Strain Name:

B6.129P2-Tcrdtm1Mom/J

Stock Number:

002120

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Availability:

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Use Restrictions Apply, see Terms of Use
Mice harboring this T-cell receptor delta chain (Tcrd) knock-out are deficient in receptor expression in all adult lymphoid and epithelial organs, and these mice may be useful for studying immunology and gamma delta T-cell function.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129P2 via E14TG2a ES cell line
GenerationN12F44 (11-DEC-13)
Generation Definitions
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Tcrdtm1Mom targeted mutation are viable and fertile. Gamma delta T-cell receptor expression is deficient in all adult lymphoid and epithelial organs. There is normal development of the alpha beta T-cell lineage. Patterns of CD4+CD8- and CD4-CD8+ alpha beta T-cells are apparently normal. Mice do not develop inflammatory bowel disease.

Development
The Tcrdtm1Mom targeted mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology. A replacement targeting vector containing Pgk-neo was used which resulted in a 4 kb deletion encompassing most of the delta chain constant region coding sequences. The C57BL/6J strain was generated by backcrossing mice carrying the Tcrdtm1Mom mutation 12 times to C57BL/6J inbred mice.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Tcrdtm1Mom     (6 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tcrdtm1Mom/Tcrdtm1Mom

        B6.129P2-Tcrdtm1Mom
  • immune system phenotype
  • *normal* immune system phenotype
    • no evidence of spontaneous dermatitis, allergic or irritant contact dermatitis   (MGI Ref ID J:75915)
  • cellular phenotype
  • increased apoptosis
    • apoptosis levels in the epidermis are 3 fold higher than in controls   (MGI Ref ID J:94872)
  • integument phenotype
  • *normal* integument phenotype
    • no skin abnormalities   (MGI Ref ID J:75915)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tcrdtm1Mom/Tcrdtm1Mom

        FVB.129P2-Tcrdtm1Mom
  • immune system phenotype
  • dermatitis
    • no overt signs of spontaneous dermatitis on this background   (MGI Ref ID J:75915)
  • increased susceptibility to type IV hypersensitivity reaction
    • aggravated allergic contact dermatitis in response to DNFAB and irritant contact dermatitis   (MGI Ref ID J:75915)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function
    • transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions   (MGI Ref ID J:106782)
  • integument phenotype
  • abnormal skin condition
    • less extensive ear thickening   (MGI Ref ID J:75915)
  • dermatitis
    • no overt signs of spontaneous dermatitis on this background   (MGI Ref ID J:75915)
  • impaired skin barrier function
    • transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions   (MGI Ref ID J:106782)

Tcrdtm1Mom/Tcrdtm1Mom

        either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)
  • immune system phenotype
  • abnormal gamma-delta T cell differentiation
    • rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur   (MGI Ref ID J:3865)
  • absent gamma-delta T cells
    • gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control   (MGI Ref ID J:3865)
  • hematopoietic system phenotype
  • abnormal gamma-delta T cell differentiation
    • rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur   (MGI Ref ID J:3865)
  • absent gamma-delta T cells
    • gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control   (MGI Ref ID J:3865)

Tcrdtm1Mom/Tcrdtm1Mom

        B6;129P2-Tcrdtm1Mom/J
  • respiratory system phenotype
  • abnormal respiratory system physiology
    • ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation   (MGI Ref ID J:125656)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tcrdtm1Mom related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
      Inflammatory bowel disease
T Cell Receptor Signaling Defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tcrdtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) C-delta-; TCRdelta KO; TCRdelta-; delta-; delta0; gammadelta TCR-;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Tcrd, T cell receptor delta chain
Chromosome 14
Gene Common Name(s) Tcr delta; Tcrdelta;
Molecular Note A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showedan absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. [MGI Ref ID J:3865] [MGI Ref ID J:91942]

Genotyping

Genotyping Information

Genotyping Protocols

tcrdtm1Mom, Standard PCR
Generic Neo Melt Curve Analysis, Melt Curve Analysis


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72(3):337-48. [PubMed: 8381716]  [MGI Ref ID J:3865]

Additional References

Cardona AE; Teale JM. 2002. gamma/delta T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis. J Immunol 169(6):3163-71. [PubMed: 12218134]  [MGI Ref ID J:78958]

Dalton JE; Howell G; Pearson J; Scott P; Carding SR. 2004. Fas-Fas ligand interactions are essential for the binding to and killing of activated macrophages by gammadelta T cells. J Immunol 173(6):3660-7. [PubMed: 15356111]  [MGI Ref ID J:92754]

