Strain Name:

CFW-Mpv17/J

Stock Number:

002208

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Rudolf Jaenisch,   Whitehead Institute (MIT)

Development
This strain was generated via the insertion of a recombinant retrovirus into a subsequently cloned gene, Mpv17. This insertion disrupted expression of the gene. CFW pre-implantation embryos were used.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Alport Syndrome, Autosomal Recessive
Mitochondrial DNA Depletion Syndrome 3 (hepatocerebral Type); MTDPS3
Nephrotic Syndrome, Type 2; NPHS2
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Mitochondrial DNA Depletion Syndrome 6 (hepatocerebral Type); MTDPS6   (MPV17)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Mpv17/Mpv17

        involves: CFW
  • mortality/aging
  • premature death
    • death between 2 and 9 months of age   (MGI Ref ID J:10661)
    • homozygotes are fertile and live long enough to reproduce   (MGI Ref ID J:27358)
    • survival to 52 weeks of age has been reported   (MGI Ref ID J:62419)
    • median life span is 645 days unlike in wild-type mice that survive longer   (MGI Ref ID J:143355)
  • growth/size/body phenotype
  • decreased body weight
    • after 1 year of age   (MGI Ref ID J:143355)
    • cachexia
      • weight loss associated with death   (MGI Ref ID J:10661)
  • behavior/neurological phenotype
  • hypoactivity
    • become inactive prior to death   (MGI Ref ID J:10661)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • unlike human patients with the hepatocerebral form of mitochondrial DNA depletion syndrome, mice fail to exhibit hypoglycemia or abnormal glucose tolerance   (MGI Ref ID J:143355)
    • abnormal blood homeostasis   (MGI Ref ID J:10661)
      • abnormal circulating protein level
        • beginning at 5 months, lactate levels are moderately higher than in wild-type mice   (MGI Ref ID J:143355)
        • decreased circulating serum albumin level   (MGI Ref ID J:62419)
          • at 6-8 weeks of age   (MGI Ref ID J:10661)
        • increased circulating alanine transaminase level
          • beginning at 5 months   (MGI Ref ID J:143355)
        • increased circulating aspartate transaminase level
          • beginning at 5 months   (MGI Ref ID J:143355)
        • increased circulating creatine kinase level
          • beginning at 5 months, serum creatine kinase levels are higher than in wild-type mice   (MGI Ref ID J:143355)
      • increased blood urea nitrogen level
        • at 6-8 weeks of age   (MGI Ref ID J:10661)
      • increased circulating cholesterol level
        • at 6-8 weeks of age   (MGI Ref ID J:10661)
      • increased circulating creatinine level
        • at 6-8 weeks of age   (MGI Ref ID J:10661)
    • decreased urine osmolality   (MGI Ref ID J:59102)
    • increased urine protein level   (MGI Ref ID J:108252)
      • at 6-8 weeks of age   (MGI Ref ID J:10661)
      • at 18 months without changes in the creatinine and urea serum levels   (MGI Ref ID J:143355)
      • albuminuria
        • 95% of proteinuria due to albuminuria   (MGI Ref ID J:108252)
        • evident at 8 weeks of age   (MGI Ref ID J:62419)
    • increased urine sodium level   (MGI Ref ID J:59102)
  • hematopoietic system phenotype
  • anemia
    • severe normocytic and normochromic anemia seen between 2 and 6 months of age   (MGI Ref ID J:10661)
  • decreased erythrocyte cell number
    • reduced RBC count at 6-8 weeks of age   (MGI Ref ID J:10661)
  • decreased hemoglobin content
    • reduced hemoglobin levels at 6-8 weeks of age   (MGI Ref ID J:10661)
  • renal/urinary system phenotype
  • abnormal renal glomerulus morphology
    • 2-fold increase in reactive oxygen species   (MGI Ref ID J:108252)
    • 2.5-fold increase in lipid peroxidation adducts   (MGI Ref ID J:108252)
    • the amount of mitochondrial DNA in glomeruli at 6 months and 2 years is decreased compared to in wild-type mice   (MGI Ref ID J:143355)
    • abnormal glomerular capillary morphology
      • capillaries collapse   (MGI Ref ID J:10661)
    • cortical renal glomerulopathies
      • glomeruli become enlarged and capillaries collapse   (MGI Ref ID J:10661)
      • glomeruli become occluded with hyaline material   (MGI Ref ID J:10661)
