Strain Name:

C57BL/6J-ApcMin/J

Stock Number:

002020

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Availability:

Level 4

Homozygous C57BL/6J-ApcMin/J mice are not viable. Heterozygotes develop anemia and are highly susceptible to spontaneous intestinal adenoma formation. A small number of C57BL/6J-ApcMin heterozygous female mice develop mammary tumors.

Description

Strain Information

Type Chemically Induced Mutation; Coisogenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemInbred x Heterozygote         (Female x Male)   18-SEP-08
(C57BL/6J x Heterozygote)
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
GenerationN79pN14 (05-AUG-14)
Generation Definitions
 
Donating InvestigatorDr. William F. Dove,   University of Wisconsin- Madison
Donating InvestigatorDr. Alexandra Shedlovsky,   University of Wisconsin , Madison

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Related Genotype: a/a

Description
The C57BL/6J-ApcMin/J strain is highly susceptible to spontaneous intestinal adenoma formation. Homozygous mice are not viable. It was initially reported that one hundred percent of the C57BL/6J-ApcMin heterozygous mice raised on a high fat diet develop in excess of 30 adenomas throughout the intestinal tract and most die by 120 days of age. Heterozygotes also develop anemia. (Moser et al., 1990, Su et al., 1992). A small number of C57BL/6J-ApcMin heterozygous female mice develop mammary tumors. A subsequent publication indicates that this strain may carry a dominant modifier (Mom2) gene that reduces the number and incidence of polyp formation in C57BL/6J-ApcMin heterozygous mice (Silverman et al., 2002).

This strain ships with a JAXTagTM affixed. Learn more about JAXTagTM.

Development
Following N-ethyl-N-nitrosourea (ENU) treatments to induce mutations in founder C57BL/6J mice, a forward genetic screen identified a AKR/JxB6 F1 female displaying circling behavior. This female was mated to C57BL/6J males. Some progeny from this backcross developed adult onset anemia and multiple intestinal neoplasia (Min). A tumor suppressor gene, Apc (adenomatosis polyposis coli), mutations of which have been identified in colorectal cancers and familial adenomatous polyposis (FAP), was found to cosegregate with the Min phenotype. Sequencing of Apc identified a T to A transversion of nucleotide 2549 resulting in a Leucine to a Stop codon nonsense mutation. The circling behavior was determined to be a separate heritable trait and was eliminated through subsequent crosses to C57BL/6J. These ApcMin mice maintained on a C57BL/6J background when they were sent to The Jackson Laboratory in 1992.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Apc
009045   C57BL/6-Apctm1Tyj/J
View Strains carrying other alleles of Apc     (1 strain)

Additional Web Information

JAX® NOTES, Fall 1993; 455. The C57BL/6J-Min/+ Mouse.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Colorectal Cancer; CRC
Familial Adenomatous Polyposis 1; FAP1
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Desmoid Disease, Hereditary   (APC)
Gastric Cancer   (APC)
Hepatocellular Carcinoma   (APC)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

ApcMin/Apc+

        C57BL/6J-ApcMin
  • tumorigenesis
  • increased colonic adenoma incidence   (MGI Ref ID J:160399)
    • tubular adenomas in the colon   (MGI Ref ID J:158733)
  • increased intestinal adenoma incidence
    • tubular adenomas in the intestine   (MGI Ref ID J:158733)
    • most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter   (MGI Ref ID J:85142)
    • mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15   (MGI Ref ID J:85142)
    • at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males   (MGI Ref ID J:85142)
    • mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet   (MGI Ref ID J:85142)
  • homeostasis/metabolism phenotype
  • increased circulating free fatty acid level
    • females exhibit increased free fatty acid levels at 15 weeks of age   (MGI Ref ID J:86036)
  • increased circulating triglyceride level
    • females show increased triglyceride levels at 15 weeks of age   (MGI Ref ID J:86036)
  • increased prostaglandin level
    • increase in luminal prostaglandin E2 at 15 weeks of age   (MGI Ref ID J:85142)
  • liver/biliary system phenotype
  • hepatic steatosis
    • centrilobular-restricted steatosis is seen in the livers of mutants at 15 weeks of age   (MGI Ref ID J:86036)
  • growth/size/body phenotype
  • postnatal growth retardation
    • regular chow-fed males stop gaining weight, lose more weight, and are smaller at 15 weeks than beef-fed males   (MGI Ref ID J:85142)
  • hematopoietic system phenotype
  • decreased macrophage cell number
    • fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments   (MGI Ref ID J:85142)
    • however, luminal IgA, IL-12, and TNF-alpha concentrations are normal   (MGI Ref ID J:85142)
  • immune system phenotype
  • decreased macrophage cell number
    • fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments   (MGI Ref ID J:85142)
    • however, luminal IgA, IL-12, and TNF-alpha concentrations are normal   (MGI Ref ID J:85142)

ApcMin/Apc+

        involves: C57BL/6J
  • mortality/aging
  • premature death
    • heterozygotes begin to die at 7 months of age   (MGI Ref ID J:94108)
  • tumorigenesis
  • increased intestinal adenoma incidence
    • small and large adenomas are seen throughout the intestine with more lesions found in the ileum compared to Apctm1Cip heterozygotes   (MGI Ref ID J:94108)
  • increased mammary adenocarcinoma incidence
    • 12% of heterozygotes developed mammary adenocanthomas   (MGI Ref ID J:94108)
  • digestive/alimentary phenotype
  • abnormal enterocyte proliferation
    • reduced proliferation of cells in the colon in ovariectomized   (MGI Ref ID J:118600)
    • however, 17beta-estradiol replacement increases colonocyte proliferation 2-fold   (MGI Ref ID J:118600)
  • abnormal intestinal mucosa morphology
    • ovariectomized mice exhibit abnormal submucosal with thickening of the muscularis mucosae and enrichment of stromal components compared with control mice   (MGI Ref ID J:118600)
    • abnormal intestinal goblet cell morphology
      • fewer mature goblet cells in the colon with prevelant pregoblet cells in ovariectomized mcie treated with 17beta-estradiol   (MGI Ref ID J:118600)
      • the goblet cell ratio in ovariectomized mice is increased compared to in intact mice   (MGI Ref ID J:118600)
    • abnormal large intestine crypts of Lieberkuhn morphology
      • ovariectomized mice exhibit reduced crypt length and distortion of surface epithelial cells in the colon compared with control mice   (MGI Ref ID J:118600)
  • intestine polyps   (MGI Ref ID J:191217)
  • rectal prolapse
    • rectal prolapse is seen in 28% of surviving mutants at 7 months of age   (MGI Ref ID J:94108)
  • cellular phenotype
  • abnormal enterocyte proliferation
    • reduced proliferation of cells in the colon in ovariectomized   (MGI Ref ID J:118600)
    • however, 17beta-estradiol replacement increases colonocyte proliferation 2-fold   (MGI Ref ID J:118600)
  • endocrine/exocrine gland phenotype
  • abnormal large intestine crypts of Lieberkuhn morphology
    • ovariectomized mice exhibit reduced crypt length and distortion of surface epithelial cells in the colon compared with control mice   (MGI Ref ID J:118600)

ApcMin/Apc+

        involves: C57BL/6 * C57BL/6J
  • mortality/aging
  • premature death
    • mice die at 169 days   (MGI Ref ID J:134087)
  • digestive/alimentary phenotype
  • intestine polyps
    • mice develop more and bigger polyps than in ApcMin Myctm1Jlc heterozygotes   (MGI Ref ID J:134087)

ApcMin/Apc+

        B6(AKR)-ApcMin
  • mortality/aging
  • premature death
    • mutant mice do not a have a normal life-span, most rarely survive longer than 120 days of age   (MGI Ref ID J:10209)
    • average life-span has not decreased after N6 of backcrossing, suggesting genetic background influences effects of the mutation   (MGI Ref ID J:10209)
  • tumorigenesis
  • increased intestinal adenocarcinoma incidence
    • in N4-N8 backcross mice tumors are presesnt throughout the small and large intestines   (MGI Ref ID J:10209)
    • localization of tumors in the small and large intestines varies among mice   (MGI Ref ID J:10209)
  • increased intestinal adenoma incidence   (MGI Ref ID J:10209)
  • increased mammary gland tumor incidence
    • on this background colony maintenance data show that mammary tumors occasionally develop in heterozygous females but not in wild-type female siblings   (MGI Ref ID J:15101)
  • reproductive system phenotype
  • abnormal pregnancy
    • females are rarely able to maintain a pregnancy due to compromised health   (MGI Ref ID J:10209)
  • hematopoietic system phenotype
  • anemia
    • anemia is diagnosed by 60 days of age   (MGI Ref ID J:10209)
    • follows development of multiple adenomas which bleed into the intestinal lumen   (MGI Ref ID J:10209)
  • endocrine/exocrine gland phenotype
  • mammary gland hyperplasia
    • females of this genotype have an increased susceptibility to developing mammary neoplasia   (MGI Ref ID J:15101)
  • integument phenotype
  • mammary gland hyperplasia
    • females of this genotype have an increased susceptibility to developing mammary neoplasia   (MGI Ref ID J:15101)

