Strain Name:

EL/SuzSeyFrkJ

Stock Number:

001956

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names EL/Suz    (Changed: 15-DEC-04 )
Epilepsy    (Changed: 15-DEC-04 )
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
H2 Haplotypeb

Appearance
albino
Related Genotype: Tyrc/Tyrc

Description
The EL/Suz inbred strain provides a polygenic model for the study of epilepsy. EL/Suz mice experience recurrent seizures that resemble a common partial complex epilepsy seen in humans. Seizures occur spontaneously beginning around 90-100 days of age, but can be induced in younger mice and analyzed as a semi-quantitative trait after gentle rhythmic stimulation. Quantitative trait analysis has revealed multiple loci (e.g. El1, El2, and El3) that contribute to this phenotype whose effects vary depending on the genetic background. The inbred strain DDY/Jcl (Stock No. 002243) may serve as a control strain for EL/Suz as they are is less susceptible to seizures under similar conditions.

Related Strains

EL Strains
002813   EL/EFrkJ
View EL Strains     (1 strain)

Strains carrying   El1EL allele
003015   ABP.EL-El1EL/FrkJ
View Strains carrying   El1EL     (1 strain)

Strains carrying   El2EL allele
002815   ABP.EL-El2EL/FrkJ
View Strains carrying   El2EL     (1 strain)

Phenotype

Phenotype Information

View Phenotypic Data

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Epilepsy

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol El1EL
Allele Name EL
Allele Type QTL
Common Name(s) EL;
Strain of OriginEL
Gene Symbol and Name El1, epilepsy 1
Chromosome 9
Gene Common Name(s) El; El-1;
General Note The EL mouse strain was developed from mice with an increased susceptibility for epilepsy. These mice were first reported as a spontaneous mutation arising in the DDY strain. The succeptibility for epilepsy was subsequently shown to be the result of alleles at two or more loci.
Molecular Note This allele confers susceptibility to epileptic seizures compared to ABP/LeJ and DBA/2J. [MGI Ref ID J:11381]
 
Allele Symbol El2EL
Allele Name EL
Allele Type QTL
Common Name(s) EL;
Strain of OriginEL
Gene Symbol and Name El2, epilepsy 2
Chromosome 2
Gene Common Name(s) El-2;
General Note The EL mouse strain was developed from mice with an increased succeptibility for epilepsy. These mice were first reported as a spontaneous mutation arising in the DDY strain. The succeptibility for epilepsy was subsequently shown to be the result of alleles at two or more loci.
Molecular Note This allele confers susceptibility to epileptic seizures compared to ABP/LeJ. [MGI Ref ID J:11381]
 
Allele Symbol El3EL/Suz
Allele Name EL/Suz
Allele Type QTL
Strain of OriginEL/SuzSeyFrkJ
Gene Symbol and Name El3, epilepsy 3
Chromosome 10
Molecular Note This allele confers seizure susceptibility compared to ABP/LeJ. [MGI Ref ID J:30433]
 
Allele Symbol El4EL/Suz
Allele Name EL/Suz
Allele Type QTL
Strain of OriginEL/SuzSeyFrkJ
Gene Symbol and Name El4, epilepsy 4
Chromosome 9
General Note This allele is consistent with additive or recessive inheritance. El4 participates in epistatic interactions with El5.
Molecular Note This allele confers seizure susceptibility compared to ABP/LeJ and DDY/Jcl. [MGI Ref ID J:30433]
 
Allele Symbol El5EL/Suz
Allele Name EL/Suz
Allele Type QTL
Strain of OriginEL/SuzSeyFrkJ
Gene Symbol and Name El5, epilepsy 5
Chromosome 14
General Note This allele is consistent with additive or dominant inheritance. El5 participates in epistatic interactions with El4.
Molecular Note This allele confers seizure susceptibility compared to DDY/Jcl. [MGI Ref ID J:30433]
 
Allele Symbol El6EL/Suz
Allele Name EL/Suz
Allele Type QTL
Strain of OriginEL/SuzSeyFrkJ
Gene Symbol and Name El6, epilepsy 6
Chromosome 11

