Strain Name:

B6.129P2-Lipctm1Unc/J

Stock Number:

002056

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Mice homozygous for the Lipctm1Unc targeted mutation show increased levels of total plasma cholesterol, plasma phospholipids, and high density lipoprotein.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129P2 via E14TG2a ES cell line
 
Donating InvestigatorDr. Nobuyo Maeda,   University of North Carolina at Chapel Hill

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Lipctm1Unc targeted mutation are viable and fertile. They show increased levels of total plasma cholesterol, plasma phospholipids, and high density lipoprotein. Triglyceride levels in the plasma are equivalent to those in wildtype mice. Homozygous mice also show a doubling of plasma HDL in response to a high fat diet.

Development
The C57BL/6J strain was generated by backcrossing mice carrying the Lipctm1Unc mutation 10 times to C57BL/6J inbred mice.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Diabetes Mellitus, Noninsulin-Dependent; NIDDM   (LIPC)
Hepatic Lipase Deficiency   (LIPC)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Lipctm1Unc/Lipctm1Unc

        B6.129P2-Lipctm1Unc
  • homeostasis/metabolism phenotype
  • decreased circulating corticosterone level
    • levels in response to ACTH are significantly reduced   (MGI Ref ID J:108412)
  • increased circulating cholesterol level
    • mice have elevated levels of serum cholesterol (>200 mg/dl)   (MGI Ref ID J:120962)
  • increased circulating triglyceride level
    • mice have elevated levels of triglycerides   (MGI Ref ID J:120962)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lipctm1Unc/Lipctm1Unc

        involves: 129
  • homeostasis/metabolism phenotype
  • abnormal circulating cholesterol level   (MGI Ref ID J:22938)
    • increased circulating cholesterol level
      • 30% increase   (MGI Ref ID J:22938)
      • increased circulating HDL cholesterol level
        • levels are only significantly elevated in females   (MGI Ref ID J:22938)
        • increased 2X on a high fat diet   (MGI Ref ID J:22938)
  • abnormal circulating phospholipid level
    • significantly increased   (MGI Ref ID J:22938)

Lipctm1Unc/Lipctm1Unc

        involves: 129P2/OlaHsd * C57BL/6J
  • homeostasis/metabolism phenotype
  • abnormal circulating cholesterol level   (MGI Ref ID J:22938)
    • increased circulating cholesterol level
      • 30% increase   (MGI Ref ID J:22938)
      • increased circulating HDL cholesterol level
        • levels are only significantly elevated in females   (MGI Ref ID J:22938)
        • increased 2X on a high fat diet   (MGI Ref ID J:22938)
  • abnormal circulating phospholipid level
    • significantly increased   (MGI Ref ID J:22938)
  • reproductive system phenotype
  • abnormal reproductive system physiology   (MGI Ref ID J:75665)
    • decreased litter size
      • by an average of 1.7 pups per litter   (MGI Ref ID J:75665)
    • decreased ovulation rate
      • about half as many oocytes released as normal   (MGI Ref ID J:75665)
  • small ovary
    • ovary size is reduced 20-40% subsequent to superovulation   (MGI Ref ID J:75665)
  • endocrine/exocrine gland phenotype
  • small ovary
    • ovary size is reduced 20-40% subsequent to superovulation   (MGI Ref ID J:75665)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lipctm1Unc related

Cardiovascular Research
Hypercholesterolemia

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lipctm1Unc
Allele Name targeted mutation 1, University of North Carolina
Allele Type Targeted (Null/Knockout)
Common Name(s) HL-deficient; hl-;
Mutation Made ByDr. Nobuyo Maeda,   University of North Carolina at Chapel Hill
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Lipc, lipase, hepatic
Chromosome 9
Gene Common Name(s) AI256194; HDLCQ12; HL; HTGL; Hpl; LIPH; expressed sequence AI256194; hepatic lipase;
Molecular Note A neomycin resistance cassette was inserted into exon 4 of the gene. [MGI Ref ID J:22938]

Genotyping

Genotyping Information

Genotyping Protocols

Lipctm1Unc, Standard PCR
Lipctm1Unc, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Homanics GE; de Silva HV; Osada J; Zhang SH; Wong H; Borensztajn J; Maeda N. 1995. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J Biol Chem 270(7):2974-80. [PubMed: 7852377]  [MGI Ref ID J:22938]

Additional References

Wade RL; Van Andel RA; Rice SG; Banka CL; Dyer CA. 2002. Hepatic lipase deficiency attenuates mouse ovarian progesterone production leading to decreased ovulation and reduced litter size. Biol Reprod 66(4):1076-82. [PubMed: 11906928]  [MGI Ref ID J:75665]

