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Former Names B6C3Fe a/a-Atp7aMo-8J (Changed: 30-JUN-06 ) B6C3Fe-a/a-Atp7aMo-8J (Changed: 15-DEC-04 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation +Nep Description
Hemizygous males die 7-12 days after birth.Development
The mottled 8 Jackson mutation (Atp7aMo-8J) arose spontaneously at The Jackson Laboratory in strain B6C3Fe a/a-Glrbspa/J (Stock No. 000241) in 1992 when that strain was at generation N35F1. The first affected female was crossed to a B6C3Fe-a/a F1 male and each generation an affected female was backcrossed to this hybrid. It was cryopreserved in 1993 by mating heterozygous females at N3 to B6C3Fe-a/a F1 males.
Strains carrying a allele
View Strains carrying a (104 strains)
Strains carrying other alleles of Atp7a
000535 B6.Cg-Atp7aMo-blo/J 001381 B6.Cg-Atp7aMo-pew2J/J 000053 B6.Cg-Atp7aMo-to/J 002044 B6Ei.Cg-Atp7aMo-blo/J 002566 C57BL/6-Atp7aMo-br/J 000813 CBA/J-Atp7aMo-pew/J 000623 TR/DiEiJ View Strains carrying other alleles of Atp7a (7 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (81 strains)
| Allele Symbol | Atp7aMo-8J | ||
|---|---|---|---|
| Allele Name | mottled 8 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6C3Fe a/a-Glrbspa/J | ||
| Gene Symbol and Name | Atp7a, ATPase, Cu++ transporting, alpha polypeptide | ||
| Chromosome | X | ||
| Gene Common Name(s) | Blo; FLJ17790; MK; MNK; Menkes protein; Mo; blotchy; br; mottled; | ||
| Molecular Note | A spontaneous mutation that arose at The Jackson Laboratory. | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Atp7aMo-8J relatedReed V; Boyd Y. 1997. Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease. Hum Mol Genet 6(3):417-23. [PubMed: 9147645] [MGI Ref ID J:38978]
Sweet HO. 1993. Remutations at The Jackson Laboratory Mouse Genome 91(4):862-65. [MGI Ref ID J:16313]
Colony Maintenance
Breeding & Husbandry Hemizygous males die 7-12 days after birth.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Purchasing Information
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Contact Information
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Fax: 1-207-288-6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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