Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Background Strain C57BL/6J Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2) Generation N6F5p   Donating Investigator Arthur Beaudet,   Baylor College of Medicine

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Icam1^tm1Bay targeted mutation are viable and fertile but lack surface ICAM1 expression. There is a mild increase in neutrophil count and impaired neutrophil emigration. Contact hypersensitivity is suppressed. A severe defect in T-cells does not allow function as stimulator cells in the mixed lymphocyte reaction. Mice from this targeted mutation express residual amounts of ICAM1 in the thymus and lung. ICAM1 expression is the result of alternative splicing of RNA causing the mutated exon 5 to be skipped causing three different alternative isoforms. Additional isoforms have been identified in wildtype mice. All alternatively spliced isoforms of ICAM1 detected are missing complete extracellular immunoglobulin domains. In addition, all, except one, retain the ability to bind to the counter-receptor LFA1.

Development
The Icam1^tm1Bay mutant strain was developed in the laboratory of Dr. Arthur Beaudet at Baylor College of Medicine. A targeting vector was used that resulted in the disruption of exon 5 of the Icam1 gene. The 129-derived AB1 ES cell line was used.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Related Strains

Strains carrying   Icam1^tm1Bay allele

002285

B6.129S7-Icam1tm1Bay Selptm1Bay/J

View Strains carrying   Icam1^tm1Bay     (1 strain)

Strains carrying other alleles of Icam1

002867	B6.129S4-Icam1tm1Jcgr/J
006351	NOD.129S4(B6)-Icam1tm1Jcgr/J
005983	NOD.129S4(B6)-Icam1tm1Jcgr/SmtnJ

View Strains carrying other alleles of Icam1     (3 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Icam1^tm1Bay/Icam1^tm1Bay

        B6.129S7-Icam1^tm1Bay

• growth/size phenotype
• increased body weight (MGI Ref ID J:48271)
  • mice are ~20% heavier than wild-type or Sell^tm1Tft mutant mice
• immune system phenotype
• abnormal leukocyte migration/homing (MGI Ref ID J:24239)
  • Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 64% after 4 hours
• abnormal leukocyte rolling (MGI Ref ID J:48271)
  • Tnfa (TNFalpha) treatment increases leukocyte rolling flux fraction slightly compared to wild-type
  • rolling velocities of leukocytes are slightly greater compared to wild-type mice at times <30 minutes after surgery; >60 minutes after surgery-induced inflammation, rolling velocities are significantly faster than wild-type (58 vs 38 um/second)
  • similar results on rolling velocity are observed with Tnfa-activated rolling as induced by surgical trauma
• abnormal leukocyte transmigration (MGI Ref ID J:48271)
  • 2 hours after thioglycollate-induced peritonitis, neutrophil entry into peritoneum is significantly inhibited by 61% compared to wild-type
• decreased susceptibility to endotoxin shock (MGI Ref ID J:123460)
  • following treatment with a lethal dose of LPS, mice succumb after 10 hours compared to wild-type mice that succumb after 8 hours
  • mice only develop mild liver injury in response to low doses of LPS at 8 hours that does not worsen compared to wild-type mice that exhibit liver severe injury at 6 hours
• increased eosinophil cell number (MGI Ref ID J:48271)
  • increased significantly compared to wild-type (178% of wild-type)
• increased lymphocyte cell number (MGI Ref ID J:48271)
  • number of circulating lymphocytes is increased over wild-type (47% of wild-type number)
• increased monocyte cell number (MGI Ref ID J:48271)
  • number of circulating monocytes is increased over wild-type (223% of wild-type number)
• increased neutrophil cell number (MGI Ref ID J:24239)
  • 4-5 fold increase in numbers of circulating neutrophils
  • number of circulating neutrophils is increased over wild-type (190% of wild-type number)
• hematopoietic system phenotype
• increased eosinophil cell number (MGI Ref ID J:48271)
  • increased significantly compared to wild-type (178% of wild-type)
• increased lymphocyte cell number (MGI Ref ID J:48271)
  • number of circulating lymphocytes is increased over wild-type (47% of wild-type number)
• increased monocyte cell number (MGI Ref ID J:48271)
  • number of circulating monocytes is increased over wild-type (223% of wild-type number)
• increased neutrophil cell number (MGI Ref ID J:24239)
  • 4-5 fold increase in numbers of circulating neutrophils
  • number of circulating neutrophils is increased over wild-type (190% of wild-type number)
• tumorigenesis
• increased tumor growth/size (MGI Ref ID J:108135)
  • when injected with melanoma cells, mice exhibit a 2.6 fold increase in tumor volume on day 14 compared to wild-type mice

Icam1^tm1Bay/Icam1^tm1Bay

        either: B6.129S7-Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

• hematopoietic system phenotype
• increased leukocyte cell number (MGI Ref ID J:31374)
  • systemic leukocyte counts are ~7670/ul (~62% neutrophils, ~36% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)
• immune system phenotype
• abnormal leukocyte rolling (MGI Ref ID J:31374)
  • blocking of L-selection with monoclonal antibodies reduces rolling flux fraction of leukocytes to ~30 from 49%, but causes a greater reduction to ~6% in wild-type
• increased leukocyte cell number (MGI Ref ID J:31374)
  • systemic leukocyte counts are ~7670/ul (~62% neutrophils, ~36% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)

