Strain Name:

129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J

Stock Number:

002211

Availability:

Repository- Live

Description

Strain Information

Type Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
GenerationF?+36 (04-DEC-07)
 
Donating Investigator Richard Palmiter,   University of Washington

Appearance
white-bellied agouti
Related Genotype: Aw/Aw

Description
Mice homozygous for the Mt1tm1Bri Mt2tm1Bri mutation are viable and fertile. They show an increased sensitivity to hepatic poisoning by cadmium. Most homozygous mice given daily injections of cadmium die within 4 days, with most of the males dying within 2 days.

Development
The Mt1tm1Bri Mt2tm1Bri mutant strain was developed in the laboratory of Dr. Richard Palmiter at the University of Washington and Dr. Ralph Brinster at the University of Pennsylvania. Both the Mt1 and Mt2 genes were knocked out in a single targeting event. The 129-derived AB-1 ES cell line was used. R. Palmiter (10/30/02) points out that, contrary to what is published in PNAS 91, 585 (Fig. 1), the oligo that is inserted into exon 1of the Mt1 gene is inverted (it still has the KpnI site and in-frame termination codons) and the other oligo insertion (labeled "d") is not present. These errors do not affect the phenotype but could impact PCR genotyping strategies.

Control Information

  Control
   002448 129S1/SvImJ (approximate)
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Mt1     (14 strains)

Additional Web Information

New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Mt1tm1Bri/Mt1tm1Bri Mt2tm1Bri/Mt2tm1Bri

        129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:16487)
    • death occurs between 2-4 days after administration of cadmium, no deaths are observed in control mice
    • males die earlier and more often than females after cadmium injection
  • liver/biliary system phenotype
  • abnormal liver morphology (MGI Ref ID J:16487)
    • 4 days after administration of cadmium, livers exhibit focal areas of cellular degeneration, necrosis, congestion and hemorrhaging
    • hepatic necrosis (MGI Ref ID J:16487)
      • necrosis observed following administration of cadmium
    • liver degeneration (MGI Ref ID J:16487)
      • degeneration observed following administration of cadmium
  • homeostasis/metabolism phenotype
  • abnormal circulating enzyme level (MGI Ref ID J:16487)
    • untreated females have 2-fold higher levels of serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) than untreated controls
    • following 2 days of cadmium treatment, males exhibit a significant increase in SGOT and SGPT levels over treated control males
    • increased circulating alkaline phosphatase level (MGI Ref ID J:16487)
      • increased levels observed in untreated males and females as compared to controls
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Internal/Organ Research
Liver Defects

Mt1tm1Bri related

Metabolism Research

Genes & Alleles

Gene & Allele Information

Allele Symbol Mt1tm1Bri
Allele Name targeted mutation 1, Ralph L Brinster
Allele Type Targeted (knock-out)
Common Name(s) MT-KO; Mt1tm/Bri; Mt1tm1Br; Mt1tm1Bri;
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Mt1, metallothionein 1
Chromosome 8
Gene Common Name(s) MGC32848; MT-I; MT1S; MTC; Mt; Mt-1;
Molecular Note Both the Mt1 and Mt2 genes were simultaneously disrupted using a vector that inserted in-frame stop codons into the exons of the two genes. Mutant alleles are transcribed but not translated. [MGI Ref ID J:16487]
 
Allele Symbol Mt2tm1Bri
Allele Name targeted mutation 1, Ralph L Brinster
Allele Type Targeted (knock-out)
Common Name(s) Mt2tm/Bri; Mt2tm1Bri;
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Mt2, metallothionein 2
Chromosome 8
Gene Common Name(s) AA409533; MT-II; Mt-2; expressed sequence AA409533;
Molecular Note Both the Mt1 and Mt2 genes were simultaneously disrupted using a vector that inserted in-frame stop codons into the exons of the two genes. Mutant alleles are transcribed but not translated. [MGI Ref ID J:16487]

Genotyping

Genotyping Information

Genotyping Protocols

Mt1tm1Bri, STD PCR, vers. 1
Mt2tm1Bri, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Masters BA; Kelly EJ; Quaife CJ; Brinster RL; Palmiter RD. 1994. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci U S A 91(2):584-8. [PubMed: 8290567]  [MGI Ref ID J:16487]