Kikuchi K; Yanagawa Y; Aranami T; Iwabuchi C; Iwabuchi K; Onoe K. 2003. Tumour necrosis factor-alpha but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation. Immunology 108(1):42-9. [PubMed: 12519301]  [MGI Ref ID J:81751]

Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709]  [MGI Ref ID J:15221]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Ponomarev ED; Novikova M; Yassai M; Szczepanik M; Gorski J; Dittel BN. 2004. Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol 173(3):1587-95. [PubMed: 15265886]  [MGI Ref ID J:92038]

Ramsburg E; Tigelaar R; Craft J; Hayday A. 2003. Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite. J Exp Med 198(9):1403-14. [PubMed: 14597739]  [MGI Ref ID J:86462]

Siegmund B; Sennello JA; Lehr HA; Senaldi G; Dinarello CA; Fantuzzi G. 2004. Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Eur J Immunol 34(9):2356-64. [PubMed: 15307168]  [MGI Ref ID J:91767]

Tam S; King DP; Beaman BL. 2001. Increase of gammadelta T lymphocytes in murine lungs occurs during recovery from pulmonary infection by Nocardia asteroides. Infect Immun 69(10):6165-71. [PubMed: 11553556]  [MGI Ref ID J:71648]

Toth B; Alexander M; Daniel T; Chaudry IH; Hubbard WJ; Schwacha MG. 2004. The role of {gamma}{delta} T cells in the regulation of neutrophil-mediated tissue damage after thermal injury. J Leukoc Biol 76(3):545-552. [PubMed: 15197233]  [MGI Ref ID J:91999]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

Welniak LA; Khaled AR; Anver MR; Komschlies KL; Wiltrout RH; Durum S; Ruscetti FR; Blazar BR; Murphy WJ. 2001. Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation. J Immunol 166(5):2924-8. [PubMed: 11207240]  [MGI Ref ID J:67603]

Xiong N; Kang C; Raulet DH. 2002. Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity 16(3):453-63. [PubMed: 11911829]  [MGI Ref ID J:75624]

Yang H; Antony PA; Wildhaber BE; Teitelbaum DH. 2004. Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol 172(7):4151-8. [PubMed: 15034027]  [MGI Ref ID J:88716]

Yoshimasu T; Nishide T; Seo N; Hiroi A; Ohtani T; Uede K; Furukawa F. 2004. Susceptibility of T cell receptor-alpha chain knock-out mice to ultraviolet B light and fluorouracil: a novel model for drug-induced cutaneous lupus erythematosus. Clin Exp Immunol 136(2):245-54. [PubMed: 15086387]  [MGI Ref ID J:89210]

Tcrdtm1Mom related

Aifantis I; Bassing CH; Garbe AI; Sawai K; Alt FW; von Boehmer H. 2006. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med 203(6):1543-50. [PubMed: 16754716]  [MGI Ref ID J:124376]

Alcon VL; Luther C; Balce D; Takei F. 2009. B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity. Eur J Immunol 39(3):826-32. [PubMed: 19197938]  [MGI Ref ID J:146477]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178(6):3740-9. [PubMed: 17339472]  [MGI Ref ID J:144277]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949]  [MGI Ref ID J:93752]

Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302-5. [PubMed: 20220849]  [MGI Ref ID J:157973]

Anderson BE; McNiff JM; Matte C; Athanasiadis I; Shlomchik WD; Shlomchik MJ. 2004. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 104(5):1565-73. [PubMed: 15150080]  [MGI Ref ID J:92701]

Andrew EM; Newton DJ; Dalton JE; Egan CE; Goodwin SJ; Tramonti D; Scott P; Carding SR. 2005. Delineation of the function of a major gamma delta T cell subset during infection. J Immunol 175(3):1741-50. [PubMed: 16034115]  [MGI Ref ID J:105477]

Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. [PubMed: 23529621]  [MGI Ref ID J:199531]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Arwert EN; Lal R; Quist S; Rosewell I; van Rooijen N; Watt FM. 2010. Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc Natl Acad Sci U S A 107(46):19903-8. [PubMed: 21041641]  [MGI Ref ID J:166606]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baban B; Chandler PR; Johnson BA 3rd; Huang L; Li M; Sharpe ML; Francisco LM; Sharpe AH; Blazar BR; Munn DH; Mellor AL. 2011. Physiologic control of IDO competence in splenic dendritic cells. J Immunol 187(5):2329-35. [PubMed: 21813777]  [MGI Ref ID J:179269]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. [PubMed: 23835849]  [MGI Ref ID J:202249]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670]  [MGI Ref ID J:112329]

