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| This is a congenic strain used in transplant studies because it carries the differential B cell antigen originally designated Ly5.1 and CD45.1. The b allele of Ptprc is normally present in the BALB and C57BL inbred strains. | ||||||||||||||||||
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- Disease & phenotype
- Genes & alleles
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Description
Strain Information
Former Names B6.SJL-Ptprca Pep3b/BoyJ (Changed: 02-MAR-06 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is an exceptional breeder. Species laboratory mouse Background Strain C57BL/6 Donor Strain SJL/J Generation N25F9 (17-SEP-12)
Generation Definitions
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Related Genotype: a/aDescription
This is a congenic strain used in transplant studies because it carries the differential B cell antigen originally designated Ly5.1 and CD45.1 The current use of the Ptprc designation for Cd45 and Ly5 was based on work in humans following the report of Charbonneau and colleagues who first showed that a protein-tyrosine phosphatase (human placental protein-tyrosine phosphatase 1B) was homologous to the CD45 protein. Ptprc is one of a family of protein-tyrosine phosphatase genes involved in the regulation of cell growth. The b allele is normally present in the BALB and C57BL inbred strains.Development
The Ptprca allele and closely linked Pepcb allele were serially backcrossed from SJL/J onto C57BL/6 with selection at each generation for Ptprca by serotyping (Shen et al., 1985). In 1990 this strain, then housed at Sloan Kettering, was imported into The Jackson Laboratory from Edward Boyse at generation N22. Since its arrival, the strain has been maintained by sibling inbreeding. In 2005 it reached generation N22F55.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pepcb allele
006259 B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J View Strains carrying Pepcb (1 strain)
008451 B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ 007594 B6.129P2-Ptrpca Ightm1Mnz/J 006259 B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J 013198 B6.Cg-Ptprca Mir223tm1Fcam/J 018869 C.129S4(Cg)-Il13tm2.1Lky/J 006584 CBy.SJL(B6)-Ptprca/J
000824 LT.B6-Pepca/J
007172 129S6.129X1(B6)-Ptprctm1Weis/J 002725 B6.129-Ptprctm1Holm/J 007171 B6.129X1-Ptprctm1Weis/J 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J 007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J 007686 BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J 007173 C.129X1(B6)-Ptprctm1Weis/J 016091 C57BL/6-Ptprcltng/J 014149 NOD.B6-Ptprcb/6908MrkTacJ 005616 NOD.C-(Ptprc-D1Mit262)/WehiJ
Additional Web Information
JAX® NOTES, Summer 1994; 458. Ly5 Gene Nomenclature, C57BL/6J and SJL/J - A History of Change.
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Hepatitis C Virus, Susceptibility to (PTPRC)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive (PTPRC)
This mouse can be used to support research in many areas including:
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Research Tools
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: B cell specific marker
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Pepcb | ||
|---|---|---|---|
| Allele Name | b variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Pep3b; | ||
| Gene Symbol and Name | Pepc, peptidase C | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | Dip-1; Pep-3; Pep3; dipeptidase 1; peptidase 3; | ||
| Molecular Note | The Pepc gene controls electrophoretic variation of peptidase C (PEP-C; EC 3.4.11.-) of red blood cells. The allele Pepcb determines a faster migrating band and is found in the CBA/J and A/He strains. | ||
| Allele Symbol | Ptprca | ||
| Allele Name | a variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | CD45.1; Ly5a; PtprcSJL; | ||
| Gene Symbol and Name | Ptprc, protein tyrosine phosphatase, receptor type, C | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | B220; CD45; CD45 antigen; CD45R; Cd45; GP180; L-CA; LCA; LY5; Ly-5; Lyt-4; RT7; T-lymphocyte antigen 4; T200; lymphocyte antigen 5; | ||
| Molecular Note |
Ptprca is found in strains SJL/J, STS/A, and DA. Ptprcb is found in strains C57BL/6, C3H/An, DBA/2, AKR, and many others (J:13367, J:12054, J:12077, J:8603). Twelve nucleotide differences between the a and b alleles have been identified. These base substitutions correspond to five amino-acid changes within the extracellular domain of the encoded protein. These amino-acid differences are clustered in a region that also contains the greatest divergence between mouse and rat sequences (J:22485). Note that the allele designations originally described were reversed in 1987 (J:8603); all publications prior to 1987 show SJL/J, STS/A, and DA as having the b allele and the C57BL/6J group as having the a allele (J:22341). [MGI Ref ID J:12548] [MGI Ref ID J:22485] [MGI Ref ID J:8080] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Ptprcab End Point, End Point Analysis
Ptprcab, Pyrosequencing
The Jackson Laboratory has not developed a genotyping assay for the B6.SJL-Ptprca Pepcb/BoyJ mouse strain. The following reference describes an assay: Zebedee SL et al. 1991. Eur J Immunogenet 1991 Jun;18(3):155-63. PMID: 1834169. Alternatively, antibodies for Ptprca (CD45.1, Ly5.1) can be used with FACS analysis.
