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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Species laboratory mouse H2 Haplotype b Generation F124 (21-JUL-11)
Generation DefinitionsAppearance
light-bellied agouti chinchilla
Related Genotype: Aw/Aw Tyrc-ch/Tyrc-chDescription
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997.
Related Strains
129 Strains
001137 129P1/ReJ 000690 129P3/J 002357 129P3/JEmsJ 001198 129P4/RrRkJ 002448 129S1/SvImJ 009104 129S4/SvJaeJ 012809 129S8/SvEvNimrJ 002064 129T2/SvEms 000691 129X1/SvJ View 129 Strains (9 strains)
001137 129P1/ReJ 000690 129P3/J 001198 129P4/RrRkJ 002448 129S1/SvImJ 002064 129T2/SvEms 000691 129X1/SvJ 002282 BTBR T+ Itpr3tf/J 002243 DDY/JclSidSeyFrkJ 001800 FVB/NJ 000676 LP/J 000686 SJL/J 000689 SWR/J
Additional Web Information
New 129 Nomenclature Bulletin
Phenotype
Phenotype Information
Mouse Phenome Database
Festing Inbred Strain Characteristics: 129
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Schizophrenia 9; SCZD9 (DISC1)
Schizophrenia; SCZD (DISC1)
This mouse can be used to support research in many areas including:
Cancer Research
Increased Tumor Incidence
Gonadal Tumors
Gonadal Tumors: testicular teratomas
Reproductive Biology Research
Gonadal Tumors
testicular teratomas
Research Tools
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Production of Targeted Mutations (Knockouts)
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Disc1del | ||
|---|---|---|---|
| Allele Name | deletion | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Disc1129S6; Disc1delta6; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Disc1, disrupted in schizophrenia 1 | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | C1orf136; SCZD9; | ||
| General Note | This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189). | ||
| Molecular Note | A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244] | ||
References
References provided by MGI
Selected Reference(s)
Festing MF; Simpson EM; Davisson MT; Mobraaten LE. 1999. Revised nomenclature for strain 129 mice. Mamm Genome 10(8):836. [PubMed: 10430671] [MGI Ref ID J:56500]
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119] [MGI Ref ID J:89298]
Simpson EM; Linder CC; Sargent EE; Davisson MT; Mobraaten LE; Sharp JJ. 1997. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet 16(1):19-27. [PubMed: 9140391] [MGI Ref ID J:40222]
Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863] [MGI Ref ID J:29502]
Threadgill DW; Yee D; Matin A; Nadeau JH; Magnuson T. 1997. Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome 8(6):390-3. [PubMed: 9166580] [MGI Ref ID J:40661]
Additional References
Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659] [MGI Ref ID J:111837]
Nguyen PV; Duffy SN; Young JZ. 2000. Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice. J Neurophysiol 84(5):2484-93. [PubMed: 11067991] [MGI Ref ID J:71278]
Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. 2000. Genetic heterogeneity of angiogenesis in mice. FASEB J 14(7):871-6. [PubMed: 10783140] [MGI Ref ID J:61808]
Zheng QY; Johnson KR; Erway LC. 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130(1-2):94-107. [PubMed: 10320101] [MGI Ref ID J:54812]
Disc1del relatedClapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659] [MGI Ref ID J:111837]
Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :. [MGI Ref ID J:118317]
Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369] [MGI Ref ID J:107244]
Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. [PubMed: 21903668] [MGI Ref ID J:177560]
Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. [PubMed: 23563120] [MGI Ref ID J:195189]
Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826] [MGI Ref ID J:185685]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $125.00 Female or Male Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $162.50 Female or Male Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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