ApcMin/ApcMin

        involves: C57BL/6J
  • cellular phenotype
  • abnormal cell physiology
    • cultured adenomatous tissue form highly clonogenic spheroids   (MGI Ref ID J:187862)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

ApcMin/Apc+

        involves: AKR/J * C57BL/6J
  • tumorigenesis
  • increased intestinal adenocarcinoma incidence
    • locally invasive tumors seen in older animals but no metastasis   (MGI Ref ID J:10209)
    • sometimes small areas of carcinomas in anemic animals only   (MGI Ref ID J:10209)
    • if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age   (MGI Ref ID J:10209)
  • increased intestinal adenoma incidence
    • visible tumors of the large and small intestine   (MGI Ref ID J:10209)
    • either polyploid, papillary or sessile adenomas   (MGI Ref ID J:10209)
  • digestive/alimentary phenotype
  • melena
    • bloody feces   (MGI Ref ID J:10209)
  • hematopoietic system phenotype
  • anemia
    • progressive adult onset anemia beconming severe and chronic   (MGI Ref ID J:10209)
    • diagnosed in mutant mice by 60 days of age   (MGI Ref ID J:10209)
    • with few exceptions, likely the cause of lethality by 120 days of age   (MGI Ref ID J:10209)
  • decreased hematocrit
    • moribund animals with hematocrits around 10-20%   (MGI Ref ID J:10209)
  • homeostasis/metabolism phenotype
  • hyperlipidemia   (MGI Ref ID J:10209)
  • mortality/aging
  • premature death   (MGI Ref ID J:10209)

ApcMin/Apc+

        B6.Cg-Brca2tm1Mbn ApcMin
  • growth/size/body phenotype
  • decreased body weight
    • body weight of mice at time of sacrifice differs significantly from Brca2-heterozygous and wild-type animals; mice show lower weight gain from start to end of experiment compared to other experimental genotypes   (MGI Ref ID J:67445)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • only observed in 1/9 ENU-treated males, similar to wild-type males (1/9)   (MGI Ref ID J:67445)
    • abnormal ovarian follicle morphology
      • remaining follicles are degenerating in ENU-treated females   (MGI Ref ID J:67445)
      • abnormal ovarian folliculogenesis
        • arrested follicular development is 6-fold more prevalent compared to ENU-treated Brca2-deficient mice   (MGI Ref ID J:67445)
        • absent mature ovarian follicles   (MGI Ref ID J:67445)
    • abnormal vagina epithelium morphology
      • reduced in thickness and lined with vacuolated cells indicative of anestrus in ENU-treated females   (MGI Ref ID J:67445)
    • absent corpus luteum
      • absent in 26% of ENU-treated females   (MGI Ref ID J:67445)
    • ovary atrophy
      • complete loss of follicles (ovarian atrophy) is observed in about 25% of ENU-treated mutants, whereas almost no incidence is observed in ENU-treated wild-type or Brca2-mutant females   (MGI Ref ID J:67445)
    • uterus atrophy
      • observed in ENU-treated females displaying ovarian failure (atrophy); endometrium and myometrium appear immature   (MGI Ref ID J:67445)
  • tumorigenesis
  • increased incidence of induced tumors
    • multiple intestinal tumors are observed in ENU-treated mice, similar to Apc-heterozygous mice   (MGI Ref ID J:67445)
  • increased mammary gland tumor incidence
    • by 65 days after ENU treatment, 100% of females develop mammary tumors with a multiplicity of 6.7 +/- 2.8   (MGI Ref ID J:67445)
    • males develop tumors at a very low incidence and with a tumor multiplicity of 0.4 +/- 0.5, whereas no wild-type or Brca2-heterozygous males developed mammary tumors   (MGI Ref ID J:67445)
    • tumors in male and female mice are adenoacanthomas, characterized by undifferentiated acini and tubules with centrally confined squamous cells and keratin; most tumors contain proportions of adenomatous and squamous cell types   (MGI Ref ID J:67445)
    • tumors with predominantly squamous differentiation, moderate to marked inflammation in and around tumors is observed, with areas of fibrosis; in some cases, squamous component becomes cystic and is filled with keratinous debris   (MGI Ref ID J:67445)
    • invasion or metastases into the mammary lymph nodes was not observed during time course of study   (MGI Ref ID J:67445)
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland development
    • in ENU treated mice, male mammary ducts are elongated and in most males have extended to the lymph node of the fourth mammary gland, whereas wild-type and Brca2-heterozygous males are born with a small mammary gland rudiment, which grows no further, and no nipple   (MGI Ref ID J:67445)
    • no differences are observed in branching of female mammary glands among genotypes or wild-type females   (MGI Ref ID J:67445)
    • absent nipple   (MGI Ref ID J:67445)
  • abnormal ovarian follicle morphology
    • remaining follicles are degenerating in ENU-treated females   (MGI Ref ID J:67445)
    • abnormal ovarian folliculogenesis
      • arrested follicular development is 6-fold more prevalent compared to ENU-treated Brca2-deficient mice   (MGI Ref ID J:67445)
      • absent mature ovarian follicles   (MGI Ref ID J:67445)
  • absent corpus luteum
    • absent in 26% of ENU-treated females   (MGI Ref ID J:67445)
  • adrenal gland hyperplasia
    • females exhibit some adrenal hyperplasia, while none is observed in males   (MGI Ref ID J:67445)
  • ovary atrophy
    • complete loss of follicles (ovarian atrophy) is observed in about 25% of ENU-treated mutants, whereas almost no incidence is observed in ENU-treated wild-type or Brca2-mutant females   (MGI Ref ID J:67445)
  • integument phenotype
  • abnormal mammary gland development
    • in ENU treated mice, male mammary ducts are elongated and in most males have extended to the lymph node of the fourth mammary gland, whereas wild-type and Brca2-heterozygous males are born with a small mammary gland rudiment, which grows no further, and no nipple   (MGI Ref ID J:67445)
    • no differences are observed in branching of female mammary glands among genotypes or wild-type females   (MGI Ref ID J:67445)
    • absent nipple   (MGI Ref ID J:67445)

ApcMin/Apc+

        involves: 129P2/OlaHsd * C57BL/6
  • tumorigenesis
  • *normal* tumorigenesis
    • no gastric adenomas are observed   (MGI Ref ID J:95893)
    • at 30 days, no colonic adenomas are found and normal colonic architecture and cellular morphology is observed   (MGI Ref ID J:95893)

ApcMin/Apc+

        involves: 129/Sv * C57BL/6
  • digestive/alimentary phenotype
  • intestine polyps
    • macroscopic lesions primarily within the proximal portion of the small intestine in mutant (n=22)   (MGI Ref ID J:156864)
  • hematopoietic system phenotype
  • decreased NK cell number
    • decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
  • decreased T cell number
    • reduction in splenic CD3+ T cells at 17 weeks old   (MGI Ref ID J:156864)
  • decreased splenocyte number
    • a strong reduction of mature single positive CD4+ and CD8+ cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
    • a less pronounced reduction in immature double positive CD4+,CD8+ cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
    • reduction in splenic CD3+ T cells at 17 weeks old   (MGI Ref ID J:156864)
    • decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
  • immune system phenotype
  • decreased NK cell number
    • decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
  • decreased T cell number
    • reduction in splenic CD3+ T cells at 17 weeks old   (MGI Ref ID J:156864)
  • decreased splenocyte number
    • a strong reduction of mature single positive CD4+ and CD8+ cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
    • a less pronounced reduction in immature double positive CD4+,CD8+ cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)
    • reduction in splenic CD3+ T cells at 17 weeks old   (MGI Ref ID J:156864)
    • decreased DX5+, CD3- NK-cells in the spleen at 17 weeks old   (MGI Ref ID J:156864)

