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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C3A Pde6brd1.O20/A-RdsRd2/J (Changed: 08-DEC-06 ) C3A Pde6brd1.O20/A-Prph2Rd2 (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Important Note
See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.Development
This strain was developed in the laboratory of Dr. Willem J. De Grip at Erasmus Universiteit, Rotterdam, the Netherlands. Mice of strains homozygous for Prph2Rd2 and for Pde6brd1 were crossed to produce double heterozygotes; these F1 animals were then intercrossed, and mice homozygous for both mutations were selected from the F2 for further breeding. The Pde6brd1 strain used was derived from an intercross following 8 generations of backcrossing the wild type Pde6b allele from C57BL/LiA onto the C3Hf/HeA background; this homozygous Pde6brd1/Pde6brd1 line was the partner strain of the homozygous Pde6b wildtype strain C3A.BLiA-+Pdeb (Stock No. 001912), derived from the same intercross. The latter was the parent strain of the Prph2Rd2 strain, C3HeA.BLiA-+Pde6b.O20A-Prph2Rd2 (see Stock No. 001979), used in the initial cross leading to the present strain (Schalken et al. 1990; S. Sanyal, personal communication). Thus, the background of Stock No. 001957 is primarily C3Hf/HeA, but small regions of the genome may be derived from O20/A and/or from C57BL/LiA.
Control Information
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Control for Pde6brd1 alone: C3HeA.BLiA-+Pde6b.020-RdsRd2 (Stock No. 001979) Control for RdsRd2 alone: C3H/HeJ (Stock No. 000659) | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001981 O20/A-Prph2Rd2/J
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004821 C57BL/6J-Prph2Nmf193/J
Additional Web Information
JAX® NOTES, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Pde6brd1/Pde6brd1 Prph2Rd2/Prph2Rd2
either: C.Cg-Pde6brd1 Prph2Rd2 or C3.Cg-Pde6brd1 Prph2Rd2
- vision/eye phenotype
- abnormal Muller cell morphology (MGI Ref ID J:27850)
- increase in density of Muller cells and fibers is intermediate compared to the single homozygotes
- absent photoreceptor outer segment (MGI Ref ID J:27850)
- remaining photoreceptor cells lack outer segments
- retinal photoreceptor degeneration (MGI Ref ID J:27850)
- the rate of photoreceptor loss is slower than in Pde6brd1 single homozygotes
- nervous system phenotype
- abnormal Muller cell morphology (MGI Ref ID J:27850)
- increase in density of Muller cells and fibers is intermediate compared to the single homozygotes
- absent photoreceptor outer segment (MGI Ref ID J:27850)
- remaining photoreceptor cells lack outer segments
- retinal photoreceptor degeneration (MGI Ref ID J:27850)
- the rate of photoreceptor loss is slower than in Pde6brd1 single homozygotes
Pde6brd1/Pde6brd1 Prph2Rd2/Prph2Rd2
involves: C3Hf/HeA * C57BL/LiA * O20/A
- vision/eye phenotype
- retinal outer nuclear layer degeneration (MGI Ref ID J:12044)
- mice exhibit a lesser degeneration than in Pde6brd1 homozygotes
Prph2Rd2/Prph2Rd2
involves: BALB/c * O20/AThis mouse can be used to support research in many areas including:Pde6brd1 related
Prph2Rd2 relatedMouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Mouse/Human Gene Homologs
retinal degeneration, slow
Research Tools
Sensorineural Research
retinal degeneration
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Pde6brd1 | ||
|---|---|---|---|
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| General Note | CBA/J mice carry this allele. | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
| Allele Symbol | Prph2Rd2 | ||
| Allele Name | retinal degeneration 2 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Prph2Rds; Rd-2; Rds; RdsRd2; rds-; retinal degeneration slow; | ||
| Strain of Origin | O20/A | ||
