JAX Mice Database - 002032 NOD.SW-H2<q>/J

Strain Name:	NOD.SW-H2^q/J
Stock Number:	002032
Availability:	Repository- Live

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Former Names NOD.SWR-H2^q/J (Changed: 15-DEC-04 )

Type Congenic; Major Histocompatibility Congenic; Mutant Strain;
Additional information on Genetically Engineered Mutant Mice.

Mating System Homozygote x Homozygote (Female x Male)

Species laboratory mouse

Background Strain NOD/ShiLt

Donor Strain SWR/Bm

Generation N20F39 (05-JUN-07)

Appearance
albino
Related Genotype: Tyr^c/Tyr^c
Description
This congenic strain carries the diabetes-resistant MHC from the from SWR/J (Stock No. 000689) and is used as a comparison to the NOD/ShiLtJ (Stock No. 001976). These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.

Control Information

	Control
	001976 NOD/ShiLtJ

Considerations for Choosing Controls

Related Strains

Strains carrying H2^q allele

002024 B10.D1-H2^q/SgJ

000945 B6.SW/1CyJ

View Strains carrying H2^q (2 strains)

Strains carrying other alleles of H2

000471 A.SW-H2^s H2-T18^b/SnJ

002089 AK.B6-H2^b Fv1^b/J

002090 AK.B6-H2^b/J

001094 AK.L-H2^b/1CyTyJ

003851 ALR.NOD-(D17Mit30-D17Mit123)/Lt

000469 B10.A-H2^a H2-T18^a/SgSnJ

000468 B10.A-H2^h2/(2R)SgSnJ

001150 B10.A-H2^h4/(4R)SgDvEgJ

000467 B10.A-H2ⁱ⁵ H2-T18^a/(5R)SgSnJ

000465 B10.BR-H2^k H2-T18^a/SgSnJ

004804 B10.BR-H2^k H2-T18^a/SgSnJJrep

005308 B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ

005534 B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ

006102 B10.Cg-H2^k Tg(Il2/NFAT-luc)83Rinc/J

006100 B10.Cg-H2^k Tg(NFkB/Fos-luc)26Rinc/J

005895 B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J

000462 B10.D2-H2^d/n2SnJ

001153 B10.D2-H2ⁱ⁷/(107R)EgJ

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000461 B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

003147 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J

001953 B10.S-H2^s/SgMcdJ

002995 B6 x C.B10-H2^b/LiMcdJ-Fbn2^fp-2J/J

005717 B6(NOD) H2^g7-Sostdc1^shk/J

003584 B6.129S2-H2^dlAb1-Ea/J

001148 B6.AK-H2^k/FlaEgJ

001895 B6.AK-H2^k/J

000360 B6.C-H2^d Mdmg1^BALB/cBy/aByJ

000359 B6.C-H2^d/bByJ

005715 B6.Cg H2^g7-Tg(Ins2-CD80)3B7Flv/LwnJ

003068 B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J

003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ

003069 B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ

003071 B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J

003067 B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J

003066 B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J

000944 B6.SJL-H2^b C3^c/2CyJ

000966 B6.SJL-H2^s C3^c/1CyJ

003374 B6;129S2-H2^dlAb1-Ea/J

003240 B6;B10.A-H2^a-Tg(H2KmPCC)2939Stoe/J

002844 BALB.5R-H2ⁱ⁵/LilJ

001041 BKS.B6-H2^b/J

001892 BRVR.B10-H2^b/J

001893 BRVR.D2-H2^d/J

001952 C.B10-H2^b/LilMcdJ

001951 C.C3-H2^k/LilMcdJ

000438 C3.SW-H2^b/SnJ

000437 D1.C-H2^d H2-T18^c/SnJ

000435 D1.LP-H2^b H2-T18^b^?/SnJ

001383 LT.MA-Glo1^b H2^k/J

002591 NOD.B10Sn-H2^b/J

004447 NOD.Cg-H2^h4/DilTacUmmJ

001627 NON.NOD-H2^g7/LtJ

003153 WLC.C-H2^d.GR-Mtv2/MorJ

003154 WLC.C-H2^d/MorJ

View Strains carrying other alleles of H2 (56 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report
JAX^® NOTES, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ MHC Congenics)

H2^q related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information

Allele Symbol		H2^q
Allele Name		q variant
Allele Type		Not Applicable
Gene Symbol and Name		H2, histocompatibility-2, MHC
Chromosome		17
Gene Common Name(s)		H-2; MHC-II;
General Note		The q variant has been observed in the following strains: DBA/1, DBA/1J, BUB/BnJ, STOLI/Lw, SWR/J Genbank ID for this allele: M14827

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

Selected Reference(s)

Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. [PubMed: 8666141] [MGI Ref ID J:33688]

Additional References

H2^q related

Chen K; Wei Y; Sharp GC; Braley-Mullen H. 2001. Induction of experimental autoimmune thyroiditis in IL-12-/- mice. J Immunol 167(3):1720-7. [PubMed: 11466396] [MGI Ref ID J:120397]

Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]

Hultqvist M; Olofsson P; Holmberg J; Backstrom BT; Tordsson J; Holmdahl R. 2004. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A 101(34):12646-51. [PubMed: 15310853] [MGI Ref ID J:92437]

Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. [PubMed: 16804066] [MGI Ref ID J:111874]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin. [MGI Ref ID J:110093]

Lin H; Rathmell JC; Gray GS; Thompson CB; Leiden JM; Alegre ML. 1998. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med 188(1):199-204. [PubMed: 9653096] [MGI Ref ID J:115143]

