Strain Name:

B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J

Stock Number:

002122

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129P2 via E14TG2a ES cell line
GenerationN12F35 (12-NOV-08)
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for both the Tcrbtm1Mom and the Tcrdtm1Mom targeted mutations express no alpha beta T-cell receptor nor any gamma delta T-cell receptor. Under certain housing conditions homozygous mutant mice develop mild inflammatory bowel disease.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tcrbtm1Mom allele
002118   B6.129P2-Tcrbtm1Mom/J
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002117   B6;129P2-Tcrbtm1Mom/J
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003447   CBy.129P2(B6)-Tcrbtm1Mom/SzJ
007081   CByJ.129P2(B6)-Tcrbtm1Mom/J
View Strains carrying   Tcrbtm1Mom     (6 strains)

Strains carrying   Tcrdtm1Mom allele
002120   B6.129P2-Tcrdtm1Mom/J
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002119   B6;129P2-Tcrdtm1Mom/J
008312   CBy.129P2(B6)-Tcrdtm1Mom/SzJ
003448   CByJ.129P2(B6)-Tcrdtm1Mom/Sz
View Strains carrying   Tcrdtm1Mom     (5 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
007962   B6.FVB-Tg(MMTV-neu/OT-I/OT-II)CBnel Tg(Trp53R172H)8512Jmr/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
004194   C57BL/6-Tg(TcraTcrb)425Cbn/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
007080   CByJ.B6-Tg(TcraTcrb)1100Mjb/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/Dvs
004259   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/+ Tg(TcrbAI4)1Dvs/+
004348   NOD.Cg-Rag1tm1Mom Tg(TcrbAI4)1Dvs/DvsJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi/DoiJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
003868   NOD/ShiLt-Tg(TcraAI4)1Dvs/+ Tg(TcrbAI4)1Dvs/+
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (33 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
  • immune system phenotype
  • decreased IgE level (MGI Ref ID J:125656)
    • IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type
  • decreased IgG level (MGI Ref ID J:125656)
    • in OVA-treated mutants, serum IgG is reduced below saline-treated control levels
    • decreased IgG1 level (MGI Ref ID J:125656)
      • IgG1 is not detected in serum after OVA challenge
  • respiratory system phenotype
  • abnormal respiratory system physiology (MGI Ref ID J:125656)
    • ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        FVB.129P2-Tcrbtm1Mom Tcrdtm1Mom
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:75915)
    • no sign of spontaneous or contact dermatitis

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        involves: 129P2/OlaHsd * C57BL/6
  • respiratory system phenotype
  • abnormal respiratory system morphology (MGI Ref ID J:119344)
    • after 4 weeks, mice show absence of vascular remodeling of the airways in response to Mycoplasma pulmonis infection wherease wild-type show complex growth and reorganization ot the vascular beds
  • abnormal respiratory system physiology (MGI Ref ID J:119344)
    • abnormalities in epithelial cell differentiation and mucus secretion are intermediate between wild-type and Igh-6 deficient mice after M. pulmonis infection
  • immune system phenotype
  • *normal* immune system phenotype (MGI Ref ID J:126867)
    • proliferation of intestinal epithelial cells (IECs) and MHC class II expression on IECs is comparable to controls
    • abnormal response to infection (MGI Ref ID J:119344)
      • bacteria are present in liver and kidney of mice after 4 weeks of M. pulmonis infection, but bacteria are absent from wild-type mouse tissue
      • airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection
    • decreased IgG level (MGI Ref ID J:119344)
      • mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected

Tcrbtm1Mom/Tcrbtm1Mom Tcrdtm1Mom/Tcrdtm1Mom

        involves: 129 * BALB/c * C57BL/6
  • immune system phenotype
  • absent CD4-positive T cells (MGI Ref ID J:3206)
    • cells are absent in the thymus
  • absent CD8-positive T cells (MGI Ref ID J:3206)
    • cells are absent in the thymus
  • arrested T cell differentiation (MGI Ref ID J:3206)
    • most T cells in the thymus do no progress to the double negative stage
  • colitis (MGI Ref ID J:15221)
    • very mild colitis occurs in some aged mice
  • decreased double-positive T cell number (MGI Ref ID J:3206)
    • double positive cells are not present
  • thymus hypoplasia (MGI Ref ID J:3206)
    • about a 95% reduction in number of total thymocytes
  • digestive/alimentary phenotype
  • colitis (MGI Ref ID J:15221)
    • very mild colitis occurs in some aged mice
  • hematopoietic system phenotype
  • absent CD4-positive T cells (MGI Ref ID J:3206)
    • cells are absent in the thymus
  • absent CD8-positive T cells (MGI Ref ID J:3206)
    • cells are absent in the thymus
  • arrested T cell differentiation (MGI Ref ID J:3206)
    • most T cells in the thymus do no progress to the double negative stage
  • decreased double-positive T cell number (MGI Ref ID J:3206)
    • double positive cells are not present
  • thymus hypoplasia (MGI Ref ID J:3206)
    • about a 95% reduction in number of total thymocytes
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tcrb related

