Strain Name:

B6;129S2-Tcratm1Mom/J

Stock Number:

002115

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
GenerationF?+9p
 
Donating Investigator Peter Mombaerts,   The Rockefeller University

Description
Mice homozygous mice for the Tcratm1Mom targeted mutation are viable and fertile. They are deficient in the alpha beta T-cell receptor. The thymus is devoid of CD4+CD8- and CD4-CD8+ cells. Normal numbers of CD4+CD8+ cells are retained without the IL2 receptor. There are normal numbers of CD4-CD8- cells. ~1% of the thymocytes express the gamma delta TCR. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age.

Development
The Tcratm1Mom mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A targeting vector with the Pgk-neo gene disrupting exon 1 of Tcra was used. The 129-derived D3 ES cell line was used.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tcratm1Mom allele
002116   B6.129S2-Tcratm1Mom/J
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
View Strains carrying   Tcratm1Mom     (2 strains)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
007962   B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
004194   C57BL/6-Tg(TcraTcrb)425Cbn/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
007080   CByJ.B6-Tg(TcraTcrb)1100Mjb/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/Dvs
004259   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/+ Tg(TcrbAI4)1Dvs/+
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi/DoiJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
003868   NOD/ShiLt-Tg(TcraAI4)1Dvs/+ Tg(TcrbAI4)1Dvs/+
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (33 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Tcratm1Mom/Tcratm1Mom

        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • abnormal response to infection (MGI Ref ID J:119344)
    • airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection
  • decreased IgG level (MGI Ref ID J:119344)
    • mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
  • respiratory system phenotype
  • abnormal respiratory system morphology (MGI Ref ID J:119344)
    • M. pulmonis infected mice show a diminished or intermediate airway remodeling phenotype when compared to wild-type or Igh-6 deficient mice

Tcratm1Mom/Tcratm1Mom

        involves: 129 * C57BL/6
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:15221)
    • mortality rates increase after six months of age
    • few mice survive longer than one year
  • immune system phenotype
  • arrested T cell differentiation (MGI Ref ID J:3206)
    • T cells in the thymus do not pass the double positive stage
  • colitis (MGI Ref ID J:15221)
    • colitis occurs in mice as they age (4 months and over)
    • disease resembles the human disease ulcerative colitis
  • decreased CD4-positive T cell number (MGI Ref ID J:3206)
    • very few T cells are found in the thymus or periphery
  • decreased CD8-positive T cell number (MGI Ref ID J:3206)
    • very few CD8 T cells are found in the thymus or periphery
  • increased gamma-delta intraepithelial T cell number (MGI Ref ID J:15221)
    • numbers are markedly increased
  • digestive/alimentary phenotype
  • abnormal intestinal goblet cells (MGI Ref ID J:15221)
    • pronounced depletion of goblet cells resulting from inflammation
  • chronic diarrhea (MGI Ref ID J:15221)
    • is observed in older mice
  • colitis (MGI Ref ID J:15221)
    • colitis occurs in mice as they age (4 months and over)
    • disease resembles the human disease ulcerative colitis
  • crypts of Lieberkuhn abscesses (MGI Ref ID J:15221)
    • caused by neutrophil infiltration
  • intestinal ulcer (MGI Ref ID J:15221)
    • occurs in rare cases
  • rectal prolapse (MGI Ref ID J:15221)
    • occurs in mice over 4 months of age
  • endocrine/exocrine gland phenotype
  • crypts of Lieberkuhn abscesses (MGI Ref ID J:15221)
    • caused by neutrophil infiltration
  • hematopoietic system phenotype
  • arrested T cell differentiation (MGI Ref ID J:3206)
    • T cells in the thymus do not pass the double positive stage
  • decreased CD4-positive T cell number (MGI Ref ID J:3206)
    • very few T cells are found in the thymus or periphery
  • decreased CD8-positive T cell number (MGI Ref ID J:3206)
    • very few CD8 T cells are found in the thymus or periphery
  • increased gamma-delta intraepithelial T cell number (MGI Ref ID J:15221)
    • numbers are markedly increased