| Gene Symbol and Name | Prph2, peripherin 2 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | AOFMD; AVMD; Nmf193; PRPH; RDS; RP7; RSRDS; Rd-2; Rd2; Rds; TSPAN22; neuroscience mutagenesis facility, 193; retinal degeneration 2; retinal degeneration, slow; retinal degeneration, slow (retinitis pigmentosa 7); | ||
| Molecular Note | The mutation is an insertion of approximately 10 kb in the gene after nucleotide 899 (numbering of the encoded mRNA), disrupting the protein coding sequence in exon 2. The inserted DNA was similar to both the TSE of mice, repeated elements found in the H2 complex, and to the mouse early transposon (ETn). Northern blot analysis demonstrated that an aberrant 12 kb transcript was produced from this allele, although at reduced levels compared to wild-type. This allele is predicted to encode a truncated protein with its carboxy terminal 116 amino acids replaced by 35 amino acids from sequences in the insertion. Mutant mice doubly homozygous for two retinal degeneration mutations (Pde6brd1 and RdsRd2) shows an intermediate level of mRNAs for the beta subunit of cGMP-PDE and for several other phototransduction related proteins, suggesting an interaction between Pde6brd1 and RdsRd2. [MGI Ref ID J:2579] [MGI Ref ID J:9635] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9. [PubMed: 2137350] [MGI Ref ID J:109932]
Additional References
Pde6brd1 relatedPrph2Rd2 relatedAcosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. [PubMed: 16163270] [MGI Ref ID J:103970]
Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. [PubMed: 19524569] [MGI Ref ID J:151412]
Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. [PubMed: 18326735] [MGI Ref ID J:133024]
Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. [PubMed: 17471069] [MGI Ref ID J:122802]
Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. [PubMed: 15451375] [MGI Ref ID J:92980]
Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. [PubMed: 16626665] [MGI Ref ID J:109668]
Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. [PubMed: 15003290] [MGI Ref ID J:121036]
Ardayfio P; Moon J; Leung KK; Youn-Hwang D; Kim KS. 2008. Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Neurobiol Dis :. [PubMed: 18573342] [MGI Ref ID J:136304]
Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye. Mol Vis 11:298-308. [PubMed: 15889014] [MGI Ref ID J:98579]
Azadi S; Paquet-Durand F; Medstrand P; van Veen T; Ekstrom PA. 2006. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31(4):759-73. [PubMed: 16503160] [MGI Ref ID J:108601]
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Ball SL; Powers PA; Shin HS; Morgans CW; Peachey NS; Gregg RG. 2002. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci 43(5):1595-603. [PubMed: 11980879] [MGI Ref ID J:80080]
Bi A; Cui J; Ma YP; Olshevskaya E; Pu M; Dizhoor AM; Pan ZH. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50(1):23-33. [PubMed: 16600853] [MGI Ref ID J:122947]
Bibb LC; Holt JK; Tarttelin EE; Hodges MD; Gregory-Evans K; Rutherford A; Lucas RJ; Sowden JC; Gregory-Evans CY. 2001. Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet 10(15):1571-9. [PubMed: 11468275] [MGI Ref ID J:70841]
Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. J Comp Neurol 174(2):317-27. [PubMed: 864040] [MGI Ref ID J:5812]
Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] Proc Natl Acad Sci U S A 86(24):9722-6. [PubMed: 2481314] [MGI Ref ID J:10184]
Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] Nature 347(6294):677-80. [PubMed: 1977087] [MGI Ref ID J:10777]
Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 90(7):2955-9. [PubMed: 8385352] [MGI Ref ID J:4366]
Bumsted KM; Rizzolo LJ; Barnstable CJ. 2001. Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Exp Eye Res 73(3):383-92. [PubMed: 11520113] [MGI Ref ID J:115620]
Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. Am J Anat 133(2):179-212. [PubMed: 5009246] [MGI Ref ID J:5250]