Icam1^tm1Bay/Icam1^tm1Bay

        B6.129S7-Icam1^tm1Bay/J

• life span-post-weaning/aging
• premature death (MGI Ref ID J:118466)
  • mutants and wild-type mice treated with streptozotocin to induce diabetes display significantly increased mortality after 12 months of disease compared to untreated controls
• vision/eye phenotype
• abnormal eye physiology (MGI Ref ID J:118466)
  • in the diabetes models, 11-month diabetic mutants have decreased numbers of injured endothelial cells (<5%) compared to diabetic wild-type controls
• abnormal retina morphology (MGI Ref ID J:118466)
  • in the galactose- and streptozotocin-induced diabetes models, after 11 months, mutants have fewer adherent leukocytes in the retina compared to diabetic controls; number of adherent leukocytes in the retina in 11-month diabetic mutants does not differ from number in non-diabetic controls
  • diabetic wild-type mice at 11 months of disease have a 3.1-fold increase in adherent leukocyte number compared with non-diabetic controls
  • compared to diabetic wild-type controls, number of endothelial cells in diabetic mutants are higher and comparable to non-diabetic wild-type controls
  • 11-month diabetic wild-type mice have 3.8-fold more acellular capillaries compared to non-diabetic controls; in diabetic mutants, this pathology is suppressed by 56% with number of acellular capillaries similar to that in non-diabetic wild-type controls
  • at 11 months, numbers of normal appearing pericytes in retinas of diabetic mutants are significantly greater than number in diabetic wild-type controls
  • at 22 months, galactosemic mutants show almost less endothelial cell loss (19% vs 25% in galactosemic wild-type mice), no pericyte loss, and less acellular capillary formation (by 55%) than galactosemic wild-type controls compared to euglycemic wild-type mice
  • no basement membrane thickening is observed in diabetic and galactosemic mutants compared to that observed in diabetic and galactosemic wild-type controls
  • following laser photocoagulation (1,2, and 4 weeks after), significantly less pathologically significant leakage (fewer grade-2B lesions) develops in mutants compared to wild-type
  • at weeks 1 and 4, mutants have fewer grade-2B lesions than wild-type mice
  • mice have more nonleaky (grade 0) lesions than Icam1-null or wild-type mice at week 4
• abnormal retinal vasculature (MGI Ref ID J:118466)
  • in diabetes models, mutants exhibit decreased retinal-blood barrier breakdown compared to diabetic controls at 11 months
• increased resistance to induced choroidal neovascularization (MGI Ref ID J:119416)
  • at 2 weeks after laser injury, volume of choroidal neovascularization (CNV) is reducedby ~75.7% compared to wild-type mice
  • mutants have markedly smaller CNV membranes 2 weeks after injury compared to wild-type
• homeostasis/metabolism phenotype
• increased circulating glucose level (MGI Ref ID J:118466)
  • blood glucose levels are significantly increased in mutants and controls with streptozotocin treatment or high galactose diet
• cardiovascular system phenotype
• abnormal retinal vasculature (MGI Ref ID J:118466)
  • in diabetes models, mutants exhibit decreased retinal-blood barrier breakdown compared to diabetic controls at 11 months
• increased resistance to induced choroidal neovascularization (MGI Ref ID J:119416)
  • at 2 weeks after laser injury, volume of choroidal neovascularization (CNV) is reducedby ~75.7% compared to wild-type mice
  • mutants have markedly smaller CNV membranes 2 weeks after injury compared to wild-type

Icam1^tm1Bay/Icam1^tm1Bay

        B6.129S7-Icam1^tm1Bay

• cardiovascular system phenotype
• decreased angiogenesis (MGI Ref ID J:118196)
  • in a disk angiogenesis assay, no increase in capillary density in response to Vegfa is observed in the dermal vasculature overlying implanted disks, whereas wild-type mice show a clear increase in capillary density in response to Vegfa
• cellular phenotype
• abnormal cell physiology (MGI Ref ID J:118196)
  • endothelial cells show attenuated chemotactic response to Vegfa in transwell chemotactic assays compared with wild-type control cells
• abnormal cell migration (MGI Ref ID J:118196)
• homeostasis/metabolism phenotype
• abnormal nitric oxide homeostasis (MGI Ref ID J:118196)
  • in endothelial cell culture, Vegf-dependent and basal nitric oxide production is attenuated relative to wild-type cells

