Strain Name:

B6;129P2-Tcrdtm1Mom/J

Stock Number:

002119

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use
Mice harboring this T-cell receptor delta chain (Tcrd) targeted mutation may be useful for studying immunology and gamma delta T-cell function.

Description

Strain Information

Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
GenerationF?+F1
 
Donating Investigator Peter Mombaerts,   The Rockefeller University

Description
Mice homozygous for the Tcrdtm1Mom targeted mutation are viable and fertile. Gamma delta T-cell receptor expression is deficient in all adult lymphoid and epithelial organs. There is normal development of the alpha beta T-cell lineage. Patterns of CD4+CD8- and CD4-CD8+ alpha beta T-cells are apparently normal. Mice do not develop inflammatory bowel disease.

Development
The Tcrdtm1Mom targeted mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A replacement targeting vector containing Pgk-neo was used which resulted in a 4 kb deletion encompassing most of the delta chain constant region coding sequences.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tcrdtm1Mom allele
002122   B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
002120   B6.129P2-Tcrdtm1Mom/J
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
008312   CBy.129P2(B6)-Tcrdtm1Mom/SzJ
003448   CByJ.129P2(B6)-Tcrdtm1Mom/Sz
View Strains carrying   Tcrdtm1Mom     (5 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Tcrdtm1Mom/Tcrdtm1Mom

        B6;129P2-Tcrdtm1Mom/J
  • respiratory system phenotype
  • abnormal respiratory system physiology (MGI Ref ID J:125656)
    • ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tcrdtm1Mom/Tcrdtm1Mom

        FVB.129P2-Tcrdtm1Mom
  • immune system phenotype
  • dermatitis (MGI Ref ID J:75915)
    • no overt signs of spontaneous dermatitis on this background
  • increased susceptibility to type IV hypersensitivity reaction (MGI Ref ID J:75915)
    • aggravated allergic contact dermatitis in response to DNFAB and irritant contact dermatitis
  • skin/coat/nails phenotype
  • abnormal skin condition (MGI Ref ID J:75915)
    • less extensive ear thickening
  • dermatitis (MGI Ref ID J:75915)
    • no overt signs of spontaneous dermatitis on this background
  • impaired skin barrier function (MGI Ref ID J:106782)
    • transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions
  • homeostasis/metabolism phenotype
  • impaired skin barrier function (MGI Ref ID J:106782)
    • transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions

Tcrdtm1Mom/Tcrdtm1Mom

        B6.129P2-Tcrdtm1Mom
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:75915)
    • no evidence of spontaneous dermatitis, allergic or irritant contact dermatitis
  • skin/coat/nails phenotype
  • *normal* skin/coat/nails phenotype (MGI Ref ID J:75915)
    • no skin abnormalities
  • cellular phenotype
  • increased apoptosis (MGI Ref ID J:94872)
    • apoptosis levels in the epidermis are 3 fold higher than in controls

Tcrdtm1Mom/Tcrdtm1Mom

        either: (involves: 129 * BALB/cJ) or (involves: 129 * C57BL/6)
  • immune system phenotype
  • abnormal gamma-delta T cell differentiation (MGI Ref ID J:3865)
    • rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur
  • absent gamma-delta T cells (MGI Ref ID J:3865)
    • gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control
  • hematopoietic system phenotype
  • abnormal gamma-delta T cell differentiation (MGI Ref ID J:3865)
    • rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur
  • absent gamma-delta T cells (MGI Ref ID J:3865)
    • gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tcrdtm1Mom related

Hematological Research
Immunological Defects

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects

Research Tools
Immunology and Inflammation Research (T Cell Receptor Deficiency)

Genes & Alleles

Gene & Allele Information

Allele Symbol Tcrdtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (knock-out)
Common Name(s) C-delta-; TCRdelta KO; TCRdelta-; delta-; delta0; gamadelta TCR<->;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129
ES Cell Line NameOther (see notes)
ES Cell Line Strain129
Gene Symbol and Name Tcrd, T-cell receptor delta chain
Chromosome 14
Gene Common Name(s) TCRDV1; TRD; Tcr delta; Tcrdelta;
General Note ES cell line = E14 (129P2/OlaHsd) or D3 (129S2/SvPas).
Molecular Note A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showedan absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. [MGI Ref ID J:3865] [MGI Ref ID J:91942]

Genotyping

Genotyping Information

Genotyping Protocols

NEOTD (Generic Neo), STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72(3):337-48. [PubMed: 8381716]  [MGI Ref ID J:3865]

