Strain Name:

B6Ei.LT-Y(IsXPAR;Y)Ei/EiJ

Stock Number:

002021

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names Y*    (Changed: 18-JAN-12 )
B6Ei.LT-Y*/EiJ    (Changed: 18-JAN-12 )
B6Ei.LT-Y*    (Changed: 11-JUL-07 )
B6Ei.LT-T(x;InY)8Ei    (Changed: 15-DEC-04 )
Type Chromosome Aberration; Translocation;
Additional information on Mice with Chromosomal Aberrations.
Type Consomic;
Additional information on Consomic Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Background Strain C57BL/6JEiJ
Donor Strain LT/SvEi
 
Donating Investigator Eva Eicher,   The Jackson Laboratory

Description
This strain contains an abnormal LT/Sv-derived Y Chromosome comprising a spontaneous rearrangement (Eicher et al. 1991), formally designated Y(IsXPAR;Y)Ei and informally called Y*. Burgoyne et. al, (1998), updated the original description of the cytogenetic changes in this abnormal Y Chromosome, as an end-to-end fusion of two pseudoautosomal regions (PAR). Males with this abnormal Y Chromosome (XY*) are fully fertile and can be used to transmit this chromosomal aberration. Duplication of the PAR in Y* males permits generation of X and Y reciprocal translocation products during meiosis (see figure 1 in Eicher et.al 1991). Sperm produced by XY* males contain either a normal X Chromosome, the intact, complete Y*, a large marker sex chromosome comprising an X Chromosome and most of the Y (Y*), or a tiny cytogenetic marker sex chromosome (YX). Among offspring are the following genotypes and corresponding phenotypes:
XY*, which are fully fertile males
XX, normal females
XXY*, which are sterile males in which gonad development is normal but spermatogenesis fails resulting in smaller testes after puberty. These males can be classified by manually palpating for testes size after 6 weeks of age. The testes are significantly smaller compared with any normal control male of the same age. Also these mice have a very large marker Chromosome (Fig 1, Eicher et al. 1991) easily seen after simple Giemsa staining (G-banding is not necessary. Alternatively these mice have nearly 2 complete X Chromosomes so these mice can be differentiated from normal XY<*> males by an Xist expression assay (Werler et al. 2011).
XY*X females, which are fertile but litter size and number of litters produced will be less than expected for C57BL/6. These mice have a tiny cytogenetic marker (Fig 1, Eicher et al. 1991) easily seen after Giemsa staining of mitotic metaphase preparations.

Development
Y(IsXPAR;Y)Ei, also called Y*, was backcrossed along with Tyrp1B-lt from the strain LT/SvEi-Y* onto C57BL/6JEi by consecutive crosses of a male carrying an abnormal LT Y chromosome, XY*, to a C57BL/6JEi female. In 1994 embryos were cryopreserved from C57BL/6JEi females bred to carrier males at backcross generation N21, still segregating for Tyrp1B-lt. That frozen bankstock is Stock No. 017764. The strain remained on the shelf maintained by backcrossing to C57BL/6JEi; Tyrp1B-lt was bred out subsequent to the 1994 freeze. In 1998 this line was rescued by in vitro fertilization using a male at generation N28 and C57BL/6J females and the rescued line continued to be maintained by backcrossing to C57BL/6JEi. In 2007 sperm were cryopreserved for this C57BL/6JEi consomic from a carrier male at generation N28N1N13.

Related Strains

View Y Chromosomal Aberrations     (17 strains)

Strains carrying   Y(IsXPAR;Y)Ei allele
017764   B6Ei.LT-Y(IsXPAR;Y)Ei Tyrp1B-lt/EiJ
View Strains carrying   Y(IsXPAR;Y)Ei     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

X/Y(IsXPAR;Y)Ei

        LT/SvEi
  • reproductive system phenotype
  • abnormal chromosome pairing during meiosis
    • a structural anomaly in the Y chromosome permits ectopic exchange of X and Y chromatin during meiosis   (MGI Ref ID J:2277)
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Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Genetics Research
Reproductive Biology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Y(IsXPAR;Y)Ei
Allele Name Chr Y, insertion of X pseudoautosomal region to Y pseudoautosomal region, Eicher
Allele Type Spontaneous
Common Name(s) T(XA1?;InY)8Ei; T8Ei; Y star; Y*;
Strain of OriginLT/Sv
Gene Symbol and Name Y(IsXPAR;Y)Ei, Chr Y, insertion of X PAR region to Y PAR region, Eva Eicher
Chromosome Y
Gene Common Name(s) T(X;InY)8Ei; T8Ei; Y*;
Molecular Note The Y* PAR chromosome has resulted from an end to end fusion of an X and a Y PAR. Furthermore, it was shown that in conjuction with this PAR-PAR fusion, there has been a deletion of both copies of the distally located pseudoautosomal gene Steroid sulfatase (Sts). The arrangement of the two PAR regions permits reciprocal translocation of X and Y chromatin at every meiotic event in the male resulting in half of the sperm produced bearing one of two abnormal sex chromosome. [MGI Ref ID J:48823]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Burgoyne PS; Evans EP. 2000. A high frequency of XO offspring from X(Paf)Y* male mice: evidence that the Paf mutation involves an inversion spanning the X PAR boundary. Cytogenet Cell Genet 91(1-4):57-61. [PubMed: 11173831]  [MGI Ref ID J:67199]

