down Syndrome.
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Ts(1716)65Dn/0
involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J
- reproductive system phenotype
- abnormal male germ cell morphology (MGI Ref ID J:117029)
- significantly more sperm with head abnormalities
- oligozoospermia (MGI Ref ID J:117029)
- sperm concentration was significantly reduced below controls
- abnormal sperm motility (MGI Ref ID J:117029)
- significantly reduced frequencies of sperm with progressive motility
- abnormal spermatogenesis (MGI Ref ID J:117029)
- spermatocytes beyond pachytene stage and round spermatids are significantly reduced in number, while elongated spermatids are rare and remaining spermatids have deformed nuclei
- arrest of male meiosis (MGI Ref ID J:117029)
- many tubules contain germ cells in arrested at meiotic metaphase 1
- oligozoospermia (MGI Ref ID J:117029)
- sperm concentration was significantly reduced below controls
- abnormal testis morphology (MGI Ref ID J:96650)
- Leydig cells are clustered loosely in expanded interstitial compartment
- abnormal Sertoli cell morphology (MGI Ref ID J:96650)
- only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
- decreased testis weight (MGI Ref ID J:117029)
- significantly smaller testes than controls
- testes are 37.9% of control testes weights
- male infertility (MGI Ref ID J:117029)
- presence of an intact extra chromosome interferes with chromosome pairing in meiosis
- produced no progeny
- fail to produce a vaginal plug
- growth/size phenotype
- decreased body size (MGI Ref ID J:96650)
- mice are ~20% smaller in size compared to normal littermates postnatally
- decreased body weight (MGI Ref ID J:94569)
- nervous system phenotype
- abnormal CNS synapse formation (MGI Ref ID J:94569)
- the area of presynaptic elements (p38+) is increased in the fascia dentate and motor cortex
- in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40% in the cortex
- 18% of dendritic spines are enlarged and display irregular heads or a globular shape
- average synapse length is increased 34% in the hippocampus and 25% in the cortex
- glutamatergic synapses are distributed 33% on the dendritic shaft (compared to 51% in wild-type mice) and 67% (compared to 49% in wild-type mice) on the heads or necks of the dendritic spines
- abnormal granule neuron (MGI Ref ID J:94569)
- dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
- abnormal neuron morphology (MGI Ref ID J:96650)
- in fascia dentate, spine density is significantly decreased on dendrites of granule cells; dendritic spines are significantly enlarged; dendritic width is similar to controls
- abnormal dendrite morphology (MGI Ref ID J:94569)
- dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
- 18% of spines are enlarged and display irregular heads or a globular shape
- basal dentritic spine density in CA1 is increased
- endocrine/exocrine gland phenotype
- abnormal testis morphology (MGI Ref ID J:96650)
- Leydig cells are clustered loosely in expanded interstitial compartment
Ts(1716)65Dn/0
involves: C3H/HeJ * C57BL/6 * DBA/2J
- nervous system phenotype
- abnormal granule neuron (MGI Ref ID J:121764)
- granule cell density is reduced to 76% of that in control mice
- decreased Purkinje cell number (MGI Ref ID J:121764)
- Purkinje cell density is reduced to 90% of that in control mice
- increased brain size (MGI Ref ID J:121764)
- small cerebellum (MGI Ref ID J:121764)
- cerebellar volume is reduced to 88% of that in control mice
- behavior/neurological phenotype
- abnormal spatial learning (MGI Ref ID J:121764)
- mice show impairment in a Morris water maze test
- growth/size phenotype
- decreased body weight (MGI Ref ID J:121764)