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tcratm1Mom/Tcratm1Mom

        involves: 129S2/SvPas
  • immune system phenotype
  • abnormal immune system cell morphology (MGI Ref ID J:3206)
    • absent T cells (MGI Ref ID J:88620)
    • increased mature gamma-delta T cell number (MGI Ref ID J:135597)
      • there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice
  • colitis (MGI Ref ID J:135597)
    • a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts
  • hematopoietic system phenotype
  • absent T cells (MGI Ref ID J:88620)
  • increased mature gamma-delta T cell number (MGI Ref ID J:135597)
    • there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice
  • digestive/alimentary phenotype
  • abnormal large intestine morphology (MGI Ref ID J:135597)
    • colitis results in lengthening of the colon
    • the large intestine weight to body weight ratio at 28 weeks of age is twice as great than what is observed in wild-type mice
    • rectal prolapse (MGI Ref ID J:135597)
      • rectal prolapse occurs in about 18% of mice 24 to 60 weeks of age
  • colitis (MGI Ref ID J:135597)
    • a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts

Tcratm1Mom/Tcratm1Mom

        B6.129S2-Tcratm1Mom
  • immune system phenotype
  • abnormal response to transplant (MGI Ref ID J:91742)
    • mice fail to reject tail skin from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen )
  • increased susceptibility to bacterial infection (MGI Ref ID J:106241)
    • greatly increased susceptibility to infection with Mycobacterium paratuberculosis
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Immunology and Inflammation Research (T Cell Receptor Deficiency)

Tcra related

Immunology and Inflammation Research
Inflammation

Tcratm1Mom related

Hematological Research
Immunological Defects

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects

Research Tools
Cancer Research (specific T cell deficiency)

Genes & Alleles

Gene & Allele Information

Allele Symbol Tcratm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (knock-out)
Common Name(s) C-alpha-; TCR alpha-; TCR alpha<0>; TCRalpha KO; TCRalpha-; alpha-;
Mutation Made By Peter Mombaerts,   The Rockefeller University
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Tcra, T-cell receptor alpha chain
Chromosome 14
Gene Common Name(s) OTTMUSG00000015028; Tcr alpha; Tcralpha; predicted gene, OTTMUSG00000015028;
Molecular Note A PGK-neo cassette was used to disrupt exon 1, which encodes the majority of the extracellular domain. The targeting event was confirmed by Southern analysis. [MGI Ref ID J:113136] [MGI Ref ID J:126027] [MGI Ref ID J:3206]

Genotyping

Genotyping Information

Genotyping Protocols

Tcratm1Mom, STD PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Mombaerts P; Clarke AR; Rudnicki MA; Iacomini J; Itohara S; Lafaille JJ; Wang L; Ichikawa Y; Jaenisch R; Hooper ML; Tonegawa S. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491] Nature 360(6401):225-31. [PubMed: 1359428]  [MGI Ref ID J:3206]

Rhim JA; Sandgren EP; Degen JL; Palmiter RD; Brinster RL. 1994. Replacement of diseased mouse liver by hepatic cell transplantation. Science 263(5150):1149-52. [PubMed: 8108734]  [MGI Ref ID J:92451]

Additional References

Eichelberger M; McMickle A; Blackman M; Mombaerts P; Tonegawa S; Doherty PC. 1995. Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice. J Immunol 154(4):1569-76. [PubMed: 7836742]  [MGI Ref ID J:22818]

Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709]  [MGI Ref ID J:15221]

Tcratm1Mom related

Albu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389]  [MGI Ref ID J:128515]

Almeida AR; Borghans JA; Freitas AA. 2001. T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med 194(5):591-9. [PubMed: 11535628]  [MGI Ref ID J:118033]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195]  [MGI Ref ID J:125748]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Baldwin TA; Sandau MM; Jameson SC; Hogquist KA. 2005. The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med 202(1):111-21. [PubMed: 15998791]  [MGI Ref ID J:100651]

Baron JL; Gardiner L; Nishimura S; Shinkai K; Locksley R; Ganem D. 2002. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16(4):583-94. [PubMed: 11970881]  [MGI Ref ID J:113520]

Baur N; Nerz G; Nil A; Eichmann K. 2001. Expression and selection of productively rearranged TCRbeta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alphabeta T cells. Int Immunol 13(8):1031-42. [PubMed: 11470773]  [MGI Ref ID J:71151]

