Strain Name:

C57BL/6J-Mitfmi-vit/J

Stock Number:

002134

 Order this mouse

Availability:

Research Strain

Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse

Appearance
black, white spotting with retinal degeneration
Related Genotype: a/a Mitfmi-vit/Mitfmi-vit

Description
Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the vitiligo spontaneous mutation Mitfmi-vit are only mildly affected compared to other Mitf alleles. Homozygous mutant mice have a lighter initial coat color than normal with extensive white spotting. After eight weeks of age, the mice producing increasing numbers of white hairs with each hair cycles resembling human vitiligo. Homozygotes exhibit uneven pigmentation of the retina and slow, progressive photoreceptor cell loss, eventually leading to blindness.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Mitf     (12 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Ocular, with Sensorineural Deafness   (MITF)
Tietz Syndrome   (MITF)
Waardenburg Syndrome, Type 2A; WS2A   (MITF)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Mitfmi-vit/Mitfmi-vit

        C57BL/6J-Mitfmi-vit
  • pigmentation phenotype
  • abnormal melanocyte morphology
    • degenerative changes are prevalent   (MGI Ref ID J:102101)
  • abnormal retinal pigment epithelium morphology
    • dorsally, abnormally multilayered at E12 to E13   (MGI Ref ID J:33910)
    • mosaic for hypopigmented and hyperpigmented cells   (MGI Ref ID J:33910)
    • cells of postnatal mice have abnormally short, compact, apical microvilli without melanosomes or connection to rod outer segments   (MGI Ref ID J:33910)
    • abnormal retinal pigmentation
      • by 2 years of age, residual neural retina is invaded by heavily pigmented cells   (MGI Ref ID J:33910)
  • absent coat pigmentation
    • from 8 weeks of age on, the number of white hairs inceases with successive molts   (MGI Ref ID J:14091)
    • by 6- 12 months of age, mice are nearly entirely white   (MGI Ref ID J:102101)
  • diluted coat color
    • slightly less intense than nonagouti of C57BL/6J   (MGI Ref ID J:14091)
  • variable depigmentation   (MGI Ref ID J:102101)
  • white spotting
    • located on back,neck and entire abdomen   (MGI Ref ID J:14091)
  • immune system phenotype
  • abnormal Langerhans cell physiology   (MGI Ref ID J:102101)
  • growth/size phenotype
  • fetal growth retardation   (MGI Ref ID J:33910)
  • nervous system phenotype
  • absent retinal cone cells
    • by 2 years of age, all cone cells are gone   (MGI Ref ID J:33910)
    • results are similar to early function abnormalities in human retinitis pigmentosa   (MGI Ref ID J:33910)
  • absent retinal rod cells
    • by 2 years of age, all rod cells are gone   (MGI Ref ID J:33910)
  • retinal photoreceptor degeneration
    • cell degeneration follows a radial gradient, more severe centrally and more advanced superiorly   (MGI Ref ID J:33910)
    • from 60 to 500 days of age photoreceptor nuclei progressively decrease in number, shedding into the subretinal space   (MGI Ref ID J:33910)
  • vision/eye phenotype
  • abnormal retinal pigment epithelium morphology
    • dorsally, abnormally multilayered at E12 to E13   (MGI Ref ID J:33910)
    • mosaic for hypopigmented and hyperpigmented cells   (MGI Ref ID J:33910)
    • cells of postnatal mice have abnormally short, compact, apical microvilli without melanosomes or connection to rod outer segments   (MGI Ref ID J:33910)
    • abnormal retinal pigmentation
      • by 2 years of age, residual neural retina is invaded by heavily pigmented cells   (MGI Ref ID J:33910)
  • abnormal rod electrophysiology
    • electroretinograms show a significant reduction of rod dominated maximum ERG a-wave and b-wave amplitude as early as 2 weeks of age   (MGI Ref ID J:33910)
  • absent retinal cone cells
    • by 2 years of age, all cone cells are gone   (MGI Ref ID J:33910)
    • results are similar to early function abnormalities in human retinitis pigmentosa   (MGI Ref ID J:33910)
  • absent retinal rod cells
    • by 2 years of age, all rod cells are gone   (MGI Ref ID J:33910)
  • retinal detachment
    • more prominent than in most other retinal degenerations and begins as rod outer segments degenerate   (MGI Ref ID J:33910)
  • retinal photoreceptor degeneration
    • cell degeneration follows a radial gradient, more severe centrally and more advanced superiorly   (MGI Ref ID J:33910)
    • from 60 to 500 days of age photoreceptor nuclei progressively decrease in number, shedding into the subretinal space   (MGI Ref ID J:33910)
  • integument phenotype
  • abnormal hair follicle morphology
    • extracellular granular material found in amelanotic hair follicles   (MGI Ref ID J:102101)
  • absent coat pigmentation
    • from 8 weeks of age on, the number of white hairs inceases with successive molts   (MGI Ref ID J:14091)
    • by 6- 12 months of age, mice are nearly entirely white   (MGI Ref ID J:102101)
  • diluted coat color
    • slightly less intense than nonagouti of C57BL/6J   (MGI Ref ID J:14091)
  • variable depigmentation   (MGI Ref ID J:102101)
  • white spotting
    • located on back,neck and entire abdomen   (MGI Ref ID J:14091)

