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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation F?+5p+F1
Related Strains
Strains carrying H2b allele
002089 AK.B6-H2b Fv1b/J 001094 AK.L-H2b/1CyTyJ 002995 B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J 000944 B6.SJL-H2b C3c/2CyJ 001041 BKS.B6-H2b/J 001892 BRVR.B10-H2b/J 001952 C.B10-H2b/LilMcdJ 000438 C3.SW-H2b/SnJ 000435 D1.LP-H2b H2-T18b?/SnJ 002591 NOD.B10Sn-H2b/J View Strains carrying H2b (10 strains)
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
Currently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:H2b related
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2b | ||
|---|---|---|---|
| Allele Name | b variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The b variant has been observed in the following strains: C57BL/10, C57BL/10SnJ, BXSB/MpJ, C57BL/6J, C57L/J, LP/J, 129P3/J | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
H2b relatedArancibia-Carcamo CV; Osawa H; Arnett HA; Haskova Z; George AJ; Ono SJ; Ting JP; Streilein JW. 2004. A CIITA-independent pathway that promotes expression of endogenous rather than exogenous peptides in immune-privileged sites. Eur J Immunol 34(2):471-80. [PubMed: 14768052] [MGI Ref ID J:115470]
Bakir HY; Tomiyama-Miyaji C; Watanabe H; Nagura T; Kawamura T; Sekikawa H; Abo T. 2006. Reasons why DBA/2 mice are resistant to malarial infection: expansion of CD3int B220+ gammadelta T cells with double-negative CD4- CD8- phenotype in the liver. Immunology 117(1):127-35. [PubMed: 16423048] [MGI Ref ID J:106141]
Bergmann CC; Ramakrishna C; Kornacki M; Stohlman SA. 2001. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J Immunol 167(3):1575-83. [PubMed: 11466379] [MGI Ref ID J:120484]
Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215] [MGI Ref ID J:120213]
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Buhlmann JE; Gonzalez M; Ginther B; Panoskaltsis-Mortari A; Blazar BR; Greiner DL; Rossini AA; Flavell R; Noelle RJ. 1999. Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. J Immunol 162(8):4373-6. [PubMed: 10201970] [MGI Ref ID J:119788]
Campbell IK; Hamilton JA; Wicks IP. 2000. Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis. Eur J Immunol 30(6):1568-75. [PubMed: 10898492] [MGI Ref ID J:62698]
Chan K; Lee DJ; Schubert A; Tang CM; Crain B; Schoenberger SP; Corr M. 2001. The roles of MHC class II, CD40, and B7 costimulation in CTL induction by plasmid DNA. J Immunol 166(5):3061-6. [PubMed: 11207256] [MGI Ref ID J:126695]
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Croxford AL; Akilli-Ozturk O; Rieux-Laucat F; Forster I; Waisman A; Buch T. 2008. MHC-restricted T cell receptor signaling is required for alphabeta TCR replacement of the pre T cell receptor. Eur J Immunol 38(2):391-9. [PubMed: 18203137] [MGI Ref ID J:131357]
D'Orazio SE; Halme DG; Ploegh HL; Starnbach MN. 2003. Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection. J Immunol 171(1):291-8. [PubMed: 12817010] [MGI Ref ID J:123815]
D'Orazio SE; Shaw CA; Starnbach MN. 2006. H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes. J Exp Med 203(2):383-91. [PubMed: 16461341] [MGI Ref ID J:118952]
Dalloul AH; Ngo K; Fung-Leung WP. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol 26(1):213-8. [PubMed: 8566069] [MGI Ref ID J:112982]
El-Sawy T; Belperio JA; Strieter RM; Remick DG; Fairchild RL. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112(3):320-31. [PubMed: 15998678] [MGI Ref ID J:117219]
Evans CF; Rall GF; Killeen N; Littman D; Oldstone MB. 1993. CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus. J Immunol 151(11):6259-64. [PubMed: 7902375] [MGI Ref ID J:110661]
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Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915] [MGI Ref ID J:139556]