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Icam1^tm1Bay/Icam1^tm1Bay

        involves: 129S7/SvEvBrd * C57BL/6J

• immune system phenotype
• abnormal immune system physiology (MGI Ref ID J:14565)
  • spleen cells show a marked reduction in ability to function as stimulator cells in a mixed lymphocyte reaction (MLR) assay, compared to wild-type cells; however, isolated T cells respond similarly to wild-type cells to allogeneic stimulaton
• abnormal leukocyte transmigration (MGI Ref ID J:14565)
  • in an induced peritonitis model, total numbers of neutrophils that underwent transendothelial migration into the peritoneal cavity, as well as percentage of neutrophils relative to all leukocytes in exudate are reduced relative to controls
  • 3 hours after thioglycollate injection to induce peritonitis, neutrophil count in blood is elevated above resting state and, 8 hours after peritonitis induction, peritonitis analysis shows 76% neutrophils wild-type compared to 43% in mutants; this indicates a defect in transendothelial migration, not just a delay
• decreased susceptibility to type IV hypersensitivity reaction (MGI Ref ID J:14565)
  • application of DTNB to the ear of mutant mice 7-19 weeks old 5 days following sensitization to DTNB shows a 74% reduction in ear swelling compared to wild-type after 24 hours
• increased neutrophil cell number (MGI Ref ID J:14565)
  • count in peripheral blood is increased to ~4.1x10⁵ in mutants from 1.0x10⁵ in controls at 2-4 months
  • 3 hours after thioglycollate injection to induce peritonitis, neutrophil count in blood is elevated above resting state
• hematopoietic system phenotype
• increased neutrophil cell number (MGI Ref ID J:14565)
  • count in peripheral blood is increased to ~4.1x10⁵ in mutants from 1.0x10⁵ in controls at 2-4 months
  • 3 hours after thioglycollate injection to induce peritonitis, neutrophil count in blood is elevated above resting state

Icam1^tm1Bay/Icam1^tm1Bay

        involves: 129S7/SvEvBrd * C57BL/6

• immune system phenotype
• impaired neutrophil recruitment (MGI Ref ID J:112286)
  • dermal neutrophil emigration is reduced by 61% compared to wild-type in croton oil-induced dermatitis in 7-14 week old animals
• increased neutrophil cell number (MGI Ref ID J:112286)
  • circulating neutrophils are increased in mutants and this increases with age of mice
• large intestinal inflammation (MGI Ref ID J:111227)
  • mutants treated with dextran sodium sulfate (DSS) show attenuated eosinophilic inflammation and lower luminal erythropoietin activity than DSS-treated wild-type mice
• decreased susceptibility to induced colitis (MGI Ref ID J:111227)
  • DSS-treated mice show significantly attenuated colonic injury compared to DSS-treated wild-type mice; physical symptoms (disease activity index, diarrhea, rectal bleeding) and histopathological features (epithelial layer ulceration, sumbucosa edema, crypt damage) are reduced compared to wild-type controls
• hematopoietic system phenotype
• increased neutrophil cell number (MGI Ref ID J:112286)
  • circulating neutrophils are increased in mutants and this increases with age of mice
• digestive/alimentary phenotype
• large intestinal inflammation (MGI Ref ID J:111227)
  • mutants treated with dextran sodium sulfate (DSS) show attenuated eosinophilic inflammation and lower luminal erythropoietin activity than DSS-treated wild-type mice
• decreased susceptibility to induced colitis (MGI Ref ID J:111227)
  • DSS-treated mice show significantly attenuated colonic injury compared to DSS-treated wild-type mice; physical symptoms (disease activity index, diarrhea, rectal bleeding) and histopathological features (epithelial layer ulceration, sumbucosa edema, crypt damage) are reduced compared to wild-type controls

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Internal/Organ Research
Wound Healing (delayed/impaired)

Icam1^tm1Bay related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation

Genes & Alleles

Gene & Allele Information

Allele Symbol		Icam1tm1Bay
Allele Name		targeted mutation 1, Baylor College of Medicine
Allele Type		Targeted (knock-out)
Common Name(s)		CD54-; ICAM-1-;
Mutation Made By		Arthur Beaudet,   Baylor College of Medicine
Strain of Origin		129S7/SvEvBrd-Hprt1<+>
ES Cell Line Name		AB1
ES Cell Line Strain		129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name		Icam1, intercellular adhesion molecule 1
Chromosome		9
Gene Common Name(s)		BB2; CD54; ICAM; Icam-1; Ly-47; MALA-2; MGC:6195; P3.58; lymphocyte antigen 47;
Molecular Note		A neomycin resistance cassette was inserted into exon 5 of the gene. Subsequent analysis reported by King, et. al. (J:25530) revealed the presence of alternatively spliced transcripts in both wild-type and homozygous mutant mice. Protein expression was detected in mutant mice in medullary stromal cells of the thymus, as well as in the lung and spleen. Variable splicing of exons 2 through 6, encoding extracellular Ig domains, results in the production of 3 isoforms (2-6, 3-6, 4-6, where the numbers refer to spliced exons) in mutant mice. In addition to the 3 found in mutant mice, 2 other alternative splice forms including exon 5 were identified in wild-type mice. The reading frame and exons 1 and 7, encoding the signal sequence and both the transmembrane and cytosolic domains, are left intact in each isoform. [MGI Ref ID J:14565] [MGI Ref ID J:25530]

