| |||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation F?+10p Donating Investigator Peter Mombaerts, The Rockefeller University Description
Mice homozygous for the Tcrbtm1Mom targeted mutation are viable and fertile. Mice are deficient in alpha beta T-cell receptor. The total number of cells in the thymus is ~8% that of wildtype; CD4+CD8+ cells ~6% of wildtype. The proportion of CD4-CD8- (IL2 receptor positive) cells increases to about 50% of the total cell number. Alpha beta thymocyte differentiation is blocked at an earlier stage than the Tcratm1Mom strain. There is normal differentiation of gamma delta thymocytes. Mice may develop inflammatory bowel disease beginning at ~4-6 months of age.Development
The Tcrbtm1Mom mutant was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A targeting replacement vector was used which resulted in a 15-kb deletion encompassing the Tcrb locus from J-beta-1.3 to downstream of C-beta-2. The mutant contains the Pgk-neo gene in reverse transcriptional orientation. The 129-derived E14 ES cell line was used.
Control Information
| Control | ||
|---|---|---|
| 100903 B6129PF2/J | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tcrbtm1Mom allele
002122 B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J 002118 B6.129P2-Tcrbtm1Mom/J 002121 B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J 004364 C.Cg-Tcratm1Mom Tcrbtm1Mom/J 003447 CBy.129P2(B6)-Tcrbtm1Mom/SzJ 007081 CByJ.129P2(B6)-Tcrbtm1Mom/J View Strains carrying Tcrbtm1Mom (6 strains)
Phenotype
Phenotype Information
assigned by genotype
Tcrbtm1Mom/Tcrbtm1Mom
B6;129P2-Tcrbtm1Mom/J
- respiratory system phenotype
- abnormal respiratory system physiology (MGI Ref ID J:125656)
- ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tcrbtm1Mom/Tcrbtm1Mom
involves: 129P2/OlaHsd
- immune system phenotype
- abnormal immune system cell morphology (MGI Ref ID J:3206)
- abnormal immune system organ morphology (MGI Ref ID J:3206)
Tcrbtm1Mom/Tcrbtm1Mom
involves: 129P2/OlaHsd * BALB/c
- immune system phenotype
- arrested T cell differentiation (MGI Ref ID J:3206)
- most T cells in the thymus do no progress to the double negative stage
- colitis (MGI Ref ID J:15221)
- mild colitis-like disease occurs in mice over one year in age
- decreased CD4-positive T cell number (MGI Ref ID J:3206)
- very few T cells are found in the thymus or periphery
- decreased CD8-positive T cell number (MGI Ref ID J:3206)
- very few CD8 T cells are found in the thymus or periphery
- decreased double-positive T cell number (MGI Ref ID J:3206)
- 94% reduction in number of double positive cells
- thymus hypoplasia (MGI Ref ID J:3206)
- 92% reduction in number of total thymocytes
- digestive/alimentary phenotype
- colitis (MGI Ref ID J:15221)
- mild colitis-like disease occurs in mice over one year in age
- hematopoietic system phenotype
- arrested T cell differentiation (MGI Ref ID J:3206)
- most T cells in the thymus do no progress to the double negative stage
- decreased CD4-positive T cell number (MGI Ref ID J:3206)
- very few T cells are found in the thymus or periphery
- decreased CD8-positive T cell number (MGI Ref ID J:3206)
- very few CD8 T cells are found in the thymus or periphery
- decreased double-positive T cell number (MGI Ref ID J:3206)
- 94% reduction in number of double positive cells
- thymus hypoplasia (MGI Ref ID J:3206)
- 92% reduction in number of total thymocytes
This mouse can be used to support research in many areas including:
Tcrb relatedResearch Tools
Immunology and Inflammation Research (T Cell Receptor Deficiency)
Tcrbtm1Mom relatedImmunology and Inflammation Research
Inflammation
Hematological Research
Immunological Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tcrbtm1Mom | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Peter Mombaerts | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | TCR-Cbeta-; TCRbeta-; beta-; | ||
| Mutation Made By | Peter Mombaerts, Max Planck Institute of Biophysics | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Tcrb, T-cell receptor beta chain | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | TRB; Tib; | ||
| Molecular Note | 15kb of sequence was deleted by the insertion of a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. [MGI Ref ID J:22591] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tcrbtm1Mom, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Mombaerts P; Clarke AR; Rudnicki MA; Iacomini J; Itohara S; Lafaille JJ; Wang L; Ichikawa Y; Jaenisch R; Hooper ML; Tonegawa S. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491] Nature 360(6401):225-31. [PubMed: 1359428] [MGI Ref ID J:3206]
Additional References
Mombaerts P; Clarke AR; Hooper ML; Tonegawa S. 1991. Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc Natl Acad Sci U S A 88(8):3084-7. [PubMed: 1826563] [MGI Ref ID J:22591]
Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709] [MGI Ref ID J:15221]
