Strain Name:

B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J

Stock Number:

002121

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Cryopreserved - Ready for recovery

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Mice homozygous for both the Tcrbtm1Mom and the Tcrdtm1Mom targeted mutations express no alpha beta T-cell receptor nor any gamma delta T-cell receptor. Homozygous mutant mice may develop mild inflammatory bowel disease.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
 
Donating Investigator Peter Mombaerts,   Max Planck Research Unit for Neurogenetics

Description
Mice homozygous for both the Tcrbtm1Mom and the Tcrdtm1Mom targeted mutations express no alpha beta T-cell receptor nor any gamma delta T-cell receptor. Under certain housing conditions homozygous mutant mice develop mild inflammatory bowel disease.

Development
The Tcrbtm1Mom Tcrdtm1Mom double targeted mutant strain was developed by Dr. Peter Mombaerts in the laboratory of Dr. Susumu Tonegawa at the Center for Cancer Research, Massachusetts Institute of Technology, by mating Tcrbtm1Mom and Tcrdtm1Mom targeted mutant mice produced in the same laboratory.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Tcrbtm1Mom     (6 strains)

View Strains carrying   Tcrdtm1Mom     (6 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
008430   B6.Cg-Tg(Tcrb)HRBAll/J
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
003303   C.Cg-Tg(DO11.10)10Dlo/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (44 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        involves: 129P2/OlaHsd * C57BL/6
  • respiratory system phenotype
  • abnormal respiratory system morphology
    • after 4 weeks, mice show absence of vascular remodeling of the airways in response to Mycoplasma pulmonis infection wherease wild-type show complex growth and reorganization ot the vascular beds   (MGI Ref ID J:119344)
  • abnormal respiratory system physiology
    • abnormalities in epithelial cell differentiation and mucus secretion are intermediate between wild-type and Igh-6 deficient mice after M. pulmonis infection   (MGI Ref ID J:119344)
  • immune system phenotype
  • *normal* immune system phenotype
    • proliferation of intestinal epithelial cells (IECs) and MHC class II expression on IECs is comparable to controls   (MGI Ref ID J:126867)
    • abnormal response to infection
      • bacteria are present in liver and kidney of mice after 4 weeks of M. pulmonis infection, but bacteria are absent from wild-type mouse tissue   (MGI Ref ID J:119344)
      • airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection   (MGI Ref ID J:119344)
    • decreased IgG level
      • mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected   (MGI Ref ID J:119344)
  • hematopoietic system phenotype
  • decreased IgG level
    • mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected   (MGI Ref ID J:119344)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        FVB.129P2-Tcrbtm1Mom Tcrdtm1Mom
  • immune system phenotype
  • *normal* immune system phenotype
    • no sign of spontaneous or contact dermatitis   (MGI Ref ID J:75915)

