Strain Name:

B6.129S2-Trp53tm1Tyj/J

Stock Number:

002101

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHeterozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129S2 via D3 ES cell line
GenerationN11F13 (20-DEC-06)
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Trp53tm1Tyj mutation show no visible phenotype but most develop tumors (principally lymphomas and osteosarcoma) at three to six months of age. Heterozygous mice develop tumors at about 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome, a form of familial breast cancer with mutations in TRP53. Homozygous mice may produce a litter before succumbing to tumors.

Development
The Trp53tm1Tyj mutant strain was developed in the laboratory of Dr. Tyler Jacks at the Center for Cancer Research at the Massachusetts Institute of Technology. The 129-derived D3 ES cell line was used. The C57BL/6J strain was produced by backcrossing the Trp53tm1Tyj mutation 10 times to C57BL/6J inbred mice.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Trp53tm1Tyj allele
002080   129-Trp53tm1Tyj/J
008191   B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J
002103   B6;129S2-Trp53tm1Tyj/J
002526   C.129S2(B6)-Trp53tm1Tyj/J
002547   C3Ou.129S2(B6)-Trp53tm1Tyj/J
002899   FVB.129S2(B6)-Trp53tm1Tyj/J
View Strains carrying   Trp53tm1Tyj     (6 strains)

View Strains carrying other alleles of Trp53     (11 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report
JAX® NOTES, Spring 2003; 489. Medulloblastoma Mouse Models.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Li-Fraumeni Syndrome 1; LFS1 - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Trp53tm1Tyj/Trp53+

        involves: C57BL/6
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:95318)
    • heterozygous mutants die between 150 to 750 days after birth
  • tumorigenesis
  • carcinoma (MGI Ref ID J:95318)
    • 12% of heterozygous mutants developed carcinomas, which are rare in homozygotes
  • lymphoma (MGI Ref ID J:95318)
    • 32% of heterozygous mutants developed lymphomas
  • sarcoma (MGI Ref ID J:95318)
    • 56% of heterozygous mutants developed sarcomas

Trp53tm1Tyj/Trp53tm1Tyj

        involves: C57BL/6
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:95318)
    • homozygous mutants die between ~50 to 250 days after birth
  • tumorigenesis
  • lymphoma (MGI Ref ID J:95318)
    • 56% of homozygous nulls developed lymphomas
  • sarcoma (MGI Ref ID J:95318)
    • 40% of homozygous nulls developed sarcomas
  • cellular phenotype
  • decreased cellular sensitivity to gamma-irradiation (MGI Ref ID J:95318)
    • irradiated E13.5 heterozygous embryos showed no evidence of apoptosis in the hypothalamus compared to wildtype and heterozygotes that showed a high number of apoptotic cells
  • increased cell proliferation (MGI Ref ID J:95318)
    • MEFs initially did not show any significant differences in growth rate but by day 4, grew more rapidly than wildtype or heterozygous MEFs

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Trp53tm1Tyj/Trp53+

        involves: 129S2/SvPas * C57BL/6
  • tumorigenesis
  • increased tumor incidence (MGI Ref ID J:17728)
    • age of onset 9 months

Trp53tm1Tyj/Trp53+

        involves: 129/Sv * C57BL/6
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:135509)
    • less than 5% of mice live past two years due to cancerous tumors
  • tumorigenesis
  • increased tumor incidence (MGI Ref ID J:72391)
    • over 95% of mice have tumors by 2 years of age
    • adenoma (MGI Ref ID J:72391)
    • carcinoma (MGI Ref ID J:72391)
    • leukemia (MGI Ref ID J:135509)
      • is observed in 2.6% of mice by 24 months of age
    • lymphoma (MGI Ref ID J:72391)
      • is observed in 18.4% of mice by 24 months of age
    • sarcoma (MGI Ref ID J:72391)