Yi N; Diament A; Chiu S; Kim K; Allison DB; Fisler JS; Warden CH. 2004. Characterization of epistasis influencing complex spontaneous obesity in the BSB model. Genetics 167(1):399-409. [PubMed: 15166164]  [MGI Ref ID J:90614]

Lipctm1Unc related

Amigo L; Mardones P; Ferrada C; Zanlungo S; Nervi F; Miquel JF; Rigotti A. 2003. Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice. Hepatology 38(3):726-34. [PubMed: 12939599]  [MGI Ref ID J:105914]

Bartelt A; Beil FT; Muller B; Koehne T; Yorgan TA; Heine M; Yilmaz T; Ruther W; Heeren J; Schinke T; Niemeier A. 2014. Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity. Bone 62:90-8. [PubMed: 24440515]  [MGI Ref ID J:207978]

Bergeron N; Kotite L; Verges M; Blanche P; Hamilton RL; Krauss RM; Bensadoun A; Havel RJ. 1998. Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. Proc Natl Acad Sci U S A 95(26):15647-52. [PubMed: 9861024]  [MGI Ref ID J:119773]

Braschi S; Couture N; Gambarotta A; Gauthier BR; Coffill CR; Sparks DL; Maeda N; Schultz JR. 1998. Hepatic lipase affects both HDL and ApoB-containing lipoprotein levels in the mouse. Biochim Biophys Acta 1392(2-3):276-90. [PubMed: 9630674]  [MGI Ref ID J:48486]

Brown RJ; Lagor WR; Sankaranaravanan S; Yasuda T; Quertermous T; Rothblat GH; Rader DJ. 2010. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res 107(3):357-64. [PubMed: 20558822]  [MGI Ref ID J:175039]

Chiu HK; Qian K; Ogimoto K; Morton GJ; Wisse BE; Agrawal N; McDonald TO; Schwartz MW; Dichek HL. 2010. Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis. Endocrinology 151(3):993-1001. [PubMed: 20056822]  [MGI Ref ID J:168270]

Dallinga-Thie GM; Zonneveld-de Boer AJ; van Vark-van der Zee LC; van Haperen R; van Gent T; Jansen H; De Crom R; van Tol A. 2007. Appraisal of hepatic lipase and lipoprotein lipase activities in mice. J Lipid Res 48(12):2788-91. [PubMed: 17872590]  [MGI Ref ID J:129933]

Diament AL; Farahani P; Chiu S; Fisler J; Warden CH. 2004. A novel mouse Chromosome 2 congenic strain with obesity phenotypes. Mamm Genome 15(6):452-9. [PubMed: 15181537]  [MGI Ref ID J:90700]

Dichek HL; Agrawal N; El Andaloussi N; Qian K. 2006. Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology. Am J Physiol Endocrinol Metab 290(5):E908-15. [PubMed: 16368783]  [MGI Ref ID J:108412]

Dichek HL; Qian K; Agrawal N. 2004. Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis. Arterioscler Thromb Vasc Biol 24(9):1696-702. [PubMed: 15205216]  [MGI Ref ID J:134693]

Dichek HL; Qian K; Agrawal N. 2004. The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient 'apoB-48-only' and 'apoB-100-only' mice. J Lipid Res 45(3):551-60. [PubMed: 14679168]  [MGI Ref ID J:88634]

Escola-Gil JC; Chen X; Julve J; Quesada H; Santos D; Metso J; Tous M; Jauhiainen M; Blanco-Vaca F. 2013. Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. Biochim Biophys Acta 1831(4):691-7. [PubMed: 23328279]  [MGI Ref ID J:199042]

Farahani P; Fisler JS; Wong H; Diament AL; Yi N; Warden CH. 2004. Reciprocal Hemizygosity Analysis of Mouse Hepatic Lipase Reveals Influence on Obesity. Obes Res 12(2):292-305. [PubMed: 14981222]  [MGI Ref ID J:88297]

Freeman L; Amar MJ; Shamburek R; Paigen B; Brewer HB Jr; Santamarina-Fojo S; Gonzalez-Navarro H. 2007. Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice. J Lipid Res 48(1):104-13. [PubMed: 17071916]  [MGI Ref ID J:117481]

Gonzalez-Navarro H; Nong Z; Amar MJ; Shamburek RD; Najib-Fruchart J; Paigen BJ; Brewer HB Jr; Santamarina-Fojo S. 2004. The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. J Biol Chem 279(44):45312-21. [PubMed: 15304509]  [MGI Ref ID J:94495]

