Strain Name:

B6.129S2-Tcratm1Mom/J

Stock Number:

002116

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Availability:

Level 4

Use Restrictions Apply, see Terms of Use
Mice homozygous mice for the Tcratm1Mom targeted mutation are deficient in the alpha beta T-cell receptor. The thymus is devoid of CD4+CD8- and CD4-CD8+ cells. Normal numbers of CD4+CD8+ cells are retained without the IL2 receptor. There are normal numbers of CD4-CD8- cells. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129S2 via D3 ES cell line
GenerationN13F27 (14-AUG-14)
Generation Definitions
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
Mice homozygous mice for the Tcratm1Mom targeted mutation are viable and fertile. They are deficient in the alpha beta T-cell receptor. The thymus is devoid of CD4+CD8- and CD4-CD8+ cells. Normal numbers of CD4+CD8+ cells are retained without the IL2 receptor. There are normal numbers of CD4-CD8- cells. ~1% of the thymocytes express the gamma delta TCR. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age.

Development
The Tcratm1Mom mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A targeting vector with the Pgk-neo gene disrupting exon 1 of Tcra was used. The 129-derived D3 ES cell line was used. The C57BL/6J strain was generated by backcrossing mice carrying the Tcratm1Mom mutation 12 times to C57BL/6J inbred mice.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tcratm1Mom allele
002115   B6;129S2-Tcratm1Mom/J
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
View Strains carrying   Tcratm1Mom     (2 strains)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
007848   BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
003303   C.Cg-Tg(DO11.10)10Dlo/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (46 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tcratm1Mom/Tcratm1Mom

        B6.129S2-Tcratm1Mom
  • immune system phenotype
  • abnormal response to transplant
    • mice fail to reject tail skin from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen )   (MGI Ref ID J:91742)
  • colitis
    • a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts   (MGI Ref ID J:135597)
  • increased mature gamma-delta T cell number
    • there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice   (MGI Ref ID J:135597)
  • increased susceptibility to bacterial infection
    • greatly increased susceptibility to infection with Mycobacterium paratuberculosis   (MGI Ref ID J:106241)
  • digestive/alimentary phenotype
  • abnormal large intestine morphology
    • colitis results in lengthening of the colon   (MGI Ref ID J:135597)
    • the large intestine weight to body weight ratio at 28 weeks of age is twice as great than what is observed in wild-type mice   (MGI Ref ID J:135597)
    • rectal prolapse
      • rectal prolapse occurs in about 18% of mice 24 to 60 weeks of age   (MGI Ref ID J:135597)
  • colitis
    • a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts   (MGI Ref ID J:135597)
  • hematopoietic system phenotype
  • increased mature gamma-delta T cell number
    • there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice   (MGI Ref ID J:135597)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tcratm1Mom/Tcratm1Mom

        involves: 129S2/SvPas
  • immune system phenotype
  • absent T cells   (MGI Ref ID J:88620)
  • hematopoietic system phenotype
  • absent T cells   (MGI Ref ID J:88620)

Tcratm1Mom/Tcratm1Mom

        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • abnormal response to infection
    • airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection   (MGI Ref ID J:119344)
  • arrested T cell differentiation
    • T cells in the thymus do not pass the double positive stage   (MGI Ref ID J:3206)
  • colitis
    • colitis occurs in mice as they age (4 months and over)   (MGI Ref ID J:15221)
    • disease resembles the human disease ulcerative colitis   (MGI Ref ID J:15221)
  • decreased CD4-positive, alpha beta T cell number
    • very few T cells are found in the thymus or periphery   (MGI Ref ID J:3206)
  • decreased CD8-positive, alpha-beta T cell number
    • very few CD8 T cells are found in the thymus or periphery   (MGI Ref ID J:3206)
  • decreased IgG level
    • mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected   (MGI Ref ID J:119344)
  • increased gamma-delta intraepithelial T cell number
    • numbers are markedly increased   (MGI Ref ID J:15221)
  • respiratory system phenotype
  • abnormal respiratory system morphology
    • M. pulmonis infected mice show a diminished or intermediate airway remodeling phenotype when compared to wild-type or Igh-6 deficient mice   (MGI Ref ID J:119344)
  • hematopoietic system phenotype
  • arrested T cell differentiation
    • T cells in the thymus do not pass the double positive stage   (MGI Ref ID J:3206)
  • decreased CD4-positive, alpha beta T cell number
    • very few T cells are found in the thymus or periphery   (MGI Ref ID J:3206)
  • decreased CD8-positive, alpha-beta T cell number
    • very few CD8 T cells are found in the thymus or periphery   (MGI Ref ID J:3206)
  • decreased IgG level
    • mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected   (MGI Ref ID J:119344)
  • increased gamma-delta intraepithelial T cell number
    • numbers are markedly increased   (MGI Ref ID J:15221)
  • digestive/alimentary phenotype
  • abnormal intestinal goblet cell morphology
    • pronounced depletion of goblet cells resulting from inflammation   (MGI Ref ID J:15221)
  • chronic diarrhea
    • is observed in older mice   (MGI Ref ID J:15221)
  • colitis
    • colitis occurs in mice as they age (4 months and over)   (MGI Ref ID J:15221)
    • disease resembles the human disease ulcerative colitis   (MGI Ref ID J:15221)
  • crypts of Lieberkuhn abscesses
    • caused by neutrophil infiltration   (MGI Ref ID J:15221)
  • intestinal ulcer
    • occurs in rare cases   (MGI Ref ID J:15221)
  • rectal prolapse
    • occurs in mice over 4 months of age   (MGI Ref ID J:15221)
  • endocrine/exocrine gland phenotype
  • crypts of Lieberkuhn abscesses
    • caused by neutrophil infiltration   (MGI Ref ID J:15221)
  • mortality/aging
  • premature death
    • mortality rates increase after six months of age   (MGI Ref ID J:15221)
    • few mice survive longer than one year   (MGI Ref ID J:15221)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Deficiency