Additional References

Hanada K. 2000. Photoprotective role of metallothionein in UV-injury - metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B J Dermatol Sci 23(## Suppl 1):S51-6. [PubMed: 10764993]  [MGI Ref ID J:62369]

Lyons BL; Lynes MA; Burzenski L; Joliat MJ; Hadjout N; Shultz LD. 2003. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient 'viable motheaten' mice. Exp Hematol 31(3):234-43. [PubMed: 12644021]  [MGI Ref ID J:82283]

Qu W; Diwan BA; Liu J; Goyer RA; Dawson T; Horton JL; Cherian MG; Waalkes MP. 2002. The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. Am J Pathol 160(3):1047-56. [PubMed: 11891201]  [MGI Ref ID J:75301]

Waelput W; Broekaert D; Vandekerckhove J; Brouckaert P; Tavernier J; Libert C. 2001. A mediator role for metallothionein in tumor necrosis factor-induced lethal shock. J Exp Med 194(11):1617-24. [PubMed: 11733576]  [MGI Ref ID J:73099]

Zhou Z; Wang L; Song Z; Saari JT; McClain CJ; Kang YJ. 2004. Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury. Am J Pathol 164(5):1547-56. [PubMed: 15111301]  [MGI Ref ID J:89568]

Mt1tm1Bri related

Abe T; Yamamoto O; Gotoh S; Yan Y; Todaka N; Higashi K. 2000. Cadmium-induced mRNA expression of Hsp32 is augmented in metallothionein-I and -II knock-out mice Arch Biochem Biophys 382(1):81-8. [PubMed: 11051100]  [MGI Ref ID J:64768]

Andrews GK; Geiser J. 1999. Expression of the mouse metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency. J Nutr 129(9):1643-8. [PubMed: 10460198]  [MGI Ref ID J:103039]

Asanuma M; Miyazaki I; Higashi Y; Tanaka K; Haque ME; Fujita N; Ogawa N. 2002. Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Neurosci Lett 327(1):61-5. [PubMed: 12098501]  [MGI Ref ID J:107961]

Bobillier-Chaumont S; Nicod L; Richert L; Berthelot A. 2003. Antioxidant status in the liver of hypertensive and metallothionein-deficient mice. Can J Physiol Pharmacol 81(10):929-36. [PubMed: 14608409]  [MGI Ref ID J:136413]

Carrasco J; Penkowa M; Giralt M; Camats J; Molinero A; Campbell IL; Palmiter RD; Hidalgo J. 2003. Role of metallothionein-III following central nervous system damage. Neurobiol Dis 13(1):22-36. [PubMed: 12758064]  [MGI Ref ID J:126845]

Carrasco J; Penkowa M; Hadberg H; Molinero A; Hidalgo J. 2000. Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice. Eur J Neurosci 12(7):2311-22. [PubMed: 10947810]  [MGI Ref ID J:89429]

Ceballos D; Lago N; Verdu E; Penkowa M; Carrasco J; Navarro X; Palmiter RD; Hidalgo J. 2003. Role of metallothioneins in peripheral nerve function and regeneration. Cell Mol Life Sci 60(6):1209-16. [PubMed: 12861386]  [MGI Ref ID J:115685]

Conrad CC; Grabowski DT; Walter CA; Sabia M; Richardson A. 2000. Using MT(-/-) mice to study metallothionein and oxidative stress. Free Radic Biol Med 28(3):447-62. [PubMed: 10699757]  [MGI Ref ID J:61310]

Crowthers KC; Kline V; Giardina C; Lynes MA. 2000. Augmented humoral immune function in metallothionein-null mice. Toxicol Appl Pharmacol 166(3):161-72. [PubMed: 10906280]  [MGI Ref ID J:110643]

Davis SR; McMahon RJ; Cousins RJ. 1998. Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. J Nutr 128(5):825-31. [PubMed: 9566988]  [MGI Ref ID J:47419]

Davis SR; Samuelson DA; Cousins RJ. 2001. Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice. J Nutr 131(2):215-22. [PubMed: 11160536]  [MGI Ref ID J:107225]

Deng DX; Cai L; Chakrabarti S; Cherian MG. 1999. Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein. Toxicology 134(1):39-49. [PubMed: 10413187]  [MGI Ref ID J:57169]