Tcrbtm1Mom relatedAlugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649] [MGI Ref ID J:125443]
Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949] [MGI Ref ID J:93752]
Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760] [MGI Ref ID J:117042]
Ashcroft AJ; Cruickshank SM; Croucher PI; Perry MJ; Rollinson S; Lippitt JM; Child JA; Dunstan C; Felsburg PJ; Morgan GJ; Carding SR. 2003. Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity 19(6):849-61. [PubMed: 14670302] [MGI Ref ID J:86997]
Astrakhan A; Omori M; Nguyen T; Becker-Herman S; Iseki M; Aye T; Hudkins K; Dooley J; Farr A; Alpers CE; Ziegler SF; Rawlings DJ. 2007. Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nat Immunol 8(5):522-31. [PubMed: 17401368] [MGI Ref ID J:122410]
Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283] [MGI Ref ID J:119344]
Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670] [MGI Ref ID J:112329]
Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018] [MGI Ref ID J:113283]
Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272] [MGI Ref ID J:97167]
Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809] [MGI Ref ID J:118092]
Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439] [MGI Ref ID J:131997]
Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174] [MGI Ref ID J:133531]
Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161(10):5210-6. [PubMed: 9820492] [MGI Ref ID J:115026]
Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693] [MGI Ref ID J:132284]
Borchers MT; Wesselkamper SC; Eppert BL; Motz GT; Sartor MA; Tomlinson CR; Medvedovic M; Tichelaar JW. 2008. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci 105(1):188-99. [PubMed: 18515264] [MGI Ref ID J:139766]
Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352] [MGI Ref ID J:87077]
Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529] [MGI Ref ID J:115023]
Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689] [MGI Ref ID J:108283]
Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183] [MGI Ref ID J:118094]
Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256] [MGI Ref ID J:120419]
Cariappa A; Mazo IB; Chase C; Shi HN; Liu H; Li Q; Rose H; Leung H; Cherayil BJ; Russell P; von Andrian U; Pillai S. 2005. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23(4):397-407. [PubMed: 16226505] [MGI Ref ID J:113277]
Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546] [MGI Ref ID J:109239]
Chandler P; Frater AJ; Douek DC; Viney JL; Kay G; Owen MJ; Hayday AC; Simpson E; Altmann DM. 1995. Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells. Immunology 85(4):531-7. [PubMed: 7558145] [MGI Ref ID J:28872]
Chin EY; Dangler CA; Fox JG; Schauer DB. 2000. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice. Comp Med 50(6):586-94. [PubMed: 11200563] [MGI Ref ID J:66813]
Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364] [MGI Ref ID J:81809]
Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077] [MGI Ref ID J:112051]
Colombo MJ; Alugupalli KR. 2008. Complement Factor H-Binding Protein, a Putative Virulence Determinant of Borrelia hermsii, Is an Antigenic Target for Protective B1b Lymphocytes. J Immunol 180(7):4858-64. [PubMed: 18354209] [MGI Ref ID J:133379]
Compton SR; Ball-Goodrich LJ; Johnson LK; Johnson EA; Paturzo FX; Macy JD. 2004. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comp Med 54(6):681-9. [PubMed: 15679267] [MGI Ref ID J:96019]
Corthay A; Johansson A; Vestberg M; Holmdahl R. 1999. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol 11(7):1065-73. [PubMed: 10383939] [MGI Ref ID J:56725]
Cretin N; Bracy J; Hanson K; Iacomini J. 2002. The role of T cell help in the production of antibodies specific for Gal alpha 1-3Gal. J Immunol 168(3):1479-83. [PubMed: 11801692] [MGI Ref ID J:112060]
Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563] [MGI Ref ID J:125656]
Crosby JR; Shen HH; Borchers MT; Justice JP; Ansay T; Lee JJ; Lee NA. 2002. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am J Physiol Lung Cell Mol Physiol 282(1):L99-108. [PubMed: 11741821] [MGI Ref ID J:107840]
Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938] [MGI Ref ID J:117988]
Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. [PubMed: 18178849] [MGI Ref ID J:130944]
Degermann S; Sollami G; Karjalainen K. 1999. Impaired NK1.1 T cell development in mice transgenic for a T cell receptor beta chain lacking the large, solvent-exposed cbeta FG loop. J Exp Med 190(9):1357-62. [PubMed: 10544207] [MGI Ref ID J:58321]
Dianda L; Gulbranson-Judge A; Pao W; Hayday AC; MacLennan IC; Owen MJ. 1996. Germinal center formation in mice lacking alpha beta T cells. Eur J Immunol 26(7):1603-7. [PubMed: 8766567] [MGI Ref ID J:113041]
Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391] [MGI Ref ID J:93676]
Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906] [MGI Ref ID J:82106]