Trp53tm1Tyj/Trp53+

        involves: 129S2/SvPas
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:95316)
    • mean life span is 15.4 months
  • tumorigenesis
  • increased tumor incidence (MGI Ref ID J:95316)
    • 19% have multiple tumors compared to 44% of Trp53tm3.1Tyj heterozygotes
    • carcinoma (MGI Ref ID J:95316)
      • 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma
  • cellular phenotype
  • increased cell proliferation (MGI Ref ID J:95316)
    • a larger fraction of MEFs are in S phase compared to wild-type mice

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas * C57BL/6
  • tumorigenesis
  • increased tumor incidence (MGI Ref ID J:17728)
    • most mice dead by 6 months
    • predominantly lymphomas with sarcomas and teratomas

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129/Sv * C57BL/6
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:72391)
    • average life span 160 days
    • 90% had succumbed to tumors and died by 7 months of age
  • tumorigenesis
  • increased tumor incidence (MGI Ref ID J:72391)
    • adenoma (MGI Ref ID J:72391)
    • carcinoma (MGI Ref ID J:72391)
    • lymphoma (MGI Ref ID J:72391)
      • thymic lymphoma (MGI Ref ID J:87501)
        • 75% of observed tumors were thymic lymphomas
    • sarcoma (MGI Ref ID J:72391)
  • cellular phenotype
  • abnormal apoptosis (MGI Ref ID J:87501)
  • chromosome breakage (MGI Ref ID J:87501)
    • aneuploidy

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas
  • lethality-prenatal/perinatal
  • prenatal lethality (MGI Ref ID J:95316)
    • a slight decrease is seen in the number of females born
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:95316)
    • mean life span is 4.4 months
    • majority of mice (82%) die before 9 months of age, or are euthanized due to occurrence of obvious tumor mass
  • nervous system phenotype
  • abnormal neurogenesis (MGI Ref ID J:102702)
    • GNPs from mutants show ~50% levels of proliferation compared to Cdkn2c, Trp53-double null cells after 3 days in culture and levels of cells incorporating BrdU are still less in single mutants in tests where cells are stimulated with Shh after culture
  • tumorigenesis
  • increased tumor incidence (MGI Ref ID J:95316)
    • 32% have multiple tumors
    • T cell derived lymphoma (MGI Ref ID J:95316)
      • 66% of homozygotes display hematological malignancies, primarily T cell lymphomas
    • hemangiosarcoma (MGI Ref ID J:95316)
      • the incidence of hemangiosarcomas is 32% compared to 62% in Trp53tm1Tyj/Trp53tm2.1Tyj mice
    • medulloblastoma (MGI Ref ID J:102702)
      • 13/19 (68%) of animals receiving 4 Gy radiation at P5 or 6 develop cerebellar tumors
  • cellular phenotype
  • abnormal cell cycle checkpoint function (MGI Ref ID J:77907)
    • gamma-irradiation fails to produce an increase in the relative number of cells in G1 compared to S phase
  • decreased cellular sensitivity to ultraviolet irradiation (MGI Ref ID J:77907)
    • reduced sensitivity to UV-induced cell death in MEFs compared to wild-type cells
  • increased cell proliferation (MGI Ref ID J:77907)
    • in MEFs
  • polyploidy (MGI Ref ID J:109354)
    • after irradiation with UVC light, MEFs from null mice show higher levels of polyploidy than Trp53tm2Xu homozygotes
  • hematopoietic system phenotype
  • decreased T cell apoptosis (MGI Ref ID J:109354)
    • thymocytes are essentially resistant to Trp53-mediated apoptosis
  • immune system phenotype
  • decreased T cell apoptosis (MGI Ref ID J:109354)
    • thymocytes are essentially resistant to Trp53-mediated apoptosis
  • cardiovascular system phenotype
  • abnormal cardiovascular system physiology (MGI Ref ID J:120332)
    • better systolic function than control
  • cardiac hypertrophy (MGI Ref ID J:120332)
    • increased hypertrophy as a result of transverse aortic restriction
  • increased angiogenesis (MGI Ref ID J:120332)
    • increased number of microvessels form 2 weeks after transverse aortic constriction

