| |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names C3A.BLiA-Pde6b+.O20-RdsRd2/J (Changed: 08-DEC-06 ) C3A.BLiA-Pde6b+.O20-Prph2Rd2 (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Donor Strain C57BL/LiA Generation ?+F69 (20-DEC-04) Appearance
agouti
Related Genotype: A/ADevelopment
This strain was developed in the laboratory of Dr. Willem J. De Grit at Erasmus Universiteit, Rotterdam, the Netherlands. The Prph2Rd2 allele was transferred from strain O20/A to C3A.BLiA-Pde6b+ via more than 20 backcross-intercross cycles (Schalken et al. 1990; S. Sanyal, personal communication). C3A.BLiA-Pde6b+ is a congenic strain having the wildtype Pde6b allele of C57BL/LiA on the C3Hf/HeA background. Since its arrival at The Jackson Laboratory, Stock No. 001979 has been maintained by sibling mating of mice homozygous for both Pde6b+ and Prph2Rd2.
Control Information
| Control | ||
|---|---|---|
| 001912 C3A.BLiA-Pde6b+/J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pde6b+ allele
005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying Pde6b+ (7 strains)
001957 C3A Pde6brd1.O20/A-Prph2Rd2/J 001981 O20/A-Prph2Rd2/J
004821 C57BL/6J-Prph2Nmf193/J
Phenotype
Phenotype Information
Retinitis Pigmentosa 7; RP7 - Models with phenotypic similarity to human disease where etiologies involve orthologs.1 Retinitis Pigmentosa; RP - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
assigned by genotype
Prph2Rd2/Prph2+
either: (involves: C3H * O20/A) or (involves: C57BL/LiA * O20/A)
- vision/eye phenotype
- abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
- in pigmented heterozygous mice outer segments resemble those in albino mice but have more disc membranes that appear more tightly packed and less vacuolated
- nervous system phenotype
- abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
- in pigmented heterozygous mice outer segments resemble those in albino mice but have more disc membranes that appear more tightly packed and less vacuolated
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Prph2Rd2/Prph2+
either: (involves: BALB/c * O20/A) or (involves: GR/A * O20/A) or (involves: O20/A * STS/A)
- vision/eye phenotype
- abnormal eye development (MGI Ref ID J:25582)
- at P14, considerable portions of the retinal surface have fewer outer segments and those present have disc structures that are irregularly oriented
- abnormal retinal layer morphology (MGI Ref ID J:25582)
- abnormal retinal photoreceptor morphology (MGI Ref ID J:25582)
- at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons
- abnormal photoreceptor inner segment morphology (MGI Ref ID J:25582)
- occasional inner segments with swollen endoplasmic reticuli and vacuoles
- abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
- outer segments are delayed in development but eventually appear throughout the retinal surface
- outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes
- these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated
- at 18 months, outer segments become reduced and somewhat patchy
- increased retinal cone cell number (MGI Ref ID J:25582)
- the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina
- abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
- pigment epithelial cells contain larger and more numerous phagosomes
- peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period
- thin retinal outer nuclear layer (MGI Ref ID J:25582)
- maximal outer nuclear layer thickness is only 50-60% of wild-type
- at 18 months, outer nuclear layer thickness is markedly decreased
- thinning of the outer nuclear layer is first seen in the peripheral retina and later seen in the central retina
- nervous system phenotype
- abnormal retinal photoreceptor morphology (MGI Ref ID J:25582)
- at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons
- abnormal photoreceptor inner segment morphology (MGI Ref ID J:25582)
- occasional inner segments with swollen endoplasmic reticuli and vacuoles
- abnormal photoreceptor outer segment morphology (MGI Ref ID J:25582)
- outer segments are delayed in development but eventually appear throughout the retinal surface
- outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes
- these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated
- at 18 months, outer segments become reduced and somewhat patchy
- increased retinal cone cell number (MGI Ref ID J:25582)
- the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina
- pigmentation phenotype
- abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
- pigment epithelial cells contain larger and more numerous phagosomes
- peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period
Prph2Rd2/Prph2+
either: C.O20-Prph2Rd2 or C3.O20-Prph2Rd2
- vision/eye phenotype
- abnormal Muller cell morphology (MGI Ref ID J:27850)
- at 2 months, high numbers of Muller cells and lower numbers of fibrillar tangles and horizontal fibers are seen relative to homozygous mice
- at 16 months, the density of Muller cells is increased compared to 2 months
- thin retinal outer nuclear layer (MGI Ref ID J:27850)
- at 16 months, the outer nuclear layer is reduced to 3 to 4 rows
- nervous system phenotype
- abnormal Muller cell morphology (MGI Ref ID J:27850)
- at 2 months, high numbers of Muller cells and lower numbers of fibrillar tangles and horizontal fibers are seen relative to homozygous mice
- at 16 months, the density of Muller cells is increased compared to 2 months
Prph2Rd2/Prph2Rd2
O20/A-Prph2Rd2
- vision/eye phenotype
- abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
- phagosomes containing debris from the outer nuclear layer are absent
- absent retinal rod cells (MGI Ref ID J:6051)
- at 7-10 months rods are absent
- retinal degeneration (MGI Ref ID J:6051)
- slight degenerative changes are seen in the outer nuclear layer starting at 5 weeks
- degeneration slowly progresses until at 7-10 months rods are absent and the photoreceptor cell nuclei are reduced to 1 row
- retinal outer nuclear layer degeneration (MGI Ref ID J:6051)
- slow degeneration beginning at 5 weeks and progressing until at 7-10 months rods are absent and the photoreceptor cell nuclei are reduced to 1 row
- nervous system phenotype
- absent retinal rod cells (MGI Ref ID J:6051)
- at 7-10 months rods are absent
- pigmentation phenotype
- abnormal retinal pigment epithelium morphology (MGI Ref ID J:25582)
- phagosomes containing debris from the outer nuclear layer are absent
Prph2Rd2/Prph2Rd2
either: C.O20-Prph2Rd2 or C3.O20-Prph2Rd2
- vision/eye phenotype
- abnormal Muller cell morphology (MGI Ref ID J:27850)
- at P11 small numbers of Muller cells and radial fibers are found in the outer plexiform layer
- at P28 the number of Muller cells is increased, the cells tend to be unevenly distributed, and occasional fibrillar tangles are seen in the inner plexiform layer
- at 2 months of age the density of Muller cells has increased dramatically, in the periphery these cells have fibers that penetrate the outer nuclear layer and cover it externally, and the number of fibrillar tangles is increased
- at 9 months of age the density of Muller cells, fibrillar tangles, and horizontal fibers in the plexiform layers is further increased
- thin retinal outer nuclear layer (MGI Ref ID J:27850)
- at 9 months, the outer nuclear layer is reduced to 2 to 3 rows
- at 18 months, no recognizable outer nuclear layer is seen
- nervous system phenotype
- abnormal Muller cell morphology (MGI Ref ID J:27850)
- at P11 small numbers of Muller cells and radial fibers are found in the outer plexiform layer
