Strain Name: |
B6.129P2-Hbbtm1Unc/J |
|---|---|
Stock Number: |
002204 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Hbb; Hbbtm1Unc; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse Background Strain C57BL/6J Donor Strain 129P2 via E14TG2a ES cell line Donating Investigator Oliver Smithies, University of North Carolina Generation N9+1 Appearance
white-bellied agouti
Related Genotype: Aw/AwStrain Description
Mice homozygous for this mutation die perinatally due to severe anemia.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Hbbtm1Unc | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, University of North Carolina | ||
| Common Name(s) | Hbbth-3; | ||
| Mutation Made By | Oliver Smithies, University of North Carolina | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14TG2a | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Hbb, hemoglobin beta chain complex | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | CD113t-C; HBD; | ||
| Molecular Note | A neomycin resistance cassette was inserted into exon 2 of the beta1 gene. No protein for the targeted gene was detected via cellulose electrophoresis of hemoglobin from homozygous mutant mice. [MGI Ref ID J:4932] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Hbbtm1Unc | Wild-type from the colony | |
| Hbbtm1Unc | 000664 C57BL/6J | |
| Considerations for Choosing Controls | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying other alleles of Hbb
000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000432 B10.C-H1b Hbbd Tyrc/(41N)SnJ 000562 B6(Cg)-Tubtub/J 000383 B6.C-Tyrc H1b Hbbd/ByJ 002074 B6.Cg-Gpi1a Hbbd H1b/DehJ 003250 B6;129P2-Hbbtm2Unc/J 000899 C.B6-Tyr+ Hbbs/J 000996 C57BL/6J-Hbbd3th/J 000758 C57BL/6J-Hbbp Hrrh-7J/J 003342 STOCK Hbatm1Paz Hbbtm1Tow Tg(HBA-HBBs)41Paz/J View Strains carrying other alleles of Hbb (11 strains)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Hbbtm1Unc relatedHematological Research
Hemoglobin Defects (betaO-thalassemia)
Hemoglobin Defects (thalassemia)
Hematological Research
Hemoglobin Defects
Mouse/Human Gene Homologs
thalassemia, beta
References
Selected Reference(s)
Additional ReferencesShehee WR; Oliver P; Smithies O. 1993. Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc Natl Acad Sci U S A 90(8):3177-81. [PubMed: 8475058] [MGI Ref ID J:4932]
Price and Supply Information
| Strain Name: | B6.129P2-Hbbtm1Unc/J |
| Stock Number: | 002204 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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