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Janowska-Wieczorek A; Majka M; Kijowski J; Baj-Krzyworzeka M; Reca R; Turner AR; Ratajczak J; Emerson SG; Kowalska MA; Ratajczak MZ. 2001. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood 98(10):3143-9. [PubMed: 11698303] [MGI Ref ID J:109863]
Schluns KS; Williams K; Ma A; Zheng XX; Lefrancois L. 2002. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168(10):4827-31. [PubMed: 11994430] [MGI Ref ID J:109854]
Yang G; Hisha H; Cui Y; Fan T; Jin T; Li Q; Lian Z; Hosaka N; Li Y; Ikehara S. 2002. A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cells. Stem Cells 20(3):241-8. [PubMed: 12004082] [MGI Ref ID J:109853]
Additional References
Charbonneau H; Tonks NK; Walsh KA; Fischer EH. 1988. The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. Proc Natl Acad Sci U S A 85(19):7182-6. [PubMed: 2845400] [MGI Ref ID J:22340]
Held W; Clevers H; Grosschedl R. 2003. Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Eur J Immunol 33(5):1393-8. [PubMed: 12731066] [MGI Ref ID J:85394]
Morse HC 3rd. 1992. Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563] J Immunol 149(10):3129-34. [PubMed: 1431091] [MGI Ref ID J:3170]
Morse HC 3rd; Shen FW; Hammerling U. 1987. Genetic nomenclature for loci controlling mouse lymphocyte antigens. Immunogenetics 25(2):71-8. [PubMed: 3817907] [MGI Ref ID J:8603]
Shen FW; Saga Y; Litman G; Freeman G; Tung JS; Cantor H; Boyse EA. 1985. Cloning of Ly-5 cDNA. Proc Natl Acad Sci U S A 82(21):7360-3. [PubMed: 3864163] [MGI Ref ID J:8080]
Pepcb relatedPtprca relatedBasu S; Ray A; Dittel BN. 2011. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol 187(11):5720-32. [PubMed: 22048769] [MGI Ref ID J:179699]
Chapman VM; Ruddle FH; Roderick TH. 1971. Linkage of isozyyme loci in the mouse: phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1). Biochem Genet 5(2):101-10. [PubMed: 4397868] [MGI Ref ID J:5216]
De Santo C; Arscott R; Booth S; Karydis I; Jones M; Asher R; Salio M; Middleton M; Cerundolo V. 2010. Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol 11(11):1039-46. [PubMed: 20890286] [MGI Ref ID J:166540]
Del Cid N; Shen L; Belleisle J; Raghavan M. 2012. Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. PLoS One 7(7):e41727. [PubMed: 22848581] [MGI Ref ID J:189698]
Harandi OF; Hedge S; Wu DC; McKeone D; Paulson RF. 2010. Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors. J Clin Invest 120(12):4507-19. [PubMed: 21060151] [MGI Ref ID J:171872]
Huber S; Hoffmann R; Muskens F; Voehringer D. 2010. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 116(17):3311-20. [PubMed: 20625006] [MGI Ref ID J:165869]
Iijima N; Mattei LM; Iwasaki A. 2011. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A 108(1):284-9. [PubMed: 21173243] [MGI Ref ID J:169008]
Jiang S; Alberich-Jorda M; Zagozdzon R; Parmar K; Fu Y; Mauch P; Banu N; Makriyannis A; Tenen DG; Avraham S; Groopman JE; Avraham HK. 2011. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood 117(3):827-38. [PubMed: 21063029] [MGI Ref ID J:168507]
Kitano M; Moriyama S; Ando Y; Hikida M; Mori Y; Kurosaki T; Okada T. 2011. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34(6):961-72. [PubMed: 21636294] [MGI Ref ID J:174014]
Leskov IL; Whitsett J; Vasquez-Vivar J; Stokes KY. 2011. NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction. Free Radic Biol Med 51(12):2300-8. [PubMed: 22033010] [MGI Ref ID J:179407]