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
  • immune system phenotype
  • abnormal transitional stage B cell morphology
    • ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice   (MGI Ref ID J:187766)
  • decreased IgE level
    • IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type   (MGI Ref ID J:125656)
  • decreased IgG level   (MGI Ref ID J:187766)
    • in OVA-treated mutants, serum IgG is reduced below saline-treated control levels   (MGI Ref ID J:125656)
    • decreased IgG1 level
      • IgG1 is not detected in serum after OVA challenge   (MGI Ref ID J:125656)
  • decreased T cell number
    • in the spleen   (MGI Ref ID J:187766)
  • decreased autoantibody level
    • decrease in anti-chromatin IgG, anti-histone IgG, and anti-dsDNA IgG   (MGI Ref ID J:187766)
  • decreased plasma cell number
    • mutants exhibit a reduction in plasma cells (B220low IgD-CD138+)   (MGI Ref ID J:187766)
  • increased B cell number
    • in the spleen   (MGI Ref ID J:187766)
    • increased immature B cell number
      • 16-18 week old mutants exhibit increased numbers of immature B cells   (MGI Ref ID J:187766)
      • increased transitional stage T2 B cell number
        • mutants exhibit an elevation in T2 and to a lesser extent T3 B cells   (MGI Ref ID J:187766)
      • increased transitional stage T3 B cell number
        • mutants exhibit an elevation in T2 and to a lesser extent T3 B cells   (MGI Ref ID J:187766)
    • increased mature B cell number
      • mutants exhibit an elevation in mature B cells, including both marginal zone and follicular mature B-cell subsets   (MGI Ref ID J:187766)
      • increased follicular B cell number   (MGI Ref ID J:187766)
      • increased marginal zone B cell number   (MGI Ref ID J:187766)
  • increased IgM level
    • mutants exhibit elevated levels of IgM deposition within kidney glomeruli   (MGI Ref ID J:187766)
  • respiratory system phenotype
  • abnormal respiratory system physiology
    • ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation   (MGI Ref ID J:125656)
  • hematopoietic system phenotype
  • abnormal transitional stage B cell morphology
    • ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice   (MGI Ref ID J:187766)
  • decreased IgE level
    • IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type   (MGI Ref ID J:125656)
  • decreased IgG level   (MGI Ref ID J:187766)
    • in OVA-treated mutants, serum IgG is reduced below saline-treated control levels   (MGI Ref ID J:125656)
    • decreased IgG1 level
      • IgG1 is not detected in serum after OVA challenge   (MGI Ref ID J:125656)
  • decreased T cell number
    • in the spleen   (MGI Ref ID J:187766)
  • decreased plasma cell number
    • mutants exhibit a reduction in plasma cells (B220low IgD-CD138+)   (MGI Ref ID J:187766)
  • increased B cell number
    • in the spleen   (MGI Ref ID J:187766)
    • increased immature B cell number
      • 16-18 week old mutants exhibit increased numbers of immature B cells   (MGI Ref ID J:187766)
      • increased transitional stage T2 B cell number
        • mutants exhibit an elevation in T2 and to a lesser extent T3 B cells   (MGI Ref ID J:187766)
      • increased transitional stage T3 B cell number
        • mutants exhibit an elevation in T2 and to a lesser extent T3 B cells   (MGI Ref ID J:187766)
    • increased mature B cell number
      • mutants exhibit an elevation in mature B cells, including both marginal zone and follicular mature B-cell subsets   (MGI Ref ID J:187766)
      • increased follicular B cell number   (MGI Ref ID J:187766)
      • increased marginal zone B cell number   (MGI Ref ID J:187766)
  • increased IgM level
    • mutants exhibit elevated levels of IgM deposition within kidney glomeruli   (MGI Ref ID J:187766)
  • renal/urinary system phenotype
  • abnormal renal glomerulus morphology
    • mutants exhibit elevated levels of IgM deposition within kidney glomeruli, however IgG deposition in the glomeruli is not seen   (MGI Ref ID J:187766)

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        involves: 129 * BALB/c * C57BL/6
  • immune system phenotype
  • absent CD4-positive, alpha beta T cells
    • cells are absent in the thymus   (MGI Ref ID J:3206)
  • absent CD8-positive, alpha-beta T cells
    • cells are absent in the thymus   (MGI Ref ID J:3206)
  • arrested T cell differentiation
    • most T cells in the thymus do no progress to the double negative stage   (MGI Ref ID J:3206)
  • colitis
    • very mild colitis occurs in some aged mice   (MGI Ref ID J:15221)
  • decreased double-positive T cell number
    • double positive cells are not present   (MGI Ref ID J:3206)
  • thymus hypoplasia
    • about a 95% reduction in number of total thymocytes   (MGI Ref ID J:3206)
  • digestive/alimentary phenotype
  • colitis
    • very mild colitis occurs in some aged mice   (MGI Ref ID J:15221)
  • hematopoietic system phenotype
  • absent CD4-positive, alpha beta T cells
    • cells are absent in the thymus   (MGI Ref ID J:3206)
  • absent CD8-positive, alpha-beta T cells
    • cells are absent in the thymus   (MGI Ref ID J:3206)
  • arrested T cell differentiation
    • most T cells in the thymus do no progress to the double negative stage   (MGI Ref ID J:3206)
  • decreased double-positive T cell number
    • double positive cells are not present   (MGI Ref ID J:3206)
  • thymus hypoplasia
    • about a 95% reduction in number of total thymocytes   (MGI Ref ID J:3206)
  • endocrine/exocrine gland phenotype
  • thymus hypoplasia
    • about a 95% reduction in number of total thymocytes   (MGI Ref ID J:3206)