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Frankel WN; Valenzuela A; Lutz CM; Johnson EW; Dietrich WF; Coffin JM. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6(12):830-8. [PubMed: 8747920]  [MGI Ref ID J:30433]

Wang H; Burdette LJ; Frankel WN; Masukawa LM. 1997. Paroxysmal discharges in the EL mouse, a genetic model of epilepsy. Brain Res 760(1-2):266-71. [PubMed: 9237545]  [MGI Ref ID J:41700]

El1EL related

Akasaki Y. 1993. The effect of phenobarbital on the multiple neuronal activity in the hippocampus of El mice. Jpn J Psychiatry Neurol 47(1):121-9. [PubMed: 8411783]  [MGI Ref ID J:16541]

Buchhalter JR. 1993. Animal models of inherited epilepsy. Epilepsia 34 Suppl 3:S31-41. [PubMed: 8500431]  [MGI Ref ID J:13333]

Flavin HJ; Seyfried TN. 1994. Enhanced aspartate release related to epilepsy in (EL) mice. J Neurochem 63(2):592-5. [PubMed: 7913488]  [MGI Ref ID J:19277]

Frankel WN; Johnson EW; Lutz CM. 1995. Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci. Mamm Genome 6(12):839-43. [PubMed: 8747921]  [MGI Ref ID J:30434]

Green RC; Seyfried TN. 1991. Kindling susceptibility and genetic seizure predisposition in inbred mice. Epilepsia 32(1):22-6. [PubMed: 1985826]  [MGI Ref ID J:25806]

Honda T. 1984. Amino acid metabolism in the brain with convulsive disorders. Part 2: The effects of anticonvulsants on convulsions and free amino acid patterns in the brain of El mouse. Brain Dev 6(1):22-6. [PubMed: 6329016]  [MGI Ref ID J:7468]

Imaizumi K. 1959. Epilepsy-like anomaly of mice Bull Exp Anim 8:6-10.  [MGI Ref ID J:26433]

Imaizumi K; Nakano T. 1964. El Mouse News Lett 31:57.  [MGI Ref ID J:13427]

Kabuto H; Yokoi I; Takei M; Kurimoto T; Mori A. 1994. The anticonvulsant effect of citalopram on El mice, and the levels of tryptophan and tyrosine and their metabolites in the brain. Neurochem Res 19(4):463-7. [PubMed: 7520538]  [MGI Ref ID J:20749]

Kai T; Onishi H; Koide S; Katayama M; Yamagami S. 1998. Developmental and regional alteration of kappa-opioid receptors in seizure-susceptible EL mouse brain. Neurochem Res 23(2):163-8. [PubMed: 9475510]  [MGI Ref ID J:47517]

King JT Jr; LaMotte CC. 1989. El mouse as a model of focal epilepsy: a review. Epilepsia 30(3):257-65. [PubMed: 2498069]  [MGI Ref ID J:109509]

Koide S; Onishi H; Katayama M; Kai T; Yamagami S. 1995. HPLC/RIA analysis of bioactive methionine enkephalin content in the seizure-susceptible El mouse brain. Neurochem Res 20(9):1115-8. [PubMed: 8570017]  [MGI Ref ID J:29830]

Koide S; Onishi H; Katayama M; Yamagami S. 1993. Endogenous methionine enkephalin may play an anticonvulsant role in the seizure-susceptible El mouse. Neurochem Res 18(12):1259-62. [PubMed: 8272192]  [MGI Ref ID J:21562]

Koide S; Onishi H; Katayama M; Yamagami S. 1995. Metabolic profile of opioid peptides differs in the hippocampus and striatum of seizure-susceptible E1 mice. Neurochem Res 20(3):279-83. [PubMed: 7609826]  [MGI Ref ID J:28334]

Lambert JD; Fueta Y; Roepstorff A; Andreasen M. 1996. Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El. Epilepsy Res 26(1):15-23. [PubMed: 8985682]  [MGI Ref ID J:40115]