Immunology and Inflammation Research
Inflammation

Tcrbtm1Mom related

Hematological Research
Immunological Defects

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects

Tcrdtm1Mom related

Hematological Research
Immunological Defects

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation (Inflammatory bowel disease)
T Cell Receptor Signaling Defects

Research Tools
Immunology and Inflammation Research (T Cell Receptor Deficiency)

Genes & Alleles

Gene & Allele Information

Allele Symbol Tcrbtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (knock-out)
Common Name(s) TCR-Cbeta-; TCRbeta-; beta-;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Tcrb, T-cell receptor beta chain
Chromosome 6
Gene Common Name(s) TRB; Tib;
Molecular Note 15kb of sequence was deleted by the insertion of a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. [MGI Ref ID J:22591]
 
Allele Symbol Tcrdtm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (knock-out)
Common Name(s) C-delta-; TCRdelta KO; TCRdelta-; delta-; delta0; gamadelta TCR<->;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129
ES Cell Line NameOther (see notes)
ES Cell Line Strain129
Gene Symbol and Name Tcrd, T-cell receptor delta chain
Chromosome 14
Gene Common Name(s) TCRDV1; TRD; Tcr delta; Tcrdelta;
General Note ES cell line = E14 (129P2/OlaHsd) or D3 (129S2/SvPas).
Molecular Note A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showedan absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. [MGI Ref ID J:3865] [MGI Ref ID J:91942]

Genotyping

Genotyping Information

Genotyping Protocols

NEOTD (Generic Neo), STD PCR, vers. 1
Tcrbtm1Mom, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Mombaerts P; Clarke AR; Rudnicki MA; Iacomini J; Itohara S; Lafaille JJ; Wang L; Ichikawa Y; Jaenisch R; Hooper ML; Tonegawa S. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages [published erratum appears in Nature 1992 Dec 3;360(6403):491] Nature 360(6401):225-31. [PubMed: 1359428]  [MGI Ref ID J:3206]

Additional References

Allen CD; Ansel KM; Low C; Lesley R; Tamamura H; Fujii N; Cyster JG. 2004. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 5(9):943-52. [PubMed: 15300245]  [MGI Ref ID J:92218]

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72(3):337-48. [PubMed: 8381716]  [MGI Ref ID J:3865]

Jude BA; Pobezinskaya Y; Bishop J; Parke S; Medzhitov RM; Chervonsky AV; Golovkina TV. 2003. Subversion of the innate immune system by a retrovirus. Nat Immunol 4(6):573-8. [PubMed: 12730691]  [MGI Ref ID J:83088]

Mombaerts P; Mizoguchi E; Grusby MJ; Glimcher LH; Bhan AK; Tonegawa S. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice [see comments] Cell 75(2):274-82. [PubMed: 8104709]  [MGI Ref ID J:15221]

Ngo VN; Cornall RJ; Cyster JG. 2001. Splenic T zone development is B cell dependent. J Exp Med 194(11):1649-60. [PubMed: 11733579]  [MGI Ref ID J:73100]

Peters W; Cyster JG; Mack M; Schlondorff D; Wolf AJ; Ernst JD; Charo IF. 2004. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol 172(12):7647-53. [PubMed: 15187146]  [MGI Ref ID J:90822]

Seagal J; Melamed D. 2004. Contribution of alphabeta and gammadelta T cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin- mu-deficient/lpr mice. Immunology 112(2):265-73. [PubMed: 15147570]  [MGI Ref ID J:90503]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

Tcrbtm1Mom related

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949]  [MGI Ref ID J:93752]

Arnold CN; Campbell DJ; Lipp M; Butcher EC. 2007. The germinal center response is impaired in the absence of T cell-expressed CXCR5. Eur J Immunol 37(1):100-9. [PubMed: 17171760]  [MGI Ref ID J:117042]

Ashcroft AJ; Cruickshank SM; Croucher PI; Perry MJ; Rollinson S; Lippitt JM; Child JA; Dunstan C; Felsburg PJ; Morgan GJ; Carding SR. 2003. Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity 19(6):849-61. [PubMed: 14670302]  [MGI Ref ID J:86997]

Astrakhan A; Omori M; Nguyen T; Becker-Herman S; Iseki M; Aye T; Hudkins K; Dooley J; Farr A; Alpers CE; Ziegler SF; Rawlings DJ. 2007. Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nat Immunol 8(5):522-31. [PubMed: 17401368]  [MGI Ref ID J:122410]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670]  [MGI Ref ID J:112329]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272]  [MGI Ref ID J:97167]

Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809]  [MGI Ref ID J:118092]

Blais ME; Brochu S; Giroux M; Belanger MP; Dulude G; Sekaly RP; Perreault C. 2008. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180(4):2299-312. [PubMed: 18250439]  [MGI Ref ID J:131997]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Bonorino C; Nardi NB; Zhang X; Wysocki LJ. 1998. Characteristics of the strong antibody response to mycobacterial Hsp70: a primary, T cell-dependent IgG response with no evidence of natural priming or gamma delta T cell involvement. J Immunol 161(10):5210-6. [PubMed: 9820492]  [MGI Ref ID J:115026]

Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693]  [MGI Ref ID J:132284]

Borchers MT; Wesselkamper SC; Eppert BL; Motz GT; Sartor MA; Tomlinson CR; Medvedovic M; Tichelaar JW. 2008. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci 105(1):188-99. [PubMed: 18515264]  [MGI Ref ID J:139766]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Buchanan RM; Arulanandam BP; Metzger DW. 1998. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells. J Immunol 161(10):5525-33. [PubMed: 9820529]  [MGI Ref ID J:115023]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Caccamo N; Sireci G; Meraviglia S; Dieli F; Ivanyi J; Salerno A. 2006. gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis. Eur J Immunol 36(10):2681-90. [PubMed: 16981183]  [MGI Ref ID J:118094]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Cariappa A; Mazo IB; Chase C; Shi HN; Liu H; Li Q; Rose H; Leung H; Cherayil BJ; Russell P; von Andrian U; Pillai S. 2005. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity 23(4):397-407. [PubMed: 16226505]  [MGI Ref ID J:113277]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chandler P; Frater AJ; Douek DC; Viney JL; Kay G; Owen MJ; Hayday AC; Simpson E; Altmann DM. 1995. Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells. Immunology 85(4):531-7. [PubMed: 7558145]  [MGI Ref ID J:28872]

Chin EY; Dangler CA; Fox JG; Schauer DB. 2000. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice. Comp Med 50(6):586-94. [PubMed: 11200563]  [MGI Ref ID J:66813]

Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364]  [MGI Ref ID J:81809]

Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077]  [MGI Ref ID J:112051]

Colombo MJ; Alugupalli KR. 2008. Complement Factor H-Binding Protein, a Putative Virulence Determinant of Borrelia hermsii, Is an Antigenic Target for Protective B1b Lymphocytes. J Immunol 180(7):4858-64. [PubMed: 18354209]  [MGI Ref ID J:133379]

Compton SR; Ball-Goodrich LJ; Johnson LK; Johnson EA; Paturzo FX; Macy JD. 2004. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comp Med 54(6):681-9. [PubMed: 15679267]  [MGI Ref ID J:96019]

Corthay A; Johansson A; Vestberg M; Holmdahl R. 1999. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol 11(7):1065-73. [PubMed: 10383939]  [MGI Ref ID J:56725]

Cretin N; Bracy J; Hanson K; Iacomini J. 2002. The role of T cell help in the production of antibodies specific for Gal alpha 1-3Gal. J Immunol 168(3):1479-83. [PubMed: 11801692]  [MGI Ref ID J:112060]

Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563]  [MGI Ref ID J:125656]

Crosby JR; Shen HH; Borchers MT; Justice JP; Ansay T; Lee JJ; Lee NA. 2002. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am J Physiol Lung Cell Mol Physiol 282(1):L99-108. [PubMed: 11741821]  [MGI Ref ID J:107840]

Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938]  [MGI Ref ID J:117988]

Deepe GS Jr; Gibbons RS. 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180(2):1088-97. [PubMed: 18178849]  [MGI Ref ID J:130944]

Degermann S; Sollami G; Karjalainen K. 1999. Impaired NK1.1 T cell development in mice transgenic for a T cell receptor beta chain lacking the large, solvent-exposed cbeta FG loop. J Exp Med 190(9):1357-62. [PubMed: 10544207]  [MGI Ref ID J:58321]

Dianda L; Gulbranson-Judge A; Pao W; Hayday AC; MacLennan IC; Owen MJ. 1996. Germinal center formation in mice lacking alpha beta T cells. Eur J Immunol 26(7):1603-7. [PubMed: 8766567]  [MGI Ref ID J:113041]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906]  [MGI Ref ID J:82106]

Egan CE; Dalton JE; Andrew EM; Smith JE; Gubbels MJ; Striepen B; Carding SR. 2005. A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology. J Immunol 175(12):8191-9. [PubMed: 16339558]  [MGI Ref ID J:122276]

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