Strain Name:

129T2/SvEmsJ

Stock Number:

002065

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Availability:

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This is a substrain of the 129 family that does not carry the teratoma gene (Dnd1Ter).

Description

Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a challenging breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationF125 (10-DEC-13)
Generation Definitions

Appearance
light-bellied agouti chinchilla
Related Genotype: Aw/Aw Tyrc-ch/Tyrc-ch

Description
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T).

The teratoma family of 129 sublines was derived from an outcross of the parental 129/Sv to a hybrid (WC x C57BL/6) to introduce the dominant spotting mutation (KitW). After 8 generations of backcrossing to 129/Sv a higher incidence of testicular teratomas was observed. The subline became the 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J substrain (#000091). In 1992 E.M. Simpson selected against the ter allele to establish the present substrain which was transferred to the Jackson Laboratory in 1993.

Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997.

Development
Derived from strain 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J (#000091) and selected for the wild type of the Dnd1Ter by E.M. Simpson in 1992.

Related Strains

129 Strains
001137   129P1/ReJ
000690   129P3/J
002357   129P3/JEmsJ
001198   129P4/RrRkJ
002448   129S1/SvImJ
009104   129S4/SvJaeJ
012809   129S8/SvEvNimrJ
002064   129T2/SvEms
000691   129X1/SvJ
View 129 Strains     (9 strains)

Strains carrying   Disc1del allele
001137   129P1/ReJ
000690   129P3/J
001198   129P4/RrRkJ
002448   129S1/SvImJ
002064   129T2/SvEms
000691   129X1/SvJ
002282   BTBR T+ Itpr3tf/J
002243   DDY/JclSidSeyFrkJ
001800   FVB/NJ
000676   LP/J
000686   SJL/J
000689   SWR/J
View Strains carrying   Disc1del     (12 strains)

Additional Web Information

New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

View Phenotypic Data

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Schizophrenia 9; SCZD9   (DISC1)
Schizophrenia; SCZD   (DISC1)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: testicular teratomas

Reproductive Biology Research
Gonadal Tumors
      testicular teratomas

Research Tools
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Production of Targeted Mutations (Knockouts)

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Disc1del
Allele Name deletion
Allele Type Spontaneous
Common Name(s) Disc1129S6; Disc1delta6;
Strain of Originvarious
Gene Symbol and Name Disc1, disrupted in schizophrenia 1
Chromosome 8
Gene Common Name(s) C1orf136; SCZD9;
General Note This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Disc1del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369]  [MGI Ref ID J:107244]

Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. [PubMed: 21903668]  [MGI Ref ID J:177560]

Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. [PubMed: 23563120]  [MGI Ref ID J:195189]

Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826]  [MGI Ref ID J:185685]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a challenging breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $135.00Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $175.50Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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