ApcMin/Apc+

        (AKR/J x C57BL/6J)F1
  • tumorigenesis
  • increased incidence of tumors by chemical induction   (MGI Ref ID J:15101)
  • increased intestinal adenocarcinoma incidence
    • a range of 1 to 12 with an average of 3 adenomas were found per mouse   (MGI Ref ID J:21369)
  • cellular phenotype
  • aneuploidy
    • quantitative polymerase chain reaction analysis of all intestinal adenomas sampled showed loss of Chr 18 carrying the wild-type Apc+ allele   (MGI Ref ID J:21369)
  • homeostasis/metabolism phenotype
  • increased incidence of tumors by chemical induction   (MGI Ref ID J:15101)

ApcMin/ApcMin

        involves: C57BL/6J * CAST/EiJ
  • mortality/aging
  • complete embryonic lethality
    • inferred from no recovery of mice homozygous for embryos typed as homozygous for the identifying, linked B6 D18Mitl4 marker among a significant number of E10.5 and E13.5 progeny   (MGI Ref ID J:27993)
    • at E10.5 histological analysis shows trophoblast giant cells and a small cluster of embryonic cells, source unknown   (MGI Ref ID J:27993)
    • at E13.5 decidual swellings were necrotic with remnants of trophoblast giant cells   (MGI Ref ID J:27993)

ApcMin/ApcMin

        involves: AKR/J * C57BL/6J
  • embryogenesis phenotype
  • abnormal embryogenesis/ development   (MGI Ref ID J:27993)
    • abnormal egg cylinder morphology
      • empty space is seen in the distal region where primitive ectoderm is expected   (MGI Ref ID J:27993)
    • abnormal embryo size
      • at E6.5 there is a range of abnormal development, underdeveloped embryonic tissue and associated maternal cells, with no obvious primitive ectoderm or proamniotic cavity to disorganized embryonic and extraembryonic tissue   (MGI Ref ID J:27993)
  • growth/size/body phenotype
  • abnormal embryo size
    • at E6.5 there is a range of abnormal development, underdeveloped embryonic tissue and associated maternal cells, with no obvious primitive ectoderm or proamniotic cavity to disorganized embryonic and extraembryonic tissue   (MGI Ref ID J:27993)

ApcMin/ApcMin

        involves: C57BL/6 * POMOD
  • embryogenesis phenotype
  • abnormal embryogenesis/ development
    • at E7.5 embryos are disorganized,showing significant reduction in embryo growth and reduction of primitive ectoderm   (MGI Ref ID J:27993)
    • failure of primitive ectoderm development shortly after implantation   (MGI Ref ID J:27993)
    • decreased embryo size
      • embryos are small and embedded in maternal tissue   (MGI Ref ID J:27993)
  • growth/size/body phenotype
  • decreased embryo size
    • embryos are small and embedded in maternal tissue   (MGI Ref ID J:27993)
  • mortality/aging
  • complete embryonic lethality   (MGI Ref ID J:27993)
  • embryonic lethality between implantation and placentation   (MGI Ref ID J:27993)
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Research Applications
This mouse can be used to support research in many areas including:

ApcMin related

Cancer Research
Increased Tumor Incidence
      Adenomas
      Adenomas: intestinal adenomas
      Mammary Gland Tumors
      Other Tissues/Organs
      Other Tissues/Organs: GI tract (stomach, intestine, colon)

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol ApcMin
Allele Name multiple intestinal neoplasia
Allele Type Chemically induced (ENU)
Common Name(s) ApcΔ850; Apc-; Apcdelta850; Min; Min-;
Mutation Made ByDr. William Dove,   University of Wisconsin- Madison
Strain of OriginC57BL/6J
Gene Symbol and Name Apc, adenomatosis polyposis coli
Chromosome 18
Gene Common Name(s) AI047805; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; Min; PPP1R46; RATAPC; expressed sequence AI047805; expressed sequence AU020952; expressed sequence AW124434; multiple intestinal neoplasia;
Molecular Note A transversion point mutation that alters nucleotide 2549 from a T to an A. This converts codon 850 from one encoding a leucine to a stop codon, truncating the expected polypeptide. [MGI Ref ID J:830]

Genotyping

Genotyping Information

Genotyping Protocols

ApcMinalternate1, End Point Analysis


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Moser AR; Pitot HC; Dove WF. 1990. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247(4940):322-4. [PubMed: 2296722]  [MGI Ref ID J:10209]

Su LK; Kinzler KW; Vogelstein B; Preisinger AC; Moser AR; Luongo C; Gould KA; Dove WF. 1992. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene [published erratum appears in Science 1992 May 22;256(5060):1114] Science 256(5057):668-70. [PubMed: 1350108]  [MGI Ref ID J:830]

Additional References

Andreassen A; Mollersen L; Vikse R; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2002. One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. Mutat Res 517(1-2):157-66. [PubMed: 12034317]  [MGI Ref ID J:77184]

Andreassen A; Vikse R; Steffensen IL; Paulsen JE; Alexander J. 2001. Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo. Mutagenesis 16(4):309-15. [PubMed: 11420398]  [MGI Ref ID J:70642]

Barbour K W; Davis T; White A; Baumann H; Berger F G. 2001. Haptoglobin, inflammation, and tumorigenesis in the MIN mouse. Redox Rep 6(6):366-8. [PubMed: 11865977]  [MGI Ref ID J:75249]

Bennett LM; McAllister KA; Ward T; Malphurs J; Collins NK; Seely JC; Davis BJ; Wiseman RW. 2001. Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency. Toxicol Pathol 29(1):117-25. [PubMed: 11215675]  [MGI Ref ID J:67445]

Cooper AM; Magram J; Ferrante J; Orme IM. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 186(1):39-45. [PubMed: 9206995]  [MGI Ref ID J:41494]

Davis CD; Zeng H; Finley JW. 2002. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice. J Nutr 132(2):307-9. [PubMed: 11823596]  [MGI Ref ID J:74364]

De Giovanni C; Landuzzi L; Nicoletti G; Astolfi A; Croci S; Micaroni M; Nanni P; Lollini PL. 2004. Apc10.1: an ApcMin/+ intestinal cell line with retention of heterozygosity. Int J Cancer 109(2):200-6. [PubMed: 14750170]  [MGI Ref ID J:88314]

Dinchuk JE; Focht RJ; Kelley JA; Henderson NL; Zolotarjova NI; Wynn R; Neff NT; Link J; Huber RM; Burn TC; Rupar MJ; Cunningham MR; Selling BH; Ma J; Stern AA; Hollis GF; Stein RB; Friedman PA. 2002. Absence of Post-translational Aspartyl beta -Hydroxylation of Epidermal Growth Factor Domains in Mice Leads to Developmental Defects and an Increased Incidence of Intestinal Neoplasia. J Biol Chem 277(15):12970-7. [PubMed: 11773073]  [MGI Ref ID J:75888]

Erik Paulsen J; Steffensen IL; Loberg EM; Husoy T; Namork E; Alexander J. 2001. Qualitative and Quantitative Relationship between Dysplastic Aberrant Crypt Foci and Tumorigenesis in the Min/+ Mouse Colon. Cancer Res 61(13):5010-5. [PubMed: 11431334]  [MGI Ref ID J:70170]

Ernest S; Christensen B; Gilfix BM; Mamer OA; Hosack A; Rodier M; Colmenares C; McGrath J; Bale A; Balling R; Sankoff D; Rosenblatt DS; Nadeau JH. 2002. Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm Genome 13(5):259-67. [PubMed: 12016514]  [MGI Ref ID J:76559]

Gould TD; Gray NA; Manji HK. 2003. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacol Res 48(1):49-53. [PubMed: 12770514]  [MGI Ref ID J:84200]

Greiner JW; Zeytin H; Anver MR; Schlom J. 2002. Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity. Cancer Res 62(23):6944-51. [PubMed: 12460911]  [MGI Ref ID J:80324]

Gupta RA; Wang D; Katkuri S; Wang H; Dey SK; DuBois RN. 2004. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10(3):245-7. [PubMed: 14758356]  [MGI Ref ID J:88127]