Bessette K; Lang ML; Fava RA; Grundy M; Heinen J; Horne L; Spolski R; Al-Shami A; Morse HC rd; Leonard WJ; Kelly JA. 2008. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood 111(1):344-50. [PubMed: 17890450]  [MGI Ref ID J:129993]

Buch T; Rieux-Laucat F; Forster I; Rajewsky K. 2002. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity 16(5):707-18. [PubMed: 12049722]  [MGI Ref ID J:81564]

Burchill MA; Yang J; Vang KB; Moon JJ; Chu HH; Lio CW; Vegoe AL; Hsieh CS; Jenkins MK; Farrar MA. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28(1):112-21. [PubMed: 18199418]  [MGI Ref ID J:131384]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Candeias S; Peschon JJ; Muegge K; Durum SK. 1997. Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunol Lett 57(1-3):9-14. [PubMed: 9232418]  [MGI Ref ID J:42227]

Chandler P; Frater AJ; Douek DC; Viney JL; Kay G; Owen MJ; Hayday AC; Simpson E; Altmann DM. 1995. Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells. Immunology 85(4):531-7. [PubMed: 7558145]  [MGI Ref ID J:28872]

Chang D; Valdez P; Ho T; Robey E. 2000. MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment J Immunol 165(12):6710-5. [PubMed: 11120788]  [MGI Ref ID J:66168]

Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. [PubMed: 12376619]  [MGI Ref ID J:125077]

Chen Y; Cuda C; Morel L. 2005. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 174(12):7692-702. [PubMed: 15944270]  [MGI Ref ID J:100863]

Chin EY; Dangler CA; Fox JG; Schauer DB. 2000. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice. Comp Med 50(6):586-94. [PubMed: 11200563]  [MGI Ref ID J:66813]

Chinen T; Kobayashi T; Ogata H; Takaesu G; Takaki H; Hashimoto M; Yagita H; Nawata H; Yoshimura A. 2006. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130(2):373-88. [PubMed: 16472593]  [MGI Ref ID J:124924]

Chiu NM; Wang B; Kerksiek KM; Kurlander R; Pamer EG; Wang CR. 1999. The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus. J Exp Med 190(12):1869-78. [PubMed: 10601361]  [MGI Ref ID J:131934]

Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364]  [MGI Ref ID J:81809]

Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077]  [MGI Ref ID J:112051]

Croxford AL; Akilli-Ozturk O; Rieux-Laucat F; Forster I; Waisman A; Buch T. 2008. MHC-restricted T cell receptor signaling is required for alphabeta TCR replacement of the pre T cell receptor. Eur J Immunol 38(2):391-9. [PubMed: 18203137]  [MGI Ref ID J:131357]

Czopik AK; Bynoe MS; Palm N; Raine CS; Medzhitov R. 2006. Semaphorin 7A is a negative regulator of T cell responses. Immunity 24(5):591-600. [PubMed: 16713976]  [MGI Ref ID J:113360]

Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938]  [MGI Ref ID J:117988]

Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. [PubMed: 18178849]  [MGI Ref ID J:130944]

Dianda L; Gulbranson-Judge A; Pao W; Hayday AC; MacLennan IC; Owen MJ. 1996. Germinal center formation in mice lacking alpha beta T cells. Eur J Immunol 26(7):1603-7. [PubMed: 8766567]  [MGI Ref ID J:113041]

Dillon SR; Schlissel MS. 2002. Partial restoration of B cell development in Jak-3(-/-) mice achieved by co-expression of IgH and E(mu)-myc transgenes. Int Immunol 14(8):893-904. [PubMed: 12147626]  [MGI Ref ID J:78457]

Djuretic IM; Levanon D; Negreanu V; Groner Y; Rao A; Ansel KM. 2007. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 8(2):145-53. [PubMed: 17195845]  [MGI Ref ID J:117861]

Ehst BD; Ingulli E; Jenkins MK. 2003. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am J Transplant 3(11):1355-62. [PubMed: 14525595]  [MGI Ref ID J:91742]