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        involves: 129P2/OlaHsd
  • immune system phenotype
  • *normal* immune system phenotype
    • the numbers of intraepithelial lymphocytes in the small intestine is normal   (MGI Ref ID J:97824)
    • decreased IgA level
      • in the serum compared to wild-type mice   (MGI Ref ID J:97824)
    • decreased lymphocyte cell number
      • the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice   (MGI Ref ID J:97824)
    • increased T cell number
      • the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrdtm1Mom homozygotes   (MGI Ref ID J:97824)
  • hematopoietic system phenotype
  • decreased IgA level
    • in the serum compared to wild-type mice   (MGI Ref ID J:97824)
  • decreased lymphocyte cell number
    • the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice   (MGI Ref ID J:97824)
  • increased T cell number
    • the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrdtm1Mom homozygotes   (MGI Ref ID J:97824)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Deficiency

Tcrbtm1Mom related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
      Inflammatory bowel disease
T Cell Receptor Signaling Defects

Tcrdtm1Mom related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
      Inflammatory bowel disease
T Cell Receptor Signaling Defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tcrbtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) CBeta-; TCR-Cbeta-; TCRb-; TCRbeta-; beta-;
Mutation Made By Peter Mombaerts,   Max Planck Research Unit for Neurogenetics
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Tcrb, T cell receptor beta chain
Chromosome 6
Gene Common Name(s) TCRbeta; Tib;
Molecular Note 15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. [MGI Ref ID J:22591]
 
Allele Symbol Tcrdtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) C-delta-; TCRdelta KO; TCRdelta-; delta-; delta0; gammadelta TCR-;
Mutation Made By Peter Mombaerts,   Max Planck Research Unit for Neurogenetics
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Tcrd, T cell receptor delta chain
Chromosome 14
Gene Common Name(s) Tcr delta; Tcrdelta;
Molecular Note A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showedan absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. [MGI Ref ID J:3865] [MGI Ref ID J:91942]

Genotyping

Genotyping Information

Genotyping Protocols

NEOTD (Generic Neo), Standard PCR
Tcrbtm1Mom, Melt Curve Analysis
Tcrbtm1Mom, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mombaerts P; Clarke AR; Rudnicki MA; Iacomini J; Itohara S; Lafaille JJ; Wang L; Ichikawa Y; Jaenisch R; Hooper ML; Tonegawa S. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491] Nature 360(6401):225-31. [PubMed: 1359428]  [MGI Ref ID J:3206]

Additional References

Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949]  [MGI Ref ID J:93752]

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72(3):337-48. [PubMed: 8381716]  [MGI Ref ID J:3865]

Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709]  [MGI Ref ID J:15221]

Tcrbtm1Mom related

Alcon VL; Luther C; Balce D; Takei F. 2009. B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity. Eur J Immunol 39(3):826-32. [PubMed: 19197938]  [MGI Ref ID J:146477]

Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178(6):3740-9. [PubMed: 17339472]  [MGI Ref ID J:144277]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949]  [MGI Ref ID J:93752]

Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302-5. [PubMed: 20220849]  [MGI Ref ID J:157973]

Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation. J Invest Dermatol 133(12):2695-705. [PubMed: 23752044]  [MGI Ref ID J:202870]

Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. [PubMed: 23529621]  [MGI Ref ID J:199531]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Ashcroft AJ; Cruickshank SM; Croucher PI; Perry MJ; Rollinson S; Lippitt JM; Child JA; Dunstan C; Felsburg PJ; Morgan GJ; Carding SR. 2003. Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity 19(6):849-61. [PubMed: 14670302]  [MGI Ref ID J:86997]

Astrakhan A; Omori M; Nguyen T; Becker-Herman S; Iseki M; Aye T; Hudkins K; Dooley J; Farr A; Alpers CE; Ziegler SF; Rawlings DJ. 2007. Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nat Immunol 8(5):522-31. [PubMed: 17401368]  [MGI Ref ID J:122410]

Auger JL; Haasken S; Steinert EM; Binstadt BA. 2012. Incomplete TCR-beta allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice. Eur J Immunol 42(9):2354-62. [PubMed: 22706882]  [MGI Ref ID J:187944]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baban B; Chandler PR; Johnson BA 3rd; Huang L; Li M; Sharpe ML; Francisco LM; Sharpe AH; Blazar BR; Munn DH; Mellor AL. 2011. Physiologic control of IDO competence in splenic dendritic cells. J Immunol 187(5):2329-35. [PubMed: 21813777]  [MGI Ref ID J:179269]

Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. [PubMed: 23835849]  [MGI Ref ID J:202249]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670]  [MGI Ref ID J:112329]

Bedel R; Berry R; Mallevaey T; Matsuda JL; Zhang J; Godfrey DI; Rossjohn J; Kappler JW; Marrack P; Gapin L. 2014. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A 111(1):E119-28. [PubMed: 24344267]  [MGI Ref ID J:206291]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272]  [MGI Ref ID J:97167]

Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809]  [MGI Ref ID J:118092]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439]  [MGI Ref ID J:131997]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

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Uezu K; Kawakami K; Miyagi K; Kinjo Y; Kinjo T; Ishikawa H; Saito A. 2004. Accumulation of gammadelta T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans. J Immunol 172(12):7629-34. [PubMed: 15187143]  [MGI Ref ID J:90820]

Van de Keere F; Tonegawa S. 1998. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 188(10):1875-82. [PubMed: 9815265]  [MGI Ref ID J:115028]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Veinotte LL; Greenwood CP; Mohammadi N; Parachoniak CA; Takei F. 2006. Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment. Blood 107(7):2673-9. [PubMed: 16317098]  [MGI Ref ID J:131242]

Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. [PubMed: 18227350]  [MGI Ref ID J:134359]

Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. [PubMed: 19641139]  [MGI Ref ID J:151875]

Victoratos P; Kollias G. 2009. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1):130-42. [PubMed: 19119026]  [MGI Ref ID J:143728]

Waggoner SN; Cornberg M; Selin LK; Welsh RM. 2012. Natural killer cells act as rheostats modulating antiviral T cells. Nature 481(7381):394-8. [PubMed: 22101430]  [MGI Ref ID J:180370]

Walker CR; Hautefort I; Dalton JE; Overweg K; Egan CE; Bongaerts RJ; Newton DJ; Cruickshank SM; Andrew EM; Carding SR. 2013. Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge. PLoS One 8(12):e84553. [PubMed: 24358364]  [MGI Ref ID J:209854]

Wang T; Gao Y; Scully E; Davis CT; Anderson JF; Welte T; Ledizet M; Koski R; Madri JA; Barrett A; Yin Z; Craft J; Fikrig E. 2006. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. J Immunol 177(3):1825-32. [PubMed: 16849493]  [MGI Ref ID J:138027]

Warfield KL; Olinger G; Deal EM; Swenson DL; Bailey M; Negley DL; Hart MK; Bavari S. 2005. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J Immunol 175(2):1184-91. [PubMed: 16002721]  [MGI Ref ID J:100701]

Weidanz WP; Kemp JR; Batchelder JM; Cigel FK; Sandor M; Heyde HC. 1999. Plasticity of immune responses suppressing parasitemia during acute Plasmodium chabaudi malaria. J Immunol 162(12):7383-8. [PubMed: 10358190]  [MGI Ref ID J:119884]

Wilbert OM; Weber-Arden J; Kabelitz D; Arden B. 1997. TCR-delta gene rearrangement and selection during fetal thymocyte development. J Immunol 159(7):3338-46. [PubMed: 9317132]  [MGI Ref ID J:43089]

Witherden DA; Verdino P; Rieder SE; Garijo O; Mills RE; Teyton L; Fischer WH; Wilson IA; Havran WL. 2010. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 329(5996):1205-10. [PubMed: 20813954]  [MGI Ref ID J:163519]

Wohler JE; Smith SS; Zinn KR; Bullard DC; Barnum SR. 2009. Gammadelta T cells in EAE: early trafficking events and cytokine requirements. Eur J Immunol 39(6):1516-26. [PubMed: 19384874]  [MGI Ref ID J:149481]

Wolfe DN; Karanikas AT; Hester SE; Kennett MJ; Harvill ET. 2010. IL-10 induction by Bordetella parapertussis limits a protective IFN-gamma response. J Immunol 184(3):1392-400. [PubMed: 20042578]  [MGI Ref ID J:159527]

Woodward AL; Spergel JM; Alenius H; Mizoguchi E; Bhan AK; Castigli E; Brodeur SR; Oettgen HC; Geha RS. 2001. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol 107(2):359-66. [PubMed: 11174205]  [MGI Ref ID J:106314]

