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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Gene Trap; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Mating System Heterozygote x Heterozygote (Female x Male) Species laboratory mouse Background Strain C57BL/6J Donor Strain 129S7 via AB1 ES cell line (+Hprt-bm2) Generation N13F30 (15-JAN-08) Donating Investigator William Dove, University of Wisconsin Appearance
black
Related Genotype: a/aDescription
Mice heterozygous or homozygous for the ROSA26 retroviral insertion display no distinguishing phenotype. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult mouse.Development
This strain was developed in the laboratory of Dr. Philippe Soriano at the Fred Hutchinson Cancer Center, Seattle, WA. This mutant was made by a retroviral insertion of the beta-galactosidase gene (and accompanying splice acceptor and neo sequences) into ES cells. The construct was inserted in reverse orientation in the retroviral vector pGen-.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (178 strains)
002292 129-Gt(ROSA)26Sor/J 002073 B6;129S-Gt(ROSA)26Sor/J 002955 C.129S7-Gt(ROSA)26Sor/J 005420 C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J
Additional Web Information
Congenic Nomenclature
Fluorescent Proteins/lacZ Systems
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Research Tools
lacZ Expression
Developmental Biology Research (transplantation marker for embryonic and adult tissue)
Genetics Research (Tissue/Cell Markers: transplantation marker for embryonic and adult tissue)
Reproductive Biology Research (transplantation marker for embryonic and adult tissue)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gt(ROSA)26Sor | ||
|---|---|---|---|
| Allele Name | gene trap ROSA 26, Philippe Soriano | ||
| Allele Type | Gene trapped | ||
| Common Name(s) | ROSA26; ROSA26-lacZ; Rosa26lacZ; TgR(ROSA26)26Sor; gtrosa26; | ||
| Mutation Made By | Philippe Soriano, Fred Hutchinson Cancer Research Center | ||
| Strain of Origin | 129 x C57BL/6J | ||
| Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. | ||
| General Note | No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells. | ||
| Molecular Note | Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(ROSA)26Sor, Gt(ROSA)26Sortm1Sho, MCA, vers. 2
Gt(ROSA)26Sor, Gt(ROSA)26Sortm1Sho, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Friedrich G; Soriano P. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5(9):1513-23. [PubMed: 1653172] [MGI Ref ID J:79478]
Additional References
Colnot C; Lu C; Hu D; Helms JA. 2004. Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development. Dev Biol 269(1):55-69. [PubMed: 15081357] [MGI Ref ID J:90362]
Goldowitz D; Hamre KM; Przyborski SA; Ackerman SL. 2000. Granule cells and cerebellar boundaries: analysis of Unc5h3 mutant chimeras. J Neurosci 20(11):4129-37. [PubMed: 10818148] [MGI Ref ID J:62291]
Park C; Finger JH; Cooper JA; Ackerman SL. 2002. The cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations. Genesis 32(1):32-41. [PubMed: 11835672] [MGI Ref ID J:74540]
Reiner A; Del Mar N; Meade CA; Yang H; Dragatsis I; Zeitlin S; Goldowitz D. 2001. Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice. J Neurosci 21(19):7608-19. [PubMed: 11567051] [MGI Ref ID J:71624]
Sequeira Lopez ML; Pentz ES; Robert B; Abrahamson DR; Gomez RA. 2001. Embryonic origin and lineage of juxtaglomerular cells. Am J Physiol Renal Physiol 281(2):F345-56. [PubMed: 11457727] [MGI Ref ID J:70875]
Shinohara T; Avarbock MR; Brinster RL. 2000. Functional analysis of spermatogonial stem cells in Steel and cryptorchid infertile mouse models. Dev Biol 220(2):401-11. [PubMed: 10753526] [MGI Ref ID J:61712]
Zambrowicz BP; Imamoto A; Fiering S; Herzenberg LA; Kerr WG; Soriano P. 1997. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94(8):3789-94. [PubMed: 9108056] [MGI Ref ID J:39814]
Gt(ROSA)26Sor relatedAghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. [PubMed: 16982747] [MGI Ref ID J:112935]
Ahn GO; Brown JM. 2008. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13(3):193-205. [PubMed: 18328424] [MGI Ref ID J:132946]
Anthony TE; Klein C; Fishell G; Heintz N. 2004. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41(6):881-90. [PubMed: 15046721] [MGI Ref ID J:89775]
Arnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. [PubMed: 18182616] [MGI Ref ID J:130978]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Bosman EA; Lawson KA; Debruyn J; Beek L; Francis A; Schoonjans L; Huylebroeck D; Zwijsen A. 2006. Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development 133(17):3399-409. [PubMed: 16887830] [MGI Ref ID J:112229]
Carvalho RL; Itoh F; Goumans MJ; Lebrin F; Kato M; Takahashi S; Ema M; Itoh S; van Rooijen M; Bertolino P; Ten Dijke P; Mummery CL. 2007. Compensatory signalling induced in the yolk sac vasculature by deletion of TGF receptors in mice. J Cell Sci 120(Pt 24):4269-77. [PubMed: 18029401] [MGI Ref ID J:128498]
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Chi L; Itaranta P; Zhang S; Vainio S. 2006. Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology 147(8):3777-88. [PubMed: 16675530] [MGI Ref ID J:129651]
Ciarloni L; Mallepell S; Brisken C. 2007. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A 104(13):5455-60. [PubMed: 17369357] [MGI Ref ID J:120116]
Dong F; Sun X; Liu W; Ai D; Klysik E; Lu MF; Hadley J; Antoni L; Chen L; Baldini A; Francis-West P; Martin JF. 2006. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development 133(24):4891-9. [PubMed: 17107996] [MGI Ref ID J:119660]
Fraidenraich D; Stillwell E; Romero E; Wilkes D; Manova K; Basson CT; Benezra R. 2004. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science 306(5694):247-52. [PubMed: 15472070] [MGI Ref ID J:93083]
Guerra C; Schuhmacher AJ; Canamero M; Grippo PJ; Verdaguer L; Perez-Gallego L; Dubus P; Sandgren EP; Barbacid M. 2007. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11(3):291-302. [PubMed: 17349585] [MGI Ref ID J:119988]
Hadland BK; Huppert SS; Kanungo J; Xue Y; Jiang R; Gridley T; Conlon RA; Cheng AM; Kopan R; Longmore GD. 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood 104(10):3097-105. [PubMed: 15251982] [MGI Ref ID J:94898]
Haraguchi R; Motoyama J; Sasaki H; Satoh Y; Miyagawa S; Nakagata N; Moon A; Yamada G. 2007. Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 134(3):525-33. [PubMed: 17202190] [MGI Ref ID J:119913]
Ho KJ; Bass CE; Kroemer AH; Ma C; Terwilliger E; Karp SJ. 2008. Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration. Am J Physiol Gastrointest Liver Physiol 295(2):G412-9. [PubMed: 18535290] [MGI Ref ID J:138633]
Jager R; Maurer J; Jacob A; Schorle H. 2004. Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis 38(3):145-50. [PubMed: 15048812] [MGI Ref ID J:89756]
Kohlhepp RL; Hegge LF; Moser AR. 2001. The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice. Mamm Genome 12(8):606-11. [PubMed: 11471054] [MGI Ref ID J:70825]
Kohlhepp RL; Hegge LF; Nett JE; Moser AR. 2000. ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development. Mamm Genome 11(12):1058-62. [PubMed: 11130972] [MGI Ref ID J:66060]
Li Z; Chen MJ; Stacy T; Speck NA. 2006. Runx1 function in hematopoiesis is required in cells that express Tek. Blood 107(1):106-10. [PubMed: 16174759] [MGI Ref ID J:125796]
Macatee TL; Hammond BP; Arenkiel BR; Francis L; Frank DU; Moon AM. 2003. Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development 130(25):6361-74. [PubMed: 14623825] [MGI Ref ID J:87304]
Matsumoto Y; Irie F; Inatani M; Tessier-Lavigne M; Yamaguchi Y. 2007. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 27(16):4342-50. [PubMed: 17442818] [MGI Ref ID J:121105]
Matt N; Dupe V; Garnier JM; Dennefeld C; Chambon P; Mark M; Ghyselinck NB. 2005. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development 132(21):4789-800. [PubMed: 16207763] [MGI Ref ID J:102847]
Morroni M; Giordano A; Zingaretti MC; Boiani R; De Matteis R; Kahn BB; Nisoli E; Tonello C; Pisoschi C; Luchetti MM; Marelli M; Cinti S. 2004. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc Natl Acad Sci U S A 101(48):16801-6. [PubMed: 15556998] [MGI Ref ID J:94729]
Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193] [MGI Ref ID J:131961]
Nguyen QT; Son YJ; Sanes JR; Lichtman JW. 2000. Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras. J Neurosci 20(16):6077-86. [PubMed: 10934257] [MGI Ref ID J:120388]
Nishimura EK; Jordan SA; Oshima H; Yoshida H; Osawa M; Moriyama M; Jackson IJ; Barrandon Y; Miyachi Y; Nishikawa S. 2002. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416(6883):854-60. [PubMed: 11976685] [MGI Ref ID J:130556]