Egan CE; Dalton JE; Andrew EM; Smith JE; Gubbels MJ; Striepen B; Carding SR. 2005. A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology. J Immunol 175(12):8191-9. [PubMed: 16339558] [MGI Ref ID J:122276]
Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. [PubMed: 15579444] [MGI Ref ID J:94976]
Elyaman W; Kivisakk P; Reddy J; Chitnis T; Raddassi K; Imitola J; Bradshaw E; Kuchroo VK; Yagita H; Sayegh MH; Khoury SJ. 2008. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am J Pathol 173(2):411-22. [PubMed: 18583313] [MGI Ref ID J:138298]
Emoto M; Emoto Y; Brinkmann V; Miyamoto M; Yoshizawa I; Staber M; van Rooijen N; Hamann A; Kaufmann SH. 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. J Immunol 171(2):584-93. [PubMed: 12847222] [MGI Ref ID J:123460]
Endres R; Alimzhanov MB; Plitz T; Futterer A; Kosco-Vilbois MH; Nedospasov SA; Rajewsky K; Pfeffer K. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189(1):159-68. [PubMed: 9874572] [MGI Ref ID J:119173]
Engel I; Murre C. 2002. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice. Proc Natl Acad Sci U S A 99(17):11322-7. [PubMed: 12172006] [MGI Ref ID J:78509]
Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25(3):403-15. [PubMed: 16973390] [MGI Ref ID J:113556]
Erman B; Guinter TI; Singer A. 2004. Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation. J Exp Med 199(12):1719-24. [PubMed: 15210747] [MGI Ref ID J:120401]
Ferlin WG; von der Weid T; Cottrez F; Ferrick DA; Coffman RL; Howard MC. 1998. The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb. Eur J Immunol 28(2):525-31. [PubMed: 9521062] [MGI Ref ID J:46693]
Ferrero I; Mancini SJ; Grosjean F; Wilson A; Otten L; MacDonald HR. 2006. TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation. J Immunol 177(9):6038-43. [PubMed: 17056529] [MGI Ref ID J:140526]
Fischer K; Collins H; Taniguchi M; Kaufmann SH; Schaible UE. 2002. IL-4 and T cells are required for the generation of IgG1 isotype antibodies against cardiolipin. J Immunol 168(6):2689-94. [PubMed: 11884434] [MGI Ref ID J:126854]
Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990] [MGI Ref ID J:97029]
Fournier S; Rathmell JC; Goodnow CC; Allison JP. 1997. T cell-mediated elimination of B7.2 transgenic B cells. Immunity 6(3):327-39. [PubMed: 9075933] [MGI Ref ID J:112475]
French JD; Roark CL; Born WK; O'brien RL. 2005. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A 102(41):14741-6. [PubMed: 16203967] [MGI Ref ID J:102497]
Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. [PubMed: 11171016] [MGI Ref ID J:120023]
Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673] [MGI Ref ID J:126134]
Fu YX; Huang G; Wang Y; Chaplin DD. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 187(7):1009-18. [PubMed: 9529317] [MGI Ref ID J:118756]
Funabashi H; Uchida K; Kado S; Matsuoka Y; Ohwaki M. 2001. Establishment of a Tcrb and Trp53 genes deficient mouse strain as an animal model for spontaneous colorectal cancer. Exp Anim 50(1):41-7. [PubMed: 11326422] [MGI Ref ID J:68090]
Girardi M; Lewis J; Glusac E; Filler RB; Geng L; Hayday AC; Tigelaar RE. 2002. Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation. J Exp Med 195(7):855-67. [PubMed: 11927630] [MGI Ref ID J:75915]
Godfrey DI; Kennedy J; Mombaerts P; Tonegawa S; Zlotnik A. 1994. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol 152(10):4783-92. [PubMed: 7513723] [MGI Ref ID J:18038]
Golovkina TV; Shlomchik M; Hannum L; Chervonsky A. 1999. Organogenic role of B lymphocytes in mucosal immunity. Science 286(5446):1965-8. [PubMed: 10583962] [MGI Ref ID J:124532]
Gregory GD; Robbie-Ryan M; Secor VH; Sabatino JJ Jr; Brown MA. 2005. Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis. Eur J Immunol 35(12):3478-86. [PubMed: 16285014] [MGI Ref ID J:113769]
Groom JR; Fletcher CA; Walters SN; Grey ST; Watt SV; Sweet MJ; Smyth MJ; Mackay CR; Mackay F. 2007. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med 204(8):1959-71. [PubMed: 17664289] [MGI Ref ID J:125937]
Guy-Grand D; Azogui O; Celli S; Darche S; Nussenzweig MC; Kourilsky P; Vassalli P. 2003. Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J Exp Med 197(3):333-41. [PubMed: 12566417] [MGI Ref ID J:124688]
Hahn YS; Taube C; Jin N; Takeda K; Park JW; Wands JM; Aydintug MK; Roark CL; Lahn M; O'Brien RL; Gelfand EW; Born WK. 2003. V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J Immunol 171(6):3170-8. [PubMed: 12960345] [MGI Ref ID J:120384]
Hanano R; Kaufmann SH. 1999. Effect on parasite eradication of Pneumocystis carinii-specific antibodies produced in the presence or absence of CD4(+) alphabeta T lymphocytes. Eur J Immunol 29(8):2464-75. [PubMed: 10458760] [MGI Ref ID J:115322]
Hayes SM; Li L; Love PE. 2005. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 22(5):583-93. [PubMed: 15894276] [MGI Ref ID J:99104]