Dubocovich ML; Hudson RL; Sumaya IC; Masana MI; Manna E. 2005. Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse. J Pineal Res 39(2):113-20. [PubMed: 16098087]  [MGI Ref ID J:114345]

Ebadi M; Brown-Borg H; El Refaey H; Singh BB; Garrett S; Shavali S; Sharma SK. 2005. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Brain Res Mol Brain Res 134(1):67-75. [PubMed: 15790531]  [MGI Ref ID J:97105]

Ebadi M; Sharma S. 2006. Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease. Exp Biol Med (Maywood) 231(9):1576-83. [PubMed: 17018883]  [MGI Ref ID J:129277]

Eddins D; Petro A; Pollard N; Freedman JH; Levin ED. 2008. Mercury-induced cognitive impairment in metallothionein-1/2 null mice. Neurotoxicol Teratol 30(2):88-95. [PubMed: 18226494]  [MGI Ref ID J:140078]

Fattman CL; Gambelli F; Hoyle G; Pitt BR; Ortiz LA. 2008. Epithelial expression of TIMP-1 does not alter sensitivity to bleomycin-induced lung injury in C57BL/6 mice. Am J Physiol Lung Cell Mol Physiol 294(3):L572-81. [PubMed: 18178676]  [MGI Ref ID J:132192]

Giralt M; Penkowa M; Hernandez J; Molinero A; Carrasco J; Lago N; Camats J; Campbell IL; Hidalgo J. 2002. Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiol Dis 9(3):319-38. [PubMed: 11950277]  [MGI Ref ID J:125457]

Giralt M; Penkowa M; Lago N; Molinero A; Hidalgo J. 2002. Metallothionein-1+2 protect the CNS after a focal brain injury. Exp Neurol 173(1):114-28. [PubMed: 11771944]  [MGI Ref ID J:119136]

Habeebu SS; Liu J; Liu Y; Klaassen CD. 2000. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicol Sci 55(1):223-32. [PubMed: 10788577]  [MGI Ref ID J:126669]

Habeebu SS; Liu J; Liu Y; Klaassen CD. 2000. Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicol Sci 56(1):211-9. [PubMed: 10869470]  [MGI Ref ID J:126420]

Hanada K. 2000. Photoprotective role of metallothionein in UV-injury - metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B J Dermatol Sci 23(## Suppl 1):S51-6. [PubMed: 10764993]  [MGI Ref ID J:62369]

Kelly EJ; Palmiter RD. 1996. A murine model of Menkes disease reveals a physiological function of metallothionein. Nat Genet 13(2):219-22. [PubMed: 8640230]  [MGI Ref ID J:33276]

Kelly EJ; Quaife CJ; Froelick GJ; Palmiter RD. 1996. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126(7):1782-90. [PubMed: 8683339]  [MGI Ref ID J:34407]

Kennette W; Collins OM; Zalups RK; Koropatnick J. 2005. Basal and zinc-induced metallothionein in resistance to cadmium, cisplatin, zinc, and tertbutyl hydroperoxide: studies using MT knockout and antisense-downregulated MT in mammalian cells. Toxicol Sci 88(2):602-13. [PubMed: 16150881]  [MGI Ref ID J:113269]

Kimura T; Itoh N; Takehara M; Oguro I; Ishizaki JI; Nakanishi T; Tanaka K. 2001. Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethality. Biochem Biophys Res Commun 280(1):358-62. [PubMed: 11162523]  [MGI Ref ID J:110627]

Kimura T; Oguro I; Kohroki J; Takehara M; Itoh N; Nakanishi T; Tanaka K. 2000. Metallothionein-null mice express altered genes during development. Biochem Biophys Res Commun 270(2):458-61. [PubMed: 10753647]  [MGI Ref ID J:61575]

Kondo Y; Himeno S; Endo W; Mita M; Suzuki Y; Nemoto K; Akimoto M; Lazo JS; Imura N. 1999. Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice. Carcinogenesis 20(8):1625-7. [PubMed: 10426817]  [MGI Ref ID J:56770]

Lambert JC; Zhou Z; Wang L; Song Z; McClain CJ; Kang YJ. 2004. Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice. Am J Pathol 164(6):1959-66. [PubMed: 15161632]  [MGI Ref ID J:91074]