Hedrick CC; Castellani LW; Wong H; Lusis AJ. 2001. In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions. J Lipid Res 42(4):563-70. [PubMed: 11290828]  [MGI Ref ID J:124753]

Hime NJ; Black AS; Bulgrien JJ; Curtiss LK. 2008. Leukocyte-derived hepatic lipase increases HDL and decreases en face aortic atherosclerosis in LDLr-/- mice expressing CETP. J Lipid Res 49(10):2113-23. [PubMed: 18599739]  [MGI Ref ID J:140426]

Karackattu SL; Trigatti B; Krieger M. 2006. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 26(3):548-54. [PubMed: 16397139]  [MGI Ref ID J:127979]

Kawano K; Qin S; Vieu C; Collet X; Jiang XC. 2002. Role of hepatic lipase and scavenger receptor BI in clearing phospholipid/free cholesterol-rich lipoproteins in PLTP-deficient mice. Biochim Biophys Acta 1583(2):133-40. [PubMed: 12117557]  [MGI Ref ID J:115519]

Lambert G; Amar MJ; Martin P; Fruchart-Najib J; Foger B; Shamburek RD; Brewer HB Jr; Santamarina-Fojo S. 2000. Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo. J Lipid Res 41(5):667-72. [PubMed: 10787427]  [MGI Ref ID J:120538]

Lee SJ; Kadambi S; Yu KC; David C; Azhar S; Cooper AD; Choi SY. 2005. Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase. J Lipid Res 46(1):27-35. [PubMed: 15520453]  [MGI Ref ID J:94704]

Lo JC; Wang Y; Tumanov AV; Bamji M; Yao Z; Reardon CA; Getz GS; Fu YX. 2007. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316(5822):285-8. [PubMed: 17431181]  [MGI Ref ID J:120962]

Mezdour H; Jones R; Dengremont C; Castro G; Maeda N. 1997. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 272(21):13570-5. [PubMed: 9153204]  [MGI Ref ID J:40434]

Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283(10):6449-58. [PubMed: 18175806]  [MGI Ref ID J:133757]

Nong Z; Gonzalez-Navarro H; Amar M; Freeman L; Knapper C; Neufeld EB; Paigen BJ; Hoyt RF; Fruchart-Najib J; Santamarina-Fojo S. 2003. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. J Clin Invest 112(3):367-78. [PubMed: 12897204]  [MGI Ref ID J:84922]

Pratt SM; Chiu S; Espinal GM; Shibata NM; Wong H; Warden CH. 2010. Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size. J Lipid Res 51(5):1035-48. [PubMed: 19965617]  [MGI Ref ID J:160195]

Qiu S; Bergeron N; Kotite L; Krauss RM; Bensadoun A; Havel RJ. 1998. Metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient mice. J Lipid Res 39(8):1661-8. [PubMed: 9717727]  [MGI Ref ID J:49101]

Sarahan KA; Fisler JS; Warden CH. 2011. Four out of eight genes in a mouse chromosome 7 congenic donor region are candidate obesity genes. Physiol Genomics :. [PubMed: 21730028]  [MGI Ref ID J:174565]

Wade RL; Van Andel RA; Rice SG; Banka CL; Dyer CA. 2002. Hepatic lipase deficiency attenuates mouse ovarian progesterone production leading to decreased ovulation and reduced litter size. Biol Reprod 66(4):1076-82. [PubMed: 11906928]  [MGI Ref ID J:75665]

Wang N; Weng W; Breslow JL; Tall AR. 1996. Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor under feedback control. J Biol Chem 271(35):21001-4. [PubMed: 8798380]  [MGI Ref ID J:35143]

Weng W; Brandenburg NA; Zhong S; Halkias J; Wu L; Jiang XC; Tall A; Breslow JL. 1999. ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice. J Lipid Res 40(6):1064-70. [PubMed: 10357838]  [MGI Ref ID J:55745]

van Haperen R; Samyn H; van Gent T; Zonneveld AJ; Moerland M; Grosveld F; Jansen H; Dallinga-Thie GM; van Tol A; de Crom R. 2009. Novel roles of hepatic lipase and phospholipid transfer protein in VLDL as well as HDL metabolism. Biochim Biophys Acta 1791(10):1031-6. [PubMed: 19524061]  [MGI Ref ID J:153460]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain is maintained by mating homozygous siblings. Expected coat color from breeding:Black

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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