Strain Name: |
B6 x C57BLKS-m Leprdb Myo15sh2-J/J |
|---|---|
Stock Number: |
002048 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Lepr; Leprdb; Myo15; Myo15sh2-J; m; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Coisogenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Congenic Type JAX® GEMM® Strain - Mutant Stock Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation +N1p Strain Description
Mice homozygous for the shaker 2 Jackson spontaneous mutation (Myo15sh2-J) are viable and fertile, showing only a slight reduction in both compared to wildtype mice. The shaker 2 Jackson remutation is not visibly different from the original shaker 2 (Myo15sh2, Stock No. 000109). Homozygous mutant mice of both alleles display a phenotype very similar to the behavior and pathology to shaker-1 (Myo7ash1) with the exception that the abnormalities are observed a little earlier in shaker 2 mice. This strain is also carrying the misty (m) and diabetes (Leprdb) spontaneous mutations.
Gene & Allele Details
| Allele Symbol | Leprdb | ||
|---|---|---|---|
| Allele Name | diabetes | ||
| Common Name(s) | Lepdb; Lepr-; Leprdb-1J; db; leprdb; | ||
| Strain of Origin | C57BLKS/J | ||
| Gene Symbol and Name | Lepr, leptin receptor | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | CD295; Fa; LEPROT; Leprb; Modb1; OB-RGRP; OBR; db; diabetes; leptin receptor gene-related protein; obese-like; obl; | ||
| Molecular Note | A G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and a 106 nt insertion in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function. [MGI Ref ID J:31324] [MGI Ref ID J:31327] [MGI Ref ID J:31488] | ||
| Allele Symbol | Myo15sh2-J | ||
| Allele Name | shaker 2 Jackson | ||
| Common Name(s) | sh-2J; | ||
| Strain of Origin | BKS.Cg-m +/+ Leprdb/J | ||
| Gene Symbol and Name | Myo15, myosin XV | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | DFNB3; DKFZp686N18198; FLJ17274; FLJ31311; RGD1561873; sh-2; sh2; shaker 2; | ||
| General Note | This remutation at the Myo15 locus occurred in the C57BLKS-Leprdb m colony at The Jackson Laboratory. A direct breeding test for allelism between a homozygous Myo15sh2-J mutant and a Myo15sh2 homozygote yielded all affected progeny. The visible phenotype does not differ from that of Myo15sh2 homozygotes (J:28675). | ||
| Allele Symbol | m | ||
| Allele Name | misty | ||
Genotyping Protocols
Leprdb
m (Misty)
Related Strains
Strains carrying Leprdb allele
005089 B.Cg m +/+ Leprdb-Qkqk-2J/J 000697 B6.Cg-m +/+ Leprdb/J 000699 B6.Cg-m Leprdb/+ +/J 000642 BKS.Cg-m +/+ Leprdb/J 000700 BKS.Cg-m Leprdb/+ +/J 001192 BKS.Cg-meaJ Leprdb +/+ + m/J 000707 CBA.Cg-m Leprdb/+ +/J 006654 FVB.BKS(D)-Leprdb/ChuaJ View Strains carrying Leprdb (8 strains)
005089 B.Cg m +/+ Leprdb-Qkqk-2J/J 000697 B6.Cg-m +/+ Leprdb/J 000699 B6.Cg-m Leprdb/+ +/J 000027 B6.D-Tyrp1b m/J 000642 BKS.Cg-m +/+ Leprdb/J 000700 BKS.Cg-m Leprdb/+ +/J 001049 BKS.Cg-mea2J m/+ +/J 001192 BKS.Cg-meaJ Leprdb +/+ + m/J 000707 CBA.Cg-m Leprdb/+ +/J
000709 129P3/J-Leprdb-3J/J 004939 NOD/ShiLtJ-Leprdb-5J/LtJ 006846 STOCK Leprdb-9J/Jgn
000109 STOCK Myo15sh2/J 003304 STOCK Rb(16.17)7Bnr-Myo15sh2-2J/J
Research Applications
This mouse can be used to support research in many areas including:Leprdb related
Myo15sh2-J relatedDiabetes and Obesity Research
Hyperinsulinemia
Impaired Wound Healing
Insulin Resistance
Obesity With Diabetes
Endocrine Deficiency Research
Adipose Defects
Hypothalamus/Pituitary Defects
Pancreas Defects
Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects
Internal/Organ Research
Adipose Defects
Metabolism Research
Mouse/Human Gene Homologs
obesity, morbid, with hypogonadism (rare)
Reproductive Biology Research
Fertility Defects
m relatedMouse/Human Gene Homologs
deafness, neurosensory, autosomal recessive, 3
Neurobiology Research
Tremor Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
Dermatology Research
Color and White Spotting Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6 x C57BLKS-m Leprdb Myo15sh2-J/J |
| Stock Number: | 002048 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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