Strain Name:

C3A.BLiA-Pde6b+.O20-Prph2Rd2/J

Stock Number:

001979

Availability:

Repository- Live

Description

Strain Information

Former Names C3A.BLiA-Pde6b+.O20-RdsRd2/J    (Changed: 08-DEC-06 )
C3A.BLiA-Pde6b+.O20-Prph2Rd2    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Donor Strain C57BL/LiA
Generation?+F69 (20-DEC-04)

Appearance
agouti
Related Genotype: A/A

Development
This strain was developed in the laboratory of Dr. Willem J. De Grit at Erasmus Universiteit, Rotterdam, the Netherlands. The Prph2Rd2 allele was transferred from strain O20/A to C3A.BLiA-Pde6b+ via more than 20 backcross-intercross cycles (Schalken et al. 1990; S. Sanyal, personal communication). C3A.BLiA-Pde6b+ is a congenic strain having the wildtype Pde6b allele of C57BL/LiA on the C3Hf/HeA background. Since its arrival at The Jackson Laboratory, Stock No. 001979 has been maintained by sibling mating of mice homozygous for both Pde6b+ and Prph2Rd2.

Control Information

  Control
   001912 C3A.BLiA-Pde6b+/J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Pde6b+     (7 strains)

Strains carrying   Prph2Rd2 allele
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
001981   O20/A-Prph2Rd2/J
View Strains carrying   Prph2Rd2     (2 strains)

Strains carrying other alleles of Pde6b
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
004297   B6.CXB1-Pde6brd10/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
001547   C3Sn.Cg-Cm/J
004766   C57BL/6J-Pde6brd1-2J/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying other alleles of Pde6b     (77 strains)

Strains carrying other alleles of Prph2
004821   C57BL/6J-Prph2Nmf193/J
View Strains carrying other alleles of Prph2     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Retinitis Pigmentosa 7; RP7 - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Retinitis Pigmentosa; RP - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Prph2Rd2/Prph2+

        either: (involves: C3H * O20/A) or (involves: C57BL/LiA * O20/A)
  • vision/eye phenotype
  • abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
    • in pigmented heterozygous mice outer segments resemble those in albino mice but have more disc membranes that appear more tightly packed and less vacuolated
  • nervous system phenotype
  • abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
    • in pigmented heterozygous mice outer segments resemble those in albino mice but have more disc membranes that appear more tightly packed and less vacuolated

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Prph2Rd2/Prph2+

        either: (involves: BALB/c * O20/A) or (involves: GR/A * O20/A) or (involves: O20/A * STS/A)
  • vision/eye phenotype
  • abnormal eye development (MGI Ref ID J:25582)
    • at P14, considerable portions of the retinal surface have fewer outer segments and those present have disc structures that are irregularly oriented
  • abnormal retinal layer morphology (MGI Ref ID J:25582)
    • abnormal retinal photoreceptor morphology (MGI Ref ID J:25582)
      • at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons
      • abnormal photoreceptor inner segment morphology (MGI Ref ID J:25582)
        • occasional inner segments with swollen endoplasmic reticuli and vacuoles
      • abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
        • outer segments are delayed in development but eventually appear throughout the retinal surface
        • outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes
        • these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated
        • at 18 months, outer segments become reduced and somewhat patchy
      • increased retinal cone cell number (MGI Ref ID J:25582)
        • the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina
    • abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
      • pigment epithelial cells contain larger and more numerous phagosomes
      • peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period
    • thin retinal outer nuclear layer (MGI Ref ID J:25582)
      • maximal outer nuclear layer thickness is only 50-60% of wild-type
      • at 18 months, outer nuclear layer thickness is markedly decreased
      • thinning of the outer nuclear layer is first seen in the peripheral retina and later seen in the central retina
  • nervous system phenotype
  • abnormal retinal photoreceptor morphology (MGI Ref ID J:25582)
    • at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons
    • abnormal photoreceptor inner segment morphology (MGI Ref ID J:25582)
      • occasional inner segments with swollen endoplasmic reticuli and vacuoles
    • abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
      • outer segments are delayed in development but eventually appear throughout the retinal surface
      • outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes
      • these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated
      • at 18 months, outer segments become reduced and somewhat patchy
    • increased retinal cone cell number (MGI Ref ID J:25582)
      • the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
    • pigment epithelial cells contain larger and more numerous phagosomes
    • peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period

