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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C57BL/6JEi x STOCK-T T(16;17)43H/+ T(16;17)43H/Ei (Changed: 19-DEC-06 ) C57BL/6JEi x STOCK T43H (Changed: 18-DEC-06 ) C57BL/6JEi x STOCK T(16;17)43H (Changed: 15-DEC-04 ) Type Chromosome Aberration; Translocation; Additional information on Mice with Chromosomal Aberrations. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N1 (08-JAN-04)
Related Strains
Reciprocal Translocations
View Reciprocal Translocations (46 strains)
003879 B10;TFLe-a/a T tf/+ tf/J 000405 B10ScSn.Cg-T/J 001518 B6 x STOCK T tf/th45 tf/J 000350 B6By.Cg-KitW-v MitfMi-wh T/J
Phenotype
Phenotype Information
Currently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:T related
Developmental Biology Research
Skeletal Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | T | ||
|---|---|---|---|
| Allele Name | brachyury | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | Laboratory stock | ||
| Gene Symbol and Name | T, brachyury | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75; | ||
| Molecular Note | Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb. [MGI Ref ID J:21263] | ||
| Allele Symbol | T(16;17)43H | ||
| Allele Name | reciprocal translocation, Chr 16 and 17, Harwell 43 | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | T43; Ts43H; | ||
| Strain of Origin | (C3H/HeH x 101/H)F1 | ||
| Gene Symbol and Name | T(16;17)43H, reciprocal translocation, Chr 16 and 17, Harwell 43 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | T43H; | ||
| Molecular Note | This chromosome is a result of a reciprocal translocation with one breakpoint located within the centromeric heterochromatin of Chr16, and the other located in the B3 band of Chr17. In conjunction with a normal Chr16 and two normal Chr17s, the presence of this mutation results in segmental trisomy of the proximal 30 Mb of Chr17, which includes over 310 known genes, and monosomy for the tip of centromeric heterochromatin of Chr16. [MGI Ref ID J:97039] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
T relatedT(16;17)43H relatedChesley P. 1935. Development of the short-tailed mutant in the house mouse. J Exp Zool 70:429-459. [MGI Ref ID J:13018]
Dobrovolskaia-Zavadskaia N. 1927. Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable" C R Seances Soc Biol Fil 97:114-16. [MGI Ref ID J:14909]
GRUNEBERG H. 1958. Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury. J Embryol Exp Morphol 6(3):424-43. [PubMed: 13575656] [MGI Ref ID J:15081]
Harrison SM; Houzelstein D; Dunwoodie SL; Beddington RS. 2000. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol 227(2):358-72. [PubMed: 11071760] [MGI Ref ID J:65743]
Herrmann BG; Labeit S; Poustka A; King TR; Lehrach H. 1990. Cloning of the T gene required in mesoderm formation in the mouse [see comments] Nature 343(6259):617-22. [PubMed: 2154694] [MGI Ref ID J:21263]
Kinder SJ; Tsang TE; Ang SL; Behringer RR; Tam PP. 2001. Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol 45(1 Spec No):347-55. [PubMed: 11291865] [MGI Ref ID J:74124]
King T; Beddington RS; Brown NA. 1998. The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev 79(1-2):29-37. [PubMed: 10349618] [MGI Ref ID J:52218]
Le Saux F; Besson MJ; Maurin Y. 2002. Abnormal postnatal ontogeny of the locus coeruleus in the epileptic mutant mouse quaking. Brain Res Dev Brain Res 136(2):197-205. [PubMed: 12101037] [MGI Ref ID J:109168]
Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493] [MGI Ref ID J:5003]
Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292] [MGI Ref ID J:3956]
Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG. 2007. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8(8):784-9. [PubMed: 17668009] [MGI Ref ID J:129900]
Yamaguchi TP; Takada S; Yoshikawa Y; Wu N; McMahon AP. 1999. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13(24):3185-90. [PubMed: 10617567] [MGI Ref ID J:59271]
Homolka D; Ivanek R; Capkova J; Jansa P; Forejt J. 2007. Chromosomal rearrangement interferes with meiotic X chromosome inactivation. Genome Res 17(10):1431-7. [PubMed: 17717048] [MGI Ref ID J:126747]
Lyon MF. 1966. Autosomal translocations causing male sterility and viable aneuploidy in the mouse Cytogenetics 5:335-54. [PubMed: 5958877] [MGI Ref ID J:34742]
Vacik T; Ort M; Gregorova S; Strnad P; Blatny R; Conte N; Bradley A; Bures J; Forejt J. 2005. Segmental trisomy of chromosome 17: A mouse model of human aneuploidy syndromes. Proc Natl Acad Sci U S A 102(12):4500-5. [PubMed: 15755806] [MGI Ref ID J:97039]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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General Terms and Conditions
See Terms of Use
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