Trp53tm1Tyj/Trp53tm1Tyj

        involves: 129S2/SvPas * BALB/c
  • cellular phenotype
  • increased cellular sensitivity to ionizing radiation (MGI Ref ID J:116176)
    • at P10, pattern and extent of oocyte loss in ovaries of mutants after exposure to 0.45 Gy radiation on P5 is similar to wild-type and much more sever than Trp63tm2Fmc mutants

Trp53tm1Tyj/Trp53tm1Tyj

        129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:102483)
    • mice become moribund from lymphoma involving various tissues within >30 weeks; mice with aggressive lymphoma have a mean survival time of 18 weeks
  • tumorigenesis
  • lymphoma (MGI Ref ID J:102483)
    • mice develop lymphomas
  • teratoma (MGI Ref ID J:102483)
    • median survival time of mice with teratomas is 7 weeks
    • no mice living beyond median survival age show extratesticular teratomas
    • testicular teratoma (MGI Ref ID J:102483)
  • digestive/alimentary phenotype
  • *normal* digestive/alimentary phenotype (MGI Ref ID J:102483)
    • after 7 days of dextran sodium sulfate treatment, mice develop large ulcers in the colon
  • growth/size phenotype
  • weight loss (MGI Ref ID J:102483)
    • with DSS treatment, double mutants have an average weight of 14% of body weight
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Trp53tm1Tyj related

Apoptosis Research
Endogenous Regulators

Cancer Research
Increased Tumor Incidence (Lymphomas)
Increased Tumor Incidence (Other Tissues/Organs: osteosarcoma)
Toxicology
Tumor Suppressor Genes

Immunology and Inflammation Research
Intracellular Signaling Molecules

Mouse/Human Gene Homologs
Li-Fraumeni syndrome

Research Tools
Toxicology Research (B and T cell deficiency) (xenograft transplant host)
Toxicology Research (drug/compound testing)

Genes & Alleles

Gene & Allele Information

Allele Symbol Trp53tm1Tyj
Allele Name targeted mutation 1, Tyler Jacks
Allele Type Targeted (knock-out)
Common Name(s) Trp53-; Trp53KO; p53-; p53delta; p53null;
Mutation Made By Tyler Jacks,   Massachusetts Institute of Technology
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Trp53, transformation related protein 53
Chromosome 11
Gene Common Name(s) FLJ92943; LFS1; MGC112612; p53;
General Note This mutant allele was produced by a targeted neo insertion into the Trp53 locus. Homozygotes show no visible phenotype but develop tumors at 3-6 months of age. Heterozygotes develop tumors at 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome (OMIM 151623), a form of familial breast cancer with mutations in TRP53 (J:16022)(J:16023) A specific human mutation found in hepatocellular carcinomas caused by hepatitis B infection or by aflatoxin exposure has been created in amouse model, resulting in a similar gene product (J:27363).
Molecular Note A neomycin cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6. [MGI Ref ID J:17728]

Genotyping

Genotyping Information

Genotyping Protocols

Trp53tm1Tyj, STD PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Jacks T; Remington L; Williams BO; Schmitt EM; Halachmi S; Bronson RT; Weinberg RA. 1994. Tumor spectrum analysis in p53-mutant mice. Curr Biol 4(1):1-7. [PubMed: 7922305]  [MGI Ref ID J:17728]

Additional References

Aleyasin H; Cregan SP; Iyirhiaro G; O'Hare MJ; Callaghan SM; Slack RS; Park DS. 2004. Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. J Neurosci 24(12):2963-73. [PubMed: 15044535]  [MGI Ref ID J:90221]