Additional References

Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709]  [MGI Ref ID J:15221]

Tcrdtm1Mom related

Aifantis I; Bassing CH; Garbe AI; Sawai K; Alt FW; von Boehmer H. 2006. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med 203(6):1543-50. [PubMed: 16754716]  [MGI Ref ID J:124376]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949]  [MGI Ref ID J:93752]

Anderson BE; McNiff JM; Matte C; Athanasiadis I; Shlomchik WD; Shlomchik MJ. 2004. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 104(5):1565-73. [PubMed: 15150080]  [MGI Ref ID J:92701]

Andrew EM; Newton DJ; Dalton JE; Egan CE; Goodwin SJ; Tramonti D; Scott P; Carding SR. 2005. Delineation of the function of a major gamma delta T cell subset during infection. J Immunol 175(3):1741-50. [PubMed: 16034115]  [MGI Ref ID J:105477]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670]  [MGI Ref ID J:112329]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272]  [MGI Ref ID J:97167]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161(10):5210-6. [PubMed: 9820492]  [MGI Ref ID J:115026]

Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693]  [MGI Ref ID J:132284]

Borchers MT; Wesselkamper SC; Eppert BL; Motz GT; Sartor MA; Tomlinson CR; Medvedovic M; Tichelaar JW. 2008. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci 105(1):188-99. [PubMed: 18515264]  [MGI Ref ID J:139766]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529]  [MGI Ref ID J:115023]

Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183]  [MGI Ref ID J:118094]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Cardona AE; Teale JM. 2002. gamma/delta T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis. J Immunol 169(6):3163-71. [PubMed: 12218134]  [MGI Ref ID J:78958]

Cariappa A; Mazo IB; Chase C; Shi HN; Liu H; Li Q; Rose H; Leung H; Cherayil BJ; Russell P; von Andrian U; Pillai S. 2005. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23(4):397-407. [PubMed: 16226505]  [MGI Ref ID J:113277]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. [PubMed: 12376619]  [MGI Ref ID J:125077]

Corthay A; Johansson A; Vestberg M; Holmdahl R. 1999. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol 11(7):1065-73. [PubMed: 10383939]  [MGI Ref ID J:56725]

Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563]  [MGI Ref ID J:125656]

Crosby JR; Shen HH; Borchers MT; Justice JP; Ansay T; Lee JJ; Lee NA. 2002. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am J Physiol Lung Cell Mol Physiol 282(1):L99-108. [PubMed: 11741821]  [MGI Ref ID J:107840]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906]  [MGI Ref ID J:82106]

Egan CE; Dalton JE; Andrew EM; Smith JE; Gubbels MJ; Striepen B; Carding SR. 2005. A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology. J Immunol 175(12):8191-9. [PubMed: 16339558]  [MGI Ref ID J:122276]

Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. [PubMed: 15579444]  [MGI Ref ID J:94976]

Emoto M; Nishimura H; Sakai T; Hiromatsu K; Gomi H; Itohara S; Yoshikai Y. 1995. Mice deficient in gamma delta T cells are resistant to lethal infection with Salmonella choleraesuis. Infect Immun 63(9):3736-8. [PubMed: 7642318]  [MGI Ref ID J:111169]

Endres R; Alimzhanov MB; Plitz T; Futterer A; Kosco-Vilbois MH; Nedospasov SA; Rajewsky K; Pfeffer K. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189(1):159-68. [PubMed: 9874572]  [MGI Ref ID J:119173]

Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25(3):403-15. [PubMed: 16973390]  [MGI Ref ID J:113556]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Ferlin WG; von der Weid T; Cottrez F; Ferrick DA; Coffman RL; Howard MC. 1998. The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb. Eur J Immunol 28(2):525-31. [PubMed: 9521062]  [MGI Ref ID J:46693]

Ferrero I; Mancini SJ; Grosjean F; Wilson A; Otten L; MacDonald HR. 2006. TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation. J Immunol 177(9):6038-43. [PubMed: 17056529]  [MGI Ref ID J:140526]

Fischer K; Collins H; Taniguchi M; Kaufmann SH; Schaible UE. 2002. IL-4 and T cells are required for the generation of IgG1 isotype antibodies against cardiolipin. J Immunol 168(6):2689-94. [PubMed: 11884434]  [MGI Ref ID J:126854]

Fontenot JD; Rasmussen JP; Williams LM; Dooley JL; Farr AG; Rudensky AY. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22(3):329-41. [PubMed: 15780990]  [MGI Ref ID J:97029]