Gutierrez LS; Suckow M; Lawler J; Ploplis VA; Castellino FJ. 2003. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis 24(2):199-207. [PubMed: 12584168]  [MGI Ref ID J:79641]

Hansen-Petrik MB; McEntee MF; Jull B; Shi H; Zemel MB; Whelan J. 2002. Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Cancer Res 62(2):403-8. [PubMed: 11809688]  [MGI Ref ID J:74005]

Hertervig E; Nilsson A; Nilbert M; Duan RD. 2003. Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation. Int J Colorectal Dis 18(4):309-13. [PubMed: 12774245]  [MGI Ref ID J:84197]

Hong KH; Bonventre JC; O'Leary E; Bonventre JV; Lander ES. 2001. Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A 98(7):3935-9. [PubMed: 11274413]  [MGI Ref ID J:68495]

Huang EH; Carter JJ; Whelan RL; Liu YH; Rosenberg JO; Rotterdam H; Schmidt AM; Stern DM; Forde KA. 2002. Colonoscopy in mice. Surg Endosc 16(1):22-4. [PubMed: 11961598]  [MGI Ref ID J:77864]

Huerta S; Irwin RW; Heber D; Go VL; Koeffler HP; Uskokovic MR; Harris DM. 2002. 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse. Cancer Res 62(3):741-6. [PubMed: 11830528]  [MGI Ref ID J:74361]

Iinuma T; Homma S; Noda T; Kufe D; Ohno T; Toda G. 2004. Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine. J Clin Invest 113(9):1307-17. [PubMed: 15124022]  [MGI Ref ID J:90168]

Kawajiri H; Hsi LC; Kamitani H; Ikawa H; Geller M; Ward T; Eling TE; Glasgow WC. 2002. Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. Arch Biochem Biophys 398(1):51-60. [PubMed: 11811948]  [MGI Ref ID J:74371]

Lal G; Ash C; Hay K; Redston M; Kwong E; Hancock B; Mak T; Kargman S; Evans JF; Gallinger S. 2001. Suppression of intestinal polyps in msh2-deficient and non-msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. Cancer Res 61(16):6131-6. [PubMed: 11507063]  [MGI Ref ID J:70902]

Lew JI; Guo Y; Kim RK; Vargish L; Michelassi F; Arenas RB. 2002. Reduction of Intestinal Neoplasia With Adenomatous Polyposis Coli Gene Replacement and COX-2 Inhibition Is Additive. J Gastrointest Surg 6(4):563-8. [PubMed: 12127122]  [MGI Ref ID J:77954]

Lustig B; Jerchow B; Sachs M; Weiler S; Pietsch T; Karsten U; van de Wetering M; Clevers H; Schlag PM; Birchmeier W; Behrens J. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22(4):1184-93. [PubMed: 11809809]  [MGI Ref ID J:74286]

Mabley JG; Pacher P; Bai P; Wallace R; Goonesekera S; Virag L; Southan GJ; Szabo C. 2004. Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. Mutat Res 548(1-2):107-16. [PubMed: 15063141]  [MGI Ref ID J:89155]

Mai V; Colbert LH; Berrigan D; Perkins SN; Pfeiffer R; Lavigne JA; Lanza E; Haines DC; Schatzkin A; Hursting SD. 2003. Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms. Cancer Res 63(8):1752-5. [PubMed: 12702556]  [MGI Ref ID J:82980]

Marten K; Bremer C; Khazaie K; Sameni M; Sloane B; Tung CH; Weissleder R. 2002. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology 122(2):406-14. [PubMed: 11832455]  [MGI Ref ID J:74358]

Mollersen L; Vikse R; Andreassen A; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2004. Adenomatous polyposis coli truncation mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice. Mutat Res 557(1):29-40. [PubMed: 14706516]  [MGI Ref ID J:87470]

Mutanen M; Pajari AM; Oikarinen SI. 2000. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Carcinogenesis 21(6):1167-73. [PubMed: 10837006]  [MGI Ref ID J:62978]

Niho N; Takahashi M; Kitamura T; Shoji Y; Itoh M; Noda T; Sugimura T; Wakabayashi K. 2003. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res 63(18):6090-5. [PubMed: 14522940]  [MGI Ref ID J:86036]

Oikannen SI; Pajari A; Mutanen M. 2000. Chemopreventive activity of hydroksymatairesinol in adenomatous polyposis colimultiple intestinal neoplasia (Apc)(Min) mice Cancer Lett 159(2):183-7. [PubMed: 10996730]  [MGI Ref ID J:64666]

Oikarinen S; Heinonen S; Karppinen S; Matto J; Adlercreutz H; Poutanen K; Mutanen M. 2003. Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions. Br J Nutr 90(1):119-25. [PubMed: 12844383]  [MGI Ref ID J:85024]

Paoni NF; Feldman MW; Gutierrez LS; Ploplis VA; Castellino FJ. 2003. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiol Genomics 15(3):228-35. [PubMed: 13130079]  [MGI Ref ID J:86113]

Paulsen JE; Alexander J. 2001. Growth stimulation of intestinal tumours in Apc(Min/+) mice by dietary L-methionine supplementation. Anticancer Res 21(5):3281-4. [PubMed: 11848484]  [MGI Ref ID J:75262]

Paulsen JE; Namork E; Steffensen IL; Eide TJ; Alexander J. 2000. Identification and quantification of aberrant crypt foci in the colon of Min mice--a murine model of familial adenomatous polyposis Scand J Gastroenterol 35(5):534-9. [PubMed: 10868458]  [MGI Ref ID J:62966]

Perkins S; Verschoyle RD; Hill K; Parveen I; Threadgill MD; Sharma RA; Williams ML; Steward WP; Gescher AJ. 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 11(6):535-40. [PubMed: 12050094]  [MGI Ref ID J:77168]

Rao CV; Cooma I; Rodriguez JG; Simi B; El-Bayoumy K; Reddy BS. 2000. Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate. Carcinogenesis 21(4):617-21. [PubMed: 10753194]  [MGI Ref ID J:61783]

Reuter BK; Zhang XJ; Miller MJ. 2002. Therapeutic utility of aspirin in the ApcMin/+ murine model of colon carcinogenesis. BMC Cancer 2(1):19. [PubMed: 12171603]  [MGI Ref ID J:78510]

Roy HK; Karoski WJ; Ratashak A; Smyrk TC. 2001. Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer 84(10):1412-6. [PubMed: 11355956]  [MGI Ref ID J:69899]

Schmelz EM; Roberts PC; Kustin EM; Lemonnier LA; Sullards MC; Dillehay DL; Merrill AH Jr. 2001. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res 61(18):6723-9. [PubMed: 11559543]  [MGI Ref ID J:71590]

Shailubhai K; Yu HH; Karunanandaa K; Wang JY; Eber SL; Wang Y; Joo NS; Kim HD; Miedema BW; Abbas SZ; Boddupalli SS; Currie MG; Forte LR. 2000. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res 60(18):5151-7. [PubMed: 11016642]  [MGI Ref ID J:64784]

Sibani S; Melnyk S; Pogribny IP; Wang W; Hiou-Tim F; Deng L; Trasler J; James SJ; Rozen R. 2002. Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogenesis 23(1):61-5. [PubMed: 11756224]  [MGI Ref ID J:73559]

Silverman KA; Koratkar RA; Siracusa LD; Buchberg AM. 2003. Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 ( Mom2) locus. Mamm Genome 14(2):119-29. [PubMed: 12584607]  [MGI Ref ID J:81868]

Sohn KJ; Choi M; Song J; Chan S; Medline A; Gallinger S; Kim YI. 2003. Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice. Carcinogenesis 24(2):217-24. [PubMed: 12584170]  [MGI Ref ID J:79407]

Song J; Medline A; Mason JB; Gallinger S; Kim YI. 2000. Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse Cancer Res 60(19):5434-40. [PubMed: 11034085]  [MGI Ref ID J:65027]

Steffensen IL; Schut HA; Paulsen JE; Andreassen A; Alexander J. 2001. Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts. Cancer Res 61(24):8689-96. [PubMed: 11751386]  [MGI Ref ID J:73361]

Suckow MA; Gutierrez LS; Risatti CA; Wolter WR; Taylor RE; Pollard M; Navari RM; Castellino FJ; Paoni NF. 2004. The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice. Cancer Lett 209(2):165-9. [PubMed: 15159018]  [MGI Ref ID J:90679]