Lewis WH; Truslove GM. 1969. Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet 3(5):493-8. [PubMed: 4187938] [MGI Ref ID J:5133]
Masson F; Minnich M; Olshansky M; Bilic I; Mount AM; Kallies A; Speed TP; Busslinger M; Nutt SL; Belz GT. 2013. Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation. J Immunol 190(9):4585-94. [PubMed: 23536629] [MGI Ref ID J:195516]
Moebius J; van den Broek M; Groettrup M; Basler M. 2010. Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice. Eur J Immunol 40(12):3439-49. [PubMed: 21108466] [MGI Ref ID J:174578]
Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity 37(1):147-57. [PubMed: 22727490] [MGI Ref ID J:187413]
Nobrega C; Nunes-Alves C; Cerqueira-Rodrigues B; Roque S; Barreira-Silva P; Behar SM; Correia-Neves M. 2013. T cells home to the thymus and control infection. J Immunol 190(4):1646-58. [PubMed: 23315077] [MGI Ref ID J:193323]
Pulliam-Leath AC; Ciccone SL; Nalepa G; Li X; Si Y; Miravalle L; Smith D; Yuan J; Li J; Anur P; Orazi A; Vance GH; Yang FC; Hanenberg H; Bagby GC; Clapp DW. 2010. Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia. Blood 116(16):2915-20. [PubMed: 20606166] [MGI Ref ID J:165874]
Roman E; Shino H; Qin FX; Liu YJ. 2010. Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus. J Immunol 185(7):3819-23. [PubMed: 20802149] [MGI Ref ID J:164214]
Shang X; Cancelas JA; Li L; Guo F; Liu W; Johnson JF; Ficker A; Daria D; Geiger H; Ratner N; Zheng Y. 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. J Biol Chem 286(27):24068-78. [PubMed: 21572048] [MGI Ref ID J:175297]
Siggs OM; Arnold CN; Huber C; Pirie E; Xia Y; Lin P; Nemazee D; Beutler B. 2011. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol 12(5):434-40. [PubMed: 21423172] [MGI Ref ID J:171925]
So T; Soroosh P; Eun SY; Altman A; Croft M. 2011. Antigen-independent signalosome of CARMA1, PKC{theta}, and TNF receptor-associated factor 2 (TRAF2) determines NF-{kappa}B signaling in T cells. Proc Natl Acad Sci U S A 108(7):2903-8. [PubMed: 21282629] [MGI Ref ID J:169068]
Sun S; Xia S; Ji Y; Kersten S; Qi L. 2012. The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue. Diabetes 61(6):1471-8. [PubMed: 22415881] [MGI Ref ID J:196855]
Teng EC; Racioppi L; Means AR. 2011. A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. J Leukoc Biol 90(5):897-909. [PubMed: 21816924] [MGI Ref ID J:178260]
Waterstrat A; Liang Y; Swiderski CF; Shelton BJ; Van Zant G. 2010. Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment. Blood 115(2):408-17. [PubMed: 19901263] [MGI Ref ID J:155980]
Westmuckett AD; Thacker KM; Moore KL. 2011. Tyrosine sulfation of native mouse psgl-1 is required for optimal leukocyte rolling on p-selectin in vivo. PLoS One 6(5):e20406. [PubMed: 21633705] [MGI Ref ID J:172569]
Wingender G; Hiss M; Engel I; Peukert K; Ley K; Haller H; Kronenberg M; von Vietinghoff S. 2012. Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. J Immunol 188(7):3000-8. [PubMed: 22387552] [MGI Ref ID J:183092]
de Andres-Aguayo L; Varas F; Kallin EM; Infante JF; Wurst W; Floss T; Graf T. 2011. Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice. Blood 118(3):554-64. [PubMed: 21613258] [MGI Ref ID J:174870]
Ashbaugh JJ; Brambilla R; Karmally SA; Cabello C; Malek TR; Bethea JR. 2013. IL7Ralpha Contributes to Experimental Autoimmune Encephalomyelitis through Altered T Cell Responses and Nonhematopoietic Cell Lineages. J Immunol 190(9):4525-34. [PubMed: 23530149] [MGI Ref ID J:195519]