Bento AF; Marcon R; Dutra RC; Claudino RF; Cola M; Pereira Leite DF; Calixto JB. 2011. beta-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARgamma Pathway. Am J Pathol 178(3):1153-66. [PubMed: 21356367]  [MGI Ref ID J:169691]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272]  [MGI Ref ID J:97167]

Bjordahl RL; Gapin L; Marrack P; Refaeli Y. 2012. iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. PLoS One 7(8):e42635. [PubMed: 22880059]  [MGI Ref ID J:189824]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Bonnet M; Huang F; Benoukraf T; Cabaud O; Verthuy C; Boucher A; Jaeger S; Ferrier P; Spicuglia S. 2009. Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model. J Immunol 183(12):7939-48. [PubMed: 19923469]  [MGI Ref ID J:157494]

Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161(10):5210-6. [PubMed: 9820492]  [MGI Ref ID J:115026]

Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693]  [MGI Ref ID J:132284]

Borchers MT; Wesselkamper SC; Eppert BL; Motz GT; Sartor MA; Tomlinson CR; Medvedovic M; Tichelaar JW. 2008. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci 105(1):188-99. [PubMed: 18515264]  [MGI Ref ID J:139766]

Bortnick A; Chernova I; Quinn WJ 3rd; Mugnier M; Cancro MP; Allman D. 2012. Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens. J Immunol 188(11):5389-96. [PubMed: 22529295]  [MGI Ref ID J:188747]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529]  [MGI Ref ID J:115023]

Burns AM; Chong AS. 2011. Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming. J Immunol 186(1):214-21. [PubMed: 21135169]  [MGI Ref ID J:168797]

Byeseda SE; Burns AR; Dieffenbaugher S; Rumbaut RE; Smith CW; Li Z. 2009. ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing. Am J Pathol 175(2):571-9. [PubMed: 19608878]  [MGI Ref ID J:150953]

Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183]  [MGI Ref ID J:118094]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Cai Y; Shen X; Ding C; Qi C; Li K; Li X; Jala VR; Zhang HG; Wang T; Zheng J; Yan J. 2011. Pivotal Role of Dermal IL-17-Producing gammadelta T Cells in Skin Inflammation. Immunity 35(4):596-610. [PubMed: 21982596]  [MGI Ref ID J:177652]

Cao AT; Yao S; Gong B; Elson CO; Cong Y. 2012. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. J Immunol 189(9):4666-73. [PubMed: 22993206]  [MGI Ref ID J:190633]

Cardona AE; Teale JM. 2002. gamma/delta T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis. J Immunol 169(6):3163-71. [PubMed: 12218134]  [MGI Ref ID J:78958]

Cariappa A; Mazo IB; Chase C; Shi HN; Liu H; Li Q; Rose H; Leung H; Cherayil BJ; Russell P; von Andrian U; Pillai S. 2005. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23(4):397-407. [PubMed: 16226505]  [MGI Ref ID J:113277]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chan AJ; Alikhan MA; Odobasic D; Gan PY; Khouri MB; Steinmetz OM; Mansell AS; Kitching AR; Holdsworth SR; Summers SA. 2014. Innate IL-17A-Producing Leukocytes Promote Acute Kidney Injury via Inflammasome and Toll-Like Receptor Activation. Am J Pathol 184(5):1411-8. [PubMed: 24631024]  [MGI Ref ID J:208397]

Chang JH; Hu H; Jin J; Puebla-Osorio N; Xiao Y; Gilbert BE; Brink R; Ullrich SE; Sun SC. 2014. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med 211(1):137-51. [PubMed: 24378539]  [MGI Ref ID J:208351]

Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. [PubMed: 22966002]  [MGI Ref ID J:191423]

Chen Y; Chou K; Fuchs E; Havran WL; Boismenu R. 2002. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A 99(22):14338-43. [PubMed: 12376619]  [MGI Ref ID J:125077]

Chennupati V; Worbs T; Liu X; Malinarich FH; Schmitz S; Haas JD; Malissen B; Forster R; Prinz I. 2010. Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol 185(9):5160-8. [PubMed: 20870939]  [MGI Ref ID J:165201]

Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. [PubMed: 20364087]  [MGI Ref ID J:161481]

Chodaczek G; Papanna V; Zal MA; Zal T. 2012. Body-barrier surveillance by epidermal gammadelta TCRs. Nat Immunol 13(3):272-82. [PubMed: 22327568]  [MGI Ref ID J:181476]