Hayes SM; Love PE. 2006. Stoichiometry of the murine gammadelta T cell receptor. J Exp Med 203(1):47-52. [PubMed: 16418397] [MGI Ref ID J:118806]
Hess J; Ladel C; Miko D; Kaufmann SH. 1996. Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J Immunol 156(9):3321-6. [PubMed: 8617956] [MGI Ref ID J:32521]
Huleatt JW; Lefrancois L. 1996. Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity 5(3):263-73. [PubMed: 8808681] [MGI Ref ID J:35355]
Jeannet G; Coudert JD; Held W. 2006. T and B lymphocytes exert distinct effects on the homeostasis of NK cells. Eur J Immunol 36(10):2725-34. [PubMed: 16955521] [MGI Ref ID J:118107]
Jung YJ; LaCourse R; Ryan L; North RJ. 2002. Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice. J Exp Med 196(7):991-8. [PubMed: 12370260] [MGI Ref ID J:119257]
Justice JP; Crosby J; Borchers MT; Tomkinson A; Lee JJ; Lee NA. 2002. CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung. Am J Physiol Lung Cell Mol Physiol 282(5):L1066-74. [PubMed: 11943672] [MGI Ref ID J:108354]
Kabashima K; Banks TA; Ansel KM; Lu TT; Ware CF; Cyster JG. 2005. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22(4):439-50. [PubMed: 15845449] [MGI Ref ID J:97986]
Kado S; Uchida K; Funabashi H; Iwata S; Nagata Y; Ando M; Onoue M; Matsuoka Y; Ohwaki M; Morotomi M. 2001. Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. Cancer Res 61(6):2395-8. [PubMed: 11289103] [MGI Ref ID J:68471]
Kang J; Coles M; Cado D; Raulet DH. 1998. The developmental fate of T cells is critically influenced by TCRgammadelta expression. Immunity 8(4):427-38. [PubMed: 9586633] [MGI Ref ID J:108606]
Kohyama M; Nanno M; Kawaguchi-Miyashita M; Shimada S; Watanabe M; Hibi T; Kaminogawa S; Ishikawa H. 1999. Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent. Proc Natl Acad Sci U S A 96(13):7451-5. [PubMed: 10377435] [MGI Ref ID J:56057]
Koni PA; Flavell RA. 1999. Lymph node germinal centers form in the absence of follicular dendritic cell networks. J Exp Med 189(5):855-64. [PubMed: 10049949] [MGI Ref ID J:111249]
Kuhl AA; Pawlowski NN; Grollich K; Loddenkemper C; Zeitz M; Hoffmann JC. 2007. Aggravation of intestinal inflammation by depletion/deficiency of gammadelta T cells in different types of IBD animal models. J Leukoc Biol 81(1):168-75. [PubMed: 17041003] [MGI Ref ID J:117270]
KuoLee R; Zhao X; Austin J; Harris G; Conlan JW; Chen W. 2007. Mouse model of oral infection with virulent type A Francisella tularensis. Infect Immun 75(4):1651-60. [PubMed: 17242058] [MGI Ref ID J:119508]
Kursar M; Hopken UE; Koch M; Kohler A; Lipp M; Kaufmann SH; Mittrucker HW. 2005. Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J Exp Med 201(9):1447-57. [PubMed: 15851484] [MGI Ref ID J:98197]
Kurtz BS; Witte PL; Storb U. 1997. Gamma 2b provides only some of the signals normally given via mu in B cell development. Int Immunol 9(3):415-26. [PubMed: 9088980] [MGI Ref ID J:110626]
Kwa SF; Beverley P; Smith AL. 2006. Peyer's patches are required for the induction of rapid Th1 responses in the gut and mesenteric lymph nodes during an enteric infection. J Immunol 176(12):7533-41. [PubMed: 16751400] [MGI Ref ID J:132354]
Ladel CH; Hess J; Daugelat S; Mombaerts P; Tonegawa S; Kaufmann SH. 1995. Contribution of alpha/beta and gamma/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guerin: studies with T cell receptor-deficient mutant mice. Eur J Immunol 25(3):838-46. [PubMed: 7705416] [MGI Ref ID J:26595]
Lahn M; Kanehiro A; Takeda K; Joetham A; Schwarze J; Kohler G; O'Brien R; Gelfand EW; Born W. 1999. Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells. Nat Med 5(10):1150-6. [PubMed: 10502818] [MGI Ref ID J:124003]
Le Bon A; Thompson C; Kamphuis E; Durand V; Rossmann C; Kalinke U; Tough DF. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4):2074-8. [PubMed: 16455962] [MGI Ref ID J:129128]
Leduc I; Hempel WM; Mathieu N; Verthuy C; Bouvier G; Watrin F; Ferrier P. 2000. T cell development in TCR beta enhancer-deleted mice: implications for alpha beta T cell lineage commitment and differentiation. J Immunol 165(3):1364-73. [PubMed: 10903739] [MGI Ref ID J:111637]
Lee BO; Rangel-Moreno J; Moyron-Quiroz JE; Hartson L; Makris M; Sprague F; Lund FE; Randall TD. 2005. CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol 175(9):5827-38. [PubMed: 16237075] [MGI Ref ID J:119355]
Lentz VM; Manser T. 2001. Cutting edge: germinal centers can be induced in the absence of T cells. J Immunol 167(1):15-20. [PubMed: 11418626] [MGI Ref ID J:120517]
Lentz VM; Manser T. 2000. Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance. Int Immunol 12(11):1483-97. [PubMed: 11058568] [MGI Ref ID J:110494]
Levelt CN; Mombaerts P; Iglesias A; Tonegawa S; Eichmann K. 1993. Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proc Natl Acad Sci U S A 90(23):11401-5. [PubMed: 8248261] [MGI Ref ID J:76885]