Patel V; Li L; Cobo-Stark P; Shao X; Somlo S; Lin F; Igarashi P. 2008. Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17(11):1578-90. [PubMed: 18263895] [MGI Ref ID J:135523]
R R; Speed R; Taggart M; Cooke HJ. 2003. Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells. Reproduction 126(5):599-604. [PubMed: 14611632] [MGI Ref ID J:87151]
Samokhvalov IM; Samokhvalova NI; Nishikawa S. 2007. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446(7139):1056-61. [PubMed: 17377529] [MGI Ref ID J:121435]
Sasaki T; Ito Y; Xu X; Han J; Bringas P Jr; Maeda T; Slavkin HC; Grosschedl R; Chai Y. 2005. LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol 278(1):130-43. [PubMed: 15649466] [MGI Ref ID J:96501]
Seandel M; James D; Shmelkov SV; Falciatori I; Kim J; Chavala S; Scherr DS; Zhang F; Torres R; Gale NW; Yancopoulos GD; Murphy A; Valenzuela DM; Hobbs RM; Pandolfi PP; Rafii S. 2007. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449(7160):346-50. [PubMed: 17882221] [MGI Ref ID J:126330]
Sebzda E; Hibbard C; Sweeney S; Abtahian F; Bezman N; Clemens G; Maltzman JS; Cheng L; Liu F; Turner M; Tybulewicz V; Koretzky GA; Kahn ML. 2006. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell 11(3):349-61. [PubMed: 16950126] [MGI Ref ID J:112805]
Snider P; Fix JL; Rogers R; Peabody-Dowling G; Ingram D; Lilly B; Conway SJ. 2008. Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice. Genesis 46(3):167-76. [PubMed: 18327771] [MGI Ref ID J:133342]
Takahashi Y; Kitajima S; Inoue T; Kanno J; Saga Y. 2005. Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites. Development 132(4):787-96. [PubMed: 15677726] [MGI Ref ID J:120635]
Vernet N; Dennefeld C; Guillou F; Chambon P; Ghyselinck NB; Mark M. 2006. Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. EMBO J 25(24):5816-25. [PubMed: 17124491] [MGI Ref ID J:119926]
Vidal A; Zacharoulis S; Guo W; Shaffer D; Giancotti F; Bramley AH; de la Hoz C; Jensen KK; Kato D; MacDonald DD; Knowles J; Yeh N; Frohman LA; Rafii S; Lyden D; Koff A. 2005. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A 102(19):6890-5. [PubMed: 15867156] [MGI Ref ID J:99064]
Wijgerde M; McMahon JA; Rule M; McMahon AP. 2002. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16(22):2849-64. [PubMed: 12435628] [MGI Ref ID J:80206]
Yamamoto S; Fukumoto E; Yoshizaki K; Iwamoto T; Yamada A; Tanaka K; Suzuki H; Aizawa S; Arakaki M; Yuasa K; Oka K; Chai Y; Nonaka K; Fukumoto S. 2008. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem 283(34):23139-49. [PubMed: 18559345] [MGI Ref ID J:140258]
Ybot-Gonzalez P; Savery D; Gerrelli D; Signore M; Mitchell CE; Faux CH; Greene ND; Copp AJ. 2007. Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134(4):789-99. [PubMed: 17229766] [MGI Ref ID J:119920]
Zambrowicz BP; Imamoto A; Fiering S; Herzenberg LA; Kerr WG; Soriano P. 1997. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94(8):3789-94. [PubMed: 9108056] [MGI Ref ID J:39814]
Zhang Z; Cerrato F; Xu H; Vitelli F; Morishima M; Vincentz J; Furuta Y; Ma L; Martin JF; Baldini A; Lindsay E. 2005. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development 132(23):5307-15. [PubMed: 16284121] [MGI Ref ID J:102843]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain is maintained by heterozygous sibling matings. Recovery of homozygotes is significantly reduced. Homozygous mice, heterozygous mice, and normal wildtype siblings may be ordered. Technician's Notes: For unknown reasons homozygous transgenic mice are prone to convulsions. They should be handled carefully and quietly to avoid poor breeding, loss of litters, or premature death. Expected coat color from breeding:Black Mating System Heterozygote x Heterozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $203.10 Female or Male Heterozygous for Gt(ROSA)26Sor $246.90 Female or Male Homozygous for Gt(ROSA)26Sor *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $406.20 Heterozygous for Gt(ROSA)26Sor x Heterozygous for Gt(ROSA)26Sor
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $264.10 Female or Male Heterozygous for Gt(ROSA)26Sor $321.00 Female or Male Homozygous for Gt(ROSA)26Sor *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $528.10 Heterozygous for Gt(ROSA)26Sor x Heterozygous for Gt(ROSA)26Sor
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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