Mitfmi-vit/Mitfmi-vit

        C57BL/6J-Mitfmi-vit/J
  • pigmentation phenotype
  • abnormal iris pigmentation
    • iris pigmentation is dispersed   (MGI Ref ID J:141035)
  • diluted coat color
    • at 2 months of age mice have lighter pigment   (MGI Ref ID J:100658)
  • vision/eye phenotype
  • abnormal iris pigmentation
    • iris pigmentation is dispersed   (MGI Ref ID J:141035)
  • integument phenotype
  • diluted coat color
    • at 2 months of age mice have lighter pigment   (MGI Ref ID J:100658)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Mitfmi-vit related

Dermatology Research
Color and White Spotting Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency Associated with Other Defects

Mouse/Human Gene Homologs
Waardenburg syndrome, type IIA

Neurobiology Research
Hearing Defects

Sensorineural Research
Eye Defects
Hearing Defects
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mitfmi-vit
Allele Name vitiligo
Allele Type Spontaneous
Common Name(s) Mitfmi-vitiligo; vit;
Strain of OriginC57BL/6J
Gene Symbol and Name Mitf, microphthalmia-associated transcription factor
Chromosome 6
Gene Common Name(s) BCC2; CMM8; Gsfbcc2; MI; WS2; WS2A; bHLHe32; black eyed white; bw; gsf bright coat colour 2; mi; microphthalmia; vit; vitiligo; wh;
General Note Mitfmi-vit homozygotes show a slow progressive loss of photoreceptor cells, cosegregating with the gradual depigmentation (J:28910). Details of the degenerative process have been studied extensively (J:25135).
Molecular Note G to A transition at bp 793 that leads to an aspartate to asparagine substitution at the corresponding amino acid (222) in the encoded protein. This mutation is in the helix 1 region of the protein. [MGI Ref ID J:21366]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Deol MS. 1967. The neural crest and the acoustic ganglion. J Embryol Exp Morphol 17(3):533-41. [PubMed: 6049665]  [MGI Ref ID J:5048]

Hodgkinson CA; Moore KJ; Nakayama A; Steingrimsson E; Copeland NG; Jenkins NA; Arnheiter H. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74(2):395-404. [PubMed: 8343963]  [MGI Ref ID J:13562]

Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20. [PubMed: 7852195]  [MGI Ref ID J:21682]

Raisz LG; Simmons HA; Gworek SC; Eilon G. 1977. Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators. J Exp Med 145(4):857-65. [PubMed: 870607]  [MGI Ref ID J:5804]

Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63. [PubMed: 7874168]  [MGI Ref ID J:21366]

Tachibana M; Perez-Jurado LA; Nakayama A; Hodgkinson CA; Li X; Schneider M; Miki T; Fex J; Francke U; Arnheiter H. 1994. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. Hum Mol Genet 3(4):553-7. [PubMed: 8069297]  [MGI Ref ID J:17853]

Mitfmi-vit related

Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234]  [MGI Ref ID J:141035]