Prph2Rd2/Prph2+

        either: C.O20-Prph2Rd2 or C3.O20-Prph2Rd2
  • vision/eye phenotype
  • abnormal Muller cell morphology (MGI Ref ID J:27850)
    • at 2 months, high numbers of Muller cells and lower numbers of fibrillar tangles and horizontal fibers are seen relative to homozygous mice
    • at 16 months, the density of Muller cells is increased compared to 2 months
  • thin retinal outer nuclear layer (MGI Ref ID J:27850)
    • at 16 months, the outer nuclear layer is reduced to 3 to 4 rows
  • nervous system phenotype
  • abnormal Muller cell morphology (MGI Ref ID J:27850)
    • at 2 months, high numbers of Muller cells and lower numbers of fibrillar tangles and horizontal fibers are seen relative to homozygous mice
    • at 16 months, the density of Muller cells is increased compared to 2 months

Prph2Rd2/Prph2Rd2

        O20/A-Prph2Rd2
  • vision/eye phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
    • phagosomes containing debris from the outer nuclear layer are absent
  • absent retinal rod cells (MGI Ref ID J:6051)
    • at 7-10 months rods are absent
  • retinal degeneration (MGI Ref ID J:6051)
    • slight degenerative changes are seen in the outer nuclear layer starting at 5 weeks
    • degeneration slowly progresses until at 7-10 months rods are absent and the photoreceptor cell nuclei are reduced to 1 row
  • retinal outer nuclear layer degeneration (MGI Ref ID J:6051)
    • slow degeneration beginning at 5 weeks and progressing until at 7-10 months rods are absent and the photoreceptor cell nuclei are reduced to 1 row
  • nervous system phenotype
  • absent retinal rod cells (MGI Ref ID J:6051)
    • at 7-10 months rods are absent
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
    • phagosomes containing debris from the outer nuclear layer are absent

Prph2Rd2/Prph2Rd2

        either: C.O20-Prph2Rd2 or C3.O20-Prph2Rd2
  • vision/eye phenotype
  • abnormal Muller cell morphology (MGI Ref ID J:27850)
    • at P11 small numbers of Muller cells and radial fibers are found in the outer plexiform layer
    • at P28 the number of Muller cells is increased, the cells tend to be unevenly distributed, and occasional fibrillar tangles are seen in the inner plexiform layer
    • at 2 months of age the density of Muller cells has increased dramatically, in the periphery these cells have fibers that penetrate the outer nuclear layer and cover it externally, and the number of fibrillar tangles is increased
    • at 9 months of age the density of Muller cells, fibrillar tangles, and horizontal fibers in the plexiform layers is further increased
  • thin retinal outer nuclear layer (MGI Ref ID J:27850)
    • at 9 months, the outer nuclear layer is reduced to 2 to 3 rows
    • at 18 months, no recognizable outer nuclear layer is seen
  • nervous system phenotype
  • abnormal Muller cell morphology (MGI Ref ID J:27850)
    • at P11 small numbers of Muller cells and radial fibers are found in the outer plexiform layer
    • at P28 the number of Muller cells is increased, the cells tend to be unevenly distributed, and occasional fibrillar tangles are seen in the inner plexiform layer
    • at 2 months of age the density of Muller cells has increased dramatically, in the periphery these cells have fibers that penetrate the outer nuclear layer and cover it externally, and the number of fibrillar tangles is increased
    • at 9 months of age the density of Muller cells, fibrillar tangles, and horizontal fibers in the plexiform layers is further increased

Prph2Rd2/Prph2Rd2

        involves: BALB/c * O20/A
  • vision/eye phenotype
  • abnormal eye electrophysiology (MGI Ref ID J:76490)
    • at 4 months, a small-amplitude b-wave is recorded
  • retinal degeneration (MGI Ref ID J:76490)
    • mice exhibit 8 or 9 rows of photoreceptor nuclei at 1 months and 3 or 4 rows at 4 months
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Pde6b+ related

Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype

Sensorineural Research
Retinal Degeneration
      wild-type

Prph2Rd2 related

Mouse/Human Gene Homologs
retinal degeneration, slow

Research Tools
Sensorineural Research
      retinal degeneration

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Pde6b+
Allele Name wild type
Allele Type Not Applicable
Mutation Made By Frank Kooy,   University of Antwerp
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
 