Genotyping

Genotyping Information

Genotyping Protocols

Icam1^tm1Bay, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Sligh JE Jr; Ballantyne CM; Rich SS; Hawkins HK; Smith CW; Bradley A; Beaudet AL. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A 90(18):8529-33. [PubMed: 8104338]  [MGI Ref ID J:14565]

Additional References

Bullard DC; Hurley LA; Lorenzo I; Sly LM; Beaudet AL; Staite ND. 1996. Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1. J Immunol 157(7):3153-8. [PubMed: 8816427]  [MGI Ref ID J:36071]

Hamaguchi Y; Nishizawa Y; Yasui M; Hasegawa M; Kaburagi Y; Komura K; Nagaoka T; Saito E; Shimada Y; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Am J Pathol 161(5):1607-18. [PubMed: 12414509]  [MGI Ref ID J:79905]

Kadono T; Venturi GM; Steeber DA; Tedder TF. 2002. Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol 169(8):4542-50. [PubMed: 12370391]  [MGI Ref ID J:79530]

Kato A; Gabay C; Okaya T; Lentsch AB. 2002. Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion. Am J Pathol 161(5):1797-803. [PubMed: 12414526]  [MGI Ref ID J:79907]

King PD; Sandberg ET; Selvakumar A; Fang P; Beaudet AL; Dupont B. 1995. Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing. J Immunol 154(11):6080-6093. [PubMed: 7751650]  [MGI Ref ID J:25530]

Lacha J; Bushell A; Smetana K; Rossmann P; Pribylova P; Wood K; Maly P. 2002. Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models. J Leukoc Biol 71(2):311-8. [PubMed: 11818453]  [MGI Ref ID J:74694]

Murray HW; Lu CM; Brooks EB; Fichtl RE; DeVecchio JL; Heinzel FP. 2003. Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Infect Immun 71(11):6453-62. [PubMed: 14573667]  [MGI Ref ID J:86275]

Nagaoka T; Kaburagi Y; Hamaguchi Y; Hasegawa M; Takehara K; Steeber DA; Tedder TF; Sato S. 2000. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol 157(1):237-47. [PubMed: 10880393]  [MGI Ref ID J:63135]

Selzner N; Selzner M; Odermatt B; Tian Y; Van Rooijen N; Clavien PA. 2003. ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology 124(3):692-700. [PubMed: 12612908]  [MGI Ref ID J:82107]

Shimizu A; Sasaki H; Aoyagi K; Yoshida M; Kato K; Heike Y; Ikarashi Y; Shirakawa K; Takaue Y; Miyajima A; Terada M; Nagai H; Wakasugi H. 2004. The mouse natural killer T cell-associated antigen recognized by U5A2-13 monoclonal antibody is intercellular adhesion molecule-1. Immunol Lett 92(3):227-35. [PubMed: 15081617]  [MGI Ref ID J:89516]

Sun G; Chang WL; Li J; Berney SM; Kimpel D; van der Heyde HC. 2003. Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria. Infect Immun 71(11):6553-61. [PubMed: 14573677]  [MGI Ref ID J:86276]

Icam1^tm1Bay related

Aoudjit F; Potworowski EF; Springer TA; St-Pierre Y. 1998. Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event. J Immunol 161(5):2333-8. [PubMed: 9725228]  [MGI Ref ID J:49717]

Avellino AM; Dailey AT; Harlan JM; Sharar SR; Winn RK; McNutt LD; Kliot M. 2004. Blocking of up-regulated ICAM-1 does not prevent macrophage infiltration during Wallerian degeneration of peripheral nerve. Exp Neurol 187(2):430-44. [PubMed: 15144869]  [MGI Ref ID J:90583]

Baker PJ; DuFour L; Dixon M; Roopenian DC. 2000. Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68(6):3103-7. [PubMed: 10816450]  [MGI Ref ID J:62266]

Bendjelloul F; Maly P; Mandys V; Jirkovska M; Prokesova L; Tuckova L; Tlaskalova-Hogenova H. 2000. Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis. Clin Exp Immunol 119(1):57-63. [PubMed: 10606964]  [MGI Ref ID J:110249]

Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426]  [MGI Ref ID J:132002]

Bourdillon MC; Poston RN; Covacho C; Chignier E; Bricca G; McGregor JL. 2000. ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol 20(12):2630-5. [PubMed: 11116064]  [MGI Ref ID J:103384]

Briaud SA; Ding ZM; Michael LH; Entman ML; Daniel S; Ballantyne CM. 2001. Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice. Am J Physiol Heart Circ Physiol 280(1):H60-7. [PubMed: 11123218]  [MGI Ref ID J:68056]

Broide DH; Humber D; Sullivan S; Sriramarao P. 1998. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice [published erratum appears in Blood 1998 Jul 1;92(1):343] Blood 91(8):2847-56. [PubMed: 9531595]  [MGI Ref ID J:47461]

Broide DH; Sullivan S; Gifford T; Sriramarao P. 1998. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18(2):218-25. [PubMed: 9476909]  [MGI Ref ID J:114264]