Boissy RE; Moellmann GE; Lerner AB. 1987. Morphology of melanocytes in hair bulbs and eyes of vitiligo mice. Am J Pathol 127(2):380-8. [PubMed: 3578491]  [MGI Ref ID J:102101]

Bora N; Conway SJ; Liang H; Smith SB. 1998. Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice. Dev Dyn 213(3):283-92. [PubMed: 9825864]  [MGI Ref ID J:50809]

Bora N; Defoe D; Smith SB. 1999. Evidence of decreased adhesion between the neural retina and retinal pigmented epithelium of the Mitfvit (vitiligo) mutant mouse. Cell Tissue Res 295(1):65-75. [PubMed: 9931354]  [MGI Ref ID J:52104]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Duncan T; Swint C; Smith SB; Wiggert BN. 1999. Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration. Mol Vis 5:9. [PubMed: 10385706]  [MGI Ref ID J:57216]

Evans BL; Smith SB. 1997. Analysis of esterification of retinoids in the retinal pigmented epithelium of the Mitf-vit (vitiligo) mutant mouse. Mol Vis 3:11. [PubMed: 9383334]  [MGI Ref ID J:45737]

Gelineau-van Waes J; Smith L; van Waes M; Wilberding J; Eudy JD; Bauer LK; Maddox J. 2008. Altered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitf(mi) and Mitf(vitiligo) mouse mutants. Exp Eye Res 86(2):419-33. [PubMed: 18191835]  [MGI Ref ID J:132493]

Hansdottir AG; Palsdottir K; Favor J; Neuhauser-Klaus A; Fuchs H; de Angelis MH; Steingrimsson E. 2004. The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins. Genomics 83(5):932-5. [PubMed: 15081122]  [MGI Ref ID J:89276]

Kosaras B; Rosario C; Ruiz M; Sidman R; Tang M; Wertheim S. 1992. Vitiligo (mivit) linkage and retinal abnormalities Mouse Genome 90(3):421.  [MGI Ref ID J:2589]

Kosaras B; Sidman RL. 1996. Phagosome number and distribution in retinal pigment epithelial cells of vitiligo mutant mice. Exp Eye Res 63(2):151-8. [PubMed: 8983972]  [MGI Ref ID J:37937]

Kurita K; Nishito M; Shimogaki H; Takada K; Yamazaki H; Kunisada T. 2005. Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice. J Invest Dermatol 125(3):538-44. [PubMed: 16117796]  [MGI Ref ID J:100658]

Lamoreux ML; Boissy RE; Womack JE; Nordlund JJ. 1992. The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse. J Hered 83(6):435-9. [PubMed: 1460250]  [MGI Ref ID J:3383]

Lerner AB. 1986. Vitiligo (vit). Mouse News Lett 74:125.  [MGI Ref ID J:14091]

Lerner AB; Shiohara T; Boissy RE; Jacobson KA; Lamoreux ML; Moellmann GE. 1986. A mouse model for vitiligo. J Invest Dermatol 87(3):299-304. [PubMed: 3525691]  [MGI Ref ID J:102100]

Morii E; Ito A; Jippo T; Koma Y; Oboki K; Wakayama T; Iseki S; Lamoreux ML; Kitamura Y. 2004. Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily. Am J Pathol 165(2):491-9. [PubMed: 15277223]  [MGI Ref ID J:91476]

Nir I; Ransom N; Smith SB. 1995. Ultrastructural features of retinal dystrophy in mutant vitiligo mice. Exp Eye Res 61(3):363-77. [PubMed: 7556499]  [MGI Ref ID J:29290]

Nishimura EK; Granter SR; Fisher DE. 2005. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307(5710):720-4. [PubMed: 15618488]  [MGI Ref ID J:96016]

Sidman RL; Kosaras B; Tang M. 1996. Pigment epithelial and retinal phenotypes in the vitiligo mivit, mutant mouse. Invest Ophthalmol Vis Sci 37(6):1097-115. [PubMed: 8631625]  [MGI Ref ID J:33910]

Sidman RL; Neumann P. 1988. Vitiligo: a new retinal degeneration mutation Mouse News Lett 81:60.  [MGI Ref ID J:14141]