Lewis SM; Lee FS; Todorova M; Seyfried TN; Ueda T. 1997. Synaptic vesicle glutamate uptake in epileptic (EL) mice. Neurochem Int 31(4):581-5. [PubMed: 9308008]  [MGI Ref ID J:45739]

Masuda Y; Miura N; Kawarada Y; Kawagoe M; Shimizu T; Sugiyama T; Hishikawa Y. 1996. Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El. Biochem Biophys Res Commun 223(1):60-3. [PubMed: 8660379]  [MGI Ref ID J:33499]

Mita T; Sashihara S; Aramaki I; Fueta Y; Hirano H. 1991. Unusual biochemical development of genetically seizure-susceptible El mice. Brain Res Dev Brain Res 64(1-2):27-35. [PubMed: 1664788]  [MGI Ref ID J:76]

Morioka R; Kato A; Fueta Y; Sugiyama H. 2001. Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse. Neurosci Lett 313(1-2):99-101. [PubMed: 11684349]  [MGI Ref ID J:107940]

Murashima YL; Kassamo K; Suzuki J. 1996. Developmental and seizure-related regional differences in immediate early gene expression and GABAergic abnormalities in the brain of EL mice. Epilepsy Res 26(1):3-14. [PubMed: 8985681]  [MGI Ref ID J:37961]

Nagatomo I; Akasaki Y; Kuchiiwa S; Nakagawa S; Takigawa M. 1996. Sparse distribution of NADPH diaphorase neurons in the hippocampal formation of the inbred mutant strain EL mouse. Brain Res 730(1-2):223-6. [PubMed: 8883907]  [MGI Ref ID J:35418]

Nagatomo I; Akasaki Y; Nagase F; Nomaguchi M; Takigawa M. 1996. Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. Brain Res 731(1-2):190-8. [PubMed: 8883869]  [MGI Ref ID J:35422]

Nagatomo I; Akasaki Y; Uchida M; Kuchiiwa S; Nakagawa S; Takigawa M. 1998. Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse. Brain Res 789(2):213-20. [PubMed: 9573368]  [MGI Ref ID J:47598]

Nagatomo I; Akasaki Y; Uchida M; Tominaga M; Hashiguchi W; Kuchiiwa S; Nakagawa S; Takigawa M. 2000. Age-related alterations of nitric oxide production in the brains of seizure-susceptible EL mice. Brain Res Bull 53(3):301-6. [PubMed: 11113584]  [MGI Ref ID J:102825]

Nakagawa Y; Asai H; Miura T; Kitoh J; Mori H; Nakano K. 1998. Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice. Brain Res Mol Brain Res 58(1-2):132-7. [PubMed: 9685612]  [MGI Ref ID J:49051]

Nakagawa Y; Mishima T; Murashima YL; Nakano K. 2002. Increased expression of mitochondrial respiratory enzymes in the brain of epilepsy-prone, naive EL mice. Brain Res Mol Brain Res 101(1-2):59-61. [PubMed: 12007832]  [MGI Ref ID J:109336]

Nakano H; Saito K; Ogashiwa M; Suzuki K. 1993. Referential derivation of epidural electroencephalogram in El mice. J Vet Med Sci 55(1):39-43. [PubMed: 8461425]  [MGI Ref ID J:12209]

Nakano H; Saito K; Suzuki K. 1994. Chronic implantation technique for monopolar EEG monitoring of epileptic seizures in mice. Brain Res Bull 35(3):261-8. [PubMed: 7812807]  [MGI Ref ID J:37880]

Nakano H; Saito K; Suzuki K. 1996. Clinico-ECoG correlate of megimide-induced epileptic seizures in epilepsy-prone El and its mother strain nonepileptic ddY mice. Physiol Behav 60(3):809-16. [PubMed: 8873255]  [MGI Ref ID J:35600]

Oguro K; Ito M; Tsuda H; Mutoh K; Shiraishi H; Shirasaka Y; Mikawa H. 1991. Association of NMDA receptor sites and seizures of El mice. Epilepsy Res 9(3):225-30. [PubMed: 1835927]  [MGI Ref ID J:535]