- at P28 the number of Muller cells is increased, the cells tend to be unevenly distributed, and occasional fibrillar tangles are seen in the inner plexiform layer
- at 2 months of age the density of Muller cells has increased dramatically, in the periphery these cells have fibers that penetrate the outer nuclear layer and cover it externally, and the number of fibrillar tangles is increased
- at 9 months of age the density of Muller cells, fibrillar tangles, and horizontal fibers in the plexiform layers is further increased
Prph2Rd2/Prph2Rd2
involves: BALB/c * O20/AThis mouse can be used to support research in many areas including:Pde6b+ related
Prph2Rd2 relatedMouse/Human Gene Homologs
retinitis pigmentosa, wildtype
Sensorineural Research
Retinal Degeneration
wild-type
Mouse/Human Gene Homologs
retinal degeneration, slow
Research Tools
Sensorineural Research
retinal degeneration
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Pde6b+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Mutation Made By | Frank Kooy, University of Antwerp | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| Allele Symbol | Prph2Rd2 | ||
| Allele Name | retinal degeneration 2 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Prph2Rds; Rd-2; Rds; RdsRd2; rds-; retinal degeneration slow; | ||
| Strain of Origin | O20/A | ||
| Gene Symbol and Name | Prph2, peripherin 2 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | AOFMD; AVMD; Nmf193; PRPH; RDS; RP7; RSRDS; Rd-2; Rd2; Rds; TSPAN22; neuroscience mutagenesis facility, 193; retinal degeneration 2; retinal degeneration, slow; retinal degeneration, slow (retinitis pigmentosa 7); | ||
| Molecular Note | The mutation is an insertion of approximately 10 kb in the gene after nucleotide 899 (numbering of the encoded mRNA), disrupting the protein coding sequence in exon 2. The inserted DNA was similar to both the TSE of mice, repeated elements found in the H2 complex, and to the mouse early transposon (ETn). Northern blot analysis demonstrated that an aberrant 12 kb transcript was produced from this allele, although at reduced levels compared to wild-type. This allele is predicted to encode a truncated protein with its carboxy terminal 116 amino acids replaced by 35 amino acids from sequences in the insertion. Mutant mice doubly homozygous for two retinal degeneration mutations (Pde6brd1 and RdsRd2) shows an intermediate level of mRNAs for the beta subunit of cGMP-PDE and for several other phototransduction related proteins, suggesting an interaction between Pde6brd1 and RdsRd2. [MGI Ref ID J:2579] [MGI Ref ID J:9635] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9. [PubMed: 2137350] [MGI Ref ID J:109932]
Additional References
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Pde6b+ relatedPrph2Rd2 relatedSakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587] [MGI Ref ID J:142108]
Agarwal N. 1994. Diurnal expression of NGF1-A mRNA in retinal degeneration slow (rds) mutant mouse retina. FEBS Lett 339(3):253-7. [PubMed: 8112464] [MGI Ref ID J:16898]
Agarwal N; Jomary C; Jones SE; O'Rourke K; Chaitin M; Wordinger RJ; Murphy BF. 1996. Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas. Biochem Biophys Res Commun 225(1):84-91. [PubMed: 8769098] [MGI Ref ID J:34976]
Agarwal N; Nir I; Papermaster DS. 1994. Loss of diurnal arrestin gene expression in rds mutant mouse retinas. Exp Eye Res 58(1):1-8. [PubMed: 8157095] [MGI Ref ID J:28768]
Ali RR; Reichel MB; Kanuga N; Munro PM; Alexander RA; Clarke AR; Luthert PJ; Bhattacharya SS; Hunt DM. 1998. Absence of p53 delays apoptotic photoreceptor cell death in the rds mouse. Curr Eye Res 17(9):917-23. [PubMed: 9746439] [MGI Ref ID J:111968]
Ali RR; Sarra GM; Stephens C; Alwis Md; Bainbridge JW; Munro PM; Fauser S; Reichel MB; Kinnon C; Hunt DM; Bhattacharya SS; Thrasher AJ. 2000. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy Nat Genet 25(3):306-10. [PubMed: 10888879] [MGI Ref ID J:63124]