      • enlargement slight at 50 days of age   (MGI Ref ID J:108252)
      • glomerulosclerosis
        • glomeruli eventually become totally obliterated by hyaline masses   (MGI Ref ID J:10661)
        • at 18 months, mice exhibit focal segmental glomerulosclerosis that by 2 years of age develops into frank degenerative changes of the glomeruli unlike in wild-type mice   (MGI Ref ID J:143355)
    • expanded mesangial matrix
      • segmental mesangial sclerosis at 50 days of age   (MGI Ref ID J:108252)
    • renal glomerulus hypertrophy
      • glomeruli become enlarged   (MGI Ref ID J:10661)
      • enlargement slight at 50 days of age   (MGI Ref ID J:108252)
  • abnormal renal tubule morphology
    • hyaline and scarred segmental lesions at 180 days   (MGI Ref ID J:108252)
    • dilated renal tubules
      • microcystic dilation of renal tubules   (MGI Ref ID J:10661)
  • abnormal renal/urinary system physiology   (MGI Ref ID J:59102)
    • decreased urine osmolality   (MGI Ref ID J:59102)
    • increased urine protein level   (MGI Ref ID J:108252)
      • at 6-8 weeks of age   (MGI Ref ID J:10661)
      • at 18 months without changes in the creatinine and urea serum levels   (MGI Ref ID J:143355)
      • albuminuria
        • 95% of proteinuria due to albuminuria   (MGI Ref ID J:108252)
        • evident at 8 weeks of age   (MGI Ref ID J:62419)
    • increased urine sodium level   (MGI Ref ID J:59102)
    • kidney failure   (MGI Ref ID J:48662)
    • polyuria
      • increased urinary volume   (MGI Ref ID J:59102)
  • fused podocyte foot processes
    • early fusion of foot processes in glomerular visceral epithelial cells   (MGI Ref ID J:10661)
    • eventual diffuse fusion of foot processes and vacuolation of cell cytoplasm   (MGI Ref ID J:10661)
  • increased kidney weight
    • increased kidney weight at 52 weeks of age   (MGI Ref ID J:62419)
  • kidney degeneration
    • at 2 years of age, degenerative changes in the glomeruli are accompanied by degenerative abnormalities in the tubular system, with dilation and formation of pseudocysts, parenchymal loss, and interstitial fibrosis unlike in wild-type mice   (MGI Ref ID J:143355)
    • at 2 years, kidney mitochondrial DNA content is reduced 47% compared to in wild-type mice   (MGI Ref ID J:143355)
  • podocyte foot process effacement
    • almost complete flattening of the foot processes at 180 days   (MGI Ref ID J:108252)
  • renal interstitial fibrosis
    • at 2 years of age   (MGI Ref ID J:143355)
  • cardiovascular system phenotype
  • abnormal glomerular capillary morphology
    • capillaries collapse   (MGI Ref ID J:10661)
  • abnormal liver sinusoid morphology
    • beginning at 5 months, sinusoidal spaces collapse unlike in wild-type mice   (MGI Ref ID J:143355)
  • hypertension
    • significant hypertension   (MGI Ref ID J:59102)
  • increased heart rate   (MGI Ref ID J:59102)
  • hearing/vestibular/ear phenotype
  • abnormal auditory brainstem response
    • at 2 months of age, poor brainstem evoked responses are obtained at 1-32 kHz   (MGI Ref ID J:48661)
    • increased or absent threshold for auditory brainstem response
      • by 7 months of age, no brainstem evoked responses can be elicited   (MGI Ref ID J:48661)
  • abnormal cochlea morphology   (MGI Ref ID J:48653)
    • abnormal scala media morphology   (MGI Ref ID J:48653)
      • cochlear outer hair cell degeneration
        • pronounced OHC loss at 2 months of age   (MGI Ref ID J:48662)
      • organ of Corti degeneration   (MGI Ref ID J:48653)
        • severe degeneration of the organ of Corti by 7 months   (MGI Ref ID J:48662)
      • spiral ligament degeneration   (MGI Ref ID J:48653)
        • severe degeneration of the spiral ligament by 7 months   (MGI Ref ID J:48662)
      • stria vascularis degeneration   (MGI Ref ID J:48653)
        • moderate degenerative alterations at 2 months of age   (MGI Ref ID J:48662)
        • severe degeneration of the stria vascularis by 7 months   (MGI Ref ID J:48662)
  • sensorineural hearing loss   (MGI Ref ID J:48662)
    • severe sensorineural hearing loss as early as 2 months after birth   (MGI Ref ID J:48661)
  • nervous system phenotype
