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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6 x STOCK In17Rk (Changed: 15-DEC-04 ) Type Chromosome Aberration; Inversion; Additional information on Mice with Chromosomal Aberrations. Type Chemically Induced Mutation; Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Dr. Thomas Roderick, The Jackson Laboratory Description
This triethylene melamine-induced inversion of approximately 60 cM has its proximal breakpoint in intron 2 of Txlnb and its distal breakpoint in intron 3 of Hmga2. A fusion transcript of Hmg2a exons 4 and 5 and Txlnb exons 1 and 2 was identified in embryonic day 12.5 samples. Homozygotes have a pygmy phenotype, initially designated pygmy Jackson, which was proven allelic by comlementation test with Hmg2apg. These homozygotes are small and sterile. Although heterozygotes have reduced levels of Tlxnb in heart and femur muscle and homozygotes lack wildtype Txlnb transcript, which is usually expressed specifically in muscle, a muscle phenotype has not been found.Development
DBA/2J males were treated with .3mg/kg body weight triethylene melamine and these treated males were bred with C57BL/6J females. In(10)17Rk was found in the offspring. This mutation was maintained by Tom Roderick and the KitlSl mutation was crossed into the stock as a repulsion marker for maintenance. Embryos were cryopreserved from C57BL/6J females bred with In(10)17Rk +/+ KitlSl repulsion males. Steel colored cryo-recovered pups will not have the inversion while non-steel pups will.
Related Strains
Inversions
View Inversions (48 strains)
002644 B6.Cg-Hmga2pg-Tg40BCha/BmJ 000233 C3Wf.Cg-Hmga2pg/BmJ
Phenotype
Phenotype Information
assigned by genotype
In(10)17Rk/+
involves: C57BL/6J * DBA/2J
- reproductive system phenotype
- abnormal male meiosis
- male heterozygotes have an anaphase bridge frequency of approximately 65%, these are lumpy, and there are many telophase bridges (MGI Ref ID J:23389)
In(10)17Rk/In(10)17Rk
involves: C57BL/6J * DBA/2J
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | In(10)17Rk | ||
|---|---|---|---|
| Allele Name | inversion, Chr 10, Roderick 17 | ||
| Allele Type | Chemically induced (other) | ||
| Common Name(s) | Hmga2pg-J; In17Rk; pygmy Jackson; | ||
| Strain of Origin | DBA/2J | ||
| Gene Symbol and Name | In(10)17Rk, inversion, Chr 10, Roderick 17 | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | Hmga2pg-J; In17Rk; pygmy Jackson; | ||
| Molecular Note | This triethylene melamine-induced inversion of approximately 60 cM causes a homozygous pygmy phenotype, it is allelic by complementation test with Hmga2pg, the distal breakpoint is in intron 3 of Hmga2, and the proximal breakpoint is in intron2 of Txlnb. A 3.7 kb fusion transcript of Hmg2a exons 4 and 5 and Txlnb exons 1 and 2 is produced. No other Txlnb transcript was found by northern blot of homozygous heart or femur. [MGI Ref ID J:28571] [MGI Ref ID J:43743] [MGI Ref ID J:74548] | ||
| Gene Symbol and Name | In(10)17Rk-p, inversion, Chr 10, Roderick 17, proximal | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | In17Rk; | ||
| Gene Symbol and Name | In(10)17Rk-d, inversion, Chr 10, Roderick 17, distal | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | In(10)17Rk; In17Rk; | ||
| Gene Symbol and Name | Hmga2, high mobility group AT-hook 2 | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | 9430083A20Rik; BABL; HMGI-C; HMGIC; Hmgic; LIPO; RIKEN cDNA 9430083A20 gene; STQTL9; high mobility group protein I, isoform C; pg; pygmy; | ||
| Gene Symbol and Name | Txlnb, taxilin beta | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | 2310001N14Rik; C6orf198; LST001; MDP77; RGD1307979; RIKEN cDNA 2310001N14 gene; dJ522B19.2; | ||
References
References provided by MGI
Selected Reference(s)
Benson KF; Chada K. 2002. Molecular Characterization of the Mouse In(10)17Rk Inversion and Identification of a Novel Muscle-Specific Gene at the Proximal Breakpoint. Genetics 160(1):279-87. [PubMed: 11805063] [MGI Ref ID J:74548]
Additional References
In(10)17Rk relatedLyon MF; Rastan S; Brown SDM. 1996. . In: Genetic Variants and Strains of the Laboratory Mouse. Oxford University Press, Oxford. [MGI Ref ID J:43743]
Roderick TH. 1979. Chromosomal inversions in studies of mammalian mutagenesis. Genetics 92(1 Pt 1 Suppl):s121-6. [PubMed: 385432] [MGI Ref ID J:137335]
Roderick TH. 1983. Using inversions to detect and study recessive lethals and detrimentals in mice. In: Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Plenum Publishing Corp.. [MGI Ref ID J:23389]
Zhou X; Benson KF; Ashar HR; Chada K. 1995. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C [see comments] Nature 376(6543):771-4. [PubMed: 7651535] [MGI Ref ID J:28571]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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