Basu S; Ray A; Dittel BN. 2011. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol 187(11):5720-32. [PubMed: 22048769] [MGI Ref ID J:179699]
Cho RH; Sieburg HB; Muller-Sieburg CE. 2008. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 111(12):5553-61. [PubMed: 18413859] [MGI Ref ID J:162992]
Coleman MA; Bridge JA; Lane SW; Dixon CM; Hill GR; Wells JW; Thomas R; Steptoe RJ. 2013. Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood 121(6):1049-58. [PubMed: 23233664] [MGI Ref ID J:194614]
De Santo C; Arscott R; Booth S; Karydis I; Jones M; Asher R; Salio M; Middleton M; Cerundolo V. 2010. Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol 11(11):1039-46. [PubMed: 20890286] [MGI Ref ID J:166540]
Del Cid N; Shen L; Belleisle J; Raghavan M. 2012. Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. PLoS One 7(7):e41727. [PubMed: 22848581] [MGI Ref ID J:189698]
Ewald SJ; McKenzie IFC. 1979. Immunochemical characterization of the Ly-5 alloantigens on thymocytes. Immunogenetics 8:583-587. [MGI Ref ID J:13367]
Gardam S; Turner VM; Anderton H; Limaye S; Basten A; Koentgen F; Vaux DL; Silke J; Brink R. 2011. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood 117(15):4041-51. [PubMed: 21300983] [MGI Ref ID J:172843]
Gerloff J; Korshunov VA. 2012. Immune modulation of vascular resident cells by axl orchestrates carotid intima-media thickening. Am J Pathol 180(5):2134-43. [PubMed: 22538191] [MGI Ref ID J:183990]
Glass AM; Wolf BJ; Schneider KM; Princiotta MF; Taffet SM. 2013. Connexin43 is dispensable for phagocytosis. J Immunol 190(9):4830-5. [PubMed: 23554311] [MGI Ref ID J:195494]
Harp JA; Davis BS; Ewald SJ. 1984. Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera. J Immunol 133(1):10-5. [PubMed: 6233370] [MGI Ref ID J:7453]
Held W; Clevers H; Grosschedl R. 2003. Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Eur J Immunol 33(5):1393-8. [PubMed: 12731066] [MGI Ref ID J:85394]
Hirahara K; Ghoreschi K; Yang XP; Takahashi H; Laurence A; Vahedi G; Sciume G; Hall AO; Dupont CD; Francisco LM; Chen Q; Tanaka M; Kanno Y; Sun HW; Sharpe AH; Hunter CA; O'Shea JJ. 2012. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity 36(6):1017-30. [PubMed: 22726954] [MGI Ref ID J:187415]
Huber S; Hoffmann R; Muskens F; Voehringer D. 2010. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 116(17):3311-20. [PubMed: 20625006] [MGI Ref ID J:165869]
Iijima N; Mattei LM; Iwasaki A. 2011. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A 108(1):284-9. [PubMed: 21173243] [MGI Ref ID J:169008]
Jiang S; Alberich-Jorda M; Zagozdzon R; Parmar K; Fu Y; Mauch P; Banu N; Makriyannis A; Tenen DG; Avraham S; Groopman JE; Avraham HK. 2011. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood 117(3):827-38. [PubMed: 21063029] [MGI Ref ID J:168507]
Kasai M; Leclerc JC; Shen FW; Cantor H. 1979. Identification of Ly 5 on the surface of `natural killer' cells in normal and athymic inbred mouse strains. Immunogenetics 8:153-159. [MGI Ref ID J:12054]
Kitano M; Moriyama S; Ando Y; Hikida M; Mori Y; Kurosaki T; Okada T. 2011. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34(6):961-72. [PubMed: 21636294] [MGI Ref ID J:174014]
Komuro K ; Itakura K ; Boyse EA ; John M. 1975. Ly-5: a new lymphocyte antigen system. Immunogenetics 1:452-456. [MGI Ref ID J:12077]
Leskov IL; Whitsett J; Vasquez-Vivar J; Stokes KY. 2011. NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction. Free Radic Biol Med 51(12):2300-8. [PubMed: 22033010] [MGI Ref ID J:179407]