  • cochlear ganglion degeneration
    • marked loss of spiral ganglion cells by 7 months   (MGI Ref ID J:48662)
  • cochlear ganglion hypoplasia
    • loss of cochlear neurons   (MGI Ref ID J:48653)
  • cochlear outer hair cell degeneration
    • pronounced OHC loss at 2 months of age   (MGI Ref ID J:48662)
  • adipose tissue phenotype
  • decreased subcutaneous adipose tissue amount
  • cellular phenotype
  • *normal* cellular phenotype
    • despite defects in mitochondria morphology, mice exhibit normal mitochondrial response to hypothermia   (MGI Ref ID J:143355)
    • abnormal mitochondrial crista morphology
      • older mice exhibit disappearance of internal cristae unlike in wild-type mice   (MGI Ref ID J:143355)
    • decreased mitochondrial DNA content
      • the mitochondrial DNA content in the liver and muscle is very low compared to in wild-type mice   (MGI Ref ID J:143355)
      • proliferating and non-proliferating mouse embryonic fibroblast exhibit a decrease in mitochondrial DNA over time compared to an increase in wild-type cells   (MGI Ref ID J:143355)
      • the amount of mitochondrial DNA in glomeruli at 6 months and 2 years is decreased compared to in wild-type mice   (MGI Ref ID J:143355)
      • at 2 years, kidney mitochondrial DNA content is reduced 47% compared to in wild-type mice   (MGI Ref ID J:143355)
      • however, mitochondrial DNA content in the brain is normal   (MGI Ref ID J:143355)
    • dilated mitochondria
      • older mice exhibit mitochondrial ballooning unlike in wild-type mice   (MGI Ref ID J:143355)
  • endocrine/exocrine gland phenotype
  • abnormal sebaceous gland morphology
    • at 2 years, sebaceous gland and annexa size and numbers are decreased compared to in wild-type mice   (MGI Ref ID J:143355)
    • small sebaceous gland
  • liver/biliary system phenotype
  • *normal* liver/biliary system phenotype
    • despite abnormal liver morphology, mice do not exhibit increased susceptibility to chemically-induced liver damage using valporic acid   (MGI Ref ID J:143355)
    • abnormal liver lobule morphology
      • beginning at 5 months, scattered degeneration of discrete areas of hepatic lobules occurs unlike in wild-type mice   (MGI Ref ID J:143355)
      • abnormal hepatocyte morphology
        • beginning at 5 months, hepatocytes are swollen with shrunken nuclei unlike wild-type cells   (MGI Ref ID J:143355)
      • abnormal liver sinusoid morphology
        • beginning at 5 months, sinusoidal spaces collapse unlike in wild-type mice   (MGI Ref ID J:143355)
    • abnormal portal triad morphology
      • beginning at 5 months, inflammatory infiltrate concentrates on the portal triads unlike in wild-type mice   (MGI Ref ID J:143355)
  • pigmentation phenotype
  • abnormal coat/hair pigmentation
    • mice develop gray coat color 5 to 6 months after birth unlike wild-type mice   (MGI Ref ID J:143355)
  • integument phenotype
  • abnormal coat/hair pigmentation
    • mice develop gray coat color 5 to 6 months after birth unlike wild-type mice   (MGI Ref ID J:143355)
  • abnormal hypodermis muscle layer morphology
    • at 2 years of age, mice exhibit disorganization of the muscle layer   (MGI Ref ID J:143355)
  • abnormal sebaceous gland morphology
    • at 2 years, sebaceous gland and annexa size and numbers are decreased compared to in wild-type mice   (MGI Ref ID J:143355)
    • small sebaceous gland
  • abnormal skin morphology
    • at 2 years, mice exhibit severe atrophy of the skin layers, with thinning of the epidermis unlike in wild-type mice   (MGI Ref ID J:143355)
    • thin epidermis
    • thin skin
  • decreased hair follicle number
    • at 2 years, hair follicles are hypotrophic compared to in wild-type mice   (MGI Ref ID J:143355)
  • decreased subcutaneous adipose tissue amount
  • muscle phenotype
  • abnormal hypodermis muscle layer morphology
    • at 2 years of age, mice exhibit disorganization of the muscle layer   (MGI Ref ID J:143355)
  • skeleton phenotype
  • spiral ligament degeneration   (MGI Ref ID J:48653)
    • severe degeneration of the spiral ligament by 7 months   (MGI Ref ID J:48662)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Mpv17 related