Cameron MA; Pozdeyev N; Vugler AA; Cooper H; Iuvone PM; Lucas RJ. 2009. Light regulation of retinal dopamine that is independent of melanopsin phototransduction. Eur J Neurosci 29(4):761-7. [PubMed: 19200071] [MGI Ref ID J:146469]
Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17(6):489-98. [PubMed: 659071] [MGI Ref ID J:5988]
Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8(4):423-30. [PubMed: 9054517] [MGI Ref ID J:39262]
Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408] [MGI Ref ID J:59343]
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323(5911):256-9. [PubMed: 19131628] [MGI Ref ID J:143166]
Cohen AI; Blazynski C. 1990. Dopamine and its agonists reduce a light-sensitive pool of cyclic AMP in mouse photoreceptors. Vis Neurosci 4(1):43-52. [PubMed: 1702315] [MGI Ref ID J:78184]
Danciger M; Bowes C; Kozak CA; LaVail MM; Farber DB. 1990. Fine mapping of a putative rd cDNA and its co-segregation with rd expression. Invest Ophthalmol Vis Sci 31(8):1427-32. [PubMed: 1974892] [MGI Ref ID J:10689]
Daniels DM; Stoddart CW; Martin-Iverson MT; Lai CM; Redmond TM; Rakoczy PE. 2003. Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65(-/-) mice. Physiol Behav 79(4-5):701-11. [PubMed: 12954412] [MGI Ref ID J:96439]
Davis RJ; Tosi J; Janisch KM; Kasanuki JM; Wang NK; Kong J; Tsui I; Cilluffo M; Woodruff ML; Fain GL; Lin CS; Tsang SH. 2008. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci 49(11):5067-76. [PubMed: 18658088] [MGI Ref ID J:141984]
Delyfer MN; Forster V; Neveux N; Picaud S; Leveillard T; Sahel JA. 2005. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol Vis 11:688-96. [PubMed: 16163266] [MGI Ref ID J:103968]
Demos C; Bandyopadhyay M; Rohrer B. 2008. Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 14:1639-49. [PubMed: 18776951] [MGI Ref ID J:140115]
Doonan F; Donovan M; Cotter TG. 2003. Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 23(13):5723-31. [PubMed: 12843276] [MGI Ref ID J:84389]
Drager UC; Hubel DH. 1978. Studies of visual function and its decay in mice with hereditary retinal degeneration. J Comp Neurol 180(1):85-114. [PubMed: 649791] [MGI Ref ID J:5980]
Du Y; Davisson MT; Kafadar K; Gardiner K. 2006. A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene 382:39-46. [PubMed: 16904273] [MGI Ref ID J:115050]
Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29(9):1363-71. [PubMed: 3417421] [MGI Ref ID J:27850]
Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. [PubMed: 17600127] [MGI Ref ID J:123928]
Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. J Neurochem 46(4):1240-5. [PubMed: 3005510] [MGI Ref ID J:12044]
Foster RG; Argamaso S; Coleman S; Colwell CS; Lederman A; Provencio I. 1993. Photoreceptors regulating circadian behavior: a mouse model. J Biol Rhythms 8 Suppl:S17-23. [PubMed: 8274758] [MGI Ref ID J:17940]
Foster RG; Provencio I; Hudson D; Fiske S; De Grip W; Menaker M. 1991. Circadian photoreception in the retinally degenerate mouse (rd/rd). J Comp Physiol [A] 169(1):39-50. [PubMed: 1941717] [MGI Ref ID J:83743]
Frasson M; Picaud S; Leveillard T; Simonutti M; Mohand-Said S; Dreyfus H; Hicks D; Sabel J. 1999. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci 40(11):2724-34. [PubMed: 10509671] [MGI Ref ID J:57866]
Frasson M; Sahel JA; Fabre M; Simonutti M; Dreyfus H; Picaud S. 1999. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 5(10):1183-7. [PubMed: 10502823] [MGI Ref ID J:57986]
Gao H; Hollyfield JG. 1995. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev Biol 169(1):168-184. [PubMed: 7750636] [MGI Ref ID J:25273]
Garcia-Fernandez JM; Jimenez AJ; Foster RG. 1995. The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (rd/rd): implications for circadian organization. Neurosci Lett 187(1):33-6. [PubMed: 7617296] [MGI Ref ID J:25157]