Onishi H; Yamagami S; Mori K; Kawakita Y. 1984. Effect of convulsions of the synthesis of heterogeneous nuclear RNA associated with polyadenylate and oligoadenylate sequences from El mouse brain as a convulsive strain. Exp Neurol 83(1):98-107. [PubMed: 6690328]  [MGI Ref ID J:7270]

Ono T; Fueta Y; Janjua NA; Ohmori O; Ohno K; Murai Y; Mita T. 1997. Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice. Brain Res 745(1-2):165-72. [PubMed: 9037406]  [MGI Ref ID J:38137]

Rise M; Seyfried T. 1990. Localization of a gene for hippocampal epilepsy to Chromosome 9. Mouse Genome 86:219-20.  [MGI Ref ID J:14263]

Rise ML; Frankel WN; Coffin JM; Seyfried TN. 1991. Genes for epilepsy mapped in the mouse. Science 253(5020):669-73. [PubMed: 1871601]  [MGI Ref ID J:11381]

Sashihara S; Yanagihara N; Izumi F; Murai Y; Mita T. 1994. Differential up-regulation of voltage-dependent Na+ channels induced by phenytoin in brains of genetically seizure-susceptible (E1) and control (ddY) mice. Neuroscience 62(3):803-11. [PubMed: 7870308]  [MGI Ref ID J:21829]

Seyfried TN; Todorova MT; Poderycki MJ. 1999. Experimental models of multifactorial epilepsies: the EL mouse and mice susceptible to audiogenic seizures. Adv Neurol 79:279-90. [PubMed: 10514820]  [MGI Ref ID J:59738]

Shiotani T; Nakamoto Y; Watabe S; Yoshii M; Nabeshima T. 2000. Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res 859(2):255-61. [PubMed: 10719072]  [MGI Ref ID J:61116]

Takaki M; Ueda Y; Doi T; Nagatomo K; Murashima YL; Kannan H. 2008. Molecular regulation of antioxidant ability in the hippocampus of EL mice. Brain Res 1228:1-5. [PubMed: 18621028]  [MGI Ref ID J:139981]

Takaki M; Ueda Y; Doi T; Nagatomo K; Murashima YL; Nakajima A; Kannan H. 2007. Age-dependent changes in the hippocampal antioxidant ability of EL mice. Neurosci Res 58(3):336-8. [PubMed: 17482702]  [MGI Ref ID J:136760]

Takeda A; Hanajima T; Ijiro H; Ishige A; Iizuka S; Okada S; Oku N. 1999. Release of zinc from the brain of El (epilepsy) mice during seizure induction. Brain Res 828(1-2):174-8. [PubMed: 10320739]  [MGI Ref ID J:55041]

Tsuda H; Ito M; Oguro K; Mutoh K; Shiraishi H; Shirasaka Y; Mikawa H. 1993. Age- and seizure-related changes in noradrenaline and dopamine in several brain regions of epileptic El mice. Neurochem Res 18(2):111-7. [PubMed: 8474554]  [MGI Ref ID J:3754]

Uchibori M; Saito K; Yokoyama S; Sakamoto Y; Suzuki H; Tsuji T; Suzuki K. 2002. Foci identification of spike discharges in the EEGs of sleeping El mice based on the electric field model and wavelet decomposition of multi monopolar derivations. J Neurosci Methods 117(1):51-63. [PubMed: 12084564]  [MGI Ref ID J:102974]

Uchida M; Nagatomo I; Akasaki Y; Tominaga M; Hashiguchi W; Kuchiiwa S; Nakagawa S; Takigawa M. 1999. Nitric oxide production is decreased in the brain of the seizure susceptible EL mouse. Brain Res Bull 50(4):223-7. [PubMed: 10582520]  [MGI Ref ID J:102803]

Wang H; Burdette LJ; Frankel WN; Masukawa LM. 1997. Paroxysmal discharges in the EL mouse, a genetic model of epilepsy. Brain Res 760(1-2):266-71. [PubMed: 9237545]  [MGI Ref ID J:41700]

