Description

Strain Information

Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote         (Female x Male)   01-MAR-06 Species laboratory mouse Generation F17 (18-JAN-02) Generation Definitions

Appearance
albino, cataract, vascular cornea
Related Genotype: Tyr^c/Tyr^c Em/Em

Control Information

	Control
	None Available
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Em/?

        CFW-Em

• vision/eye phenotype
• cataracts
  • lens opacities appear as early as 6 to 8 months in mutant mice and progress to a dense opaque central zone, with a shrunken appearance and loss of wet and dry weight of the lens mice exhibit bilateral cataracts   (MGI Ref ID J:6825)
  • cataracts development is associated with the conversion of soluble to insoluble proteins, with lower total protein and lower glutathione than in wild-type mice   (MGI Ref ID J:7009)
  • severity of cataracts developed is decreased in mice fed a calorie restricted diet   (MGI Ref ID J:24254)
  • after 6 months of age, female mice develop more severe cataracts than male mice   (MGI Ref ID J:79371)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Em related

Sensorineural Research
Cataracts
      cortical

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Em
Allele Name		Emory cataract
Allele Type		Spontaneous
Strain of Origin		CFW
Gene Symbol and Name		Em, Emory cataract
Chromosome		UN

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Em related

Barron BC; Kuck JF; Kuck KD. 1984. The Emory mouse cataract: changes in the beta and gamma-crystallins during aging and cataractogenesis as revealed by isoelectric focusing of the native soluble proteins. Curr Eye Res 3(12):1365-72. [PubMed: 6525877]  [MGI Ref ID J:7732]

Congdon NT; West ST; Duncan DT; Fisher DT; Vitale ST; Rieger KT; Urist JT; Hazelwood DT; Sanchez AT; Pham T; Cole L; McNaughton C. 2000. The effect of pantethine and ultraviolet-B radiation on the development of lenticular opacity in the emory mouse. Curr Eye Res 20(1):17-24. [PubMed: 10611711]  [MGI Ref ID J:60335]

Gong X; Shang F; Obin M; Palmer H; Scrofano MM; Jahngen-Hodge J; Smith DE; Taylor A. 1997. Antioxidant enzyme activities in lens, liver and kidney of calorie restricted Emory mice Mech Ageing Dev 99(3):181-92. [PubMed: 9483491]  [MGI Ref ID J:45556]

Kuck JF; Kuck KD. 1983. The Emory mouse cataract: loss of soluble protein, glutathione, protein sulfhydryl and other changes. Exp Eye Res 36(3):351-62. [PubMed: 6832231]  [MGI Ref ID J:7009]

Kuck JF; Kuwabara T; Kuck KD. 1981. The Emory mouse cataract: an animal model for human senile cataract. Curr Eye Res 1(11):643-9. [PubMed: 7346236]  [MGI Ref ID J:6825]

Mura CV; Gong X; Taylor A; Villalobos-Molina R; Scrofano MM. 1996. Effects of calorie restriction and aging on the expression of antioxidant enzymes and ubiquitin in the liver of Emory mice. Mech Ageing Dev 91(2):115-29. [PubMed: 8905609]  [MGI Ref ID J:36217]

Scrofano MM; Shang F; Nowell TR Jr; Gong X; Smith DE; Kelliher M; Dunning J; Mura CV; Taylor A. 1998. Aging, calorie restriction and ubiquitin-dependent proteolysis in the livers of Emory mice. Mech Ageing Dev 101(3):277-96. [PubMed: 9622231]  [MGI Ref ID J:47470]

Shang F; Nowell T; Gong X; Smith DE; Dallal GE; Khu P; Taylor A. 2002. Sex-linked Differences in Cataract Progression in Emory Mice. Exp Eye Res 75(1):109-11. [PubMed: 12123642]  [MGI Ref ID J:79371]

Taylor A; Lipman RD; Jahngen-Hodge J; Palmer V; Smith D; Padhye N; Dallal GE; Cyr DE; Laxman E; Shepard D; Morrow F; Salomon R; Perrone G; Asmundsson G; Meydani M; Blumberg J; Mune M; Harrison DE; Archer JR; Shigenaga M.. 1995. Dietary calorie restriction in the Emory mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity,nd cancer. Mech Ageing Dev 79(1):33-57. [PubMed: 7540704]  [MGI Ref ID J:24254]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Homozygote x Homozygote         (Female x Male)   01-MAR-06

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	None Available
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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