Lau JC; Cherian MG. 1998. Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. Biochem Cell Biol 76(4):615-23. [PubMed: 10099782]  [MGI Ref ID J:53230]

Leazer TM; Daston GP; Keen CL; Rogers JM. 2003. The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein induction. Toxicol Sci 73(2):442-7. [PubMed: 12700403]  [MGI Ref ID J:125434]

Levin ED; Perraut C; Pollard N; Freedman JH. 2006. Metallothionein expression and neurocognitive function in mice. Physiol Behav 87(3):513-8. [PubMed: 16430929]  [MGI Ref ID J:112813]

Liu J; Corton C; Dix DJ; Liu Y; Waalkes MP; Klaassen CD. 2001. Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicol Appl Pharmacol 176(1):1-9. [PubMed: 11578143]  [MGI Ref ID J:126651]

Liu J; Liu Y; Goyer RA; Achanzar W; Waalkes MP. 2000. Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals. Toxicol Sci 55(2):460-7. [PubMed: 10828279]  [MGI Ref ID J:126451]

Liu J; Liu Y; Hartley D; Klaassen CD; Shehin-Johnson SE; Lucas A; Cohen SD. 1999. Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. J Pharmacol Exp Ther 289(1):580-6. [PubMed: 10087053]  [MGI Ref ID J:120459]

Liu Y; Liu J; Habeebu SM; Waalkes MP; Klaassen CD. 2000. Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicol Sci 57(1):167-76. [PubMed: 10966523]  [MGI Ref ID J:126620]

Lyons BL; Lynes MA; Burzenski L; Joliat MJ; Hadjout N; Shultz LD. 2003. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient 'viable motheaten' mice. Exp Hematol 31(3):234-43. [PubMed: 12644021]  [MGI Ref ID J:82283]

McAuliffe JJ; Joseph B; Hughes E; Miles L; Vorhees CV. 2008. Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments. Brain Res 1190:175-85. [PubMed: 18083145]  [MGI Ref ID J:130838]

Miura N; Koizumi S. 2005. Gene expression profiles in the liver and kidney of metallothionein-null mice. Biochem Biophys Res Commun 332(4):949-55. [PubMed: 15913548]  [MGI Ref ID J:99118]

Miyazaki I; Asanuma M; Hozumi H; Miyoshi K; Sogawa N. 2007. Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity. FEBS Lett 581(25):5003-8. [PubMed: 17910954]  [MGI Ref ID J:126937]

Nachman-Clewner M; Giblin FJ; Dorey CK; Blanks RH; Dang L; Dougherty CJ; Blanks JC. 2008. Selective degeneration of central photoreceptors after hyperbaric oxygen in normal and metallothionein-knockout mice. Invest Ophthalmol Vis Sci 49(7):3207-15. [PubMed: 18579766]  [MGI Ref ID J:137160]

Oliver JR; Jiang S; Cherian MG. 2006. Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide. Toxicol Appl Pharmacol 210(3):190-9. [PubMed: 15979673]  [MGI Ref ID J:105679]

Oliver JR; Mara TW; Cherian MG. 2005. Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy. Exp Biol Med (Maywood) 230(1):61-7. [PubMed: 15618127]  [MGI Ref ID J:109814]

Ono S; Koropatnick DJ; Cherian MG. 1997. Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice. Toxicology 124(1):1-10. [PubMed: 9392450]  [MGI Ref ID J:44523]

Oshima Y; Fujio Y; Nakanishi T; Itoh N; Yamamoto Y; Negoro S; Tanaka K; Kishimoto T; Kawase I; Azuma J. 2005. STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart. Cardiovasc Res 65(2):428-35. [PubMed: 15639482]  [MGI Ref ID J:134625]

Oz HS; Chen T; de Villiers WJ; McClain CJ. 2005. Metallothionein overexpression does not protect against inflammatory bowel disease in a murine colitis model. Med Sci Monit 11(3):BR69-73. [PubMed: 15735556]  [MGI Ref ID J:127866]

Penkowa M; Carrasco J; Giralt M; Moos T; Hidalgo J. 1999. CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J Neurosci 19(7):2535-45. [PubMed: 10087067]  [MGI Ref ID J:53929]