Suganuma M; Ohkura Y; Okabe S; Fujiki H. 2001. Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice. J Cancer Res Clin Oncol 127(1):69-72. [PubMed: 11206275]  [MGI Ref ID J:67939]

Suzui M; Okuno M; Tanaka T; Nakagama H; Moriwaki H. 2002. Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation. Cancer Lett 183(1):31-41. [PubMed: 12049812]  [MGI Ref ID J:77169]

Symolon H; Schmelz EM; Dillehay DL; Merrill AH Jr. 2004. Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and Apc(Min/+) Mice. J Nutr 134(5):1157-1161. [PubMed: 15113963]  [MGI Ref ID J:90172]

Trasler J; Deng L; Melnyk S; Pogribny I; Hiou-Tim F; Sibani S; Oakes C; Li E; James SJ; Rozen R. 2003. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis 24(1):39-45. [PubMed: 12538347]  [MGI Ref ID J:81577]

Tucker J; Davis C; Kitchens M; Bunni M; Priest D; Spencer H; Berger F. 2002. Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. Cancer Lett 187(1-2):153. [PubMed: 12359363]  [MGI Ref ID J:79692]

Wagenaar-Miller RA; Hanley G; Shattuck-Brandt R; DuBois RN; Bell RL; Matrisian LM; Morgan DW. 2003. Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Br J Cancer 88(9):1445-52. [PubMed: 12778076]  [MGI Ref ID J:83488]

Wang D; Wang H; Shi Q; Katkuri S; Walhi W; Desvergne B; Das SK; Dey SK; DuBois RN. 2004. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6(3):285-95. [PubMed: 15380519]  [MGI Ref ID J:93551]

Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. [PubMed: 11956084]  [MGI Ref ID J:76201]

Weyant MJ; Carothers AM; Dannenberg AJ; Bertagnolli MM. 2001. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res 61(1):118-25. [PubMed: 11196148]  [MGI Ref ID J:67060]

Weyant MJ; Carothers AM; Mahmoud NN; Bradlow HL; Remotti H; Bilinski RT; Bertagnolli MM. 2001. Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res 61(6):2547-51. [PubMed: 11289129]  [MGI Ref ID J:68469]

Yamada T; Mori Y; Hayashi R; Takada M; Ino Y; Naishiro Y; Kondo T; Hirohashi S. 2003. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res 63(5):895-901. [PubMed: 12615699]  [MGI Ref ID J:82288]

Yamada Y; Hata K; Hirose Y; Hara A; Sugie S; Kuno T; Yoshimi N; Tanaka T; Mori H. 2002. Microadenomatous lesions involving loss of apc heterozygosity in the colon of adult apc(min/+) mice. Cancer Res 62(22):6367-70. [PubMed: 12438216]  [MGI Ref ID J:80301]

Yang K; Fan K; Kurihara N; Shinozaki H; Rigas B; Augenlicht L; Kopelovich L; Edelmann W; Kucherlapati R; Lipkin M. 2003. Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis 24(3):605-11. [PubMed: 12663524]  [MGI Ref ID J:82832]

Yu CF; Whiteley L; Carryl O; Basson MD. 2001. Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig Dis Sci 46(7):1367-80. [PubMed: 11478486]  [MGI Ref ID J:70920]

Ziegler CC; Rainwater L; Whelan J; McEntee MF. 2004. Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134(1):5-10. [PubMed: 14704285]  [MGI Ref ID J:88124]

ApcMin related

Ahn B; Ohshima H. 2001. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61(23):8357-60. [PubMed: 11731407]  [MGI Ref ID J:73152]

Akitake-Kawano R; Seno H; Nakatsuji M; Kimura Y; Nakanishi Y; Yoshioka T; Kanda K; Kawada M; Kawada K; Sakai Y; Chiba T. 2013. Inhibitory role of Gas6 in intestinal tumorigenesis. Carcinogenesis 34(7):1567-74. [PubMed: 23430954]  [MGI Ref ID J:199029]

Akporiaye ET; Bradley-Dunlop D; Gendler SJ; Mukherjee P; Madsen CS; Hahn T; Besselsen DG; Dial SM; Cui H; Trevor K. 2007. Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas. Vaccine 25(39-40):6965-74. [PubMed: 17707958]  [MGI Ref ID J:128727]

Alferez D; Wilkinson RW; Watkins J; Poulsom R; Mandir N; Wedge SR; Pyrah IT; Smith NR; Jackson L; Ryan AJ; Goodlad RA. 2008. Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice. Mol Cancer Ther 7(3):590-8. [PubMed: 18347145]  [MGI Ref ID J:145378]

Alferez DG; Ryan AJ; Goodlad RA; Wright NA; Wilkinson RW. 2010. Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model. Int J Oncol 37(4):767-72. [PubMed: 20811697]  [MGI Ref ID J:178668]

Andreassen A; Mollersen L; Vikse R; Steffensen IL; Mikalsen A; Paulsen JE; Alexander J. 2002. One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene. Mutat Res 517(1-2):157-66. [PubMed: 12034317]  [MGI Ref ID J:77184]

Andreassen A; Vikse R; Mikalsen A; Adamovic T; Steffensen IL; Hjertholm H; Levan G; Alexander J. 2006. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with Apc(Min) mutation. Mutat Res 604(1-2):60-70. [PubMed: 16574467]  [MGI Ref ID J:107714]

Andreassen A; Vikse R; Steffensen IL; Paulsen JE; Alexander J. 2001. Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo. Mutagenesis 16(4):309-15. [PubMed: 11420398]  [MGI Ref ID J:70642]

Andres SF; Simmons JG; Mah AT; Santoro MA; Van Landeghem L; Lund PK. 2013. Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation. J Cell Sci 126(Pt 24):5645-56. [PubMed: 24127567]  [MGI Ref ID J:211908]

Angus-Hill ML; Elbert KM; Hidalgo J; Capecchi MR. 2011. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A 108(12):4914-9. [PubMed: 21383188]  [MGI Ref ID J:170088]

Aparicio T; Kotelevets L; Tsocas A; Laigneau JP; Sobhani I; Chastre E; Lehy T. 2005. Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice. Gut 54(8):1136-45. [PubMed: 15857934]  [MGI Ref ID J:194729]

Arenas RB; Fichera A; Mok P; Blanco MC; Michelassi F. 1996. Introduction of human adenomatous polyposis coli gene into Min mice via cationic liposomes. Surgery 120(4):712-7. [PubMed: 8862382]  [MGI Ref ID J:36700]

Babaei-Jadidi R; Li N; Saadeddin A; Spencer-Dene B; Jandke A; Muhammad B; Ibrahim EE; Muraleedharan R; Abuzinadah M; Davis H; Lewis A; Watson S; Behrens A; Tomlinson I; Nateri AS. 2011. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 208(2):295-312. [PubMed: 21282377]  [MGI Ref ID J:176848]

Bacher JW; Abdel Megid WM; Kent-First MG; Halberg RB. 2005. Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors. Mol Carcinog 44(4):285-92. [PubMed: 16240453]  [MGI Ref ID J:107080]

Backlund MG; Mann JR; Holla VR; Buchanan FG; Tai HH; Musiek ES; Milne GL; Katkuri S; DuBois RN. 2005. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem 280(5):3217-23. [PubMed: 15542609]  [MGI Ref ID J:105183]

Backlund MG; Mann JR; Holla VR; Shi Q; Daikoku T; Dey SK; DuBois RN. 2008. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res 68(22):9331-7. [PubMed: 19010907]  [MGI Ref ID J:141385]

Baek SJ; Okazaki R; Lee SH; Martinez J; Kim JS; Yamaguchi K; Mishina Y; Martin DW; Shoieb A; McEntee MF; Eling TE. 2006. Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology 131(5):1553-60. [PubMed: 17101328]  [MGI Ref ID J:120981]

Baker DJ; Jin F; Jeganathan KB; van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16(6):475-86. [PubMed: 19962666]  [MGI Ref ID J:155824]

Baker SM; Harris AC; Tsao JL; Flath TJ; Bronner CE; Gordon M ; Shibata D ; Liskay RM. 1998. Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res 58(6):1087-9. [PubMed: 9515784]  [MGI Ref ID J:46419]