Tcratm1Mom related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
      Inflammatory bowel disease
T Cell Receptor Signaling Defects

Research Tools
Cancer Research
      specific T cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tcratm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) C-alpha-; TCR Calpha-; TCR alpha-; TCR alpha0; TCRmini; TCRalpha KO; TCRalpha-; alpha-;
Mutation Made By Peter Mombaerts,   Max Planck Research Unit for Neurogenetics
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Tcra, T cell receptor alpha chain
Chromosome 14
Gene Common Name(s) Tcr alpha; Tcralpha;
General Note Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:15221, J:135597)
Molecular Note A PGK-neo cassette was used to disrupt exon 1, which encodes the majority of the extracellular domain. The targeting event was confirmed by Southern analysis. [MGI Ref ID J:113136] [MGI Ref ID J:126027] [MGI Ref ID J:3206]

Genotyping

Genotyping Information

Genotyping Protocols

NntC57BL/6J,

Separated MCA


Tcratm1Momalternate3, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mombaerts P; Clarke AR; Rudnicki MA; Iacomini J; Itohara S; Lafaille JJ; Wang L; Ichikawa Y; Jaenisch R; Hooper ML; Tonegawa S. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491] Nature 360(6401):225-31. [PubMed: 1359428]  [MGI Ref ID J:3206]

Additional References

Eichelberger M; McMickle A; Blackman M; Mombaerts P; Tonegawa S; Doherty PC. 1995. Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice. J Immunol 154(4):1569-76. [PubMed: 7836742]  [MGI Ref ID J:22818]

Huang CY; Kanagawa O. 2004. Impact of early expression of TCR alpha chain on thymocyte development. Eur J Immunol 34(6):1532-41. [PubMed: 15162422]  [MGI Ref ID J:90364]

Iwabuchi K; Iwabuchi C; Tone S; Itoh D; Tosa N; Negishi I; Ogasawara K; Uede T; Onoe K. 2001. Defective development of NK1.1(+) T-cell antigen receptor alphabeta(+) cells in zeta-associated protein 70 null mice with an accumulation of NK1.1(+) CD3(-) NK-like cells in the thymus. Blood 97(6):1765-75. [PubMed: 11238119]  [MGI Ref ID J:68078]

Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. [PubMed: 15379984]  [MGI Ref ID J:92933]

McGuire MV; Suthipinijtham P; Gascoigne NR. 2001. The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus. Mamm Genome 12(8):664-7. [PubMed: 11471063]  [MGI Ref ID J:70807]

Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709]  [MGI Ref ID J:15221]

Prinz I; Klemm U; Kaufmann SH; Steinhoff U. 2004. Exacerbated colitis associated with elevated levels of activated CD4+ T cells in TCRalpha chain transgenic mice. Gastroenterology 126(1):170-81. [PubMed: 14699498]  [MGI Ref ID J:87207]

Sha Z; Compans RW. 2000. Induction of CD4(+) T-cell-independent immunoglobulin responses by inactivated influenza virus. J Virol 74(11):4999-5005. [PubMed: 10799573]  [MGI Ref ID J:62131]