Anderson RE; Maude MB; Bok D. 2001. Low docosahexaenoic acid levels in rod outer segment membranes of mice with rds/peripherin and P216L peripherin mutations. Invest Ophthalmol Vis Sci 42(8):1715-20. [PubMed: 11431433] [MGI Ref ID J:70247]
Cayouette M; Behn D; Sendtner M; Lachapelle P; Gravel C. 1998. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 18(22):9282-93. [PubMed: 9801367] [MGI Ref ID J:50901]
Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408] [MGI Ref ID J:59343]
Chaitin MH; Ankrum MT; Wortham HS. 1996. Distribution of CD44 in the retina during development and the rds degeneration. Brain Res Dev Brain Res 94(1):92-8. [PubMed: 8816281] [MGI Ref ID J:33822]
Chakraborty D; Ding XQ; Conley SM; Fliesler SJ; Naash MI. 2009. Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet 18(5):797-808. [PubMed: 19050038] [MGI Ref ID J:145008]
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chang B; Heckenlively JR; Hawes NL; Roderick TH. 1993. New mouse primary retinal degeneration (rd-3). Genomics 16(1):45-9. [PubMed: 8486383] [MGI Ref ID J:4367]
Cheng T; Peachey NS; Li S; Goto Y; Cao Y; Naash MI. 1997. The effect of peripherin/rds haploinsufficiency on rod and cone photoreceptors. J Neurosci 17(21):8118-28. [PubMed: 9334387] [MGI Ref ID J:43692]
Conley S; Nour M; Fliesler SJ; Naash MI. 2007. Late-onset cone photoreceptor degeneration induced by R172W mutation in Rds and partial rescue by gene supplementation. Invest Ophthalmol Vis Sci 48(12):5397-407. [PubMed: 18055786] [MGI Ref ID J:132515]
Connell G; Bascom R; Molday L; Reid D; McInnes RR; Molday RS. 1991. Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse. Proc Natl Acad Sci U S A 88(3):723-6. [PubMed: 1992463] [MGI Ref ID J:10978]
Demos C; Bandyopadhyay M; Rohrer B. 2008. Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 14:1639-49. [PubMed: 18776951] [MGI Ref ID J:140115]
Ding XQ; Nour M; Ritter LM; Goldberg AF; Fliesler SJ; Naash MI. 2004. The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice. Hum Mol Genet 13(18):2075-87. [PubMed: 15254014] [MGI Ref ID J:92815]
Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29(9):1363-71. [PubMed: 3417421] [MGI Ref ID J:27850]
Farjo R; Fliesler SJ; Naash MI. 2007. Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity. J Comp Neurol 504(6):619-30. [PubMed: 17722028] [MGI Ref ID J:131880]
Farjo R; Skaggs JS; Nagel BA; Quiambao AB; Nash ZA; Fliesler SJ; Naash MI. 2006. Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors. J Cell Biol 173(1):59-68. [PubMed: 16585269] [MGI Ref ID J:107832]
Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. J Neurochem 46(4):1240-5. [PubMed: 3005510] [MGI Ref ID J:12044]
Franke H; Klimke K; Brinckmann U; Grosche J; Francke M; Sperlagh B; Reichenbach A; Liebert UG; Illes P. 2005. P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice. Neurochem Int 47(4):235-42. [PubMed: 15964665] [MGI Ref ID J:103892]
Gao H; Hollyfield JG. 1996. Basic fibroblast growth factor: increased gene expression in inherited and light-induced photoreceptor degeneration. Exp Eye Res 62(2):181-9. [PubMed: 8698078] [MGI Ref ID J:32161]
Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779] [MGI Ref ID J:59481]
Hawkins RK; Jansen HG; Sanyal S. 1985. Development and degeneration of retina in rds mutant mice: photoreceptor abnormalities in the heterozygotes. Exp Eye Res 41(6):701-20. [PubMed: 3830736] [MGI Ref ID J:25582]
Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945] [MGI Ref ID J:121993]
Hilgers J. 1979. Prph2<Rd2> - retinal degeneration-2 Mouse News Lett 60:38. [MGI Ref ID J:65320]
Horio N; Kachi S; Hori K; Okamoto Y; Yamamoto E; Terasaki H; Miyake Y. 2001. Progressive change of optical coherence tomography scans in retinal degeneration slow mice. Arch Ophthalmol 119(9):1329-32. [PubMed: 11545639] [MGI Ref ID J:115731]