Baltgalvis KA; Berger FG; Pena MM; Davis JM; Carson JA. 2008. Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps. J Appl Physiol 104(4):1137-43. [PubMed: 18239078]  [MGI Ref ID J:147321]

Baltgalvis KA; Berger FG; Pena MM; Davis JM; Muga SJ; Carson JA. 2008. Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294(2):R393-401. [PubMed: 18056981]  [MGI Ref ID J:130429]

Baltgalvis KA; Berger FG; Pena MM; Mark Davis J; White JP; Carson JA. 2010. Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. J Appl Physiol 109(4):1155-61. [PubMed: 20651218]  [MGI Ref ID J:185914]

Barak Y; Liao D; He W; Ong ES; Nelson MC; Olefsky JM; Boland R; Evans RM. 2002. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 99(1):303-8. [PubMed: 11756685]  [MGI Ref ID J:73557]

Baran AA; Silverman KA; Zeskand J; Koratkar R; Palmer A; McCullen K; Curran WJ Jr; Edmonston TB; Siracusa LD; Buchberg AM. 2007. The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression. Genome Res 17(5):566-76. [PubMed: 17387143]  [MGI Ref ID J:122207]

Barbour K W; Davis T; White A; Baumann H; Berger F G. 2001. Haptoglobin, inflammation, and tumorigenesis in the MIN mouse. Redox Rep 6(6):366-8. [PubMed: 11865977]  [MGI Ref ID J:75249]

Barker N; van Es JH; Kuipers J; Kujala P; van den Born M; Cozijnsen M; Haegebarth A; Korving J; Begthel H; Peters PJ; Clevers H. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449(7165):1003-7. [PubMed: 17934449]  [MGI Ref ID J:127123]

Barnes CJ; Lee M. 1998. Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin. Gastroenterology 114(5):873-7. [PubMed: 9558273]  [MGI Ref ID J:48008]

Barone M; Notarnicola M; Caruso MG; Scavo MP; Viggiani MT; Tutino V; Polimeno L; Pesetti B; Di Leo A; Francavilla A. 2014. Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in ApcMin/+ mice. Carcinogenesis 35(7):1613-9. [PubMed: 24632492]  [MGI Ref ID J:211552]

Barone M; Tanzi S; Lofano K; Scavo MP; Pricci M; Demarinis L; Papagni S; Guido R; Maiorano E; Ingravallo G; Comelli MC; Francavilla A; Di Leo A. 2010. Dietary-induced ERbeta upregulation counteracts intestinal neoplasia development in intact male ApcMin/+ mice. Carcinogenesis 31(2):269-74. [PubMed: 19945967]  [MGI Ref ID J:156778]

Bashir O; FitzGerald AJ; Goodlad RA. 2004. Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the ApcMin/+ mouse. Carcinogenesis 25(8):1507-15. [PubMed: 15016659]  [MGI Ref ID J:91525]

Bashir O; Fitzgerald AJ; Berlanga-Acosta J; Playford RJ; Goodlad RA. 2003. Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. Clin Sci (Lond) 105(3):323-330. [PubMed: 12749762]  [MGI Ref ID J:84232]

Batlle E; Bacani J; Begthel H; Jonkeer S; Gregorieff A; van de Born M; Malats N; Sancho E; Boon E; Pawson T; Gallinger S; Pals S; Clevers H. 2005. EphB receptor activity suppresses colorectal cancer progression. Nature 435(7045):1126-30. [PubMed: 15973414]  [MGI Ref ID J:99366]

Beazer-Barclay Y; Levy DB; Moser AR; Dove WF; Hamilton SR; Vogelstein B; Kinzler KW. 1996. Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis 17(8):1757-60. [PubMed: 8761438]  [MGI Ref ID J:101582]

Belcheva A; Green B; Weiss A; Streutker C; Martin A. 2013. Elevated incidence of polyp formation in APC(Min/(+))Msh2(-)/(-) mice is independent of nitric oxide-induced DNA mutations. PLoS One 8(5):e65204. [PubMed: 23741483]  [MGI Ref ID J:200824]

Bellis J; Duluc I; Romagnolo B; Perret C; Faux MC; Dujardin D; Formstone C; Lightowler S; Ramsay RG; Freund JN; De Mey JR. 2012. The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. J Cell Biol 198(3):331-41. [PubMed: 22851318]  [MGI Ref ID J:191316]

Bennett LM; McAllister KA; Ward T; Malphurs J; Collins NK; Seely JC; Davis BJ; Wiseman RW. 2001. Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency. Toxicol Pathol 29(1):117-25. [PubMed: 11215675]  [MGI Ref ID J:67445]

Berger FG; Kramer DL; Porter CW. 2007. Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem Soc Trans 35(Pt 2):336-9. [PubMed: 17371273]  [MGI Ref ID J:122673]

Bhandaru M; Kempe DS; Rotte A; Rexhepaj R; Kuhl D; Lang F. 2009. Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC. Am J Physiol Regul Integr Comp Physiol 297(3):R571-5. [PubMed: 19494170]  [MGI Ref ID J:152204]

Bilger A; Shoemaker AR; Gould KA; Dove WF. 1996. Manipulation of the mouse germline in the study of Min-induced neoplasia. Semin Cancer Biol 7(5):249-60. [PubMed: 9110402]  [MGI Ref ID J:40100]

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Wang L; Cao H; Lu N; Liu L; Wang B; Hu T; Israel DA; Peek RM Jr; Polk DB; Yan F. 2013. Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. PLoS One 8(2):e56666. [PubMed: 23457600]  [MGI Ref ID J:199397]

Wang X; Li X; Fan F; Jiao S; Wang L; Zhu L; Pan Y; Wu G; Ling ZQ; Fang J; Chen Y. 2012. PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers. Carcinogenesis 33(11):2228-35. [PubMed: 22828136]  [MGI Ref ID J:193153]

Wasan HS; Novelli M; Bee J; Bodmer WF. 1997. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc Natl Acad Sci U S A 94(7):3308-13. [PubMed: 9096389]  [MGI Ref ID J:39278]

Wasan HS; Park HS; Liu KC; Mandir NK; Winnett A; Sasieni P; Bodmer WF; Goodlad RA; Wright NA. 1998. APC in the regulation of intestinal crypt fission. J Pathol 185(3):246-55. [PubMed: 9771477]  [MGI Ref ID J:110641]

Watanabe K; Kawamori T; Nakatsugi S; Ohta T; Ohuchida S; Yamamoto H; Maruyama T; Kondo K; Ushikubi F; Narumiya S; Sugimura T; Wakabayashi K. 1999. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res 59(20):5093-6. [PubMed: 10537280]  [MGI Ref ID J:59509]

Watson SA; Smith AM. 2001. Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis. Cancer Res 61(2):625-31. [PubMed: 11212260]  [MGI Ref ID J:67449]

Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. [PubMed: 11956084]  [MGI Ref ID J:76201]

Wechter WJ; Kantoci D; Murray ED Jr; Quiggle DD; Leipold DD; Gibson KM ; McCracken JD. 1997. R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer. Cancer Res 57(19):4316-24. [PubMed: 9331093]  [MGI Ref ID J:43175]

Wechter WJ; Murray ED Jr; Kantoci D; Quiggle DD; Leipold DD; Gibson KM; McCracken JD. 2000. Treatment and survival study in the C57BL/6J-APC(Min)/+(Min) mouse with R-flurbiprofen. Life Sci 66(8):745-53. [PubMed: 10680582]  [MGI Ref ID J:60796]

Wetmore C; Eberhart DE; Curran T. 2001. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-6. [PubMed: 11212243]  [MGI Ref ID J:67452]

Weyant MJ; Carothers AM; Dannenberg AJ; Bertagnolli MM. 2001. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse. Cancer Res 61(1):118-25. [PubMed: 11196148]  [MGI Ref ID J:67060]

Weyant MJ; Carothers AM; Mahmoud NN; Bradlow HL; Remotti H; Bilinski RT; Bertagnolli MM. 2001. Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res 61(6):2547-51. [PubMed: 11289129]  [MGI Ref ID J:68469]

Whelan J; Chiu CH; McEntee MF. 1999. Intestinal tumor load in the Min/+ mouse model is not correlated with eicosanoid biosynthesis Adv Exp Med Biol 469:607-15. [PubMed: 10667389]  [MGI Ref ID J:60815]