Sosinowski T; Killeen N; Weiss A. 2001. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 15(3):457-66. [PubMed: 11567635]  [MGI Ref ID J:71804]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

Yoshimasu T; Nishide T; Seo N; Hiroi A; Ohtani T; Uede K; Furukawa F. 2004. Susceptibility of T cell receptor-alpha chain knock-out mice to ultraviolet B light and fluorouracil: a novel model for drug-induced cutaneous lupus erythematosus. Clin Exp Immunol 136(2):245-54. [PubMed: 15086387]  [MGI Ref ID J:89210]

Tcratm1Mom related

Akue AD; Lee JY; Jameson SC. 2012. Derivation and maintenance of virtual memory CD8 T cells. J Immunol 188(6):2516-23. [PubMed: 22308307]  [MGI Ref ID J:181867]

Albu DI; Feng D; Bhattacharya D; Jenkins NA; Copeland NG; Liu P; Avram D. 2007. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med 204(12):3003-15. [PubMed: 17998389]  [MGI Ref ID J:128515]

Almeida AR; Borghans JA; Freitas AA. 2001. T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med 194(5):591-9. [PubMed: 11535628]  [MGI Ref ID J:118033]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195]  [MGI Ref ID J:125748]

Alves NL; Huntington ND; Mention JJ; Richard-Le Goff O; Di Santo JP. 2010. Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo. J Immunol 184(11):5949-53. [PubMed: 20439914]  [MGI Ref ID J:161220]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Auger JL; Haasken S; Steinert EM; Binstadt BA. 2012. Incomplete TCR-beta allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice. Eur J Immunol 42(9):2354-62. [PubMed: 22706882]  [MGI Ref ID J:187944]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bailey-Bucktrout SL; Martinez-Llordella M; Zhou X; Anthony B; Rosenthal W; Luche H; Fehling HJ; Bluestone JA. 2013. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity 39(5):949-62. [PubMed: 24238343]  [MGI Ref ID J:208984]

Baldwin TA; Sandau MM; Jameson SC; Hogquist KA. 2005. The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med 202(1):111-21. [PubMed: 15998791]  [MGI Ref ID J:100651]

Bandukwala HS; Gagnon J; Togher S; Greenbaum JA; Lamperti ED; Parr NJ; Molesworth AM; Smithers N; Lee K; Witherington J; Tough DF; Prinjha RK; Peters B; Rao A. 2012. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A 109(36):14532-7. [PubMed: 22912406]  [MGI Ref ID J:189876]

Barber DL; Mayer-Barber KD; Feng CG; Sharpe AH; Sher A. 2011. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. J Immunol 186(3):1598-607. [PubMed: 21172867]  [MGI Ref ID J:168927]

Baron JL; Gardiner L; Nishimura S; Shinkai K; Locksley R; Ganem D. 2002. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16(4):583-94. [PubMed: 11970881]  [MGI Ref ID J:113520]

Baur N; Nerz G; Nil A; Eichmann K. 2001. Expression and selection of productively rearranged TCRbeta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alphabeta T cells. Int Immunol 13(8):1031-42. [PubMed: 11470773]  [MGI Ref ID J:71151]

Bedel R; Berry R; Mallevaey T; Matsuda JL; Zhang J; Godfrey DI; Rossjohn J; Kappler JW; Marrack P; Gapin L. 2014. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A 111(1):E119-28. [PubMed: 24344267]  [MGI Ref ID J:206291]

Bessette K; Lang ML; Fava RA; Grundy M; Heinen J; Horne L; Spolski R; Al-Shami A; Morse HC 3rd; Leonard WJ; Kelly JA. 2008. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood 111(1):344-50. [PubMed: 17890450]  [MGI Ref ID J:129993]

Bowen S; Sun P; Livak F; Sharrow S; Hodes RJ. 2014. A novel T cell subset with trans-rearranged Vgamma-Cbeta TCRs shows Vbeta expression is dispensable for lineage choice and MHC restriction. J Immunol 192(1):169-77. [PubMed: 24307734]  [MGI Ref ID J:207166]

Brodeur JF; Li S; Damlaj O; Dave VP. 2009. Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3epsilon. Int Immunol 21(12):1317-27. [PubMed: 19819936]  [MGI Ref ID J:155472]

Buch T; Rieux-Laucat F; Forster I; Rajewsky K. 2002. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity 16(5):707-18. [PubMed: 12049722]  [MGI Ref ID J:81564]