Botchkarev VA; Komarova EA; Siebenhaar F; Botchkareva NV; Komarov PG; Maurer M; Gilchrest BA; Gudkov AV. 2000. p53 is essential for chemotherapy-induced hair loss. Cancer Res 60(18):5002-6. [PubMed: 11016618]  [MGI Ref ID J:64779]

Cunningham JJ; Levine EM; Zindy F; Goloubeva O; Roussel MF; Smeyne RJ. 2002. The Cyclin-Dependent Kinase Inhibitors p19(Ink4d) and p27(Kip1) Are Coexpressed in Select Retinal Cells and Act Cooperatively to Control Cell Cycle Exit. Mol Cell Neurosci 19(3):359-74. [PubMed: 11906209]  [MGI Ref ID J:75882]

Fong LY; Ishii H; Nguyen VT; Vecchione A; Farber JL; Croce CM; Huebner K. 2003. p53 Deficiency Accelerates Induction and Progression of Esophageal and Forestomach Tumors in Zinc-deficient Mice. Cancer Res 63(1):186-95. [PubMed: 12517797]  [MGI Ref ID J:81055]

Freie B; Li X; Ciccone SL; Nawa K; Cooper S; Vogelweid C; Schantz L; Haneline LS; Orazi A; Broxmeyer HE; Lee SH; Clapp DW. 2003. Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis. Blood 102(12):4146-52. [PubMed: 12855557]  [MGI Ref ID J:84980]

Ikeda S; Hawes NL; Chang B; Avery CS; Smith RS; Nishina PM. 1999. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Invest Ophthalmol Vis Sci 40(8):1874-8. [PubMed: 10393064]  [MGI Ref ID J:55873]

Ito M; Okano HJ; Darnell RB; Roeder RG. 2002. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J 21(13):3464-75. [PubMed: 12093747]  [MGI Ref ID J:77765]

Komarova EA; Christov K; Faerman AI; Gudkov AV. 2000. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 19(33):3791-8. [PubMed: 10949934]  [MGI Ref ID J:63921]

Komarova EA; Kondratov RV; Wang K; Christov K; Golovkina TV; Goldblum JR; Gudkov AV. 2004. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 23(19):3265-71. [PubMed: 15064735]  [MGI Ref ID J:89739]

Lowe SW; Schmitt EM; Smith SW; Osborne BA; Jacks T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes [see comments] Nature 362(6423):847-9. [PubMed: 8479522]  [MGI Ref ID J:16022]

Lu YP; Lou YR; Peng QY; Xie JG; Conney AH. 2004. Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Cancer Res 64(14):5020-7. [PubMed: 15256477]  [MGI Ref ID J:91506]

McCarthy EE; Celebi JT; Baer R; Ludwig T. 2003. Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol 23(14):5056-63. [PubMed: 12832489]  [MGI Ref ID J:84329]

McGlynn KA; Hunter K; LeVoyer T; Roush J; Wise P; Michielli RA; Shen FM; Evans AA; London WT; Buetow KH. 2003. Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. Cancer Res 63(15):4594-601. [PubMed: 12907637]  [MGI Ref ID J:85696]

Opitz OG; Harada H; Suliman Y; Rhoades B; Sharpless NE; Kent R; Kopelovich L; Nakagawa H; Rustgi AK. 2002. A mouse model of human oral-esophageal cancer. J Clin Invest 110(6):761-9. [PubMed: 12235107]  [MGI Ref ID J:79110]

Reilly KM; Loisel DA; Bronson RT; McLaughlin ME; Jacks T. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects Nat Genet 26(1):109-13. [PubMed: 10973261]  [MGI Ref ID J:64364]

Sah VP; Attardi LD; Mulligan GJ; Williams BO; Bronson RT; Jacks T. 1995. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10(2):175-80. [PubMed: 7663512]  [MGI Ref ID J:23197]