Gimenez E; Montoliu L. 2001. A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab Anim 35(2):153-6. [PubMed: 11315164] [MGI Ref ID J:69558]
Golub MS; Germann SL; Mercer M; Gordon MN; Morgan DG; Mayer LP; Hoyer PB. 2008. Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse. Neurobiol Aging 29(10):1512-23. [PubMed: 17451844] [MGI Ref ID J:140912]
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Gouras P; Du J; Kjeldbye H; Yamamoto S; Zack DJ. 1994. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest Ophthalmol Vis Sci 35(8):3145-53. [PubMed: 8045709] [MGI Ref ID J:20769]
Grafstein B; Murray M; Ingoglia NA. 1972. Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors. Brain Res 44(1):37-48. [PubMed: 4115728] [MGI Ref ID J:5292]
Graham DR; Overbeek PA; Ash JD. 2005. Leukemia inhibitory factor blocks expression of crx and nrl transcription factors to inhibit photoreceptor differentiation. Invest Ophthalmol Vis Sci 46(7):2601-10. [PubMed: 15980254] [MGI Ref ID J:99409]
Grimm C; Wenzel A; Stanescu D; Samardzija M; Hotop S; Groszer M; Naash M; Gassmann M; Reme C. 2004. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci 24(25):5651-8. [PubMed: 15215287] [MGI Ref ID J:133235]
Hackam AS; Strom R; Liu D; Qian J; Wang C; Otteson D; Gunatilaka T; Farkas RH; Chowers I; Kageyama M; Leveillard T; Sahel JA; Campochiaro PA; Parmigiani G; Zack DJ. 2004. Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Invest Ophthalmol Vis Sci 45(9):2929-42. [PubMed: 15326104] [MGI Ref ID J:92921]
Hafezi F; Abegg M; Grimm C; Wenzel A; Munz K; Sturmer J; Farber DB; Reme CE. 1998. Retinal degeneration in the rd mouse in the absence of c-fos. Invest Ophthalmol Vis Sci 39(12):2239-44. [PubMed: 9804131] [MGI Ref ID J:112088]
Hanno Y; Nakahira M; Jishage K; Noda T; Yoshihara Y. 2003. Tracking mouse visual pathways with WGA transgene. Eur J Neurosci 18(10):2910-4. [PubMed: 14656342] [MGI Ref ID J:128266]
Hatori M; Le H; Vollmers C; Keding SR; Tanaka N; Schmedt C; Jegla T; Panda S. 2008. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS ONE 3(6):e2451. [PubMed: 18545654] [MGI Ref ID J:137151]
Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779] [MGI Ref ID J:59481]
Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945] [MGI Ref ID J:121993]
Hopp RM; Ransom N; Hilsenbeck SG; Papermaster DS; Windle JJ. 1998. Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. Mol Vis 4:5. [PubMed: 9485488] [MGI Ref ID J:47520]
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Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1997. Fos expression in the retina of rd/rd mice during the light/dark cycle. Neurosci Lett 232(3):143-6. [PubMed: 9310300] [MGI Ref ID J:43873]
Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1999. Spatio-temporal analysis of light-induced Fos expression in the retina of rd mutant mice. Brain Res 834(1-2):122-7. [PubMed: 10407100] [MGI Ref ID J:56973]
Hussain AA; Willmott NJ; Voaden MJ. 1992. Cyclic GMP, calcium and photoreceptor sensitivity in mice heterozygous for the rod dysplasia gene designated rd. Vision Res 32(1):29-36. [PubMed: 1323896] [MGI Ref ID J:611]
Hwang DY; Fleming SM; Ardayfio P; Moran-Gates T; Kim H; Tarazi FI; Chesselet MF; Kim KS. 2005. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. J Neurosci 25(8):2132-7. [PubMed: 15728853] [MGI Ref ID J:98209]
Ionita MA; Pittler SJ. 2007. Focus on molecules: rod cGMP phosphodiesterase type 6. Exp Eye Res 84(1):1-2. [PubMed: 16563379] [MGI Ref ID J:123170]
Jia L; Oh EC; Ng L; Srinivas M; Brooks M; Swaroop A; Forrest D. 2009. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A 106(41):17534-9. [PubMed: 19805139] [MGI Ref ID J:153683]
Johnson LE; van Veen T; Ekstrom PA. 2005. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res 320(2):213-22. [PubMed: 15789220] [MGI Ref ID J:105103]