Hughes EH; Schlichtenbrede FC; Murphy CC; Sarra GM; Luthert PJ; Ali RR; Dick AD. 2003. Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest Ophthalmol Vis Sci 44(5):2229-34. [PubMed: 12714665] [MGI Ref ID J:83027]
Iandiev I; Biedermann B; Bringmann A; Reichel MB; Reichenbach A; Pannicke T. 2006. Atypical gliosis in Muller cells of the slowly degenerating rds mutant mouse retina. Exp Eye Res 82(3):449-57. [PubMed: 16154566] [MGI Ref ID J:106873]
Jansen HG; Sanyal S. 1984. Development and degeneration of retina in rds mutant mice: electron microscopy. J Comp Neurol 224(1):71-84. [PubMed: 6715580] [MGI Ref ID J:7415]
Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125] [MGI Ref ID J:84675]
Kedzierski W; Lloyd M; Birch DG; Bok D; Travis GH. 1997. Generation and analysis of transgenic mice expressing P216L-substituted rds/peripherin in rod photoreceptors. Invest Ophthalmol Vis Sci 38(2):498-509. [PubMed: 9040483] [MGI Ref ID J:112440]
Kedzierski W; Nusinowitz S; Birch D; Clarke G; McInnes RR; Bok D; Travis GH. 2001. Deficiency of rds/peripherin causes photoreceptor death in mouse models of digenic and dominant retinitis pigmentosa. Proc Natl Acad Sci U S A 98(14):7718-23. [PubMed: 11427722] [MGI Ref ID J:77309]
Krishnamoorthy R; Agarwal N; Chaitin MH. 2000. Upregulation of CD44 expression in the retina during the rds degeneration. Brain Res Mol Brain Res 77(1):125-30. [PubMed: 10814838] [MGI Ref ID J:62192]
LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. [PubMed: 9501871] [MGI Ref ID J:46230]
Lohr HR; Kuntchithapautham K; Sharma AK; Rohrer B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83(2):380-9. [PubMed: 16626700] [MGI Ref ID J:116326]
Loscher CJ; Hokamp K; Wilson JH; Li T; Humphries P; Farrar GJ; Palfi A. 2008. A common microRNA signature in mouse models of retinal degeneration. Exp Eye Res 87(6):529-34. [PubMed: 18834879] [MGI Ref ID J:143310]
Ma J; Norton JC; Allen AC; Burns JB; Hasel KW; Burns JL; Sutcliffe JG; Travis GH. 1995. Retinal degeneration slow (rds) in mouse results from simple insertion of a t haplotype-specific element into protein-coding exon II. Genomics 28(2):212-9. [PubMed: 8530028] [MGI Ref ID J:28016]
McNally N; Kenna PF; Rancourt D; Ahmed T; Stitt A; Colledge WH; Lloyd DG; Palfi A; O'Neill B; Humphries MM; Humphries P; Farrar GJ. 2002. Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene. Hum Mol Genet 11(9):1005-16. [PubMed: 11978760] [MGI Ref ID J:76490]
Morrow EM; Furukawa T; Raviola E; Cepko CL. 2005. Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci 6(1):5. [PubMed: 15676071] [MGI Ref ID J:95886]
Mrosovsky N; Thompson S. 2008. Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging. Vision Res 48(10):1270-3. [PubMed: 18394674] [MGI Ref ID J:141715]
Nir I; Haque R; Iuvone PM. 2000. Diurnal metabolism of dopamine in dystrophic retinas of homozygous and heterozygous retinal degeneration slow (rds) mice Brain Res 884(1-2):13-22. [PubMed: 11082482] [MGI Ref ID J:66055]
Nir I; Haque R; Iuvone PM. 2001. Regulation of cAMP by light and dopamine receptors is dysfunctional in photoreceptors of dystrophic retinal degeneration slow(rds) mice. Exp Eye Res 73(2):265-72. [PubMed: 11446777] [MGI Ref ID J:70501]
Nir I; Iuvone PM. 1994. Alterations in light-evoked dopamine metabolism in dystrophic retinas of mutant rds mice. Brain Res 649(1-2):85-94. [PubMed: 7953658] [MGI Ref ID J:18990]
Nir I; Kedzierski W; Chen J; Travis GH. 2000. Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice. J Neurosci 20(6):2150-4. [PubMed: 10704489] [MGI Ref ID J:60966]
Paquet-Durand F ; Hauck SM ; van Veen T ; Ueffing M ; Ekstrom P. 2009. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem 108(3):796-810. [PubMed: 19187097] [MGI Ref ID J:146653]