Sata M; Tanaka K; Ishizaka N; Hirata Y; Nagai R. 2003. Absence of p53 Leads to Accelerated Neointimal Hyperplasia After Vascular Injury. Arterioscler Thromb Vasc Biol 23(9):1548-52. [PubMed: 12893686]  [MGI Ref ID J:84981]

Scoggins CR; Meszoely IM; Wada M; Means AL; Yang L; Leach SD. 2000. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas Am J Physiol Gastrointest Liver Physiol 279(5):G827-36. [PubMed: 11005771]  [MGI Ref ID J:65224]

Takeda K; Smyth MJ; Cretney E; Hayakawa Y; Kayagaki N; Yagita H; Okumura K. 2002. Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med 195(2):161-9. [PubMed: 11805143]  [MGI Ref ID J:74411]

Verschuren EW; Hodgson JG; Gray JW; Kogan S; Jones N; Evan GI. 2004. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res 64(2):581-9. [PubMed: 14744772]  [MGI Ref ID J:88091]

Weber GF; Bronson RT; Ilagan J; Cantor H; Schmits R; Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62(8):2281-6. [PubMed: 11956084]  [MGI Ref ID J:76201]

Wen R; Wang D; McKay C; Bunting KD; Marine JC; Vanin EF; Zambetti GP; Korsmeyer SJ; Ihle JN; Cleveland JL. 2001. Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. Mol Cell Biol 21(2):678-89. [PubMed: 11134353]  [MGI Ref ID J:67378]

Yamanishi Y; Boyle DL; Pinkoski MJ; Mahboubi A; Lin T; Han Z; Zvaifler NJ; Green DR; Firestein GS. 2002. Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis. Am J Pathol 160(1):123-30. [PubMed: 11786406]  [MGI Ref ID J:73730]

Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1):81-94. [PubMed: 15081359]  [MGI Ref ID J:90392]

Trp53tm1Tyj related

Ablamunits V; Cohen Y; Brazee IB; Gaetz HP; Vinson C; Klebanov S. 2006. Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice. Cancer Res 66(17):8897-902. [PubMed: 16951207]  [MGI Ref ID J:112412]

Aggarwal P; Lessie MD; Lin DI; Pontano L; Gladden AB; Nuskey B; Goradia A; Wasik MA; Klein-Szanto AJ; Rustgi AK; Bassing CH; Diehl JA. 2007. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev 21(22):2908-22. [PubMed: 18006686]  [MGI Ref ID J:127316]

Aghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. [PubMed: 16982747]  [MGI Ref ID J:112935]

Ahkter S; Richie CT; Zhang N; Behringer RR; Zhu C; Legerski RJ. 2005. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol 25(22):10071-8. [PubMed: 16260620]  [MGI Ref ID J:102381]

Akala OO; Park IK; Qian D; Pihalja M; Becker MW; Clarke MF. 2008. Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature 453(7192):228-32. [PubMed: 18418377]  [MGI Ref ID J:134785]

Alt JR; Greiner TC; Cleveland JL; Eischen CM. 2003. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 22(6):1442-50. [PubMed: 12628936]  [MGI Ref ID J:82477]

Artandi SE; Chang S; Lee SL; Alson S; Gottlieb GJ; Chin L; DePinho RA. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [see comments] Nature 406(6796):641-5. [PubMed: 10949306]  [MGI Ref ID J:63843]

Asakura A; Rudnicki MA. 2003. Rhabdomyosarcomagenesis-Novel pathway found. Cancer Cell 4(6):421-2. [PubMed: 14706332]  [MGI Ref ID J:88121]

Aslanian A; Iaquinta PJ; Verona R; Lees JA. 2004. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev 18(12):1413-22. [PubMed: 15175242]  [MGI Ref ID J:90855]

Ayanga B; Price R; Gu X; Lozano G; Evans SC. 2006. Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice. Genes Chromosomes Cancer 45(7):668-75. [PubMed: 16586494]  [MGI Ref ID J:108788]