Allele Symbol Prph2Rd2
Allele Name retinal degeneration 2
Allele Type Spontaneous
Common Name(s) Prph2Rds; Rd-2; Rds; RdsRd2; rds-; retinal degeneration slow;
Strain of OriginO20/A
Gene Symbol and Name Prph2, peripherin 2
Chromosome 17
Gene Common Name(s) AOFMD; AVMD; Nmf193; PRPH; RDS; RP7; RSRDS; Rd-2; Rd2; Rds; TSPAN22; neuroscience mutagenesis facility, 193; retinal degeneration 2; retinal degeneration, slow; retinal degeneration, slow (retinitis pigmentosa 7);
Molecular Note The mutation is an insertion of approximately 10 kb in the gene after nucleotide 899 (numbering of the encoded mRNA), disrupting the protein coding sequence in exon 2. The inserted DNA was similar to both the TSE of mice, repeated elements found in the H2 complex, and to the mouse early transposon (ETn). Northern blot analysis demonstrated that an aberrant 12 kb transcript was produced from this allele, although at reduced levels compared to wild-type. This allele is predicted to encode a truncated protein with its carboxy terminal 116 amino acids replaced by 35 amino acids from sequences in the insertion. Mutant mice doubly homozygous for two retinal degeneration mutations (Pde6brd1 and RdsRd2) shows an intermediate level of mRNAs for the beta subunit of cGMP-PDE and for several other phototransduction related proteins, suggesting an interaction between Pde6brd1 and RdsRd2. [MGI Ref ID J:2579] [MGI Ref ID J:9635]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9. [PubMed: 2137350]  [MGI Ref ID J:109932]

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Pde6b+ related

Sakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587]  [MGI Ref ID J:142108]

Prph2Rd2 related

Agarwal N. 1994. Diurnal expression of NGF1-A mRNA in retinal degeneration slow (rds) mutant mouse retina. FEBS Lett 339(3):253-7. [PubMed: 8112464]  [MGI Ref ID J:16898]

Agarwal N; Jomary C; Jones SE; O'Rourke K; Chaitin M; Wordinger RJ; Murphy BF. 1996. Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas. Biochem Biophys Res Commun 225(1):84-91. [PubMed: 8769098]  [MGI Ref ID J:34976]

Agarwal N; Nir I; Papermaster DS. 1994. Loss of diurnal arrestin gene expression in rds mutant mouse retinas. Exp Eye Res 58(1):1-8. [PubMed: 8157095]  [MGI Ref ID J:28768]

Ali RR; Reichel MB; Kanuga N; Munro PM; Alexander RA; Clarke AR; Luthert PJ; Bhattacharya SS; Hunt DM. 1998. Absence of p53 delays apoptotic photoreceptor cell death in the rds mouse. Curr Eye Res 17(9):917-23. [PubMed: 9746439]  [MGI Ref ID J:111968]

Ali RR; Sarra GM; Stephens C; Alwis Md; Bainbridge JW; Munro PM; Fauser S; Reichel MB; Kinnon C; Hunt DM; Bhattacharya SS; Thrasher AJ. 2000. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy Nat Genet 25(3):306-10. [PubMed: 10888879]  [MGI Ref ID J:63124]

Anderson RE; Maude MB; Bok D. 2001. Low docosahexaenoic acid levels in rod outer segment membranes of mice with rds/peripherin and P216L peripherin mutations. Invest Ophthalmol Vis Sci 42(8):1715-20. [PubMed: 11431433]  [MGI Ref ID J:70247]

Cayouette M; Behn D; Sendtner M; Lachapelle P; Gravel C. 1998. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 18(22):9282-93. [PubMed: 9801367]  [MGI Ref ID J:50901]

Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408]  [MGI Ref ID J:59343]

Chaitin MH; Ankrum MT; Wortham HS. 1996. Distribution of CD44 in the retina during development and the rds degeneration. Brain Res Dev Brain Res 94(1):92-8. [PubMed: 8816281]  [MGI Ref ID J:33822]