Penkowa M; Espejo C; Martinez-Caceres EM; Montalban X; Hidalgo J. 2003. Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis. Cell Mol Life Sci 60(1):185-97. [PubMed: 12613667]  [MGI Ref ID J:115509]

Penkowa M; Espejo C; Martinez-Caceres EM; Poulsen CB; Montalban X; Hidalgo J. 2001. Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis. J Neuroimmunol 119(2):248-60. [PubMed: 11585628]  [MGI Ref ID J:103102]

Penkowa M; Giralt M; Lago N; Camats J; Carrasco J; Hernandez J; Molinero A; Campbell IL; Hidalgo J. 2003. Astrocyte-targeted expression of IL-6 protects the CNSagainst a focal brain injury. Exp Neurol 181(2):130-48. [PubMed: 12781987]  [MGI Ref ID J:83736]

Puttaparthi K; Gitomer WL; Krishnan U; Son M; Rajendran B; Elliott JL. 2002. Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins. J Neurosci 22(20):8790-6. [PubMed: 12388585]  [MGI Ref ID J:79760]

Qu W; Diwan BA; Liu J; Goyer RA; Dawson T; Horton JL; Cherian MG; Waalkes MP. 2002. The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. Am J Pathol 160(3):1047-56. [PubMed: 11891201]  [MGI Ref ID J:75301]

Rojas P; Klaassen CD. 1999. Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neurosci Lett 273(2):113-6. [PubMed: 10505629]  [MGI Ref ID J:59769]

Sharma SK; El Refaey H; Ebadi M. 2006. Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10. Brain Res Bull 70(1):22-32. [PubMed: 16750479]  [MGI Ref ID J:112754]

Stankovic RK; Lee V; Kekic M; Harper C. 2003. The expression and significance of metallothioneins in murine organs and tissues following mercury vapour exposure. Toxicol Pathol 31(5):514-23. [PubMed: 14692620]  [MGI Ref ID J:126199]

Stankovic RK; Li Z. 2006. Decreased neurofilament density in large myelinated axons of metallothionein-I, II knockout mice. Neurosci Lett 402(1-2):1-6. [PubMed: 16600496]  [MGI Ref ID J:111123]

Suemori S; Shimazawa M; Kawase K; Satoh M; Nagase H; Yamamoto T; Hara H. 2006. Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. Invest Ophthalmol Vis Sci 47(9):3975-82. [PubMed: 16936113]  [MGI Ref ID J:116275]

Vidal E; Tortosa R; Marquez M; Serafin A; Hidalgo J; Pumarola M. 2008. Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie. Brain Res 1196:140-50. [PubMed: 18221736]  [MGI Ref ID J:131897]

Waalkes MP; Liu J; Goyer RA; Diwan BA. 2004. Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation. Cancer Res 64(21):7766-72. [PubMed: 15520181]  [MGI Ref ID J:93863]

Waalkes MP; Liu J; Kasprzak KS; Diwan BA. 2006. Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses. Int J Cancer 119(1):28-32. [PubMed: 16432836]  [MGI Ref ID J:108564]

Waalkes MP; Liu J; Kasprzak KS; Diwan BA. 2005. Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice. Int J Toxicol 24(4):215-20. [PubMed: 16126615]  [MGI Ref ID J:104179]

Waelput W; Broekaert D; Vandekerckhove J; Brouckaert P; Tavernier J; Libert C. 2001. A mediator role for metallothionein in tumor necrosis factor-induced lethal shock. J Exp Med 194(11):1617-24. [PubMed: 11733576]  [MGI Ref ID J:73099]

Wang L; Zhou Z; Saari JT; Kang YJ. 2005. Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation. Am J Pathol 167(2):337-44. [PubMed: 16049321]  [MGI Ref ID J:99953]

Wang WH; Li LF; Zhang BX; Lu XY. 2004. Metallothionein-null mice exhibit reduced tolerance to ultraviolet B injury in vivo. Clin Exp Dermatol 29(1):57-61. [PubMed: 14723724]  [MGI Ref ID J:101785]

Wastney ME; House WA. 2008. Development of a compartmental model of zinc kinetics in mice. J Nutr 138(11):2148-55. [PubMed: 18936212]  [MGI Ref ID J:140652]