Wu ZQ; Vos Q; Shen Y; Lees A; Wilson SR; Briles DE; Gause WC; Mond JJ; Snapper CM. 1999. In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions. J Immunol 163(2):659-67. [PubMed: 10395655]  [MGI Ref ID J:119892]

Xia M; Qi Q; Jin Y; Wiest DL; August A; Xiong N. 2010. Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells. J Immunol 184(12):6807-14. [PubMed: 20483745]  [MGI Ref ID J:161148]

Xiong N; Kang C; Raulet DH. 2002. Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity 16(3):453-63. [PubMed: 11911829]  [MGI Ref ID J:75624]

Xiong N; Zhang L; Kang C; Raulet DH. 2008. Gene placement and competition control T cell receptor gamma variable region gene rearrangement. J Exp Med 205(4):929-38. [PubMed: 18378791]  [MGI Ref ID J:133974]

Yager EJ; Ahmed M; Lanzer K; Randall TD; Woodland DL; Blackman MA. 2008. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med 205(3):711-23. [PubMed: 18332179]  [MGI Ref ID J:133102]

Yamazaki K; Shimada S; Kato-Nagaoka N; Soga H; Itoh T; Nanno M. 2005. Accumulation of intestinal intraepithelial lymphocytes in association with lack of polymeric immunoglobulin receptor. Eur J Immunol 35(4):1211-9. [PubMed: 15770700]  [MGI Ref ID J:97824]

Yang H; Antony PA; Wildhaber BE; Teitelbaum DH. 2004. Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol 172(7):4151-8. [PubMed: 15034027]  [MGI Ref ID J:88716]

Yang X; Hayglass KT; Brunham RC. 1998. Different roles are played by alpha beta and gamma delta T cells in acquired immunity to Chlamydia trachomatis pulmonary infection. Immunology 94(4):469-75. [PubMed: 9767433]  [MGI Ref ID J:49498]

Yang Y; Ghosn EE; Cole LE; Obukhanych TV; Sadate-Ngatchou P; Vogel SN; Herzenberg LA; Herzenberg LA. 2012. Antigen-specific antibody responses in B-1a and their relationship to natural immunity. Proc Natl Acad Sci U S A 109(14):5382-7. [PubMed: 22421134]  [MGI Ref ID J:182664]

Yang Y; Ghosn EE; Cole LE; Obukhanych TV; Sadate-Ngatchou P; Vogel SN; Herzenberg LA; Herzenberg LA. 2012. Antigen-specific memory in B-1a and its relationship to natural immunity. Proc Natl Acad Sci U S A 109(14):5388-93. [PubMed: 22421135]  [MGI Ref ID J:182663]

Yoshida S; Mohamed RH; Kajikawa M; Koizumi J; Tanaka M; Fugo K; Otsuka N; Maenaka K; Yagita H; Chiba H; Kasahara M. 2012. Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J Immunol 188(8):3972-9. [PubMed: 22403443]  [MGI Ref ID J:184082]

Yu P; Wang Y; Chin RK; Martinez-Pomares L; Gordon S; Kosco-Vibois MH; Cyster J; Fu YX. 2002. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol 168(10):5117-23. [PubMed: 11994465]  [MGI Ref ID J:127080]

Zachariadis O; Cassidy JP; Brady J; Mahon BP. 2006. gammadelta T cells regulate the early inflammatory response to bordetella pertussis infection in the murine respiratory tract. Infect Immun 74(3):1837-45. [PubMed: 16495558]  [MGI Ref ID J:107420]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhao N; Hao J; Ni Y; Luo W; Liang R; Cao G; Zhao Y; Wang P; Zhao L; Tian Z; Flavell R; Hong Z; Han J; Yao Z; Wu Z; Yin Z. 2011. Vgamma4 gammadelta T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis. J Immunol 187(10):5007-14. [PubMed: 21987663]  [MGI Ref ID J:179637]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis Tcrbtm1Mom Tcrdtm1Mom strain is maintained by mating homozygous siblings. This strain should be housed under conditions similar to Prkdcscid/Prkdcscid mice or any other immunodeficient strain. Only homozygous mice may be ordered.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   100903 B6129PF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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