Backlund MG; Trasti SL; Backlund DC; Cressman VL; Godfrey V; Koller BH. 2001. Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice. Cancer Res 61(17):6577-82. [PubMed: 11522657]  [MGI Ref ID J:71052]

Baek KH; Shin HJ; Yoo JK; Cho JH; Choi YH; Sung YC; McKeon F; Lee CW. 2003. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J Leukoc Biol 73(6):850-61. [PubMed: 12773518]  [MGI Ref ID J:121196]

Bailey DP; Kashyap M; Bouton LA; Murray PJ; Ryan JJ. 2006. Interleukin-10 induces apoptosis in developing mast cells and macrophages. J Leukoc Biol 80(3):581-9. [PubMed: 16829633]  [MGI Ref ID J:112579]

Balsitis S; Dick F; Lee D; Farrell L; Hyde RK; Griep AE; Dyson N; Lambert PF. 2005. Examination of the pRb-dependent and pRb-independent functions of E7 in vivo. J Virol 79(17):11392-402. [PubMed: 16103190]  [MGI Ref ID J:101623]

Barboza JA; Iwakuma T; Terzian T; El-Naggar AK; Lozano G. 2008. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res 6(6):947-54. [PubMed: 18567799]  [MGI Ref ID J:139880]

Barboza JA; Liu G; Ju Z; El-Naggar AK; Lozano G. 2006. p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A 103(52):19842-7. [PubMed: 17170138]  [MGI Ref ID J:118255]

Bardeesy N; Bastian BC; Hezel A; Pinkel D; DePinho RA; Chin L. 2001. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol 21(6):2144-53. [PubMed: 11238948]  [MGI Ref ID J:67799]

Bardeesy N; Morgan J; Sinha M; Signoretti S; Srivastava S; Loda M; Merlino G; DePinho RA. 2002. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol 22(2):635-43. [PubMed: 11756558]  [MGI Ref ID J:73973]

Barlow C; Brown KD; Deng CX; Tagle DA; Wynshaw-Boris A. 1997. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet 17(4):453-6. [PubMed: 9398849]  [MGI Ref ID J:76690]

Barlow C; Liyanage M; Moens PB; Deng CX; Ried T; Wynshaw-Boris A. 1997. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Nat Genet 17(4):462-6. [PubMed: 9398851]  [MGI Ref ID J:44388]

Becker KA; Lu S; Dickinson ES; Dunphy KA; Mathews L; Schneider SS; Jerry DJ. 2005. Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways. Oncogene 24(42):6345-53. [PubMed: 15940247]  [MGI Ref ID J:101763]

Beekman C; Nichane M; De Clercq S; Maetens M; Floss T; Wurst W; Bellefroid E; Marine JC. 2006. Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development. Mol Cell Biol 26(24):9291-301. [PubMed: 17000755]  [MGI Ref ID J:118144]

Bekaert S; Derradji H; Meyer TD; Michaux A; Buset J; Neefs M; Mergeay M; Jacquet P; Van Oostveldt P; Baatout S. 2005. Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development. DNA Repair (Amst) 4(9):1028-37. [PubMed: 15990362]  [MGI Ref ID J:105007]

Bender CF; Sikes ML; Sullivan R; Huye LE; Le Beau MM; Roth DB; Mirzoeva OK; Oltz EM; Petrini JH. 2002. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev 16(17):2237-51. [PubMed: 12208847]  [MGI Ref ID J:78820]

Berges RR; Furuya Y; Remington L; English HF; Jacks T; Isaacs JT. 1993. Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. Proc Natl Acad Sci U S A 90(19):8910-4. [PubMed: 8415631]  [MGI Ref ID J:111328]

Berman DM; Karhadkar SS; Hallahan AR; Pritchard JI; Eberhart CG; Watkins DN; Chen JK; Cooper MK; Taipale J; Olson JM; Beachy PA. 2002. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297(5586):1559-61. [PubMed: 12202832]  [MGI Ref ID J:79798]

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