French JD; Roark CL; Born WK; O'brien RL. 2005. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A 102(41):14741-6. [PubMed: 16203967]  [MGI Ref ID J:102497]

Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. [PubMed: 11171016]  [MGI Ref ID J:120023]

Fu YX; Huang G; Wang Y; Chaplin DD. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 187(7):1009-18. [PubMed: 9529317]  [MGI Ref ID J:118756]

Fujihashi K; McGhee JR; Kweon MN; Cooper MD; Tonegawa S; Takahashi I; Hiroi T; Mestecky J; Kiyono H. 1996. gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. J Exp Med 183(4):1929-35. [PubMed: 8666951]  [MGI Ref ID J:32719]

Fujiura Y; Kawaguchi M; Kondo Y; Obana S; Yamamoto H; Nanno M; Ishikawa H. 1996. Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice. J Immunol 156(8):2710-5. [PubMed: 8609387]  [MGI Ref ID J:111566]

Gerber DJ; Azuara V; Levraud JP; Huang SY; Lembezat MP; Pereira P. 1999. IL-4-producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen. J Immunol 163(6):3076-82. [PubMed: 10477572]  [MGI Ref ID J:118718]

Girardi M; Lewis J; Glusac E; Filler RB; Geng L; Hayday AC; Tigelaar RE. 2002. Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation. J Exp Med 195(7):855-67. [PubMed: 11927630]  [MGI Ref ID J:75915]

Girardi M; Lewis JM; Filler RB; Hayday AC; Tigelaar RE. 2006. Environmentally responsive and reversible regulation of epidermal barrier function by gammadelta T cells. J Invest Dermatol 126(4):808-14. [PubMed: 16439970]  [MGI Ref ID J:106782]

Girardi M; Oppenheim DE; Steele CR; Lewis JM; Glusac E; Filler R; Hobby P; Sutton B; Tigelaar RE; Hayday AC. 2001. Regulation of cutaneous malignancy by gammadelta T cells. Science 294(5542):605-9. [PubMed: 11567106]  [MGI Ref ID J:88981]

Golovkina TV; Shlomchik M; Hannum L; Chervonsky A. 1999. Organogenic role of B lymphocytes in mucosal immunity. Science 286(5446):1965-8. [PubMed: 10583962]  [MGI Ref ID J:124532]

Groom JR; Fletcher CA; Walters SN; Grey ST; Watt SV; Sweet MJ; Smyth MJ; Mackay CR; Mackay F. 2007. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med 204(8):1959-71. [PubMed: 17664289]  [MGI Ref ID J:125937]

Guan H; Zu G; Slater M; Elmets C; Xu H. 2002. GammadeltaT cells regulate the development of hapten-specific CD8+ effector T cells in contact hypersensitivity responses. J Invest Dermatol 119(1):137-42. [PubMed: 12164936]  [MGI Ref ID J:123420]

Guy-Grand D; Azogui O; Celli S; Darche S; Nussenzweig MC; Kourilsky P; Vassalli P. 2003. Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J Exp Med 197(3):333-41. [PubMed: 12566417]  [MGI Ref ID J:124688]

Guy-Grand D; DiSanto JP; Henchoz P; Malassis-Seris M; Vassalli P. 1998. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal. Eur J Immunol 28(2):730-44. [PubMed: 9521083]  [MGI Ref ID J:114275]

Haines BB; Ryu CJ; Chang S; Protopopov A; Luch A; Kang YH; Draganov DD; Fragoso MF; Paik SG; Hong HJ; DePinho RA; Chen J. 2006. Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell 9(2):109-20. [PubMed: 16473278]  [MGI Ref ID J:106246]

Haines BB; Ryu CJ; Chen J. 2006. Recombination activating genes (RAG) in lymphoma development. Cell Cycle 5(9):913-6. [PubMed: 16687916]  [MGI Ref ID J:115811]

Hamada K; Sasaki T; Koni PA; Natsui M; Kishimoto H; Sasaki J; Yajima N; Horie Y; Hasegawa G; Naito M; Miyazaki J; Suda T; Itoh H; Nakao K; Mak TW; Nakano T; Suzuki A. 2005. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 19(17):2054-65. [PubMed: 16107612]  [MGI Ref ID J:100493]

Hamada S; Umemura M; Shiono T; Tanaka K; Yahagi A; Begum MD; Oshiro K; Okamoto Y; Watanabe H; Kawakami K; Roark C; Born WK; O'Brien R; Ikuta K; Ishikawa H; Nakae S; Iwakura Y; Ohta T; Matsuzaki G. 2008. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver. J Immunol 181(5):3456-63. [PubMed: 18714018]  [MGI Ref ID J:138944]