Chung CS; Watkins L; Funches A; Lomas-Neira J; Cioffi WG; Ayala A. 2006. Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis. Am J Physiol Regul Integr Comp Physiol 291(5):R1338-43. [PubMed: 16793935]  [MGI Ref ID J:144693]

Cong Y; Feng T; Fujihashi K; Schoeb TR; Elson CO. 2009. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A 106(46):19256-61. [PubMed: 19889972]  [MGI Ref ID J:154759]

Conlon TM; Saeb-Parsy K; Cole JL; Motallebzadeh R; Qureshi MS; Rehakova S; Negus MC; Callaghan CJ; Bolton EM; Bradley JA; Pettigrew GJ. 2012. Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. J Immunol 188(6):2643-52. [PubMed: 22323543]  [MGI Ref ID J:181855]

Conti HR; Shen F; Nayyar N; Stocum E; Sun JN; Lindemann MJ; Ho AW; Hai JH; Yu JJ; Jung JW; Filler SG; Masso-Welch P; Edgerton M; Gaffen SL. 2009. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 206(2):299-311. [PubMed: 19204111]  [MGI Ref ID J:146451]

Corthay A; Johansson A; Vestberg M; Holmdahl R. 1999. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol 11(7):1065-73. [PubMed: 10383939]  [MGI Ref ID J:56725]

Cox MA; Barnum SR; Bullard DC; Zajac AJ. 2013. ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection. Proc Natl Acad Sci U S A 110(4):1416-21. [PubMed: 23297203]  [MGI Ref ID J:193714]

Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563]  [MGI Ref ID J:125656]

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Uezu K; Kawakami K; Miyagi K; Kinjo Y; Kinjo T; Ishikawa H; Saito A. 2004. Accumulation of gammadelta T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans. J Immunol 172(12):7629-34. [PubMed: 15187143]  [MGI Ref ID J:90820]

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Veinotte LL; Greenwood CP; Mohammadi N; Parachoniak CA; Takei F. 2006. Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment. Blood 107(7):2673-9. [PubMed: 16317098]  [MGI Ref ID J:131242]

Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. [PubMed: 18227350]  [MGI Ref ID J:134359]

Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. [PubMed: 19641139]  [MGI Ref ID J:151875]

Victoratos P; Kollias G. 2009. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1):130-42. [PubMed: 19119026]  [MGI Ref ID J:143728]

Waggoner SN; Cornberg M; Selin LK; Welsh RM. 2012. Natural killer cells act as rheostats modulating antiviral T cells. Nature 481(7381):394-8. [PubMed: 22101430]  [MGI Ref ID J:180370]

Walker CR; Hautefort I; Dalton JE; Overweg K; Egan CE; Bongaerts RJ; Newton DJ; Cruickshank SM; Andrew EM; Carding SR. 2013. Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge. PLoS One 8(12):e84553. [PubMed: 24358364]  [MGI Ref ID J:209854]

Wang T; Gao Y; Scully E; Davis CT; Anderson JF; Welte T; Ledizet M; Koski R; Madri JA; Barrett A; Yin Z; Craft J; Fikrig E. 2006. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. J Immunol 177(3):1825-32. [PubMed: 16849493]  [MGI Ref ID J:138027]

Warfield KL; Olinger G; Deal EM; Swenson DL; Bailey M; Negley DL; Hart MK; Bavari S. 2005. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175(2):1184-91. [PubMed: 16002721]  [MGI Ref ID J:100701]

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Witherden DA; Verdino P; Rieder SE; Garijo O; Mills RE; Teyton L; Fischer WH; Wilson IA; Havran WL. 2010. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 329(5996):1205-10. [PubMed: 20813954]  [MGI Ref ID J:163519]

Wohler JE; Smith SS; Zinn KR; Bullard DC; Barnum SR. 2009. Gammadelta T cells in EAE: early trafficking events and cytokine requirements. Eur J Immunol 39(6):1516-26. [PubMed: 19384874]  [MGI Ref ID J:149481]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryThis Tcrdtm1Mom strain is maintained by mating homozygous siblings. This strain should be housed under conditions similar to Prkdcscid/Prkdcscid mice or any other immunodeficient strain. Only homozygous mice may be ordered. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Tcrdtm1Mom  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Tcrdtm1Mom x Homozygous for Tcrdtm1Mom  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Tcrdtm1Mom  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Tcrdtm1Mom x Homozygous for Tcrdtm1Mom  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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General Terms and Conditions


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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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