Bullard DC; Hurley LA; Lorenzo I; Sly LM; Beaudet AL; Staite ND. 1996. Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1. J Immunol 157(7):3153-8. [PubMed: 8816427]  [MGI Ref ID J:36071]

Bullard DC; King PD; Hicks MJ; Dupont B; Beaudet AL; Elkon KB. 1997. Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality. J Immunol 159(4):2058-67. [PubMed: 9257874]  [MGI Ref ID J:42669]

Bullard DC; Qin L; Lorenzo I; Quinlin WM; Doyle NA; Bosse R; Vestweber D; Doerschuk CM; Beaudet AL. 1995. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli [see comments] J Clin Invest 95(4):1782-8. [PubMed: 7535798]  [MGI Ref ID J:24239]

Calingasan NY; Huang PL; Chun HS; Fabian A; Gibson GE. 2000. Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. J Neuropathol Exp Neurol 59(3):207-17. [PubMed: 10744059]  [MGI Ref ID J:62409]

Carrithers MD; Visintin I; Viret C; Janeway CS Jr. 2002. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol 129(1-2):51-7. [PubMed: 12161020]  [MGI Ref ID J:102957]

Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. [PubMed: 10620617]  [MGI Ref ID J:59249]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davis SL; Hawkins EP; Mason EO Jr; Smith CW; Kaplan SL. 1996. Host defenses against disseminated candidiasis are impaired in intercellular adhesion molecule 1-deficient mice. J Infect Dis 174(2):435-9. [PubMed: 8699084]  [MGI Ref ID J:34394]

Doerschuk CM; Quinlan WM; Doyle NA; Bullard DC; Vestweber D; Jones ML; Takei F; Ward PA; Beaudet AL. 1996. The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 157(10):4609-14. [PubMed: 8906840]  [MGI Ref ID J:37197]

Emoto M; Emoto Y; Brinkmann V; Miyamoto M; Yoshizawa I; Staber M; van Rooijen N; Hamann A; Kaufmann SH. 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. J Immunol 171(2):584-93. [PubMed: 12847222]  [MGI Ref ID J:123460]

Emoto M; Mittrucker HW; Schmits R; Mak TW; Kaufmann SH. 1999. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J Immunol 162(9):5094-8. [PubMed: 10227978]  [MGI Ref ID J:111009]

Eppihimer MJ; Russell J; Anderson DC; Wolitzky BA; Granger DN. 1997. Endothelial cell adhesion molecule expression in gene-targeted mice. Am J Physiol 273(4 Pt 2):H1903-8. [PubMed: 9362259]  [MGI Ref ID J:43907]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Furusho S; Myou S; Fujimura M; Kita T; Yasui M; Kasahara K; Nakao S; Takehara K; Sato S. 2006. Role of intercellular adhesion molecule-1 in a murine model of toluene diisocyanate-induced asthma. Clin Exp Allergy 36(10):1294-302. [PubMed: 17014439]  [MGI Ref ID J:135960]

Graciano AL; Bryant DD; White DJ; Horton J; Bowles NE; Giroir BP. 2001. Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-alpha transgenic mice. Am J Physiol Heart Circ Physiol 280(4):H1464-71. [PubMed: 11247755]  [MGI Ref ID J:108278]

Gregoire FM; Zhang Q; Smith SJ; Tong C; Ross D; Lopez H; West DB. 2002. Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. Am J Physiol Endocrinol Metab 282(3):E703-13. [PubMed: 11832376]  [MGI Ref ID J:75612]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hafezi-Moghadam A; Thomas KL; Prorock AJ; Huo Y; Ley K. 2001. L-selectin shedding regulates leukocyte recruitment. J Exp Med 193(7):863-72. [PubMed: 11283159]  [MGI Ref ID J:120579]

Hallahan DE; Virudachalam S. 1997. Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation. Proc Natl Acad Sci U S A 94(12):6432-7. [PubMed: 9177235]  [MGI Ref ID J:111185]

Hamaguchi Y; Nishizawa Y; Yasui M; Hasegawa M; Kaburagi Y; Komura K; Nagaoka T; Saito E; Shimada Y; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Am J Pathol 161(5):1607-18. [PubMed: 12414509]  [MGI Ref ID J:79905]

Hancock WW; Tsai TL; Madaio MP; Gasser DL. 2003. Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171(6):2778-81. [PubMed: 12960297]  [MGI Ref ID J:85380]

Hoefer IE; van Royen N; Rectenwald JE; Deindl E; Hua J; Jost M; Grundmann S; Voskuil M; Ozaki CK; Piek JJ; Buschmann IR. 2004. Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms. Circ Res 94(9):1179-85. [PubMed: 15059933]  [MGI Ref ID J:98899]

Horie Y; Wolf R; Anderson DC; Granger DN. 1997. Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion. J Clin Invest 99(4):781-8. [PubMed: 9045883]  [MGI Ref ID J:39161]