Burchill MA; Yang J; Vang KB; Moon JJ; Chu HH; Lio CW; Vegoe AL; Hsieh CS; Jenkins MK; Farrar MA. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28(1):112-21. [PubMed: 18199418]  [MGI Ref ID J:131384]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Cai Y; Shen X; Ding C; Qi C; Li K; Li X; Jala VR; Zhang HG; Wang T; Zheng J; Yan J. 2011. Pivotal Role of Dermal IL-17-Producing gammadelta T Cells in Skin Inflammation. Immunity 35(4):596-610. [PubMed: 21982596]  [MGI Ref ID J:177652]

Candeias S; Peschon JJ; Muegge K; Durum SK. 1997. Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunol Lett 57(1-3):9-14. [PubMed: 9232418]  [MGI Ref ID J:42227]

Cebula A; Seweryn M; Rempala GA; Pabla SS; McIndoe RA; Denning TL; Bry L; Kraj P; Kisielow P; Ignatowicz L. 2013. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 497(7448):258-62. [PubMed: 23624374]  [MGI Ref ID J:198754]

Chandler P; Frater AJ; Douek DC; Viney JL; Kay G; Owen MJ; Hayday AC; Simpson E; Altmann DM. 1995. Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells. Immunology 85(4):531-7. [PubMed: 7558145]  [MGI Ref ID J:28872]

Chang D; Valdez P; Ho T; Robey E. 2000. MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment J Immunol 165(12):6710-5. [PubMed: 11120788]  [MGI Ref ID J:66168]

Chapman TJ; Topham DJ. 2010. Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. J Immunol 184(7):3841-9. [PubMed: 20200271]  [MGI Ref ID J:160079]

Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. [PubMed: 12376619]  [MGI Ref ID J:125077]

Chen Y; Cuda C; Morel L. 2005. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 174(12):7692-702. [PubMed: 15944270]  [MGI Ref ID J:100863]

Cheng G; Yuan X; Tsai MS; Podack ER; Yu A; Malek TR. 2012. IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol 189(4):1780-91. [PubMed: 22786769]  [MGI Ref ID J:189754]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX30

Colony Maintenance

Breeding & HusbandryThis Tcratm1Mom strain is maintained by mating homozygous siblings. This strain should be housed under conditions similar to Prkdcscid/Prkdcscid mice or any other immunodeficient strain. Only homozygous mice may be ordered. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $106.90Female or MaleHomozygous for Tcratm1Mom  
4 weeks $106.90Female or MaleHomozygous for Tcratm1Mom  
5 weeks $106.90Female or MaleHomozygous for Tcratm1Mom  
6 weeks $112.35Female or MaleHomozygous for Tcratm1Mom  
7 weeks $117.80Female or MaleHomozygous for Tcratm1Mom  
8 weeks $123.25Female or MaleHomozygous for Tcratm1Mom  
9 weeks $128.70Female or MaleHomozygous for Tcratm1Mom  
10 weeks $134.15Female or MaleHomozygous for Tcratm1Mom  
11 weeks $139.60Female or MaleHomozygous for Tcratm1Mom  
12 weeks $145.05Female or MaleHomozygous for Tcratm1Mom  
13 weeks $150.50Female or MaleHomozygous for Tcratm1Mom  
14 weeks $155.95Female or MaleHomozygous for Tcratm1Mom  
15 weeks $161.40Female or MaleHomozygous for Tcratm1Mom  
Price per Pair (US dollars $)Pair Genotype
$224.70Homozygous for Tcratm1Mom x Homozygous for Tcratm1Mom  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $139.00Female or MaleHomozygous for Tcratm1Mom  
4 weeks $139.00Female or MaleHomozygous for Tcratm1Mom  
5 weeks $139.00Female or MaleHomozygous for Tcratm1Mom  
6 weeks $146.10Female or MaleHomozygous for Tcratm1Mom  
7 weeks $153.20Female or MaleHomozygous for Tcratm1Mom  
8 weeks $160.30Female or MaleHomozygous for Tcratm1Mom  
9 weeks $167.40Female or MaleHomozygous for Tcratm1Mom  
10 weeks $174.40Female or MaleHomozygous for Tcratm1Mom  
11 weeks $181.50Female or MaleHomozygous for Tcratm1Mom  
12 weeks $188.60Female or MaleHomozygous for Tcratm1Mom  
13 weeks $195.70Female or MaleHomozygous for Tcratm1Mom  
14 weeks $202.80Female or MaleHomozygous for Tcratm1Mom  
15 weeks $209.90Female or MaleHomozygous for Tcratm1Mom  
Price per Pair (US dollars $)Pair Genotype
$292.20Homozygous for Tcratm1Mom x Homozygous for Tcratm1Mom  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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General Terms and Conditions


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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

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