Ts(1716)65Dn/0
involves: DBA/2J
- craniofacial phenotype
- abnormal calvaria morphology (MGI Ref ID J:93223)
- cranial vault is enlarged
- small mandible (MGI Ref ID J:93223)
- mice show a Down's Syndrome-like pattern of mandible reduction
- small skull (MGI Ref ID J:93223)
- size difference was most pronounced along the rostralcaudal axis
- limbs/digits/tail phenotype
- short femur (MGI Ref ID J:93223)
- skeleton phenotype
- abnormal calvaria morphology (MGI Ref ID J:93223)
- cranial vault is enlarged
- short femur (MGI Ref ID J:93223)
- small mandible (MGI Ref ID J:93223)
- mice show a Down's Syndrome-like pattern of mandible reduction
- small skull (MGI Ref ID J:93223)
- size difference was most pronounced along the rostralcaudal axis
This mouse can be used to support research in many areas including:
Ts(1716)65Dn relatedNeurobiology Research
Behavioral and Learning Defects (Down syndrome)
Neurodegeneration (basal forebrain cholinergic neurons) (Down syndrome)
Mouse/Human Gene Homologs
Down syndrome
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Ts(1716)65Dn | ||
|---|---|---|---|
| Allele Name | trisomy, Chr 16 translocation to Chr 17, Davisson 65 | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | T(16C3-4;17A2)65Dn; Ts65Dn; | ||
| Strain of Origin | DBA/2J | ||
| Gene Symbol and Name | Ts(1716)65Dn, trisomy, Chr 16 translocation to Chr 17, Davisson 65 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | Ts65Dn; trisomy 16; | ||
| Molecular Note | About 15% of the distal end of chromosome 16 is fused to less than 10% of the centromeric end of chromosome 17 to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. [MGI Ref ID J:30229] [MGI Ref ID J:71031] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic RD Melt Curve Analysis, MCA, vers. 2
Generic RD, STD PCR, vers. 1
Trisomy QPCR, QPCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550] [MGI Ref ID J:117029]
Dierssen M; Vallina IF; Baamonde C; Garcia-Calatayud S; Lumbreras MA; Florez J. 1997. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res 749(2):238-44. [PubMed: 9138724] [MGI Ref ID J:39408]
Hill JM; Ades AM; McCune SK; Sahir N; Moody EM; Abebe DT; Crnic LS; Brenneman DE. 2003. Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome. Exp Neurol 183(1):56-65. [PubMed: 12957488] [MGI Ref ID J:85337]
Holtzman DM; Santucci D; Kilbridge J; Chua-Couzens J; Fontana DJ; Daniels SE; Johnson RM; Chen K; Sun Y; Carlson E; Alleva E; Epstein CJ; Mobley WC. 1996. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A 93(23):13333-8. [PubMed: 8917591] [MGI Ref ID J:36555]
Liu DP; Schmidt C; Billings T; Davisson MT. 2003. Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome. Biotechniques 35(6):1170-4, 1176, 1178 passim. [PubMed: 14682051] [MGI Ref ID J:112549]
Reeves RH; Irving NG; Moran TH; Wohn A; Kitt C; Sisodia SS; Schmidt C; Bronson RT; Davisson MT. 1995. A mouse model for Down syndrome exhibits learning and behaviour deficits [see comments] Nat Genet 11(2):177-84. [PubMed: 7550346] [MGI Ref ID J:29232]
Ts(1716)65Dn relatedAkeson EC; Lambert JP; Narayanswami S; Gardiner K; Bechtel LJ; Davisson MT. 2001. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Cytogenet Cell Genet 93(3-4):270-6. [PubMed: 11528125] [MGI Ref ID J:71031]
Aso S; Miyabara S; Sugihara H; Winking H. 2001. Comparative study of mouse trisomy 16 and bis-diamine treated fetuses: Discrimination of possible contribution of neural crest cells to malformations Cong Anom 41:169-176. [MGI Ref ID J:104833]
Ayberk Kurt M; Ilker Kafa M; Dierssen M; Ceri Davies D. 2004. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res 1022(1-2):101-9. [PubMed: 15353219] [MGI Ref ID J:92543]