Huleatt JW; Lefrancois L. 1996. Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity 5(3):263-73. [PubMed: 8808681]  [MGI Ref ID J:35355]

Igietseme JU; Ananaba GA; Bolier J; Bowers S; Moore T; Belay T; Lyn D; Black CM. 1999. The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice. Immunology 98(4):510-9. [PubMed: 10594682]  [MGI Ref ID J:59099]

Isaksson J; Farooque M; Olsson Y. 2000. Spinal cord injury in ICAM-1-deficient mice: assessment of functional and histopathological outcome J Neurotrauma 17(4):333-44. [PubMed: 10776916]  [MGI Ref ID J:62351]

John B; Crispe IN. 2004. Passive and active mechanisms trap activated CD8+ T cells in the liver. J Immunol 172(9):5222-9. [PubMed: 15100260]  [MGI Ref ID J:89684]

Jones SP; Trocha SD; Strange MB; Granger DN; Kevil CG; Bullard DC; Lefer DJ. 2000. Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury Am J Physiol Heart Circ Physiol 279(5):H2196-201. [PubMed: 11045953]  [MGI Ref ID J:65658]

Joussen AM; Poulaki V; Le ML; Koizumi K; Esser C; Janicki H; Schraermeyer U; Kociok N; Fauser S; Kirchhof B; Kern TS; Adamis AP. 2004. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 18(12):1450-2. [PubMed: 15231732]  [MGI Ref ID J:118466]

Kaburagi Y; Hasegawa M; Nagaoka T; Shimada Y; Hamaguchi Y; Komura K; Saito E; Yanaba K; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol 168(6):2970-8. [PubMed: 11884469]  [MGI Ref ID J:112251]

Kadono T; Venturi GM; Steeber DA; Tedder TF. 2002. Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol 169(8):4542-50. [PubMed: 12370391]  [MGI Ref ID J:79530]

Kamochi M; Kamochi F; Kim YB; Sawh S; Sanders JM; Sarembock I; Green S; Young JS; Ley K; Fu SM; Rose CE Jr. 1999. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 277(2 Pt 1):L310-9. [PubMed: 10444525]  [MGI Ref ID J:56844]

Kawasuji A; Hasegawa M; Horikawa M; Fujita T; Matsushita Y; Matsushita T; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2006. L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. J Leukoc Biol 79(4):696-705. [PubMed: 16461740]  [MGI Ref ID J:107551]

Kevil CG; Bullard DC. 2001. In vitro culture and characterization of gene targeted mouse endothelium. Acta Physiol Scand 173(1):151-7. [PubMed: 11678738]  [MGI Ref ID J:125215]

Kevil CG; Orr AW; Langston W; Mickett K; Murphy-Ullrich J; Patel RP; Kucik DF; Bullard DC. 2004. Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway. J Biol Chem 279(18):19230-8. [PubMed: 14985356]  [MGI Ref ID J:124261]

Kevil CG; Patel RP; Bullard DC. 2001. Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells. Am J Physiol Cell Physiol 281(5):C1442-7. [PubMed: 11600406]  [MGI Ref ID J:72559]

King PD; Sandberg ET; Selvakumar A; Fang P; Beaudet AL; Dupont B. 1995. Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing. J Immunol 154(11):6080-6093. [PubMed: 7751650]  [MGI Ref ID J:25530]

Kitagawa K; Matsumoto M; Ohtsuki T; Kuwabara K; Mabuchi T; Yagita Y; Hori M; Yanagihara T. 1999. Deficiency of intercellular adhesion molecule 1 fails to mitigate selective neuronal death after transient global ischemia. Brain Res 847(2):166-74. [PubMed: 10575085]  [MGI Ref ID J:58597]

Kohm AP; Miller SD. 2003. Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+regulatory T cells. J Autoimmun 21(3):261-71. [PubMed: 14599851]  [MGI Ref ID J:86435]

Komura K; Hasegawa M; Hamaguchi Y; Saito E; Kaburagi Y; Yanaba K; Kawara S; Takehara K; Seki M; Steeber DA; Tedder TF; Sato S. 2003. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. J Immunol 171(6):2855-62. [PubMed: 12960307]  [MGI Ref ID J:85377]

Kono H; Uesugi T; Froh M; Rusyn I; Bradford BU; Thurman RG. 2001. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. Am J Physiol Gastrointest Liver Physiol 280(6):G1289-95. [PubMed: 11352823]  [MGI Ref ID J:69880]

Kunkel EJ; Jung U; Bullard DC; Norman KE; Wolitzky BA; Vestweber D; Beaudet AL; Ley K. 1996. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J Exp Med 183(1):57-65. [PubMed: 8551244]  [MGI Ref ID J:31374]

Lacha J; Bushell A; Smetana K; Rossmann P; Pribylova P; Wood K; Maly P. 2002. Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models. J Leukoc Biol 71(2):311-8. [PubMed: 11818453]  [MGI Ref ID J:74694]

Langston W; Chidlow JH Jr; Booth BA; Barlow SC; Lefer DJ; Patel RP; Kevil CG. 2007. Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis. Free Radic Biol Med 42(5):720-729. [PubMed: 17291995]  [MGI Ref ID J:118196]