White JP; Baltgalvis KA; Puppa MJ; Sato S; Baynes JW; Carson JA. 2011. Muscle oxidative capacity during IL-6-dependent cancer cachexia. Am J Physiol Regul Integr Comp Physiol 300(2):R201-11. [PubMed: 21148472]  [MGI Ref ID J:169040]

White JP; Puppa MJ; Gao S; Sato S; Welle SL; Carson JA. 2013. Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. Am J Physiol Endocrinol Metab 304(10):E1042-52. [PubMed: 23531613]  [MGI Ref ID J:198215]

White JP; Puppa MJ; Narsale A; Carson JA. 2013. Characterization of the male ApcMin/+ mouse as a hypogonadism model related to cancer cachexia. Biol Open 2(12):1346-53. [PubMed: 24285707]  [MGI Ref ID J:205273]

Wilding J; Straub J; Bee J; Churchman M; Bodmer W; Dickson C; Tomlinson I; Ilyas M. 2002. Cyclin D1 Is Not an Essential Target of beta-Catenin Signaling During Intestinal Tumorigenesis, but It May Act as a Modifier of Disease Severity in Multiple Intestinal Neoplasia (Min) Mice. Cancer Res 62(16):4562-5. [PubMed: 12183406]  [MGI Ref ID J:78500]

Wilkinson RW; Ross EL; Poulsom R; Ilyas M; Straub J; Snary D; Bodmer WF; Mather SJ. 2001. Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors. Proc Natl Acad Sci U S A 98(18):10256-60. [PubMed: 11517330]  [MGI Ref ID J:71304]

Williams JL; Kashfi K; Ouyang N; del Soldato P; Kopelovich L; Rigas B. 2004. NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice. Biochem Biophys Res Commun 313(3):784-8. [PubMed: 14697260]  [MGI Ref ID J:87459]

Williams MV; Lee SH; Pollack M; Blair IA. 2006. Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice. J Biol Chem 281(15):10127-33. [PubMed: 16449227]  [MGI Ref ID J:112310]

Wilson CH; McIntyre RE; Arends MJ; Adams DJ. 2010. The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. Oncogene 29(32):4567-75. [PubMed: 20531296]  [MGI Ref ID J:168378]

Wilson CL; Heppner KJ; Labosky PA; Hogan BL; Matrisian LM. 1997. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A 94(4):1402-7. [PubMed: 9037065]  [MGI Ref ID J:38609]

Wilson JM; Coletta PL; Cuthbert RJ; Scott N; MacLennan K; Hawcroft G; Leng L; Lubetsky JB; Jin KK; Lolis E; Medina F; Brieva JA; Poulsom R; Markham AF; Bucala R; Hull MA. 2005. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 129(5):1485-503. [PubMed: 16285950]  [MGI Ref ID J:103661]

Wilson JW; Deed RW; Inoue T; Balzi M; Becciolini A; Faraoni P; Potten CS; Norton JD. 2001. Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Cancer Res 61(24):8803-10. [PubMed: 11751402]  [MGI Ref ID J:73360]

Wilson JW; Potten CS. 2000. The effect of exogenous prostaglandin administration on tumor size and yield in Min/+ mice. Cancer Res 60(16):4645-53. [PubMed: 10969819]  [MGI Ref ID J:64010]

Witherspoon M; Chen Q; Kopelovich L; Gross SS; Lipkin SM. 2013. Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer Discov 3(9):1072-81. [PubMed: 23771434]  [MGI Ref ID J:204238]

Woo DK; Green PD; Santos JH; D'Souza AD; Walther Z; Martin WD; Christian BE; Chandel NS; Shadel GS. 2012. Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol 180(1):24-31. [PubMed: 22056359]  [MGI Ref ID J:180188]

Xia D; Wang D; Kim SH; Katoh H; DuBois RN. 2012. Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224-6. [PubMed: 22270723]  [MGI Ref ID J:181279]

Xia F; Altieri DC. 2006. Mitosis-independent survivin gene expression in vivo and regulation by p53. Cancer Res 66(7):3392-5. [PubMed: 16585159]  [MGI Ref ID J:108219]

Xu C; Reichert EC; Nakano T; Lohse M; Gardner AA; Revelo MP; Topham MK; Stafforini DM. 2013. Deficiency of Phospholipase A2 Group 7 Decreases Intestinal Polyposis and Colon Tumorigenesis in ApcMin/+ Mice. Cancer Res 73(9):2806-16. [PubMed: 23361301]  [MGI Ref ID J:196880]

Xu H; Posner GH; Stevenson M; Campbell FC. 2010. Apc(MIN) modulation of vitamin D secosteroid growth control. Carcinogenesis 31(8):1434-41. [PubMed: 20488884]  [MGI Ref ID J:162653]

Xue X; Shah YM. 2013. Hypoxia-inducible factor-2alpha is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis 34(1):163-9. [PubMed: 23042097]  [MGI Ref ID J:193648]

Xue X; Taylor M; Anderson E; Hao C; Qu A; Greenson JK; Zimmermann EM; Gonzalez FJ; Shah YM. 2012. Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res 72(9):2285-93. [PubMed: 22419665]  [MGI Ref ID J:185744]

Yamada T; Mori Y; Hayashi R; Takada M; Ino Y; Naishiro Y; Kondo T; Hirohashi S. 2003. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res 63(5):895-901. [PubMed: 12615699]  [MGI Ref ID J:82288]

Yamada Y; Hata K; Hirose Y; Hara A; Sugie S; Kuno T; Yoshimi N; Tanaka T; Mori H. 2002. Microadenomatous lesions involving loss of apc heterozygosity in the colon of adult apc(min/+) mice. Cancer Res 62(22):6367-70. [PubMed: 12438216]  [MGI Ref ID J:80301]

Yamada Y; Jackson-Grusby L; Linhart H; Meissner A; Eden A; Lin H; Jaenisch R. 2005. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A 102(38):13580-5. [PubMed: 16174748]  [MGI Ref ID J:101415]

Yamada Y; Mori H. 2007. Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci 98(1):6-10. [PubMed: 17052257]  [MGI Ref ID J:120998]

Yamaguchi K; Cekanova M; McEntee MF; Yoon JH; Fischer SM; Renes IB; Van Seuningen I; Baek SJ. 2008. Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Mol Cancer Ther 7(9):2779-87. [PubMed: 18790758]  [MGI Ref ID J:152123]

Yang K; Fan KH; Lamprecht SA; Edelmann W; Kopelovich L; Kucherlapati R; Lipkin M. 2005. Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc(1638 N/+) Mlh1(+/-) double mutant mice. Int J Cancer 116(4):495-9. [PubMed: 15818612]  [MGI Ref ID J:99671]

Yang K; Popova NV; Yang WC; Lozonschi I; Tadesse S; Kent S; Bancroft L; Matise I; Cormier RT; Scherer SJ; Edelmann W; Lipkin M; Augenlicht L; Velcich A. 2008. Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res 68(18):7313-22. [PubMed: 18794118]  [MGI Ref ID J:141219]

Yang X; Wood PA; Ansell CM; Ohmori M; Oh EY; Xiong Y; Berger FG; Pena MM; Hrushesky WJ. 2009. Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice. J Biochem 145(3):289-97. [PubMed: 19106159]  [MGI Ref ID J:149073]

Yao LM; He JP; Chen HZ; Wang Y; Wang WJ; Wu R; Yu CD; Wu Q. 2012. Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. Carcinogenesis 33(2):301-11. [PubMed: 22159226]  [MGI Ref ID J:181110]

Yekkala K; Baudino TA. 2007. Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression. Mol Cancer Res 5(12):1296-303. [PubMed: 18171987]  [MGI Ref ID J:134087]

Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Cui H; Holubec H; Payne CM; Gerner EW. 2006. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Mol Carcinog 45(2):93-105. [PubMed: 16329147]  [MGI Ref ID J:107079]

Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Guillen JM; Holubec H; Payne CM; Gerner EW. 2006. Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice. Mol Carcinog 45(10):764-73. [PubMed: 16705737]  [MGI Ref ID J:115819]

Yokomine K; Nakatsura T; Senju S; Nakagata N; Minohara M; Kira J; Motomura Y; Kubo T; Sasaki Y; Nishimura Y. 2007. Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice. Cancer Sci 98(12):1930-5. [PubMed: 17892515]  [MGI Ref ID J:129988]