Jomary C; Cullen J; Jones SE. 2006. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest Ophthalmol Vis Sci 47(4):1620-9. [PubMed: 16565401] [MGI Ref ID J:108445]
Jomary C; Thomas M; Grist J; Milbrandt J; Neal MJ; Jones SE. 1999. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Invest Ophthalmol Vis Sci 40(3):568-74. [PubMed: 10067959] [MGI Ref ID J:53298]
Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125] [MGI Ref ID J:84675]
Jones SE; Jomary C; Grist J; Stewart HJ; Neal MJ. 2000. Identification by array screening of altered nm23-M2/PuF mRNA expression in mouse retinal degeneration. Mol Cell Biol Res Commun 4(1):20-5. [PubMed: 11152623] [MGI Ref ID J:66982]
Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of Pax-6 mRNA in the retinal degeneration (rd) mouse. Biochem Biophys Res Commun 252(1):236-40. [PubMed: 9813176] [MGI Ref ID J:50978]
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Hughes EH; Schlichtenbrede FC; Murphy CC; Sarra GM; Luthert PJ; Ali RR; Dick AD. 2003. Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest Ophthalmol Vis Sci 44(5):2229-34. [PubMed: 12714665] [MGI Ref ID J:83027]
Iandiev I; Biedermann B; Bringmann A; Reichel MB; Reichenbach A; Pannicke T. 2006. Atypical gliosis in Muller cells of the slowly degenerating rds mutant mouse retina. Exp Eye Res 82(3):449-57. [PubMed: 16154566] [MGI Ref ID J:106873]
Jansen HG; Sanyal S. 1984. Development and degeneration of retina in rds mutant mice: electron microscopy. J Comp Neurol 224(1):71-84. [PubMed: 6715580] [MGI Ref ID J:7415]
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Kedzierski W; Lloyd M; Birch DG; Bok D; Travis GH. 1997. Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors. Invest Ophthalmol Vis Sci 38(2):498-509. [PubMed: 9040483] [MGI Ref ID J:112440]
Kedzierski W; Nusinowitz S; Birch D; Clarke G; McInnes RR; Bok D; Travis GH. 2001. Deficiency of rds/peripherin causes photoreceptor death in mouse models of digenic and dominant retinitis pigmentosa. Proc Natl Acad Sci U S A 98(14):7718-23. [PubMed: 11427722] [MGI Ref ID J:77309]
Krishnamoorthy R; Agarwal N; Chaitin MH. 2000. Upregulation of CD44 expression in the retina during the rds degeneration. Brain Res Mol Brain Res 77(1):125-30. [PubMed: 10814838] [MGI Ref ID J:62192]
LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. [PubMed: 9501871] [MGI Ref ID J:46230]
Lohr HR; Kuntchithapautham K; Sharma AK; Rohrer B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83(2):380-9. [PubMed: 16626700] [MGI Ref ID J:116326]
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McNally N; Kenna PF; Rancourt D; Ahmed T; Stitt A; Colledge WH; Lloyd DG; Palfi A; O'Neill B; Humphries MM; Humphries P; Farrar GJ. 2002. Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene. Hum Mol Genet 11(9):1005-16. [PubMed: 11978760] [MGI Ref ID J:76490]
Morrow EM; Furukawa T; Raviola E; Cepko CL. 2005. Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci 6(1):5. [PubMed: 15676071] [MGI Ref ID J:95886]
Mrosovsky N; Thompson S. 2008. Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging. Vision Res 48(10):1270-3. [PubMed: 18394674] [MGI Ref ID J:141715]
Nir I; Haque R; Iuvone PM. 2000. Diurnal metabolism of dopamine in dystrophic retinas of homozygous and heterozygous retinal degeneration slow (rds) mice Brain Res 884(1-2):13-22. [PubMed: 11082482] [MGI Ref ID J:66055]
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Pricing
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Important Note | |
| See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485. | |
Control Information
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Control for Pde6brd1 alone: C3HeA.BLiA-+Pde6b.020-RdsRd2 (Stock No. 001979) Control for RdsRd2 alone: C3H/HeJ (Stock No. 000659) | ||
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