Liesenfeld O; Kosek J; Remington JS; Suzuki Y. 1996. Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J Exp Med 184(2):597-607. [PubMed: 8760813] [MGI Ref ID J:34802]
Lin SJ; Chen AT; Welsh RM. 2008. Immune system derived from homeostatic proliferation generates normal CD8 T-cell memory but altered repertoires and diminished heterologous immune responses. Blood 112(3):680-9. [PubMed: 18509089] [MGI Ref ID J:138419]
Liu Z; Eltoum IE; Guo B; Beck BH; Cloud GA; Lopez RD. 2008. Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer. J Immunol 180(9):6044-53. [PubMed: 18424725] [MGI Ref ID J:134677]
Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789] [MGI Ref ID J:100625]
Louten J; van Rooijen N; Biron CA. 2006. Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. J Immunol 177(5):3266-72. [PubMed: 16920967] [MGI Ref ID J:139540]
Macpherson AJ; Gatto D; Sainsbury E; Harriman GR; Hengartner H; Zinkernagel RM. 2000. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288(5474):2222-6. [PubMed: 10864873] [MGI Ref ID J:63088]
Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. [PubMed: 15797996] [MGI Ref ID J:107458]
McCoy KD; Harris NL; Diener P; Hatak S; Odermatt B; Hangartner L; Senn BM; Marsland BJ; Geuking MB; Hengartner H; Macpherson AJ; Zinkernagel RM. 2006. Natural IgE production in the absence of MHC Class II cognate help. Immunity 24(3):329-39. [PubMed: 16546101] [MGI Ref ID J:113324]
McLoughlin RM; Lee JC; Kasper DL; Tzianabos AO. 2008. IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol 181(2):1323-32. [PubMed: 18606687] [MGI Ref ID J:137477]
McLoughlin RM; Solinga RM; Rich J; Zaleski KJ; Cocchiaro JL; Risley A; Tzianabos AO; Lee JC. 2006. CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc Natl Acad Sci U S A 103(27):10408-13. [PubMed: 16801559] [MGI Ref ID J:111690]
Melichar HJ; Narayan K; Der SD; Hiraoka Y; Gardiol N; Jeannet G; Held W; Chambers CA; Kang J. 2007. Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science 315(5809):230-3. [PubMed: 17218525] [MGI Ref ID J:117301]
Mizoguchi A; Mizoguchi E; de Jong YP; Takedatsu H; Preffer FI; Terhorst C; Bhan AK. 2003. Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation. Int Immunol 15(1):97-108. [PubMed: 12502730] [MGI Ref ID J:110967]
Mombaerts P; Clarke AR; Hooper ML; Tonegawa S. 1991. Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc Natl Acad Sci U S A 88(8):3084-7. [PubMed: 1826563] [MGI Ref ID J:22591]
Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709] [MGI Ref ID J:15221]
Mombaerts P; Mizoguchi E; Ljunggren HG; Iacomini J; Ishikawa H; Wang L; Grusby MJ; Glimcher LH; Winn HJ; Bhan AK; Tonegawa S. 1994. Peripheral lymphoid development and function in TCR mutant mice. Int Immunol 6(7):1061-70. [PubMed: 7947457] [MGI Ref ID J:19834]
Moon BG; Takaki S; Miyake K; Takatsu K. 2004. The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production. J Immunol 172(10):6020-9. [PubMed: 15128785] [MGI Ref ID J:89849]
Moore TA; Moore BB; Newstead MW; Standiford TJ. 2000. Gamma delta-T cells are critical for survival and early proinflammatory cytokine gene expression during murine Klebsiella pneumonia. J Immunol 165(5):2643-50. [PubMed: 10946293] [MGI Ref ID J:120156]
Muralimohan G; Vella AT. 2006. A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs. Cell Immunol 242(1):9-22. [PubMed: 17045255] [MGI Ref ID J:116765]
Nagahama K; Ogawa A; Shirane K; Shimomura Y; Sugimoto K; Mizoguchi A. 2008. Protein kinase C theta plays a fundamental role in different types of chronic colitis. Gastroenterology 134(2):459-69. [PubMed: 18155708] [MGI Ref ID J:135589]
Naiki Y; Nishimura H; Itohara S; Yoshikai Y. 2000. gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice. Cell Immunol 202(1):61-9. [PubMed: 10873307] [MGI Ref ID J:63163]
Naiki Y; Nishimura H; Kawano T; Tanaka Y; Itohara S; Taniguchi M; Yoshikai Y. 1999. Regulatory role of peritoneal NK1.1+ alpha beta T cells in IL-12 production during Salmonella infection. J Immunol 163(4):2057-63. [PubMed: 10438944] [MGI Ref ID J:119604]
Nesic D; Santori FR; Vukmanovic S. 2000. Alpha beta TCR+ cells are a minimal fraction of peripheral CD8+ pool in MHC class I-deficient mice. J Immunol 165(4):1896-901. [PubMed: 10925270] [MGI Ref ID J:63746]
Neuhaus O; Emoto M; Blum C; Yamamoto S; Kaufmann SH. 1995. Control of thymus-independent intestinal intraepithelial lymphocytes by beta 2-microglobulin. Eur J Immunol 25(8):2332-9. [PubMed: 7664795] [MGI Ref ID J:28179]
Ngo VN; Cornall RJ; Cyster JG. 2001. Splenic T zone development is B cell dependent. J Exp Med 194(11):1649-60. [PubMed: 11733579] [MGI Ref ID J:73100]
Ngo VN; Korner H; Gunn MD; Schmidt KN; Riminton DS; Cooper MD; Browning JL; Sedgwick JD; Cyster JG. 1999. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 189(2):403-12. [PubMed: 9892622] [MGI Ref ID J:52941]
Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 168(6):2626-33. [PubMed: 11884426] [MGI Ref ID J:126867]