Lee SH; Prince JE; Rais M; Kheradmand F; Ballantyne CM; Weitz-Schmidt G; Smith CW; Corry DB. 2008. Developmental control of integrin expression regulates th2 effector homing. J Immunol 180(7):4656-67. [PubMed: 18354189]  [MGI Ref ID J:133389]

Ley K; Allietta M; Bullard DC; Morgan S. 1998. Importance of E-selectin for firm leukocyte adhesion in vivo. Circ Res 83(3):287-94. [PubMed: 9710121]  [MGI Ref ID J:110975]

Manka D; Collins RG; Ley K; Beaudet AL; Sarembock IJ. 2001. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice. Circulation 103(7):1000-5. [PubMed: 11181476]  [MGI Ref ID J:103301]

Marvin MR; Southall JC; Trokhan S; DeRosa C; Chabot J. 1998. Liver metastases are enhanced in homozygous deletionally mutant ICAM-1 or LFA-1 mice. J Surg Res 80(2):143-8. [PubMed: 9878305]  [MGI Ref ID J:52466]

Massberg S; Enders G; Matos FC; Tomic LI; Leiderer R; Eisenmenger S; Messmer K; Krombach F. 1999. Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo. Blood 94(11):3829-38. [PubMed: 10572098]  [MGI Ref ID J:58823]

McCafferty DM; Kanwar S; Granger DN; Kubes P. 2000. E/P-selectin-deficient mice: an optimal mutation for abrogating antigen but not tumor necrosis factor-alpha-induced immune responses Eur J Immunol 30(8):2362-71. [PubMed: 10940927]  [MGI Ref ID J:63951]

McCafferty DM; Smith CW; Granger DN; Kubes P. 1999. Intestinal inflammation in adhesion molecule-deficient mice: an assessment of P-selectin alone and in combination with ICAM-1 or E-selectin. J Leukoc Biol 66(1):67-74. [PubMed: 10410991]  [MGI Ref ID J:56590]

Metzler B; Mair J; Lercher A; Schaber C; Hintringer F; Pachinger O; Xu Q. 2001. Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1. Cardiovasc Res 49(2):399-407. [PubMed: 11164850]  [MGI Ref ID J:102573]

Mizgerd JP; Bullard DC; Hicks MJ; Beaudet AL; Doerschuk CM. 1999. Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin. J Immunol 162(9):5444-8. [PubMed: 10228023]  [MGI Ref ID J:112286]

Nagaoka T; Kaburagi Y; Hamaguchi Y; Hasegawa M; Takehara K; Steeber DA; Tedder TF; Sato S. 2000. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol 157(1):237-47. [PubMed: 10880393]  [MGI Ref ID J:63135]

Norman MU; James WG; Hickey MJ. 2008. Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice. J Leukoc Biol 84(1):68-76. [PubMed: 18426970]  [MGI Ref ID J:137748]

O'Brien AD; Standiford TJ; Bucknell KA; Wilcoxen SE; Paine R 3rd. 1999. Role of alveolar epithelial cell intercellular adhesion molecule-1 in host defense against Klebsiella pneumoniae. Am J Physiol 276(6 Pt 1):L961-70. [PubMed: 10362721]  [MGI Ref ID J:55939]

Ohteki T; Maki C; Koyasu S; Mak TW; Ohashi PS. 1999. Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol 162(7):3753-6. [PubMed: 10201888]  [MGI Ref ID J:53578]

Orito H; Fujimoto M; Ishiura N; Yanaba K; Matsushita T; Hasegawa M; Ogawa F; Takehara K; Sato S. 2007. Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction. J Leukoc Biol 81(5):1197-204. [PubMed: 17299025]  [MGI Ref ID J:121746]

Ostanin DV; Furr KL; Pavlick KP; Gray L; Kevil CG; Shukla D; D'Souza D; Hoffman JM; Grisham MB. 2007. T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am J Physiol Gastrointest Liver Physiol 292(6):G1706-14. [PubMed: 17332469]  [MGI Ref ID J:123696]

Papayannopoulou T; Priestley GV; Nakamoto B; Zafiropoulos V; Scott LM. 2001. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Blood 98(8):2403-11. [PubMed: 11588037]  [MGI Ref ID J:115624]

Patrick AL; Rullo J; Beaudin S; Liaw P; Fox-Robichaud AE. 2007. Hepatic leukocyte recruitment in response to time-limited expression of TNF-alpha and IL-1beta. Am J Physiol Gastrointest Liver Physiol 293(4):G663-72. [PubMed: 17656447]  [MGI Ref ID J:126664]

Pelletier SD; Hong DS; Hu Y; Liu Y; Li S. 2004. Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. Blood 104(7):2163-71. [PubMed: 15213099]  [MGI Ref ID J:93772]

Pierangeli SS; Espinola RG; Liu X; Harris EN. 2001. Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 88(2):245-50. [PubMed: 11157679]  [MGI Ref ID J:115602]