Murphy DB. 1986. Overview: the murine MHC. In: Handbook of Experimental Immunology. Vol. 3, Genetic and Molecular Immunology. Blackwell Scientific Publ., Oxford. [MGI Ref ID J:30731]

Nicholson SM; Jokinen DM; Canto MC; Kim BS; Melvold RW. 1995. Genetic analysis of susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease in the SWR strain. J Neuroimmunol 59(1-2):19-28. [PubMed: 7797616] [MGI Ref ID J:27344]

Ortman RA; Holderbaum D; Qu XM; Banerjee S; Haqqi TM. 1994. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis. J Immunol 152(8):4175-82. [PubMed: 8144978] [MGI Ref ID J:17601]

Reed-Loisel LM; Sullivan BA; Laur O; Jensen PE. 2005. An MHC class Ib-restricted TCR that cross-reacts with an MHC class Ia molecule. J Immunol 174(12):7746-52. [PubMed: 15944277] [MGI Ref ID J:109978]

Verschelde C; Michonneau D; Trescol-Biemont MC; Berberich I; Schimpl A; Bonnefoy-Berard N. 2006. Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection. Cell Death Differ 13(7):1213-21. [PubMed: 16294210] [MGI Ref ID J:126130]

Yap GS; Ortmann R; Shevach E; Sher A. 2001. A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment. J Immunol 166(9):5720-5. [PubMed: 11313414] [MGI Ref ID J:120304]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number AX12

Colony Maintenance

Mating System Homozygote x Homozygote (Female x Male)

Diet Information LabDiet® 5K52/5K67

Mating System	Homozygote x Homozygote (Female x Male)
Diet Information	LabDiet® 5K52/5K67

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$64.00	Female or Male	Homozygous for H2^q

Pairs /Price*	Pair Genotype
$128.00	Homozygous for H2^q x Homozygous for H2^q

Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423.

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$83.20	Female or Male	Homozygous for H2^q

Pairs /Price*	Pair Genotype
$166.40	Homozygous for H2^q x Homozygous for H2^q

Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	001976 NOD/ShiLtJ

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

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Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

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000471	A.SW-H2^s H2-T18^b/SnJ
002089	AK.B6-H2^b Fv1^b/J
002090	AK.B6-H2^b/J
001094	AK.L-H2^b/1CyTyJ
003851	ALR.NOD-(D17Mit30-D17Mit123)/Lt
000469	B10.A-H2^a H2-T18^a/SgSnJ
000468	B10.A-H2^h2/(2R)SgSnJ
001150	B10.A-H2^h4/(4R)SgDvEgJ
000467	B10.A-H2ⁱ⁵ H2-T18^a/(5R)SgSnJ
000465	B10.BR-H2^k H2-T18^a/SgSnJ
004804	B10.BR-H2^k H2-T18^a/SgSnJJrep
005308	B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534	B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ
006102	B10.Cg-H2^k Tg(Il2/NFAT-luc)83Rinc/J
006100	B10.Cg-H2^k Tg(NFkB/Fos-luc)26Rinc/J
005895	B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J
000462	B10.D2-H2^d/n2SnJ
001153	B10.D2-H2ⁱ⁷/(107R)EgJ
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000461	B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ
000463	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
003147	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J
001953	B10.S-H2^s/SgMcdJ
002995	B6 x C.B10-H2^b/LiMcdJ-Fbn2^fp-2J/J
005717	B6(NOD) H2^g7-Sostdc1^shk/J
003584	B6.129S2-H2^dlAb1-Ea/J
001148	B6.AK-H2^k/FlaEgJ
001895	B6.AK-H2^k/J
000360	B6.C-H2^d Mdmg1^BALB/cBy/aByJ
000359	B6.C-H2^d/bByJ
005715	B6.Cg H2^g7-Tg(Ins2-CD80)3B7Flv/LwnJ
003068	B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J
003300	B6.NOD-(D17Mit21-D17Mit10)/LtJ
003069	B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ
003071	B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J
003067	B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J
003066	B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J
000944	B6.SJL-H2^b C3^c/2CyJ
000966	B6.SJL-H2^s C3^c/1CyJ
003374	B6;129S2-H2^dlAb1-Ea/J
003240	B6;B10.A-H2^a-Tg(H2KmPCC)2939Stoe/J
002844	BALB.5R-H2ⁱ⁵/LilJ
001041	BKS.B6-H2^b/J
001892	BRVR.B10-H2^b/J
001893	BRVR.D2-H2^d/J
001952	C.B10-H2^b/LilMcdJ
001951	C.C3-H2^k/LilMcdJ
000438	C3.SW-H2^b/SnJ
000437	D1.C-H2^d H2-T18^c/SnJ
000435	D1.LP-H2^b H2-T18^b^?/SnJ
001383	LT.MA-Glo1^b H2^k/J
002591	NOD.B10Sn-H2^b/J
004447	NOD.Cg-H2^h4/DilTacUmmJ
001627	NON.NOD-H2^g7/LtJ
003153	WLC.C-H2^d.GR-Mtv2/MorJ
003154	WLC.C-H2^d/MorJ

Strain Name:

NOD.SW-H2q/J

Stock Number:

002032

Availability:

Repository- Live

Strain Information

Control Information

Related Strains

Additional Web Information

Phenotype Information

Gene & Allele Information

Genotyping Information

Helpful Links

References

Selected Reference(s)

Additional References

Health & Colony Maintenance Information

Animal Health Reports

Colony Maintenance

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Control Information

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice & Services Conditions of Use

No Warranty

No Liability

NOD.SW-H2^q/J

JAX^® Mice & Services Conditions of Use