Baxter LL; Moran TH; Richtsmeier JT; Troncoso J; Reeves RH. 2000. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet 9(2):195-202. [PubMed: 10607830] [MGI Ref ID J:59886]
Belichenko PV; Kleschevnikov AM; Salehi A; Epstein CJ; Mobley WC. 2007. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol 504(4):329-45. [PubMed: 17663443] [MGI Ref ID J:132525]
Belichenko PV; Masliah E; Kleschevnikov AM; Villar AJ; Epstein CJ; Salehi A; Mobley WC. 2004. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol 480(3):281-98. [PubMed: 15515178] [MGI Ref ID J:94569]
Berg BM; Croom J; Fernandez JM; Spears JW; Eisen EJ; Taylor IL; Daniel LR; Coles BA; Boeheim F; Mannon PJ. 2000. Peptide YY administration decreases brain aluminum in the Ts65Dn Down syndrome mouse model Growth Dev Aging 64(1-2):3-19. [PubMed: 10969882] [MGI Ref ID J:63856]
Best TK; Siarey RJ; Galdzicki Z. 2007. Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. J Neurophysiol 97(1):892-900. [PubMed: 17093127] [MGI Ref ID J:135917]
Bimonte-Nelson HA; Hunter CL; Nelson ME; Granholm AC. 2003. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav Brain Res 139(1-2):47-57. [PubMed: 12642175] [MGI Ref ID J:95711]
Casas C; Martinez S; Pritchard MA; Fuentes JJ; Nadal M; Guimera J; Arbones M; Florez J; Soriano E; Estivill X; Alcantara S. 2001. Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech Dev 101(1-2):289-92. [PubMed: 11231093] [MGI Ref ID J:68156]
Cataldo AM; Petanceska S; Peterhoff CM; Terio NB; Epstein CJ; Villar A; Carlson EJ; Staufenbiel M; Nixon RA. 2003. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23(17):6788-92. [PubMed: 12890772] [MGI Ref ID J:84685]
Cefalu JA; Croom WJ Jr; Eisen EJ; Jones EE; Daniel LR; Taylor IL. 1998. Jejunal function and plasma amino acid concentrations in the segmental trisomic Ts65Dn mouse. Growth Dev Aging 62(1-2):47-59. [PubMed: 9666356] [MGI Ref ID J:48496]
Chakrabarti L; Galdzicki Z; Haydar TF. 2007. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci 27(43):11483-95. [PubMed: 17959791] [MGI Ref ID J:127045]
Chang Q; Gold PE. 2008. Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. Neurobiol Learn Mem 89(2):167-77. [PubMed: 17644430] [MGI Ref ID J:128851]
Chrast R; Scott HS; Papasavvas MP; Rossier C; Antonarakis ES; Barras C; Davisson MT; Schmidt C; Estivill X; Dierssen M; Pritchard M; Antonarakis SE. 2000. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of down syndrome (Ts65Dn) and normals Genome Res 10(12):2006-21. [PubMed: 11116095] [MGI Ref ID J:66235]
Colas D; Valletta JS; Takimoto-Kimura R; Nishino S; Fujiki N; Mobley WC; Mignot E. 2008. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis 30(1):1-7. [PubMed: 18282758] [MGI Ref ID J:136520]
Contestabile A; Fila T; Bartesaghi R; Contestabile A; Ciani E. 2006. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J Neurochem 97(2):515-26. [PubMed: 16539660] [MGI Ref ID J:109560]
Cooper JD; Salehi A; Delcroix JD; Howe CL; Belichenko PV; Chua-Couzens J; Kilbridge JF; Carlson EJ; Epstein CJ; Mobley WC. 2001. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A 98(18):10439-44. [PubMed: 11504920] [MGI Ref ID J:95716]
Costa AC; Grybko MJ. 2005. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Neurosci Lett 382(3):317-22. [PubMed: 15925111] [MGI Ref ID J:99714]
Costa AC; Walsh K; Davisson MT. 1999. Motor dysfunction in a mouse model for Down syndrome. Physiol Behav 68(1-2):211-20. [PubMed: 10627083] [MGI Ref ID J:95719]
Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550] [MGI Ref ID J:117029]
Davisson MT; Schmidt C; Reeves RH; Irving NG; Akeson EC; Harris BS; Bronson RT. 1993. Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res 384:117-33. [PubMed: 8115398] [MGI Ref ID J:30229]