Portera-Cailliau C; Sung CH; Nathans J; Adler R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A 91(3):974-8. [PubMed: 8302876] [MGI Ref ID J:16708]
Rattner A; Chen J; Nathans J. 2004. Proteolytic shedding of the extracellular domain of photoreceptor cadherin. Implications for outer segment assembly. J Biol Chem 279(40):42202-10. [PubMed: 15284225] [MGI Ref ID J:119370]
Robb RM. 1979. Cyclic nucleotide phosphodiesterase activity in normal mice and mice with retinal degeneration. Invest Ophthalmol Vis Sci 18(10):1097-100. [PubMed: 225287] [MGI Ref ID J:6199]
Sancho-Pelluz J; Wunderlich KA; Rauch U; Romero FJ; van Veen T; Limb GA; Crocker PR; Perez MT. 2008. Sialoadhesin expression in intact degenerating retinas and following transplantation. Invest Ophthalmol Vis Sci 49(12):5602-10. [PubMed: 18641281] [MGI Ref ID J:142000]
Sanyal S; De Ruiter A; Hawkins RK. 1980. Development and degeneration of retina in rds mutant mice: light microscopy. J Comp Neurol 194(1):193-207. [PubMed: 7440795] [MGI Ref ID J:6432]
Sanyal S; Fletcher R; Liu YP; Aguirre G; Chader G. 1984. Cyclic nucleotide content and phosphodiesterase activity in the rds mouse (020/A) retina. Exp Eye Res 38(3):247-56. [PubMed: 6327341] [MGI Ref ID J:7447]
Sanyal S; Hawkins RK. 1986. Development and degeneration of retina in rds mutant mice: effects of light on the rate of degeneration in albino and pigmented homozygous and heterozygous mutant and normal mice. Vision Res 26(8):1177-85. [PubMed: 3798752] [MGI Ref ID J:25584]
Sanyal S; Jansen HG. 1981. Absence of receptor outer segments in the retina of rds mutant mice. Neurosci Lett 21(1):23-6. [PubMed: 7207866] [MGI Ref ID J:108107]
Stricker HM; Ding XQ; Quiambao A; Fliesler SJ; Naash MI. 2005. The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Biochem J 388(Pt 2):605-13. [PubMed: 15656787] [MGI Ref ID J:104527]
Takeuchi K; Nakazawa M; Mizukoshi S. 2008. Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds) mouse. Exp Eye Res 86(1):60-9. [PubMed: 17976582] [MGI Ref ID J:132513]
Travis GH; Bok D. 1993. Transgenic rescue of the photoreceptor dysplasia and degeneration in retinal degeneration slow (rds) mutant mice. Methods Neurosci 15:342-56. [MGI Ref ID J:20399]
Travis GH; Brennan MB; Danielson PE; Kozak CA; Sutcliffe JG. 1989. Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Nature 338(6210):70-3. [PubMed: 2918924] [MGI Ref ID J:9635]
Viczian A; Sanyal S; Toffenetti J; Chader GJ; Farber DB. 1992. Photoreceptor-specific mRNAs in mice carrying different allelic combinations at the rd and rds loci. Exp Eye Res 54(6):853-60. [PubMed: 1381682] [MGI Ref ID J:2579]
Wong P; Borst DE; Farber D; Danciger JS; Tenniswood M; Chader GJ; van Veen T. 1994. Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa. Biochem Cell Biol 72(9-10):439-46. [PubMed: 7605616] [MGI Ref ID J:24128]
Yang LP; Li Y; Zhu XA; Tso MO. 2007. Minocycline delayed photoreceptor death in rds mice through iNOS-dependent mechanism. Mol Vis 13:1073-82. [PubMed: 17653052] [MGI Ref ID J:123401]
van Nie R; Ivanyi D; Demant P. 1978. A new H-2-linked mutation, rds, causing retinal degeneration in the mouse. Tissue Antigens 12(2):106-8. [PubMed: 705766] [MGI Ref ID J:6051]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $94.10 Female or Male Homozygous for Prph2Rd2
Pairs /Price (US dollars $) Pair Genotype $188.20 Homozygous for Prph2Rd2 x Homozygous for Prph2Rd2
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $122.40 Female or Male Homozygous for Prph2Rd2
Pairs /Price (US dollars $) Pair Genotype $244.70 Homozygous for Prph2Rd2 x Homozygous for Prph2Rd2
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
|---|---|
| Supply Notes |
|
Control Information
| Control | ||
|---|---|---|
| 001912 C3A.BLiA-Pde6b+/J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.