Masson F; Minnich M; Olshansky M; Bilic I; Mount AM; Kallies A; Speed TP; Busslinger M; Nutt SL; Belz GT. 2013. Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation. J Immunol 190(9):4585-94. [PubMed: 23536629] [MGI Ref ID J:195516]
McAleer JP; Liu B; Li Z; Ngoi SM; Dai J; Oft M; Vella AT. 2010. Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization. J Leukoc Biol 88(1):21-31. [PubMed: 20130220] [MGI Ref ID J:162449]
McNally A; Hill GR; Sparwasser T; Thomas R; Steptoe RJ. 2011. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 108(18):7529-34. [PubMed: 21502514] [MGI Ref ID J:172217]
Meisner JK; Song J; Price RJ. 2012. Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression. PLoS One 7(9):e46312. [PubMed: 23029475] [MGI Ref ID J:191962]
Mobraaten LE. 1994. Ly5 gene nomenclature, C57BL/6J and SJL/J - A history of change JAX Notes Summer(458):2. [MGI Ref ID J:22341]
Moebius J; van den Broek M; Groettrup M; Basler M. 2010. Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice. Eur J Immunol 40(12):3439-49. [PubMed: 21108466] [MGI Ref ID J:174578]
Morse HC 3rd; Shen FW; Hammerling U. 1987. Genetic nomenclature for loci controlling mouse lymphocyte antigens. Immunogenetics 25(2):71-8. [PubMed: 3817907] [MGI Ref ID J:8603]
Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity 37(1):147-57. [PubMed: 22727490] [MGI Ref ID J:187413]
Nobrega C; Nunes-Alves C; Cerqueira-Rodrigues B; Roque S; Barreira-Silva P; Behar SM; Correia-Neves M. 2013. T cells home to the thymus and control infection. J Immunol 190(4):1646-58. [PubMed: 23315077] [MGI Ref ID J:193323]
Pepper M; Pagan AJ; Igyarto BZ; Taylor JJ; Jenkins MK. 2011. Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35(4):583-95. [PubMed: 22018468] [MGI Ref ID J:177635]
Pulliam-Leath AC; Ciccone SL; Nalepa G; Li X; Si Y; Miravalle L; Smith D; Yuan J; Li J; Anur P; Orazi A; Vance GH; Yang FC; Hanenberg H; Bagby GC; Clapp DW. 2010. Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia. Blood 116(16):2915-20. [PubMed: 20606166] [MGI Ref ID J:165874]
Raschke WC; Hendricks M; Chen CM. 1995. Genetic basis of antigenic differences between three alleles of Ly5 (CD45) in mice. Immunogenetics 41(2-3):144-7. [PubMed: 7806287] [MGI Ref ID J:22485]
Robbins CS; Chudnovskiy A; Rauch PJ; Figueiredo JL; Iwamoto Y; Gorbatov R; Etzrodt M; Weber GF; Ueno T; van Rooijen N; Mulligan-Kehoe MJ; Libby P; Nahrendorf M; Pittet MJ; Weissleder R; Swirski FK. 2012. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation 125(2):364-74. [PubMed: 22144566] [MGI Ref ID J:193795]
Roman E; Shino H; Qin FX; Liu YJ. 2010. Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus. J Immunol 185(7):3819-23. [PubMed: 20802149] [MGI Ref ID J:164214]
Seldin MF; D'Hoostelaere LA; Steinberg AD; Saga Y; Morse HC 3rd. 1987. Allelic variants of Ly-5 in inbred and natural populations of mice. Immunogenetics 26(1-2):74-8. [PubMed: 2886425] [MGI Ref ID J:8805]
Shang X; Cancelas JA; Li L; Guo F; Liu W; Johnson JF; Ficker A; Daria D; Geiger H; Ratner N; Zheng Y. 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. J Biol Chem 286(27):24068-78. [PubMed: 21572048] [MGI Ref ID J:175297]
Shen FW; Saga Y; Litman G; Freeman G; Tung JS; Cantor H; Boyse EA. 1985. Cloning of Ly-5 cDNA. Proc Natl Acad Sci U S A 82(21):7360-3. [PubMed: 3864163] [MGI Ref ID J:8080]