Demas GE; Nelson RJ; Krueger BK; Yarowsky PJ. 1998. Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav Brain Res 90(2):199-201. [PubMed: 9521551] [MGI Ref ID J:95722]
Dierssen M; Benavides-Piccione R; Martinez-Cue C; Estivill X; Florez J; Elston GN; DeFelipe J. 2003. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb Cortex 13(7):758-64. [PubMed: 12816891] [MGI Ref ID J:102148]
Dierssen M; Vallina IF; Baamonde C; Garcia-Calatayud S; Lumbreras MA; Florez J. 1997. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res 749(2):238-44. [PubMed: 9138724] [MGI Ref ID J:39408]
Escorihuela RM; Vallina IF; Martinez-Cue C; Baamonde C; Dierssen M; Tobena A; Florez J; Fernandez-Teruel A. 1998. Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 247(2-3):171-4. [PubMed: 9655620] [MGI Ref ID J:95721]
Fernandez F; Garner CC. 2008. Episodic-like memory in Ts65Dn, a mouse model of Down syndrome. Behav Brain Res 188(1):233-7. [PubMed: 17950473] [MGI Ref ID J:130535]
Galdzicki Z; Siarey R; Pearce R; Stoll J; Rapoport SI. 2001. On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res Brain Res Rev 35(2):115-45. [PubMed: 11336779] [MGI Ref ID J:69888]
Galdzicki Z; Siarey RJ. 2003. Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. Genes Brain Behav 2(3):167-78. [PubMed: 12931790] [MGI Ref ID J:104907]
Gotti S; Chiavegatto S; Sica M; Viglietti-Panzica C; Nelson RJ; Panzica G. 2004. Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome. Neurobiol Dis 16(3):563-71. [PubMed: 15262268] [MGI Ref ID J:91857]
Granholm AC; Ford KA; Hyde LA; Bimonte HA; Hunter CL; Nelson M; Albeck D; Sanders LA; Mufson EJ; Crnic LS. 2002. Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. Physiol Behav 77(2-3):371-85. [PubMed: 12419414] [MGI Ref ID J:95714]
Granholm AC; Sanders LA; Crnic LS. 2000. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp Neurol 161(2):647-63. [PubMed: 10686084] [MGI Ref ID J:60959]
Hampton TG; Stasko MR; Kale A; Amende I; Costa AC. 2004. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol Behav 82(2-3):381-9. [PubMed: 15276802] [MGI Ref ID J:95704]
Hanson JE; Blank M; Valenzuela RA; Garner CC; Madison DV. 2007. The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. J Physiol 579(Pt 1):53-67. [PubMed: 17158177] [MGI Ref ID J:140845]
Hill CA; Reeves RH; Richtsmeier JT. 2007. Effects of aneuploidy on skull growth in a mouse model of Down syndrome. J Anat 210(4):394-405. [PubMed: 17428201] [MGI Ref ID J:129637]
Hill JM; Ades AM; McCune SK; Sahir N; Moody EM; Abebe DT; Crnic LS; Brenneman DE. 2003. Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome. Exp Neurol 183(1):56-65. [PubMed: 12957488] [MGI Ref ID J:85337]
Holtzman DM; Santucci D; Kilbridge J; Chua-Couzens J; Fontana DJ; Daniels SE; Johnson RM; Chen K; Sun Y; Carlson E; Alleva E; Epstein CJ; Mobley WC. 1996. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A 93(23):13333-8. [PubMed: 8917591] [MGI Ref ID J:36555]
Huang W; Galdzicki Z; van Gelderen P; Balbo A; Chikhale EG; Schapiro MB; Rapoport SI. 2000. Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport 11(3):445-8. [PubMed: 10718292] [MGI Ref ID J:103600]
Hunter CL; Bimonte HA; Granholm AC. 2003. Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. Behav Brain Res 138(2):121-31. [PubMed: 12527443] [MGI Ref ID J:95712]
Hunter CL; Bimonte-Nelson HA; Nelson M; Eckman CB; Granholm AC. 2004. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiol Aging 25(7):873-84. [PubMed: 15212841] [MGI Ref ID J:95707]
Hunter CL; Isacson O; Nelson M; Bimonte-Nelson H; Seo H; Lin L; Ford K; Kindy MS; Granholm AC. 2003. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci Res 45(4):437-45. [PubMed: 12657457] [MGI Ref ID J:95710]