Wesselkamper SC; McDowell SA; Medvedovic M; Dalton TP; Deshmukh HS; Sartor MA; Case LM; Henning LN; Borchers MT; Tomlinson CR; Prows DR; Leikauf GD. 2006. The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol 34(1):73-82. [PubMed: 16166738]  [MGI Ref ID J:120196]

Xie T; Tong L; McCann UD; Yuan J; Becker KG; Mechan AO; Cheadle C; Donovan DM; Ricaurte GA. 2004. Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons. J Neurosci 24(32):7043-50. [PubMed: 15306638]  [MGI Ref ID J:97267]

Zhou Z; Wang L; Song Z; Saari JT; McClain CJ; Kang YJ. 2004. Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury. Am J Pathol 164(5):1547-56. [PubMed: 15111301]  [MGI Ref ID J:89568]

Zhou Z; Wang L; Song Z; Saari JT; McClain CJ; Kang YJ. 2005. Zinc Supplementation Prevents Alcoholic Liver Injury in Mice through Attenuation of Oxidative Stress. Am J Pathol 166(6):1681-90. [PubMed: 15920153]  [MGI Ref ID J:98817]

Mt2tm1Bri related

Abe T; Yamamoto O; Gotoh S; Yan Y; Todaka N; Higashi K. 2000. Cadmium-induced mRNA expression of Hsp32 is augmented in metallothionein-I and -II knock-out mice Arch Biochem Biophys 382(1):81-8. [PubMed: 11051100]  [MGI Ref ID J:64768]

Andrews GK; Geiser J. 1999. Expression of the mouse metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency. J Nutr 129(9):1643-8. [PubMed: 10460198]  [MGI Ref ID J:103039]

Asanuma M; Miyazaki I; Higashi Y; Tanaka K; Haque ME; Fujita N; Ogawa N. 2002. Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Neurosci Lett 327(1):61-5. [PubMed: 12098501]  [MGI Ref ID J:107961]

Bobillier-Chaumont S; Nicod L; Richert L; Berthelot A. 2003. Antioxidant status in the liver of hypertensive and metallothionein-deficient mice. Can J Physiol Pharmacol 81(10):929-36. [PubMed: 14608409]  [MGI Ref ID J:136413]

Carrasco J; Penkowa M; Giralt M; Camats J; Molinero A; Campbell IL; Palmiter RD; Hidalgo J. 2003. Role of metallothionein-III following central nervous system damage. Neurobiol Dis 13(1):22-36. [PubMed: 12758064]  [MGI Ref ID J:126845]

Carrasco J; Penkowa M; Hadberg H; Molinero A; Hidalgo J. 2000. Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice. Eur J Neurosci 12(7):2311-22. [PubMed: 10947810]  [MGI Ref ID J:89429]

Ceballos D; Lago N; Verdu E; Penkowa M; Carrasco J; Navarro X; Palmiter RD; Hidalgo J. 2003. Role of metallothioneins in peripheral nerve function and regeneration. Cell Mol Life Sci 60(6):1209-16. [PubMed: 12861386]  [MGI Ref ID J:115685]

Conrad CC; Grabowski DT; Walter CA; Sabia M; Richardson A. 2000. Using MT(-/-) mice to study metallothionein and oxidative stress. Free Radic Biol Med 28(3):447-62. [PubMed: 10699757]  [MGI Ref ID J:61310]

Crowthers KC; Kline V; Giardina C; Lynes MA. 2000. Augmented humoral immune function in metallothionein-null mice. Toxicol Appl Pharmacol 166(3):161-72. [PubMed: 10906280]  [MGI Ref ID J:110643]

Deng DX; Cai L; Chakrabarti S; Cherian MG. 1999. Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein. Toxicology 134(1):39-49. [PubMed: 10413187]  [MGI Ref ID J:57169]

Ebadi M; Brown-Borg H; El Refaey H; Singh BB; Garrett S; Shavali S; Sharma SK. 2005. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Brain Res Mol Brain Res 134(1):67-75. [PubMed: 15790531]  [MGI Ref ID J:97105]

Ebadi M; Sharma S. 2006. Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease. Exp Biol Med (Maywood) 231(9):1576-83. [PubMed: 17018883]  [MGI Ref ID J:129277]