Hanano R; Kaufmann SH. 1999. Effect on parasite eradication of Pneumocystis carinii-specific antibodies produced in the presence or absence of CD4(+) alphabeta T lymphocytes. Eur J Immunol 29(8):2464-75. [PubMed: 10458760]  [MGI Ref ID J:115322]

Hayes SM; Li L; Love PE. 2005. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 22(5):583-93. [PubMed: 15894276]  [MGI Ref ID J:99104]

Hempel WM; Stanhope-Baker P; Mathieu N; Huang F; Schlissel MS; Ferrier P. 1998. Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining. Genes Dev 12(15):2305-17. [PubMed: 9694796]  [MGI Ref ID J:115129]

Hess J; Ladel C; Miko D; Kaufmann SH. 1996. Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J Immunol 156(9):3321-6. [PubMed: 8617956]  [MGI Ref ID J:32521]

Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150]  [MGI Ref ID J:139648]

Hong NA; Cado D; Mitchell J; Ortiz BD; Hsieh SN; Winoto A. 1997. A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Mol Cell Biol 17(4):2151-7. [PubMed: 9121464]  [MGI Ref ID J:77676]

Huber SA; Graveline D; Newell MK; Born WK; O'Brien RL. 2000. V gamma 1+ T cells suppress and V gamma 4+ T cells promote susceptibility to coxsackievirus B3-induced myocarditis in mice. J Immunol 165(8):4174-81. [PubMed: 11035049]  [MGI Ref ID J:118442]

Huleatt JW; Lefrancois L. 1996. Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity 5(3):263-73. [PubMed: 8808681]  [MGI Ref ID J:35355]

Inagaki-Ohara K; Chinen T; Matsuzaki G; Sasaki A; Sakamoto Y; Hiromatsu K; Nakamura-Uchiyama F; Nawa Y; Yoshimura A. 2004. Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol 173(2):1390-8. [PubMed: 15240735]  [MGI Ref ID J:91942]

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Tezuka H; Abe Y; Iwata M; Takeuchi H; Ishikawa H; Matsushita M; Shiohara T; Akira S; Ohteki T. 2007. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448(7156):929-33. [PubMed: 17713535]  [MGI Ref ID J:125252]

Thoma-Uszynski S; Ladel CH; Kaufmann SH. 1997. Abscess formation in Listeria monocytogenes-infected gamma delta T cell deficient mouse mutants involves alpha beta T cells. Microb Pathog 22(2):123-8. [PubMed: 9050001]  [MGI Ref ID J:41916]

Toenjes SA; Spolski RJ; Mooney KA; Kuhn RE. 1999. gamma delta T cells do not play a major role in controlling infection in experimental cysticercosis. Parasitology 119(Pt 4):413-8. [PubMed: 10581620]  [MGI Ref ID J:59865]

Toney LM; Cattoretti G; Graf JA; Merghoub T; Pandolfi PP; Dalla-Favera R; Ye BH; Dent AL. 2000. BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol 1(3):214-20. [PubMed: 10973278]  [MGI Ref ID J:118449]

Toth B; Alexander M; Daniel T; Chaudry IH; Hubbard WJ; Schwacha MG. 2004. The role of {gamma}{delta} T cells in the regulation of neutrophil-mediated tissue damage after thermal injury. J Leukoc Biol 76(3):545-552. [PubMed: 15197233]  [MGI Ref ID J:91999]

Tramonti D; Andrew EM; Rhodes K; Newton DJ; Carding SR. 2006. Evidence for the opposing roles of different gamma delta T cell subsets in macrophage homeostasis. Eur J Immunol 36(7):1729-38. [PubMed: 16783854]  [MGI Ref ID J:115792]

Tramonti D; Rhodes K; Martin N; Dalton JE; Andrew E; Carding SR. 2008. gammadeltaT cell-mediated regulation of chemokine producing macrophages during Listeria monocytogenes infection-induced inflammation. J Pathol 216(2):262-70. [PubMed: 18767021]  [MGI Ref ID J:139664]

Tschop J; Martignoni A; Goetzman HS; Choi LG; Wang Q; Noel JG; Ogle CK; Pritts TA; Johannigman JA; Lentsch AB; Caldwell CC. 2008. Gammadelta T cells mitigate the organ injury and mortality of sepsis. J Leukoc Biol 83(3):581-8. [PubMed: 18063696]  [MGI Ref ID J:132638]