O'Brien RL; Yin X; Huber SA; Ikuta K; Born WK. 2000. Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection. J Immunol 165(11):6472-9. [PubMed: 11086087] [MGI Ref ID J:119306]
Obukhanych TV; Nussenzweig MC. 2006. T-independent type II immune responses generate memory B cells. J Exp Med 203(2):305-10. [PubMed: 16476769] [MGI Ref ID J:119148]
Ohteki T; MacDonald HR. 1996. Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver. J Exp Med 183(3):1277-82. [PubMed: 8642272] [MGI Ref ID J:131256]
Oida T; Suzuki K; Nanno M; Kanamori Y; Saito H; Kubota E; Kato S; Itoh M; Kaminogawa S; Ishikawa H. 2000. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. J Immunol 164(7):3616-26. [PubMed: 10725718] [MGI Ref ID J:112139]
Oliveira-dos-Santos AJ; Penninger JM; Rieker-Geley T; Matsumoto G; Mak TM; Wick G. 1998. Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol 28(9):2882-92. [PubMed: 9754575] [MGI Ref ID J:49877]
Opavsky MA; Penninger J; Aitken K; Wen WH; Dawood F; Mak T; Liu P. 1999. Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res 85(6):551-8. [PubMed: 10488058] [MGI Ref ID J:114217]
Ostanin DV; Pavlick KP; Bharwani S; D'Souza D; Furr KL; Brown CM; Grisham MB. 2006. T cell-induced inflammation of the small and large intestine in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol 290(1):G109-19. [PubMed: 16099868] [MGI Ref ID J:115730]
Pao W; Wen L; Smith AL; Gulbranson-Judge A; Zheng B; Kelsoe G; MacLennan IC; Owen MJ; Hayday AC. 1996. Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Curr Biol 6(10):1317-25. [PubMed: 8939571] [MGI Ref ID J:95802]
Park MK; Amichay D; Love P; Wick E; Liao F; Grinberg A; Rabin RL; Zhang HH; Gebeyehu S; Wright TM; Iwasaki A; Weng Y; DeMartino JA; Elkins KL; Farber JM. 2002. The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo. J Immunol 169(3):1433-43. [PubMed: 12133969] [MGI Ref ID J:121818]
Peng SL; Robert ME; Hayday AC; Craft J. 1996. A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice. J Exp Med 184(3):1149-54. [PubMed: 9064331] [MGI Ref ID J:35237]
Pennington DJ; Silva-Santos B; Shires J; Theodoridis E; Pollitt C; Wise EL; Tigelaar RE; Owen MJ; Hayday AC. 2003. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 4(10):991-8. [PubMed: 14502287] [MGI Ref ID J:125582]
Pennington DJ; Silva-Santos B; Silberzahn T; Escorcio-Correia M; Woodward MJ; Roberts SJ; Smith AL; Dyson PJ; Hayday AC. 2006. Early events in the thymus affect the balance of effector and regulatory T cells. Nature 444(7122):1073-7. [PubMed: 17190001] [MGI Ref ID J:117487]
Perry LL; Feilzer K; Caldwell HD. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J Immunol 158(7):3344-52. [PubMed: 9120292] [MGI Ref ID J:110834]
Peters W; Cyster JG; Mack M; Schlondorff D; Wolf AJ; Ernst JD; Charo IF. 2004. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol 172(12):7647-53. [PubMed: 15187146] [MGI Ref ID J:90822]
Pochanke V; Hatak S; Hengartner H; Zinkernagel RM; McCoy KD. 2006. Induction of IgE and allergic-type responses in fur mite-infested mice. Eur J Immunol 36(9):2434-45. [PubMed: 16909433] [MGI Ref ID J:116736]
Qiao M; Thornton AM; Shevach EM. 2007. CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive. Immunology 120(4):447-55. [PubMed: 17244157] [MGI Ref ID J:122637]
Renno T; Wilson A; Dunkel C; Coste I; Maisnier-Patin K; Benoit de Coignac A; Aubry JP; Lees RK; Bonnefoy JY; MacDonald HR; Gauchat JF. 2002. A role for CD147 in thymic development. J Immunol 168(10):4946-50. [PubMed: 11994445] [MGI Ref ID J:125675]
Roberts SJ; Ng BY; Filler RB; Lewis J; Glusac EJ; Hayday AC; Tigelaar RE; Girardi M. 2007. Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proc Natl Acad Sci U S A 104(16):6770-5. [PubMed: 17412837] [MGI Ref ID J:120942]
Roberts SJ; Smith AL; West AB; Wen L; Findly RC; Owen MJ; Hayday AC. 1996. T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci U S A 93(21):11774-9. [PubMed: 8876213] [MGI Ref ID J:35875]
Roth KA; Kapadia SB; Martin SM; Lorenz RG. 1999. Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology. J Immunol 163(3):1490-7. [PubMed: 10415051] [MGI Ref ID J:56994]
Sanders CJ; Yu Y; Moore DA rd; Williams IR; Gewirtz AT. 2006. Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol 177(5):2810-8. [PubMed: 16920916] [MGI Ref ID J:139555]
Savransky V; Molls RR; Burne-Taney M; Chien CC; Racusen L; Rabb H. 2006. Role of the T-cell receptor in kidney ischemia-reperfusion injury. Kidney Int 69(2):233-8. [PubMed: 16408111] [MGI Ref ID J:136513]
Scheckelhoff M; Deepe GS Jr. 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infect Immun 73(4):2129-34. [PubMed: 15784555] [MGI Ref ID J:97204]
Schramm CM; Puddington L; Yiamouyiannis CA; Lingenheld EG; Whiteley HE; Wolyniec WW; Noonan TC; Thrall RS. 2000. Proinflammatory roles of T-cell receptor (TCR)gammadelta and TCRalphabeta lymphocytes in a murine model of asthma. Am J Respir Cell Mol Biol 22(2):218-25. [PubMed: 10657943] [MGI Ref ID J:114246]