Hyde LA; Crnic LS. 2002. Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease. Brain Res 945(1):26-30. [PubMed: 12113948] [MGI Ref ID J:78188]
Hyde LA; Frisone DF; Crnic LS. 2001. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Behav Brain Res 118(1):53-60. [PubMed: 11163633] [MGI Ref ID J:95717]
Insausti AM; Megias M; Crespo D; Cruz-Orive LM; Dierssen M; Vallina IF; Insausti R; Florez J. 1998. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neurosci Lett 253(3):175-8. [PubMed: 9792239] [MGI Ref ID J:95720]
Kahlem P; Sultan M; Herwig R; Steinfath M; Balzereit D; Eppens B; Saran NG; Pletcher MT; South ST; Stetten G; Lehrach H; Reeves RH; Yaspo ML. 2004. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res 14(7):1258-67. [PubMed: 15231742] [MGI Ref ID J:95706]
Kirsammer G; Jilani S; Liu H; Davis E; Gurbuxani S; Le Beau MM; Crispino JD. 2008. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111(2):767-75. [PubMed: 17901249] [MGI Ref ID J:130041]
Kleschevnikov AM; Belichenko PV; Villar AJ; Epstein CJ; Malenka RC; Mobley WC. 2004. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 24(37):8153-60. [PubMed: 15371516] [MGI Ref ID J:95702]
Kurt MA; Davies DC; Kidd M; Dierssen M; Florez J. 2000. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res 858(1):191-7. [PubMed: 10700614] [MGI Ref ID J:95718]
Lorenzi HA; Reeves RH. 2006. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res 1104(1):153-9. [PubMed: 16828061] [MGI Ref ID J:111633]
Lyle R; Gehrig C; Neergaard-Henrichsen C; Deutsch S; Antonarakis SE. 2004. Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. Genome Res 14(7):1268-74. [PubMed: 15231743] [MGI Ref ID J:95705]
Martinez-Cue C; Baamonde C; Lumbreras M; Paz J; Davisson MT; Schmidt C; Dierssen M; Florez J. 2002. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 134(1-2):185-200. [PubMed: 12191805] [MGI Ref ID J:95715]
Martinez-Cue C; Rueda N; Garcia E; Davisson MT; Schmidt C; Florez J. 2005. Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav Brain Res 163(2):174-85. [PubMed: 15941601] [MGI Ref ID J:100647]
Martinez-Cue C; Rueda N; Garcia E; Florez J. 2006. Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome. Genes Brain Behav 5(5):413-22. [PubMed: 16879635] [MGI Ref ID J:123653]
Megias M; Verduga R; Dierssen M; Florez J; Insausti R; Crespo D. 1997. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport 8(16):3475-8. [PubMed: 9427310] [MGI Ref ID J:103727]
Moore CS. 2006. Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. Mamm Genome 17(10):1005-12. [PubMed: 17019652] [MGI Ref ID J:115042]
Moran TH; Capone GT; Knipp S; Davisson MT; Reeves RH; Gearhart JD. 2002. The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol Behav 77(2-3):403-9. [PubMed: 12419416] [MGI Ref ID J:95713]
O'Leary DA; Pritchard MA; Xu D; Kola I; Hertzog PJ; Ristevski S. 2004. Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS. Biochim Biophys Acta 1739(1):81-7. [PubMed: 15607120] [MGI Ref ID J:95701]
Olson LE; Richtsmeier JT; Leszl J; Reeves RH. 2004. A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science 306(5696):687-90. [PubMed: 15499018] [MGI Ref ID J:93223]
Olson LE; Roper RJ; Baxter LL; Carlson EJ; Epstein CJ; Reeves RH. 2004. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn 230(3):581-9. [PubMed: 15188443] [MGI Ref ID J:91221]
Olson LE; Roper RJ; Sengstaken CL; Peterson EA; Aquino V; Galdzicki Z; Siarey R; Pletnikov M; Moran TH; Reeves RH. 2007. Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. Hum Mol Genet 16(7):774-82. [PubMed: 17339268] [MGI Ref ID J:121764]
Palminiello S; Kida E; Kaur K; Walus M; Wisniewski KE; Wierzba-Bobrowicz T; Rabe A; Albertini G; Golabek AA. 2008. Increased levels of carbonic anhydrase II in the developing Down syndrome brain. Brain Res 1190:193-205. [PubMed: 18083150] [MGI Ref ID J:130837]