Burgoyne PS; Mahadevaiah SK; Perry J; Palmer SJ; Ashworth A. 1998. The Y* rearrangement in mice: new insights into a perplexing PAR. Cytogenet Cell Genet 80(1-4):37-40. [PubMed: 9678332]  [MGI Ref ID J:48823]

Eicher EM; Hale DW; Hunt PA; Lee BK; Tucker PK; King TR; Eppig JT; Washburn LL. 1991. The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region. Cytogenet Cell Genet 57(4):221-30. [PubMed: 1743079]  [MGI Ref ID J:2277]

Lue Y; Jentsch JD; Wang C; Rao PN; Hikim AP; Salameh W; Swerdloff RS. 2005. XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome. Endocrinology 146(9):4148-54. [PubMed: 15961558]  [MGI Ref ID J:129799]

Werler S; Poplinski A; Gromoll J; Wistuba J. 2011. Expression of selected genes escaping from X inactivation in the 41, XX(Y)* mouse model for Klinefelter's syndrome. Acta Paediatr 100(6):885-91. [PubMed: 21241365]  [MGI Ref ID J:178289]

Additional References

Liu PY; Erkkila K; Lue Y; Jentsch JD; Schwarcz MD; Abuyounes D; Hikim AS; Wang C; Lee PW; Swerdloff RS. 2010. Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice. Am J Physiol Endocrinol Metab 299(3):E446-55. [PubMed: 20570823]  [MGI Ref ID J:170029]

Y(IsXPAR;Y)Ei related

Bonthuis PJ; Rissman EF. 2013. Neural growth hormone implicated in body weight sex differences. Endocrinology 154(10):3826-35. [PubMed: 23861378]  [MGI Ref ID J:203292]

Burgoyne PS; Ojarikre OA; Turner JM. 2002. Evidence that postnatal growth retardation in XO mice is due to haploinsufficiency for a non-PAR X gene. Cytogenet Genome Res 99(1-4):252-6. [PubMed: 12900572]  [MGI Ref ID J:115690]

Eicher EM. 1982. Primary sex determining genes in mice. In: Prospects for Sexing Mammalian Sperm. Colorado Association University Press, Boulder, Colorado.  [MGI Ref ID J:15314]

Eicher EM; Washburn LL. 1986. Genetic control of primary sex determination in mice. Annu Rev Genet 20:327-60. [PubMed: 3545061]  [MGI Ref ID J:8588]

Eicher EM; Washburn LL. 1983. Inherited sex reversal in mice: identification of a new primary sex-determining gene. J Exp Zool 228(2):297-304. [PubMed: 6663259]  [MGI Ref ID J:7309]

Hunt PA. 1991. Survival of XO mouse fetuses: effect of parental origin of the X chromosome or uterine environment? Development 111(4):1137-41. [PubMed: 1879355]  [MGI Ref ID J:178895]

Hunt PA; Eicher EM. 1991. Fertile male mice with three sex chromosomes: evidence that infertility in XYY male mice is an effect of two Y chromosomes. Chromosoma 100(5):293-9. [PubMed: 1860375]  [MGI Ref ID J:178894]

Liu PY; Erkkila K; Lue Y; Jentsch JD; Schwarcz MD; Abuyounes D; Hikim AS; Wang C; Lee PW; Swerdloff RS. 2010. Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice. Am J Physiol Endocrinol Metab 299(3):E446-55. [PubMed: 20570823]  [MGI Ref ID J:170029]

Matsuura S; Yan M; Lo MC; Ahn EY; Weng S; Dangoor D; Matin M; Higashi T; Feng GS; Zhang DE. 2012. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood 119(13):3155-63. [PubMed: 22223820]  [MGI Ref ID J:182428]

Vernet N; Szot M; Mahadevaiah SK; Ellis PJ; Decarpentrie F; Ojarikre OA; Rattigan A; Taketo T; Burgoyne PS. 2014. The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. Development 141(4):855-66. [PubMed: 24496622]  [MGI Ref ID J:208433]

Wolstenholme JT; Rissman EF; Bekiranov S. 2013. Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav 12(2):166-80. [PubMed: 23210685]  [MGI Ref ID J:206774]

Yamauchi Y; Riel JM; Stoytcheva Z; Ward MA. 2014. Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science 343(6166):69-72. [PubMed: 24263135]  [MGI Ref ID J:205194]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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