Tsuchiya T; Fukuda S; Hamada H; Nakamura A; Kohama Y; Ishikawa H; Tsujikawa K; Yamamoto H. 2003. Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 171(10):5507-13. [PubMed: 14607957]  [MGI Ref ID J:106734]

Tsuji M; Suzuki K; Kitamura H; Maruya M; Kinoshita K; Ivanov II; Itoh K; Littman DR; Fagarasan S. 2008. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin a generation in the gut. Immunity 29(2):261-71. [PubMed: 18656387]  [MGI Ref ID J:139002]

Tsuji RF; Kawikova I; Ramabhadran R; Akahira-Azuma M; Taub D; Hugli TE; Gerard C; Askenase PW. 2000. Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment. J Immunol 165(3):1588-98. [PubMed: 10903768]  [MGI Ref ID J:120437]

Turner J; Frank AA; Brooks JV; Marietta PM; Vesosky B; Orme IM. 2001. Tuberculosis in aged gammadelta T cell gene disrupted mice. Exp Gerontol 36(2):245-54. [PubMed: 11226740]  [MGI Ref ID J:115393]

Uezu K; Kawakami K; Miyagi K; Kinjo Y; Kinjo T; Ishikawa H; Saito A. 2004. Accumulation of gammadelta T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans. J Immunol 172(12):7629-34. [PubMed: 15187143]  [MGI Ref ID J:90820]

Van de Keere F; Tonegawa S. 1998. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 188(10):1875-82. [PubMed: 9815265]  [MGI Ref ID J:115028]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Veinotte LL; Greenwood CP; Mohammadi N; Parachoniak CA; Takei F. 2006. Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment. Blood 107(7):2673-9. [PubMed: 16317098]  [MGI Ref ID J:131242]

Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. [PubMed: 18227350]  [MGI Ref ID J:134359]

Wang T; Gao Y; Scully E; Davis CT; Anderson JF; Welte T; Ledizet M; Koski R; Madri JA; Barrett A; Yin Z; Craft J; Fikrig E. 2006. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. J Immunol 177(3):1825-32. [PubMed: 16849493]  [MGI Ref ID J:138027]

Warfield KL; Olinger G; Deal EM; Swenson DL; Bailey M; Negley DL; Hart MK; Bavari S. 2005. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175(2):1184-91. [PubMed: 16002721]  [MGI Ref ID J:100701]

Weidanz WP; Kemp JR; Batchelder JM; Cigel FK; Sandor M; Heyde HC. 1999. Plasticity of immune responses suppressing parasitemia during acute Plasmodium chabaudi malaria. J Immunol 162(12):7383-8. [PubMed: 10358190]  [MGI Ref ID J:119884]

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Woodward AL; Spergel JM; Alenius H; Mizoguchi E; Bhan AK; Castigli E; Brodeur SR; Oettgen HC; Geha RS. 2001. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol 107(2):359-66. [PubMed: 11174205]  [MGI Ref ID J:106314]

Wu ZQ; Vos Q; Shen Y; Lees A; Wilson SR; Briles DE; Gause WC; Mond JJ; Snapper CM. 1999. In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions. J Immunol 163(2):659-67. [PubMed: 10395655]  [MGI Ref ID J:119892]

Xiong N; Kang C; Raulet DH. 2002. Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity 16(3):453-63. [PubMed: 11911829]  [MGI Ref ID J:75624]

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Yang H; Antony PA; Wildhaber BE; Teitelbaum DH. 2004. Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol 172(7):4151-8. [PubMed: 15034027]  [MGI Ref ID J:88716]

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Yu P; Wang Y; Chin RK; Martinez-Pomares L; Gordon S; Kosco-Vibois MH; Cyster J; Fu YX. 2002. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol 168(10):5117-23. [PubMed: 11994465]  [MGI Ref ID J:127080]

Zachariadis O; Cassidy JP; Brady J; Mahon BP. 2006. gammadelta T cells regulate the early inflammatory response to bordetella pertussis infection in the murine respiratory tract. Infect Immun 74(3):1837-45. [PubMed: 16495558]  [MGI Ref ID J:107420]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryThis Tcrdtm1Mom strain is maintained by mating homozygous siblings. This strain should be housed under conditions similar to Prkdcscid/Prkdcscid mice or any other immunodeficient strain. Only homozygous mice may be ordered.
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Induced Mutant Resource Colony collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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