Chakraborty D; Ding XQ; Conley SM; Fliesler SJ; Naash MI. 2009. Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet 18(5):797-808. [PubMed: 19050038]  [MGI Ref ID J:145008]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Chang B; Heckenlively JR; Hawes NL; Roderick TH. 1993. New mouse primary retinal degeneration (rd-3). Genomics 16(1):45-9. [PubMed: 8486383]  [MGI Ref ID J:4367]

Cheng T; Peachey NS; Li S; Goto Y; Cao Y; Naash MI. 1997. The effect of peripherin/rds haploinsufficiency on rod and cone photoreceptors. J Neurosci 17(21):8118-28. [PubMed: 9334387]  [MGI Ref ID J:43692]

Conley S; Nour M; Fliesler SJ; Naash MI. 2007. Late-onset cone photoreceptor degeneration induced by R172W mutation in Rds and partial rescue by gene supplementation. Invest Ophthalmol Vis Sci 48(12):5397-407. [PubMed: 18055786]  [MGI Ref ID J:132515]

Connell G; Bascom R; Molday L; Reid D; McInnes RR; Molday RS. 1991. Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse. Proc Natl Acad Sci U S A 88(3):723-6. [PubMed: 1992463]  [MGI Ref ID J:10978]

Demos C; Bandyopadhyay M; Rohrer B. 2008. Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 14:1639-49. [PubMed: 18776951]  [MGI Ref ID J:140115]

Ding XQ; Nour M; Ritter LM; Goldberg AF; Fliesler SJ; Naash MI. 2004. The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice. Hum Mol Genet 13(18):2075-87. [PubMed: 15254014]  [MGI Ref ID J:92815]

Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29(9):1363-71. [PubMed: 3417421]  [MGI Ref ID J:27850]

Farjo R; Fliesler SJ; Naash MI. 2007. Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity. J Comp Neurol 504(6):619-30. [PubMed: 17722028]  [MGI Ref ID J:131880]

Farjo R; Skaggs JS; Nagel BA; Quiambao AB; Nash ZA; Fliesler SJ; Naash MI. 2006. Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors. J Cell Biol 173(1):59-68. [PubMed: 16585269]  [MGI Ref ID J:107832]

Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. J Neurochem 46(4):1240-5. [PubMed: 3005510]  [MGI Ref ID J:12044]

Franke H; Klimke K; Brinckmann U; Grosche J; Francke M; Sperlagh B; Reichenbach A; Liebert UG; Illes P. 2005. P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice. Neurochem Int 47(4):235-42. [PubMed: 15964665]  [MGI Ref ID J:103892]

Gao H; Hollyfield JG. 1996. Basic fibroblast growth factor: increased gene expression in inherited and light-induced photoreceptor degeneration. Exp Eye Res 62(2):181-9. [PubMed: 8698078]  [MGI Ref ID J:32161]

Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779]  [MGI Ref ID J:59481]

Hawkins RK; Jansen HG; Sanyal S. 1985. Development and degeneration of retina in rds mutant mice: photoreceptor abnormalities in the heterozygotes. Exp Eye Res 41(6):701-20. [PubMed: 3830736]  [MGI Ref ID J:25582]

Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945]  [MGI Ref ID J:121993]

Hilgers J. 1979. Prph2<Rd2> - retinal degeneration-2 Mouse News Lett 60:38.  [MGI Ref ID J:65320]

Horio N; Kachi S; Hori K; Okamoto Y; Yamamoto E; Terasaki H; Miyake Y. 2001. Progressive change of optical coherence tomography scans in retinal degeneration slow mice. Arch Ophthalmol 119(9):1329-32. [PubMed: 11545639]  [MGI Ref ID J:115731]

Hughes EH; Schlichtenbrede FC; Murphy CC; Sarra GM; Luthert PJ; Ali RR; Dick AD. 2003. Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest Ophthalmol Vis Sci 44(5):2229-34. [PubMed: 12714665]  [MGI Ref ID J:83027]

Iandiev I; Biedermann B; Bringmann A; Reichel MB; Reichenbach A; Pannicke T. 2006. Atypical gliosis in Muller cells of the slowly degenerating rds mutant mouse retina. Exp Eye Res 82(3):449-57. [PubMed: 16154566]  [MGI Ref ID J:106873]

Jansen HG; Sanyal S. 1984. Development and degeneration of retina in rds mutant mice: electron microscopy. J Comp Neurol 224(1):71-84. [PubMed: 6715580]  [MGI Ref ID J:7415]

Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125]  [MGI Ref ID J:84675]

Kedzierski W; Lloyd M; Birch DG; Bok D; Travis GH. 1997. Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors. Invest Ophthalmol Vis Sci 38(2):498-509. [PubMed: 9040483]  [MGI Ref ID J:112440]

Kedzierski W; Nusinowitz S; Birch D; Clarke G; McInnes RR; Bok D; Travis GH. 2001. Deficiency of rds/peripherin causes photoreceptor death in mouse models of digenic and dominant retinitis pigmentosa. Proc Natl Acad Sci U S A 98(14):7718-23. [PubMed: 11427722]  [MGI Ref ID J:77309]

Krishnamoorthy R; Agarwal N; Chaitin MH. 2000. Upregulation of CD44 expression in the retina during the rds degeneration. Brain Res Mol Brain Res 77(1):125-30. [PubMed: 10814838]  [MGI Ref ID J:62192]

LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. [PubMed: 9501871]  [MGI Ref ID J:46230]

Lohr HR; Kuntchithapautham K; Sharma AK; Rohrer B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83(2):380-9. [PubMed: 16626700]  [MGI Ref ID J:116326]

Loscher CJ; Hokamp K; Wilson JH; Li T; Humphries P; Farrar GJ; Palfi A. 2008. A common microRNA signature in mouse models of retinal degeneration. Exp Eye Res 87(6):529-34. [PubMed: 18834879]  [MGI Ref ID J:143310]

Ma J; Norton JC; Allen AC; Burns JB; Hasel KW; Burns JL; Sutcliffe JG; Travis GH. 1995. Retinal degeneration slow (rds) in mouse results from simple insertion of a t haplotype-specific element into protein-coding exon II. Genomics 28(2):212-9. [PubMed: 8530028]  [MGI Ref ID J:28016]

McNally N; Kenna PF; Rancourt D; Ahmed T; Stitt A; Colledge WH; Lloyd DG; Palfi A; O'Neill B; Humphries MM; Humphries P; Farrar GJ. 2002. Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene. Hum Mol Genet 11(9):1005-16. [PubMed: 11978760]  [MGI Ref ID J:76490]

Morrow EM; Furukawa T; Raviola E; Cepko CL. 2005. Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci 6(1):5. [PubMed: 15676071]  [MGI Ref ID J:95886]

Mrosovsky N; Thompson S. 2008. Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging. Vision Res 48(10):1270-3. [PubMed: 18394674]  [MGI Ref ID J:141715]

Nir I; Haque R; Iuvone PM. 2000. Diurnal metabolism of dopamine in dystrophic retinas of homozygous and heterozygous retinal degeneration slow (rds) mice Brain Res 884(1-2):13-22. [PubMed: 11082482]  [MGI Ref ID J:66055]

Nir I; Haque R; Iuvone PM. 2001. Regulation of cAMP by light and dopamine receptors is dysfunctional in photoreceptors of dystrophic retinal degeneration slow(rds) mice. Exp Eye Res 73(2):265-72. [PubMed: 11446777]  [MGI Ref ID J:70501]

Nir I; Iuvone PM. 1994. Alterations in light-evoked dopamine metabolism in dystrophic retinas of mutant rds mice. Brain Res 649(1-2):85-94. [PubMed: 7953658]  [MGI Ref ID J:18990]

Nir I; Kedzierski W; Chen J; Travis GH. 2000. Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice. J Neurosci 20(6):2150-4. [PubMed: 10704489]  [MGI Ref ID J:60966]

Paquet-Durand F ; Hauck SM ; van Veen T ; Ueffing M ; Ekstrom P. 2009. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem 108(3):796-810. [PubMed: 19187097]  [MGI Ref ID J:146653]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $94.10Female or MaleHomozygous for Prph2Rd2
Pairs /Price (US dollars $)Pair Genotype
$188.20Homozygous for Prph2Rd2 x Homozygous for Prph2Rd2

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $122.40Female or MaleHomozygous for Prph2Rd2
Pairs /Price (US dollars $)Pair Genotype
$244.70Homozygous for Prph2Rd2 x Homozygous for Prph2Rd2

Additional Supply Details

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes
  • Usually shipped between four and eight weeks of age.
  • This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

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   001912 C3A.BLiA-Pde6b+/J
 
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  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
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