You S; Ohmori M; Pena MM; Nassri B; Quiton J; Al-Assad ZA; Liu L; Wood PA; Berger SH; Liu Z; Wyatt MD; Price RL; Berger FG; Hrushesky WJ. 2006. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol 87(3):227-36. [PubMed: 16709231]  [MGI Ref ID J:122752]

Young LE; Moore AE; Sokol L; Meisner-Kober N; Dixon DA. 2012. The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. Mol Cancer Res 10(1):167-80. [PubMed: 22049153]  [MGI Ref ID J:205397]

Yu CF; Whiteley L; Carryl O; Basson MD. 2001. Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig Dis Sci 46(7):1367-80. [PubMed: 11478486]  [MGI Ref ID J:70920]

Yue HH; Diehl GE; Winoto A. 2005. Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 12(1):94-7. [PubMed: 15514675]  [MGI Ref ID J:94118]

Yusta B; Holland D; Waschek JA; Drucker DJ. 2012. Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice. Endocrinology 153(6):2623-32. [PubMed: 22535770]  [MGI Ref ID J:188646]

Zeilstra J; Joosten SP; Dokter M; Verwiel E; Spaargaren M; Pals ST. 2008. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res 68(10):3655-61. [PubMed: 18483247]  [MGI Ref ID J:135025]

Zeilstra J; Joosten SP; van Andel H; Tolg C; Berns A; Snoek M; van de Wetering M; Spaargaren M; Clevers H; Pals ST. 2014. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene 33(5):665-70. [PubMed: 23318432]  [MGI Ref ID J:204874]

Zeineldin M; Cunningham J; McGuinness W; Alltizer P; Cowley B; Blanchat B; Xu W; Pinson D; Neufeld KL. 2012. A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. Oncogene 31(19):2423-37. [PubMed: 21996741]  [MGI Ref ID J:186132]

Zeineldin M; Neufeld KL. 2013. Understanding phenotypic variation in rodent models with germline Apc mutations. Cancer Res 73(8):2389-99. [PubMed: 23580574]  [MGI Ref ID J:197040]

Zell JA; Ignatenko NA; Yerushalmi HF; Ziogas A; Besselsen DG; Gerner EW; Anton-Culver H. 2007. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer 120(3):459-68. [PubMed: 17096347]  [MGI Ref ID J:117825]

Zeng Q; Phukan S; Xu Y; Sadim M; Rosman DS; Pennison M; Liao J; Yang GY; Huang CC; Valle L; Di Cristofano A; de la Chapelle A; Pasche B. 2009. Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. Cancer Res 69(2):678-86. [PubMed: 19147584]  [MGI Ref ID J:143706]

Zeytin HE; Patel AC; Rogers CJ; Canter D; Hursting SD; Schlom J; Greiner JW. 2004. Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice. Cancer Res 64(10):3668-78. [PubMed: 15150127]  [MGI Ref ID J:90258]

Zhang T; Nanney LB; Luongo C; Lamps L; Heppner KJ; DuBois RN ; Beauchamp RD. 1997. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res 57(1):169-75. [PubMed: 8988060]  [MGI Ref ID J:37447]

Zhang T; Nanney LB; Peeler MO; Williams CS; Lamps L; Heppner KJ; DuBois RN; Beauchamp RD. 1997. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res 57(9):1638-43. [PubMed: 9134999]  [MGI Ref ID J:40133]

Zheng W; Wong KE; Zhang Z; Dougherty U; Mustafi R; Kong J; Deb DK; Zheng H; Bissonnette M; Li YC. 2012. Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer 130(1):10-9. [PubMed: 21328347]  [MGI Ref ID J:178583]

Zhong Y; Krisanapun C; Lee SH; Nualsanit T; Sams C; Peungvicha P; Baek SJ. 2010. Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. Eur J Cancer 46(18):3365-74. [PubMed: 20709524]  [MGI Ref ID J:166565]

Zhou WJ; Geng ZH; Spence JR; Geng JG. 2013. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature 501(7465):107-11. [PubMed: 23903657]  [MGI Ref ID J:204377]

Zhu H; Dougherty U; Robinson V; Mustafi R; Pekow J; Kupfer S; Li YC; Hart J; Goss K; Fichera A; Joseph L; Bissonnette M. 2011. EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. Mol Cancer Res 9(7):960-75. [PubMed: 21653642]  [MGI Ref ID J:205224]

Ziegler CC; Rainwater L; Whelan J; McEntee MF. 2004. Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134(1):5-10. [PubMed: 14704285]  [MGI Ref ID J:88124]

Zimmermann S; Kiefer F; Prudenziati M; Spiller C; Hansen J; Floss T; Wurst W; Minucci S; Gottlicher M. 2007. Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. Cancer Res 67(19):9047-54. [PubMed: 17909008]  [MGI Ref ID J:152134]

de Jesus Perez VA; Yuan K; Orcholski ME; Sawada H; Zhao M; Li CG; Tojais NF; Nickel N; Rajagopalan V; Spiekerkoetter E; Wang L; Dutta R; Bernstein D; Rabinovitch M. 2012. Loss of adenomatous poliposis coli-alpha3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res 111(12):1551-64. [PubMed: 23011394]  [MGI Ref ID J:212880]

de Wind N; Dekker M; van Rossum A; van der Valk M; te Riele H. 1998. Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res 58(2):248-55. [PubMed: 9443401]  [MGI Ref ID J:45433]

de la Roche M; Ibrahim AE; Mieszczanek J; Bienz M. 2014. LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res 74(5):1495-505. [PubMed: 24419084]  [MGI Ref ID J:208159]

van Kranen HJ; van Iersel PW; Rijnkels JM; Beems DB; Alink GM; van Kreijl CF. 1998. Effects of dietary fat and a vegetable-fruit mixture on the development of intestinal neoplasia in the ApcMin mouse. Carcinogenesis 19(9):1597-601. [PubMed: 9771930]  [MGI Ref ID J:49892]

van der Weyden L; Arends MJ; Dovey OM; Harrison HL; Lefebvre G; Conte N; Gergely FV; Bradley A; Adams DJ. 2008. Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis. Oncogene 27(32):4503-8. [PubMed: 18391979]  [MGI Ref ID J:138515]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX1

Colony Maintenance

Breeding & HusbandryThis strain is maintained by breeding heterozygote males to C57BL/6J females. Female heterozygotes are not recommended because anemia and intestinal adenomas interfere with pregnancy. Breeding performance in heterozygote males declines as anemia and tumors develop.
Mating SystemInbred x Heterozygote         (Female x Male)   18-SEP-08
(C57BL/6J x Heterozygote)
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K20

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
5 weeks $260.60Female or MaleHeterozygous for ApcMin  
6 weeks $266.05Female or MaleHeterozygous for ApcMin  
7 weeks $271.50Female or MaleHeterozygous for ApcMin  
8 weeks $276.95Female or MaleHeterozygous for ApcMin  
Price per Pair (US dollars $)Pair Genotype
$288.60C57BL/6J (000664) x Heterozygous for ApcMin  
$338.10Wild-type for ApcMin x Heterozygous for ApcMin  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • This strain ships with a JAXTagTM affixed. Learn more about JAXTagTM.
  • Retired breeders are no longer available.
  • Shipped at a specific age in weeks. Mice at a precise age in days and littermates are also available.
  • Strains that must be genotyped are not available until five to seven weeks of age.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
5 weeks $338.80Female or MaleHeterozygous for ApcMin  
6 weeks $345.90Female or MaleHeterozygous for ApcMin  
7 weeks $353.00Female or MaleHeterozygous for ApcMin  
8 weeks $360.10Female or MaleHeterozygous for ApcMin  
Price per Pair (US dollars $)Pair Genotype
$375.20C57BL/6J (000664) x Heterozygous for ApcMin  
$439.60Wild-type for ApcMin x Heterozygous for ApcMin  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • This strain ships with a JAXTagTM affixed. Learn more about JAXTagTM.
  • Retired breeders are no longer available.
  • Shipped at a specific age in weeks. Mice at a precise age in days and littermates are also available.
  • Strains that must be genotyped are not available until five to seven weeks of age.
  • Strains that require genotyping are only offered at five weeks of age and older. The time required for sample collection, assay, reporting, and completion of USDA documentation required for international purchases make distribution of younger mice prohibitive. Mice at a precise age in days, littermates and retired breeders are also available. Mice older than 10 weeks of age can be requested by contacting JAX® Mice & Services.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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