Eichelberger M; McMickle A; Blackman M; Mombaerts P; Tonegawa S; Doherty PC. 1995. Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice. J Immunol 154(4):1569-76. [PubMed: 7836742]  [MGI Ref ID J:22818]

Ellmeier W; Sunshine MJ; Maschek R; Littman DR. 2002. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16(5):623-34. [PubMed: 12049715]  [MGI Ref ID J:113136]

Elyaman W; Kivisakk P; Reddy J; Chitnis T; Raddassi K; Imitola J; Bradshaw E; Kuchroo VK; Yagita H; Sayegh MH; Khoury SJ. 2008. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am J Pathol 173(2):411-22. [PubMed: 18583313]  [MGI Ref ID J:138298]

Fallah-Arani F; Schweighoffer E; Vanes L; Tybulewicz VL. 2008. Redundant role for Zap70 in B cell development and activation. Eur J Immunol 38(6):1721-33. [PubMed: 18465772]  [MGI Ref ID J:136323]

Feik N; Bilic I; Tinhofer J; Unger B; Littman DR; Ellmeier W. 2005. Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol 174(3):1513-24. [PubMed: 15661911]  [MGI Ref ID J:126027]

Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673]  [MGI Ref ID J:126134]

Gaszewska-Mastalarz A; Muranski P; Chmielowski B; Kraj P; Ignatowicz L. 2000. Altered selection of CD4+ T cells by class II MHC bound with dominant and low abundance self-peptides. J Immunol 165(11):6099-106. [PubMed: 11086042]  [MGI Ref ID J:118564]

Gavin MA; Clarke SR; Negrou E; Gallegos A; Rudensky A. 2002. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3(1):33-41. [PubMed: 11740498]  [MGI Ref ID J:109187]

Godfrey DI; Kennedy J; Mombaerts P; Tonegawa S; Zlotnik A. 1994. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol 152(10):4783-92. [PubMed: 7513723]  [MGI Ref ID J:18038]

Goux D; Coudert JD; Maurice D; Scarpellino L; Jeannet G; Piccolo S; Weston K; Huelsken J; Held W. 2005. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood 106(5):1726-33. [PubMed: 15890681]  [MGI Ref ID J:118496]

Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol 170(6):2853-61. [PubMed: 12626535]  [MGI Ref ID J:126301]

Harvill ET; Osorio M; Loving CL; Lee GM; Kelly VK; Merkel TJ. 2008. Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors. Infect Immun 76(5):2177-82. [PubMed: 18316379]  [MGI Ref ID J:134474]

Hayashi RJ; Kanagawa O. 1999. Unique CD4(+) T cells in TCR alpha chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process. Int Immunol 11(9):1581-90. [PubMed: 10464179]  [MGI Ref ID J:57698]

Hayes SM; Li L; Love PE. 2005. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 22(5):583-93. [PubMed: 15894276]  [MGI Ref ID J:99104]

Hermiston ML; Tan AL; Gupta VA; Majeti R; Weiss A. 2005. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 23(6):635-47. [PubMed: 16356861]  [MGI Ref ID J:113310]

Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150]  [MGI Ref ID J:139648]

Hong NA; Cado D; Mitchell J; Ortiz BD; Hsieh SN; Winoto A. 1997. A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Mol Cell Biol 17(4):2151-7. [PubMed: 9121464]  [MGI Ref ID J:77676]

Hori S; Haury M; Coutinho A; Demengeot J. 2002. Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Natl Acad Sci U S A 99(12):8213-8. [PubMed: 12034883]  [MGI Ref ID J:126912]

Hsieh CS; Zheng Y; Liang Y; Fontenot JD; Rudensky AY. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 7(4):401-10. [PubMed: 16532000]  [MGI Ref ID J:112554]

Iijima H; Takahashi I; Kishi D; Kim JK; Kawano S; Hori M; Kiyono H. 1999. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J Exp Med 190(5):607-15. [PubMed: 10477546]  [MGI Ref ID J:57609]

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Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryWhen held in a live colony, this Tcratm1Mom strain is maintained by mating homozygous siblings. This strain should be housed under conditions similar to Prkdcscid/Prkdcscid mice or any other immunodeficient strain. It has been cryopreserved and is currently only available from the frozen embryo repository.
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Induced Mutant Resource Colony collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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