Eddins D; Petro A; Pollard N; Freedman JH; Levin ED. 2008. Mercury-induced cognitive impairment in metallothionein-1/2 null mice. Neurotoxicol Teratol 30(2):88-95. [PubMed: 18226494]  [MGI Ref ID J:140078]

Giralt M; Penkowa M; Hernandez J; Molinero A; Carrasco J; Lago N; Camats J; Campbell IL; Hidalgo J. 2002. Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiol Dis 9(3):319-38. [PubMed: 11950277]  [MGI Ref ID J:125457]

Giralt M; Penkowa M; Lago N; Molinero A; Hidalgo J. 2002. Metallothionein-1+2 protect the CNS after a focal brain injury. Exp Neurol 173(1):114-28. [PubMed: 11771944]  [MGI Ref ID J:119136]

Habeebu SS; Liu J; Liu Y; Klaassen CD. 2000. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicol Sci 55(1):223-32. [PubMed: 10788577]  [MGI Ref ID J:126669]

Habeebu SS; Liu J; Liu Y; Klaassen CD. 2000. Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicol Sci 56(1):211-9. [PubMed: 10869470]  [MGI Ref ID J:126420]

Hanada K. 2000. Photoprotective role of metallothionein in UV-injury - metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B J Dermatol Sci 23(## Suppl 1):S51-6. [PubMed: 10764993]  [MGI Ref ID J:62369]

Kelly EJ; Palmiter RD. 1996. A murine model of Menkes disease reveals a physiological function of metallothionein. Nat Genet 13(2):219-22. [PubMed: 8640230]  [MGI Ref ID J:33276]

Kelly EJ; Quaife CJ; Froelick GJ; Palmiter RD. 1996. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126(7):1782-90. [PubMed: 8683339]  [MGI Ref ID J:34407]

Kennette W; Collins OM; Zalups RK; Koropatnick J. 2005. Basal and zinc-induced metallothionein in resistance to cadmium, cisplatin, zinc, and tertbutyl hydroperoxide: studies using MT knockout and antisense-downregulated MT in mammalian cells. Toxicol Sci 88(2):602-13. [PubMed: 16150881]  [MGI Ref ID J:113269]

Kimura T; Itoh N; Takehara M; Oguro I; Ishizaki JI; Nakanishi T; Tanaka K. 2001. Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethality. Biochem Biophys Res Commun 280(1):358-62. [PubMed: 11162523]  [MGI Ref ID J:110627]

Kimura T; Oguro I; Kohroki J; Takehara M; Itoh N; Nakanishi T; Tanaka K. 2000. Metallothionein-null mice express altered genes during development. Biochem Biophys Res Commun 270(2):458-61. [PubMed: 10753647]  [MGI Ref ID J:61575]

Kondo Y; Himeno S; Endo W; Mita M; Suzuki Y; Nemoto K; Akimoto M; Lazo JS; Imura N. 1999. Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice. Carcinogenesis 20(8):1625-7. [PubMed: 10426817]  [MGI Ref ID J:56770]

Lambert JC; Zhou Z; Wang L; Song Z; McClain CJ; Kang YJ. 2004. Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice. Am J Pathol 164(6):1959-66. [PubMed: 15161632]  [MGI Ref ID J:91074]

Lau JC; Cherian MG. 1998. Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. Biochem Cell Biol 76(4):615-23. [PubMed: 10099782]  [MGI Ref ID J:53230]

Leazer TM; Daston GP; Keen CL; Rogers JM. 2003. The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein induction. Toxicol Sci 73(2):442-7. [PubMed: 12700403]  [MGI Ref ID J:125434]

Levin ED; Perraut C; Pollard N; Freedman JH. 2006. Metallothionein expression and neurocognitive function in mice. Physiol Behav 87(3):513-8. [PubMed: 16430929]  [MGI Ref ID J:112813]

Liu J; Corton C; Dix DJ; Liu Y; Waalkes MP; Klaassen CD. 2001. Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicol Appl Pharmacol 176(1):1-9. [PubMed: 11578143]  [MGI Ref ID J:126651]

Liu J; Liu Y; Goyer RA; Achanzar W; Waalkes MP. 2000. Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals. Toxicol Sci 55(2):460-7. [PubMed: 10828279]  [MGI Ref ID J:126451]