Paz-Miguel JE; Flores R; Sanchez-Velasco P; Ocejo-Vinyals G; Escribano de Diego J; Lopez de Rego J; Leyva-Cobian F. 1999. Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome. J Immunol 163(10):5399-410. [PubMed: 10553065] [MGI Ref ID J:58452]
Paz-Miguel JE; Pardo-Manuel de Villena F; Sanchez-Velasco P; Leyva-Cobian F. 2001. H2-haplotype-dependent unequal transmission of the 17(16) translocation chromosome from Ts65Dn females. Mamm Genome 12(1):83-5. [PubMed: 11178750] [MGI Ref ID J:68688]
Pollonini G; Gao V; Rabe A; Palminiello S; Albertini G; Alberini CM. 2008. Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience 156(1):99-106. [PubMed: 18703118] [MGI Ref ID J:140854]
Rachidi M; Lopes C. 2007. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res 59(4):349-69. [PubMed: 17897742] [MGI Ref ID J:128743]
Reeves RH; Irving NG; Moran TH; Wohn A; Kitt C; Sisodia SS; Schmidt C; Bronson RT; Davisson MT. 1995. A mouse model for Down syndrome exhibits learning and behaviour deficits [see comments] Nat Genet 11(2):177-84. [PubMed: 7550346] [MGI Ref ID J:29232]
Richtsmeier JT; Baxter LL; Reeves RH. 2000. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn 217(2):137-45. [PubMed: 10706138] [MGI Ref ID J:60229]
Richtsmeier JT; Zumwalt A; Carlson EJ; Epstein CJ; Reeves RH. 2002. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317-24. [PubMed: 11840489] [MGI Ref ID J:73800]
Roper RJ; Baxter LL; Saran NG; Klinedinst DK; Beachy PA; Reeves RH. 2006. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. Proc Natl Acad Sci U S A 103(5):1452-6. [PubMed: 16432181] [MGI Ref ID J:105996]
Roper RJ; St John HK; Philip J; Lawler A; Reeves RH. 2006. Perinatal Loss of Ts65Dn Down Syndrome Mice. Genetics 172(1):437-43. [PubMed: 16172497] [MGI Ref ID J:105157]
Rueda N; Florez J; Martinez-Cue C. 2008. Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav Brain Res 188(2):355-67. [PubMed: 18178265] [MGI Ref ID J:131326]
Rueda N; Mostany R; Pazos A; Florez J; Martinez-Cue C. 2005. Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neurosci Lett 380(1-2):197-201. [PubMed: 15854777] [MGI Ref ID J:97980]
Sago H; Carlson EJ; Smith DJ; Rubin EM; Crnic LS; Huang TT; Epstein CJ. 2000. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48(5):606-13. [PubMed: 11044479] [MGI Ref ID J:86822]
Salehi A; Delcroix JD; Belichenko PV; Zhan K; Wu C; Valletta JS; Takimoto-Kimura R; Kleschevnikov AM; Sambamurti K; Chung PP; Xia W; Villar A; Campbell WA; Kulnane LS; Nixon RA; Lamb BT; Epstein CJ; Stokin GB; Goldstein LS; Mobley WC. 2006. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29-42. [PubMed: 16815330] [MGI Ref ID J:122937]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Breeding & Husbandry Male carriers are sterile. This strain is karyotyped at each generation.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse Price $202.80 Female or Male Trisomic for Chromosome 16
Pairs /Price (US dollars $) Pair Genotype $294.20 Trisomic for Chromosome 16 x B6EiC3SnF1/J (001875)
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse Price $263.70 Female or Male Trisomic for Chromosome 16
Pairs /Price (US dollars $) Pair Genotype $382.50 Trisomic for Chromosome 16 x B6EiC3SnF1/J (001875)
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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| Important Note | Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind. |
| Request Form |
Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire. |
Control Information
| Control | ||
|---|---|---|
| Wild-type littermate | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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