Yamada Y; Nakano K. 1999. Increased expression of mitochondrial respiratory enzymes in the brain of activated epilepsy-prone El mice. Brain Res Mol Brain Res 73(1-2):186-8. [PubMed: 10581412]  [MGI Ref ID J:58624]

Yoneda Y; Enomoto R; Ogita K; Kabuto H; Mori A. 1994. Possible dysfunction of ionotropic glutamate receptors in cerebellum of epileptic E1 mouse brain. Neurochem Int 25(3):273-85. [PubMed: 7833795]  [MGI Ref ID J:24029]

Yoneda Y; Ogita K; Kabutoz H; Mori A. 1993. Selectively high expression of the transcription factor AP1 in telencephalic structures of epileptic E1 mice. Neurosci Lett 161(2):161-4. [PubMed: 8272259]  [MGI Ref ID J:17918]

El2EL related

Frankel WN; Johnson EW; Lutz CM. 1995. Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci. Mamm Genome 6(12):839-43. [PubMed: 8747921]  [MGI Ref ID J:30434]

Imaizumi K. 1959. Epilepsy-like anomaly of mice Bull Exp Anim 8:6-10.  [MGI Ref ID J:26433]

Imaizumi K; Nakano T. 1964. El Mouse News Lett 31:57.  [MGI Ref ID J:13427]

King JT Jr; LaMotte CC. 1989. El mouse as a model of focal epilepsy: a review. Epilepsia 30(3):257-65. [PubMed: 2498069]  [MGI Ref ID J:109509]

Legare ME; Bartlett FS; Frankel WN. 2000. A major effect QTL determined by multiple genes in epileptic EL mice. Genome Res 10(1):42-8. [PubMed: 10645948]  [MGI Ref ID J:60160]

Mita T; Kawazu I; Hirano H; Ohmori O; Janjua N; Shibata K. 2001. E1 mice epilepsy shows genetic polymorphism for S-Adenosyl-L-homocysteine hydrolase. Neurochem Int 38(4):349-57. [PubMed: 11137630]  [MGI Ref ID J:103079]

Nakagawa Y; Mishima T; Murashima YL; Nakano K. 2002. Increased expression of mitochondrial respiratory enzymes in the brain of epilepsy-prone, naive EL mice. Brain Res Mol Brain Res 101(1-2):59-61. [PubMed: 12007832]  [MGI Ref ID J:109336]

Rise ML; Frankel WN; Coffin JM; Seyfried TN. 1991. Genes for epilepsy mapped in the mouse. Science 253(5020):669-73. [PubMed: 1871601]  [MGI Ref ID J:11381]

Todorova MT; Mantis JG; Le M; Kim CY; Seyfried TN. 2006. Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice. Genes Brain Behav 5(7):518-27. [PubMed: 17010098]  [MGI Ref ID J:114157]

El3EL/Suz related

Frankel WN; Valenzuela A; Lutz CM; Johnson EW; Dietrich WF; Coffin JM. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6(12):830-8. [PubMed: 8747920]  [MGI Ref ID J:30433]

El4EL/Suz related

Frankel WN; Johnson EW; Lutz CM. 1995. Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci. Mamm Genome 6(12):839-43. [PubMed: 8747921]  [MGI Ref ID J:30434]

Frankel WN; Valenzuela A; Lutz CM; Johnson EW; Dietrich WF; Coffin JM. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6(12):830-8. [PubMed: 8747920]  [MGI Ref ID J:30433]

Todorova MT; Mantis JG; Le M; Kim CY; Seyfried TN. 2006. Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice. Genes Brain Behav 5(7):518-27. [PubMed: 17010098]  [MGI Ref ID J:114157]

El5EL/Suz related

Frankel WN; Valenzuela A; Lutz CM; Johnson EW; Dietrich WF; Coffin JM. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6(12):830-8. [PubMed: 8747920]  [MGI Ref ID J:30433]

El6EL/Suz related

Frankel WN; Valenzuela A; Lutz CM; Johnson EW; Dietrich WF; Coffin JM. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6(12):830-8. [PubMed: 8747920]  [MGI Ref ID J:30433]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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