Shen FW; Tung JS; Boyse EA. 1986. Further definition of the Ly-5 system. Immunogenetics 24(3):146-9. [PubMed: 3489673] [MGI Ref ID J:8430]
Shulzhenko N; Morgun A; Matzinger P. 2009. Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage. Genes Immun 10(8):722-6. [PubMed: 19727123] [MGI Ref ID J:157450]
Siggs OM; Arnold CN; Huber C; Pirie E; Xia Y; Lin P; Nemazee D; Beutler B. 2011. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol 12(5):434-40. [PubMed: 21423172] [MGI Ref ID J:171925]
Silva DG; Daley SR; Hogan J; Lee SK; Teh CE; Hu DY; Lam KP; Goodnow CC; Vinuesa CG. 2011. Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells. Diabetes 60(8):2102-11. [PubMed: 21788582] [MGI Ref ID J:186792]
So T; Soroosh P; Eun SY; Altman A; Croft M. 2011. Antigen-independent signalosome of CARMA1, PKC{theta}, and TNF receptor-associated factor 2 (TRAF2) determines NF-{kappa}B signaling in T cells. Proc Natl Acad Sci U S A 108(7):2903-8. [PubMed: 21282629] [MGI Ref ID J:169068]
Sun S; Xia S; Ji Y; Kersten S; Qi L. 2012. The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue. Diabetes 61(6):1471-8. [PubMed: 22415881] [MGI Ref ID J:196855]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX4
Room Number MP14
Room Number RB05
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is an exceptional breeder. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Weeks of Age Price per mouse (US dollars $) Gender Genotypes Provided 3 weeks $51.10 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 4 weeks $51.10 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 5 weeks $51.10 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 6 weeks $53.50 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 7 weeks $55.75 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 8 weeks $58.10 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 9 weeks $60.40 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 10 weeks $62.80 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 11 weeks $65.00 Female Homozygous for Ptprca , Homozygous for Pepcb Standard Supply
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes
Volume pricing is available for this strain. View our Volume Pricing Program for information.- This strain is available from both the Bar Harbor, Maine and Sacramento, Calif. facilities.
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
| Pricing for International shipping destinations |
|
Live Mice
Weeks of Age Price per mouse (US dollars $) Gender Genotypes Provided 3 weeks $66.50 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 4 weeks $66.50 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 5 weeks $66.50 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 6 weeks $69.60 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 7 weeks $72.50 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 8 weeks $75.60 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 9 weeks $78.60 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 10 weeks $81.70 Female or Male Homozygous for Ptprca , Homozygous for Pepcb 11 weeks $84.50 Female Homozygous for Ptprca , Homozygous for Pepcb Standard Supply
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
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|
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Standard Supply
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
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See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.