Gerloni M; Castiglioni P; Zanetti M. 2005. The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice. J Immunol 175(10):6551-9. [PubMed: 16272309] [MGI Ref ID J:119394]
Ghendler Y; Hussey RE; Witte T; Mizoguchi E; Clayton LK; Bhan AK; Koyasu S; Chang HC; Reinherz EL. 1997. Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol 27(9):2279-89. [PubMed: 9341770] [MGI Ref ID J:133112]
Ghendler Y; Teng MK; Liu JH; Witte T; Liu J; Kim KS; Kern P; Chang HC; Wang JH; Reinherz EL. 1998. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95(17):10061-6. [PubMed: 9707600] [MGI Ref ID J:119802]
Grob P; Schijns VE; van den Broek MF; Cox SP; Ackermann M; Suter M. 1999. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. J Virol 73(6):4748-54. [PubMed: 10233935] [MGI Ref ID J:110066]
Gubbels MR; Jorgensen TN; Metzger TE; Menze K; Steele H; Flannery SA; Rozzo SJ; Kotzin BL. 2005. Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice. J Immunol 175(9):6190-6. [PubMed: 16237116] [MGI Ref ID J:119371]
Horwitz MS; Krahl T; Fine C; Lee J; Sarvetnick N. 1999. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon. J Virol 73(3):1756-66. [PubMed: 9971752] [MGI Ref ID J:120473]
Jenkinson EJ; Van Ewijk W; Owen JJ. 1981. Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J Exp Med 153(2):280-92. [PubMed: 6940949] [MGI Ref ID J:109960]
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Kageyama Y; Koide Y; Yoshida A; Uchijima M; Arai T; Miyamoto S; Ozeki T; Hiyoshi M; Kushida K; Inoue T. 1998. Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor. J Immunol 161(3):1542-8. [PubMed: 9686622] [MGI Ref ID J:119066]
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Laky K; Lewis JM; Tigelaar RE; Puddington L. 2003. Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life. J Immunol 170(8):4087-94. [PubMed: 12682238] [MGI Ref ID J:125438]
Lehmann-Grube F; Lohler J; Utermohlen O; Gegin C. 1993. Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene. J Virol 67(1):332-9. [PubMed: 8093219] [MGI Ref ID J:111102]
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Leng Q; Ge Q; Nguyen T; Eisen HN; Chen J. 2007. Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A 104(12):5038-43. [PubMed: 17360333] [MGI Ref ID J:120081]
Lin H; Rathmell JC; Gray GS; Thompson CB; Leiden JM; Alegre ML. 1998. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med 188(1):199-204. [PubMed: 9653096] [MGI Ref ID J:115143]
Longhi MP; Sivasankar B; Omidvar N; Morgan BP; Gallimore A. 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J Immunol 175(11):7098-102. [PubMed: 16301611] [MGI Ref ID J:122201]
Medema JP; de Jong J; van Hall T; Melief CJ; Offringa R. 1999. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J Exp Med 190(7):1033-8. [PubMed: 10510093] [MGI Ref ID J:115086]
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Oberg L; Johansson S; Michaelsson J; Tomasello E; Vivier E; Karre K; Hoglund P. 2004. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways. Eur J Immunol 34(6):1646-53. [PubMed: 15162434] [MGI Ref ID J:115484]
Panoskaltsis-Mortari A; Hermanson JR; Taras E; Wangensteen OD; Charo IF; Rollins BJ; Blazar BR. 2004. Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am J Physiol Lung Cell Mol Physiol 286(2):L284-92. [PubMed: 14527928] [MGI Ref ID J:101226]
Pereira P; Zijlstra M; McMaster J; Loring JM; Jaenisch R; Tonegawa S. 1992. Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice. EMBO J 11(1):25-31. [PubMed: 1531458] [MGI Ref ID J:111105]
Peterson KE; Iwashiro M; Hasenkrug KJ; Chesebro B. 2000. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia J Virol 74(11):5363-7. [PubMed: 10799615] [MGI Ref ID J:62492]
Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]
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Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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General Terms and Conditions
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