Seagal J; Leider N; Wildbaum G; Karin N; Melamed D. 2003. Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Igmu-deficient/lpr mice. Int Immunol 15(9):1045-52. [PubMed: 12917256] [MGI Ref ID J:85222]
Seagal J; Melamed D. 2004. Contribution of alphabeta and gammadelta T cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin- mu-deficient/lpr mice. Immunology 112(2):265-73. [PubMed: 15147570] [MGI Ref ID J:90503]
Seery JP; Wang EC; Cattell V; Carroll JM; Owen MJ; Watt FM. 1999. A central role for alpha beta T cells in the pathogenesis of murine lupus. J Immunol 162(12):7241-8. [PubMed: 10358171] [MGI Ref ID J:55527]
Selin LK; Santolucito PA; Pinto AK; Szomolanyi-Tsuda E; Welsh RM. 2001. Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells. J Immunol 166(11):6784-94. [PubMed: 11359837] [MGI Ref ID J:124516]
Shaw MH; Freeman GJ; Scott MF; Fox BA; Bzik DJ; Belkaid Y; Yap GS. 2006. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol 176(12):7263-71. [PubMed: 16751369] [MGI Ref ID J:132232]
Shimomura Y; Ogawa A; Kawada M; Sugimoto K; Mizoguchi E; Shi HN; Pillai S; Bhan AK; Mizoguchi A. 2008. A unique B2 B cell subset in the intestine. J Exp Med 205(6):1343-55. [PubMed: 18519649] [MGI Ref ID J:137039]
Siegers GM; Swamy M; Fernandez-Malave E; Minguet S; Rathmann S; Guardo AC; Perez-Flores V; Regueiro JR; Alarcon B; Fisch P; Schamel WW. 2007. Different composition of the human and the mouse {gamma}{delta} T cell receptor explains different phenotypes of CD3{gamma} and CD3{delta} immunodeficiencies. J Exp Med 204(11):2537-44. [PubMed: 17923503] [MGI Ref ID J:126111]
Singh A; Svaren J; Grayson J; Suresh M. 2004. CD8 T cell responses to lymphocytic choriomeningitis virus in early growth response gene 1-deficient mice. J Immunol 173(6):3855-62. [PubMed: 15356133] [MGI Ref ID J:92763]
Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. [PubMed: 11035735] [MGI Ref ID J:133107]
Steinhoff U; Brinkmann V; Klemm U; Aichele P; Seiler P; Brandt U; Bland PW; Prinz I; Zugel U; Kaufmann SH. 1999. Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells. Immunity 11(3):349-58. [PubMed: 10514013] [MGI Ref ID J:110543]
Strid J; Roberts SJ; Filler RB; Lewis JM; Kwong BY; Schpero W; Kaplan DH; Hayday AC; Girardi M. 2008. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nat Immunol 9(2):146-54. [PubMed: 18176566] [MGI Ref ID J:131603]
Sun Y; Blink SE; Chen JH; Fu YX. 2005. Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling. J Immunol 175(2):884-90. [PubMed: 16002686] [MGI Ref ID J:100693]
Svensson L; Lilliehook B; Larsson R; Bucht A. 2003. gammadelta T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation. Immunology 108(1):98-108. [PubMed: 12519308] [MGI Ref ID J:113627]
Taghon T; Yui MA; Pant R; Diamond RA; Rothenberg EV. 2006. Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus. Immunity 24(1):53-64. [PubMed: 16413923] [MGI Ref ID J:113313]
Tesciuba AG; Shilling RA; Agarwal MD; Bandukwala HS; Clay BS; Moore TV; Weinstock JV; Welcher AA; Sperling AI. 2008. ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes. J Immunol 181(2):1019-24. [PubMed: 18606653] [MGI Ref ID J:137473]
Tezuka H; Abe Y; Iwata M; Takeuchi H; Ishikawa H; Matsushita M; Shiohara T; Akira S; Ohteki T. 2007. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448(7156):929-33. [PubMed: 17713535] [MGI Ref ID J:125252]
Tokoro Y; Sugawara T; Yaginuma H; Nakauchi H; Terhorst C; Wang B; Takahama Y. 1998. A mouse carrying genetic defect in the choice between T and B lymphocytes. J Immunol 161(9):4591-8. [PubMed: 9794386] [MGI Ref ID J:81712]
Toney LM; Cattoretti G; Graf JA; Merghoub T; Pandolfi PP; Dalla-Favera R; Ye BH; Dent AL. 2000. BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol 1(3):214-20. [PubMed: 10973278] [MGI Ref ID J:118449]
Tsuchiya T; Fukuda S; Hamada H; Nakamura A; Kohama Y; Ishikawa H; Tsujikawa K; Yamamoto H. 2003. Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 171(10):5507-13. [PubMed: 14607957] [MGI Ref ID J:106734]
Tsuji M; Suzuki K; Kitamura H; Maruya M; Kinoshita K; Ivanov II; Itoh K; Littman DR; Fagarasan S. 2008. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin a generation in the gut. Immunity 29(2):261-71. [PubMed: 18656387] [MGI Ref ID J:139002]
Tsuji RF; Kawikova I; Ramabhadran R; Akahira-Azuma M; Taub D; Hugli TE; Gerard C; Askenase PW. 2000. Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment. J Immunol 165(3):1588-98. [PubMed: 10903768] [MGI Ref ID J:120437]
VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356] [MGI Ref ID J:72616]
VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624] [MGI Ref ID J:113544]
Veinotte LL; Greenwood CP; Mohammadi N; Parachoniak CA; Takei F. 2006. Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment. Blood 107(7):2673-9. [PubMed: 16317098] [MGI Ref ID J:131242]
Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. [PubMed: 18227350] [MGI Ref ID J:134359]
Vielhauer V; Stavrakis G; Mayadas TN. 2005. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest 115(5):1199-1209. [PubMed: 15841213] [MGI Ref ID J:98089]
Voll RE; Jimi E; Phillips RJ; Barber DF; Rincon M; Hayday AC; Flavell RA; Ghosh S. 2000. NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity 13(5):677-89. [PubMed: 11114380] [MGI Ref ID J:106461]
Vosshenrich CA; Cumano A; Muller W; Di Santo JP; Vieira P. 2003. Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Nat Immunol 4(8):773-9. [PubMed: 12872121] [MGI Ref ID J:84670]
Vosshenrich CA; Sharara LI; Guy-Grand D; Rajewsky K; Muller W; Di Santo JP. 2000. Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen. Eur J Immunol 30(6):1614-22. [PubMed: 10898497] [MGI Ref ID J:62730]
Warfield KL; Olinger G; Deal EM; Swenson DL; Bailey M; Negley DL; Hart MK; Bavari S. 2005. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175(2):1184-91. [PubMed: 16002721] [MGI Ref ID J:100701]
Wei OL; Hilliard A; Kalman D; Sherman M. 2005. Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium. Infect Immun 73(4):1978-85. [PubMed: 15784538] [MGI Ref ID J:97208]
Wensky AK; Furtado GC; Marcondes MC; Chen S; Manfra D; Lira SA; Zagzag D; Lafaille JJ. 2005. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol 174(3):1416-23. [PubMed: 15661899] [MGI Ref ID J:110017]
Williams JA; Hathcock KS; Klug D; Harada Y; Choudhury B; Allison JP; Abe R; Hodes RJ. 2005. Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint. J Immunol 175(7):4199-207. [PubMed: 16177059] [MGI Ref ID J:118996]
Wilson A; Capone M; MacDonald HR. 1999. Unexpectedly late expression of intracellular CD3epsilon and TCR gammadelta proteins during adult thymus development. Int Immunol 11(10):1641-50. [PubMed: 10508182] [MGI Ref ID J:110493]
Wilson DC; Matthews S; Yap GS. 2008. IL-12 Signaling Drives CD8+ T Cell IFN-{gamma} Production and Differentiation of KLRG1+ Effector Subpopulations during Toxoplasma gondii Infection. J Immunol 180(9):5935-45. [PubMed: 18424713] [MGI Ref ID J:134314]
Winandy S; Wu L; Wang JH; Georgopoulos K. 1999. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J Exp Med 190(8):1039-48. [PubMed: 10523602] [MGI Ref ID J:112017]
Wu ZQ; Vos Q; Shen Y; Lees A; Wilson SR; Briles DE; Gause WC; Mond JJ; Snapper CM. 1999. In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions. J Immunol 163(2):659-67. [PubMed: 10395655] [MGI Ref ID J:119892]
Wurch A; Biro J; Falk I; Mossmann H; Eichmann K. 1999. Reduced generation but efficient TCR beta-chain selection of CD4+8+ double-positive thymocytes in mice with compromised CD3 complex signaling. J Immunol 162(5):2741-7. [PubMed: 10072519] [MGI Ref ID J:110847]
Xu H; Yan J; Huang Y; Chilton PM; Ding C; Schanie CL; Wang L; Ildstad ST. 2008. Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization. Blood 111(6):3266-75. [PubMed: 17827394] [MGI Ref ID J:132727]
Yager EJ; Ahmed M; Lanzer K; Randall TD; Woodland DL; Blackman MA. 2008. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med 205(3):711-23. [PubMed: 18332179] [MGI Ref ID J:133102]
Yamazaki K; Shimada S; Kato-Nagaoka N; Soga H; Itoh T; Nanno M. 2005. Accumulation of intestinal intraepithelial lymphocytes in association with lack of polymeric immunoglobulin receptor. Eur J Immunol 35(4):1211-9. [PubMed: 15770700] [MGI Ref ID J:97824]
Yoo J; Omori M; Gyarmati D; Zhou B; Aye T; Brewer A; Comeau MR; Campbell DJ; Ziegler SF. 2005. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 202(4):541-9. [PubMed: 16103410] [MGI Ref ID J:100506]
Yoshimasu T; Nishide T; Seo N; Hiroi A; Ohtani T; Uede K; Furukawa F. 2004. Susceptibility of T cell receptor-alpha chain knock-out mice to ultraviolet B light and fluorouracil: a novel model for drug-induced cutaneous lupus erythematosus. Clin Exp Immunol 136(2):245-54. [PubMed: 15086387] [MGI Ref ID J:89210]
Yu P; Wang Y; Chin RK; Martinez-Pomares L; Gordon S; Kosco-Vibois MH; Cyster J; Fu YX. 2002. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol 168(10):5117-23. [PubMed: 11994465] [MGI Ref ID J:127080]
Zehntner SP; Brisebois M; Tran E; Owens T; Fournier S. 2003. Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease. FASEB J 17(13):1910-2. [PubMed: 12923072] [MGI Ref ID J:127902]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry This Tcrbtm1Mom strain is maintained by mating homozygous siblings. This strain should be housed under conditions similar to Prkdcscid/Prkdcscid mice or any other immunodeficient strain. It has been cryopreserved and is currently only available from the frozen embryo repository. Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
Control Information
| Control | ||
|---|---|---|
| 100903 B6129PF2/J | (approximate) | |
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
No Liability
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.