Piguet PF; Vesin C; Rochat A. 2001. Beta2 integrin modulates platelet caspase activation and life span in mice. Eur J Cell Biol 80(2):171-7. [PubMed: 11302522]  [MGI Ref ID J:102596]

Raisanen-Sokolowski A; Glysing-Jensen T; Russell ME. 1999. Donor and recipient contributions of ICAM-1 and P-selectin in parenchymal rejection and graft arteriosclerosis: insights from double knockout mice. J Heart Lung Transplant 18(8):735-43. [PubMed: 10512519]  [MGI Ref ID J:59743]

Sakurai E; Taguchi H; Anand A; Ambati BK; Gragoudas ES; Miller JW; Adamis AP; Ambati J. 2003. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 44(6):2743-9. [PubMed: 12766082]  [MGI Ref ID J:119416]

Samoilova EB; Horton JL; Chen Y. 1998. Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice. Cell Immunol 190(1):83-9. [PubMed: 9826450]  [MGI Ref ID J:51770]

Sarman G; Shappell SB; Mason EO Jr; Smith CW; Kaplan SL. 1995. Susceptibility to local and systemic bacterial infections in intercellular adhesion molecule 1-deficient transgenic mice. J Infect Dis 172(4):1001-6. [PubMed: 7561172]  [MGI Ref ID J:113037]

Saunders BM; Frank AA; Orme IM. 1999. Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis. Immunology 98(3):324-8. [PubMed: 10583589]  [MGI Ref ID J:58378]

Schneeberger EE; Vu Q; LeBlanc BW; Doerschuk CM. 2000. The accumulation of dendritic cells in the lung is impaired in CD18-/- but not in ICAM-1-/- mutant mice. J Immunol 164(5):2472-8. [PubMed: 10679084]  [MGI Ref ID J:60566]

Selzner N; Selzner M; Odermatt B; Tian Y; Van Rooijen N; Clavien PA. 2003. ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology 124(3):692-700. [PubMed: 12612908]  [MGI Ref ID J:82107]

Shimada Y; Hasegawa M; Kaburagi Y; Hamaguchi Y; Komura K; Saito E; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 170(8):4325-34. [PubMed: 12682269]  [MGI Ref ID J:125436]

Steeber DA; Campbell MA; Basit A; Ley K; Tedder TF. 1998. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc Natl Acad Sci U S A 95(13):7562-7. [PubMed: 9636189]  [MGI Ref ID J:48271]

Steeber DA; Tang ML; Green NE; Zhang XQ; Sloane JE; Tedder TF. 1999. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. J Immunol 163(4):2176-86. [PubMed: 10438959]  [MGI Ref ID J:57424]

Steinhoff U; Klemm U; Greiner M; Bordasch K; Kaufmann SH. 1998. Altered intestinal immune system but normal antibacterial resistance in the absence of P-selectin and ICAM-1. J Immunol 160(12):6112-20. [PubMed: 9637528]  [MGI Ref ID J:48760]

Sun G; Chang WL; Li J; Berney SM; Kimpel D; van der Heyde HC. 2003. Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria. Infect Immun 71(11):6553-61. [PubMed: 14573677]  [MGI Ref ID J:86276]

Tan TQ; Smith CW; Hawkins EP; Mason EO Jr; Kaplan SL. 1995. Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model. J Infect Dis 171(2):342-9. [PubMed: 7844370]  [MGI Ref ID J:22677]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Whalen MJ; Carlos TM; Dixon CE; Robichaud P; Clark RS; Marion DW; Kochanek PM. 2000. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J Leukoc Biol 67(2):160-8. [PubMed: 10670575]  [MGI Ref ID J:119906]

Wolyniec WW; De Sanctis GT; Nabozny G; Torcellini C; Haynes N; Joetham A; Gelfand EW; Drazen JM; Noonan TC. 1998. Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice. Am J Respir Cell Mol Biol 18(6):777-85. [PubMed: 9618382]  [MGI Ref ID J:48598]

Xu H; Guan H; Zu G; Bullard D; Hanson J; Slater M; Elmets CA. 2001. The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol 31(10):3085-93. [PubMed: 11592085]  [MGI Ref ID J:72353]

Yamada M; Yanaba K; Hasegawa M; Matsushita Y; Horikawa M; Komura K; Matsushita T; Kawasuji A; Fujita T; Takehara K; Steeber DA; Tedder TF; Sato S. 2006. Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. Clin Exp Immunol 143(2):216-27. [PubMed: 16412045]  [MGI Ref ID J:108135]

Yanaba K; Kaburagi Y; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. Am J Pathol 162(5):1463-73. [PubMed: 12707029]  [MGI Ref ID J:113592]

Yukami T; Hasegawa M; Matsushita Y; Fujita T; Matsushita T; Horikawa M; Komura K; Yanaba K; Hamaguchi Y; Nagaoka T; Ogawa F; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2007. Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J Leukoc Biol 82(3):519-31. [PubMed: 17595378]  [MGI Ref ID J:124291]

Health & husbandry

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Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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