Smith SB. 1995. Evidence of a difference in photoreceptor cell loss in the peripheral versus posterior regions of the vitiligo (C57BL/6J-mi(vit)/mi(vit)) mouse retina [letter; comment] Exp Eye Res 60(3):333-6. [PubMed: 7789413]  [MGI Ref ID J:25135]

Smith SB; Bora N; McCool D; Kutty G; Wong P; Kutty RK; Wiggert B. 1995. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 36(11):2193-201. [PubMed: 7558712]  [MGI Ref ID J:29729]

Smith SB; Brodjian S; Desai S; Sarthy V. 1997. Glial fibrillary acidic protein (GFAP) is synthesized in the early stages of the photoreceptor cell degeneration of the mivit/mivit (vitiligo) mouse [letter] Exp Eye Res 64(4):645-50. [PubMed: 9227283]  [MGI Ref ID J:42651]

Smith SB; Cope BK; McCoy JR; McCool DJ; Defoe DM. 1994. Reduction of phagosomes in the vitiligo (C57BL/6-mivit/mivit) mouse model of retinal degeneration. Invest Ophthalmol Vis Sci 35(10):3625-32. [PubMed: 8088952]  [MGI Ref ID J:20943]

Smith SB; Defoe DM. 1995. Autoradiographic and biochemical assessment of rod outer segment renewal in the vitiligo (C57BL/6-mivit/mivit) mouse model of retinal degeneration. Exp Eye Res 60(1):91-6. [PubMed: 7720808]  [MGI Ref ID J:23374]

Smith SB; Hamasaki DI. 1994. Electroretinographic study of the C57BL/6-mivit/mivit mouse model of retinal degeneration. Invest Ophthalmol Vis Sci 35(7):3119-23. [PubMed: 8206731]  [MGI Ref ID J:19584]

Smith SB; McClung J; Wiggert BN; Nir I. 1997. Delayed rhodopsin regeneration and altered distribution of interphotoreceptor retinoid binding protein (IRBP) in the mi(vit)/mi(vit) (vitiligo) mouse. J Neurocytol 26(9):605-13. [PubMed: 9352446]  [MGI Ref ID J:43646]

Smith SB; McCool DJ. 1995. Slow progressive loss of photoreceptor cells in vitiligo mice co-segregates with gradual depigmentation of the pelage Mouse Genome 93(3):871-3.  [MGI Ref ID J:28910]

Smith SB; Zhou BK; Orlow SJ. 1998. Expression of tyrosinase and the tyrosinase related proteins in the Mitfvit (vitiligo) mouse eye: implications for the function of the microphthalmia transcription factor. Exp Eye Res 66(4):403-10. [PubMed: 9593634]  [MGI Ref ID J:47851]

Steingrimsson E; Arnheiter H; Hallsson JH; Lamoreux ML; Copeland NG; Jenkins NA. 2003. Interallelic complementation at the mouse mitf locus. Genetics 163(1):267-76. [PubMed: 12586714]  [MGI Ref ID J:82600]

Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63. [PubMed: 7874168]  [MGI Ref ID J:21366]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Tang M; Pawlyk BS; Kosaras B; Berson EL; Sidman RL. 1997. ERG abnormalities in relation to histopathologic findings in vitiligo mutant mice. Exp Eye Res 65(2):215-22. [PubMed: 9268589]  [MGI Ref ID J:102251]

Tang M; Ruiz M; Kosaras B; Sidman RL. 1996. Increased cell genesis in retinal pigment epithelium of perinatal vitiligo mutant mice. Invest Ophthalmol Vis Sci 37(6):1116-24. [PubMed: 8631626]  [MGI Ref ID J:33911]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $116.20Female or MaleHomozygous for Mitfmi-vit  
Price per Pair (US dollars $)Pair Genotype
$232.40Homozygous for Mitfmi-vit x Homozygous for Mitfmi-vit  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $151.10Female or MaleHomozygous for Mitfmi-vit  
Price per Pair (US dollars $)Pair Genotype
$302.20Homozygous for Mitfmi-vit x Homozygous for Mitfmi-vit  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

General Supply Notes

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.2)