Internal/Organ Research
Kidney Defects

Metabolism Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mpv17
Allele Name Mpv17 retroviral insertion, kidney disease mutant
Allele Type Transgenic
Common Name(s) MPV-;
Mutation Made ByDr. Rudolf Jaenisch,   Whitehead Institute (MIT)
Strain of OriginCFW
Molecular Note The Mpv17 mutation was generated by infection of CFW preimplantation mouse embryos with a recombinant retrovirus, MPSVneo, which carries a neo gene and is a replication-defective derivative of the myeloproliferative sarcoma virus, a Moloney murine leukemia virus-related RNA virus. [MGI Ref ID J:10661]

Genotyping

Genotyping Information

Genotyping Protocols

Mpv17/J SEP PCR, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Weiher H; Noda T; Gray DA; Sharpe AH; Jaenisch R. 1990. Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. Cell 62(3):425-34. [PubMed: 1696177]  [MGI Ref ID J:10661]

Additional References

Mpv17 related

Binder CJ; Weiher H; Exner M; Kerjaschki D. 1999. Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. Am J Pathol 154(4):1067-75. [PubMed: 10233845]  [MGI Ref ID J:108252]

Clozel M; Hess P; Fischli W; Loffler BM; Zwacka RM; Reuter A; Weiher H. 1999. Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease. Exp Gerontol 34(8):1007-15. [PubMed: 10673153]  [MGI Ref ID J:59102]

Meyer zum Gottesberge AM; Felix H. 2005. Abnormal basement membrane in the inner ear and the kidney of the Mpv17-/- mouse strain: ultrastructural and immunohistochemical investigations. Histochem Cell Biol 124(6):507-16. [PubMed: 16041630]  [MGI Ref ID J:132545]

Meyer zum Gottesberge AM; Felix H; Reuter A; Weiher H. 2001. Ultrastructural and physiological defects in the cochlea of the Mpv17 mouse strain. A comparison between young and old adult animals. Hear Res 156(1-2):69-80. [PubMed: 11377883]  [MGI Ref ID J:106381]

O'Bryan T; Weiher H; Rennke HG; Kren S; Hostetter TH. 2000. Course of renal injury in the Mpv17-deficient transgenic mouse. J Am Soc Nephrol 11(6):1067-74. [PubMed: 10820170]  [MGI Ref ID J:62419]

Papeta N; Zheng Z; Schon EA; Brosel S; Altintas MM; Nasr SH; Reiser J; D'Agati VD; Gharavi AG. 2010. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest 120(11):4055-64. [PubMed: 20978358]  [MGI Ref ID J:166909]

Reuter A; Nestl A; Zwacka RM; Tuckermann J; Waldherr R; Wagner EM; Hoyhtya M; Meyer zum Gottesberge AM; Angel P; Weiher H. 1998. Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts, the kidney, and the inner ear of mice. Mol Biol Cell 9(7):1675-82. [PubMed: 9658163]  [MGI Ref ID J:48676]

Schenkel J; Zwacka RM; Rutenberg C; Reuter A; Waldherr R; Weiher H. 1995. Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue. Kidney Int 48(1):80-4. [PubMed: 7564095]  [MGI Ref ID J:27358]

Spinazzola A; Viscomi C; Fernandez-Vizarra E; Carrara F; D'Adamo P; Calvo S; Marsano RM; Donnini C; Weiher H; Strisciuglio P; Parini R; Sarzi E; Chan A; DiMauro S; Rotig A; Gasparini P; Ferrero I; Mootha VK; Tiranti V; Zeviani M. 2006. MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion. Nat Genet 38(5):570-5. [PubMed: 16582910]  [MGI Ref ID J:110091]

Viscomi C; Spinazzola A; Maggioni M; Fernandez-Vizarra E; Massa V; Pagano C; Vettor R; Mora M; Zeviani M. 2009. Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice. Hum Mol Genet 18(1):12-26. [PubMed: 18818194]  [MGI Ref ID J:143355]

Zwacka RM; Reuter A; Pfaff E; Moll J; Gorgas K; Karasawa M; Weiher H. 1994. The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. EMBO J 13(21):5129-34. [PubMed: 7957077]  [MGI Ref ID J:21477]

zum Gottesberge AMM; Weiher H; Reuter A; Felix H; Pollak A; Muller M; Smolder JWT; Klinke R. 1998. Inner ear defect similar to Alport's syndrome in the glomerulosclerosis mouse model Mpv17 Hered Deaf News 15:21-2.  [MGI Ref ID J:48653]

zum Gottesberge AMM; Weiher H; Reuter A; Felix H; Pollak A; Muller M; Smolder JWT; Klinke R. 1998. Loss of auditory function in transgenic Mpv17-deficient mice Hered Deaf News 15:22.  [MGI Ref ID J:48661]

zum Gottesberge AMM; Weiher H; Reuter A; Felix H; Pollak A; Muller M; Smolder JWT; Klinke R. 1998. Sequence of neuronal degeneration in transgenic Mpv17-deficient mice Hered Deaf News 15:22.  [MGI Ref ID J:48662]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)