Strain Name: |
SWR.M-Emv21 Emv22/J |
|---|---|
Stock Number: |
002023 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
SWR.M-Emv21/22 (Changed: 15-DEC-04
) |
| Genes & Alleles | Emv21; Emv22; Pde6b; Pde6brd1; ; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Donor Strain MEV/Ty H2 Haplotype q Generation N7F16 Appearance
albino
Related Genotype: Tyrc/TyrcImportant Note
This strain is homozygous for Pde6brd1, which causes early-onset retinal degeneration.Strain Description
This strain carries a pair of linked retroviral insertions that occurred simultaneously on Chr 18 in a MEV substrain related to MEV/1Ty. Homozygosity for one of the insertions causes a juvenile lethal wasting condition that results in death at approximately 16 days of age. The proviruses rarely recombine; during development of this incipient congenic strain, a mouse was never found to have Emv21 in the absence of Emv22. There is no evidence that either of these viruses causes germline or somatic infection resulting in integration of new germline copies. (brs per personal communication from B. Taylor)Strain Development
SWR/J was made congenic for a pair of linked retroviral insertions, identified as Emv21 and Emv22, in the laboratory of Dr. Benjamin Taylor by an initial cross to a strain closely related to MEV/1Ty followed by backcrossing of progeny at the N1 and subsequent generations to SWR/J for 6 generations (to N7). Siblings from the final backcross were then intercrossed to make the strain homozygous, after which it was maintained by brother-sister inbreeding.
Gene & Allele Details
| Gene Symbol and Name | Emv22, endogenous ecotropic MuLV 22 | ||
|---|---|---|---|
| Chromosome | 19 | ||
| Gene Common Name(s) | Emv-22; | ||
| Gene Symbol and Name | Emv21, endogenous ecotropic MuLV 21 | ||
| Chromosome | 18 | ||
| Gene Common Name(s) | Emv-21; | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Pde6brd1 relatedDevelopmental Biology Research
Perinatal Lethality (Homozygous)
Research Tools
Genetics Research (Gene Mapping)
Virology Research
Linkage Testing Stock
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Price and Supply Information
| Strain Name: | SWR.M-Emv21 Emv22/J |
| Stock Number: | 002023 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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