Liu J; Liu Y; Hartley D; Klaassen CD; Shehin-Johnson SE; Lucas A; Cohen SD. 1999. Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. J Pharmacol Exp Ther 289(1):580-6. [PubMed: 10087053]  [MGI Ref ID J:120459]

Liu Y; Liu J; Habeebu SM; Waalkes MP; Klaassen CD. 2000. Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicol Sci 57(1):167-76. [PubMed: 10966523]  [MGI Ref ID J:126620]

Lyons BL; Lynes MA; Burzenski L; Joliat MJ; Hadjout N; Shultz LD. 2003. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient 'viable motheaten' mice. Exp Hematol 31(3):234-43. [PubMed: 12644021]  [MGI Ref ID J:82283]

McAuliffe JJ; Joseph B; Hughes E; Miles L; Vorhees CV. 2008. Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments. Brain Res 1190:175-85. [PubMed: 18083145]  [MGI Ref ID J:130838]

Miura N; Koizumi S. 2005. Gene expression profiles in the liver and kidney of metallothionein-null mice. Biochem Biophys Res Commun 332(4):949-55. [PubMed: 15913548]  [MGI Ref ID J:99118]

Nachman-Clewner M; Giblin FJ; Dorey CK; Blanks RH; Dang L; Dougherty CJ; Blanks JC. 2008. Selective degeneration of central photoreceptors after hyperbaric oxygen in normal and metallothionein-knockout mice. Invest Ophthalmol Vis Sci 49(7):3207-15. [PubMed: 18579766]  [MGI Ref ID J:137160]

Oliver JR; Jiang S; Cherian MG. 2006. Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide. Toxicol Appl Pharmacol 210(3):190-9. [PubMed: 15979673]  [MGI Ref ID J:105679]

Oliver JR; Mara TW; Cherian MG. 2005. Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy. Exp Biol Med (Maywood) 230(1):61-7. [PubMed: 15618127]  [MGI Ref ID J:109814]

Ono S; Koropatnick DJ; Cherian MG. 1997. Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice. Toxicology 124(1):1-10. [PubMed: 9392450]  [MGI Ref ID J:44523]

Oshima Y; Fujio Y; Nakanishi T; Itoh N; Yamamoto Y; Negoro S; Tanaka K; Kishimoto T; Kawase I; Azuma J. 2005. STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart. Cardiovasc Res 65(2):428-35. [PubMed: 15639482]  [MGI Ref ID J:134625]

Penkowa M; Carrasco J; Giralt M; Moos T; Hidalgo J. 1999. CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J Neurosci 19(7):2535-45. [PubMed: 10087067]  [MGI Ref ID J:53929]

Penkowa M; Espejo C; Martinez-Caceres EM; Montalban X; Hidalgo J. 2003. Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis. Cell Mol Life Sci 60(1):185-97. [PubMed: 12613667]  [MGI Ref ID J:115509]

Penkowa M; Espejo C; Martinez-Caceres EM; Poulsen CB; Montalban X; Hidalgo J. 2001. Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis. J Neuroimmunol 119(2):248-60. [PubMed: 11585628]  [MGI Ref ID J:103102]

Penkowa M; Giralt M; Lago N; Camats J; Carrasco J; Hernandez J; Molinero A; Campbell IL; Hidalgo J. 2003. Astrocyte-targeted expression of IL-6 protects the CNSagainst a focal brain injury. Exp Neurol 181(2):130-48. [PubMed: 12781987]  [MGI Ref ID J:83736]

Puttaparthi K; Gitomer WL; Krishnan U; Son M; Rajendran B; Elliott JL. 2002. Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins. J Neurosci 22(20):8790-6. [PubMed: 12388585]  [MGI Ref ID J:79760]

Qu W; Diwan BA; Liu J; Goyer RA; Dawson T; Horton JL; Cherian MG; Waalkes MP. 2002. The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. Am J Pathol 160(3):1047-56. [PubMed: 11891201]  [MGI Ref ID J:75301]

Rojas P; Klaassen CD. 1999. Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neurosci Lett 273(2):113-6. [PubMed: 10505629]  [MGI Ref ID J:59769]

Sharma SK; El Refaey H; Ebadi M. 2006. Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10. Brain Res Bull 70(1):22-32. [PubMed: 16750479]  [MGI Ref ID J:112754]

Stankovic RK; Lee V; Kekic M; Harper C. 2003. The expression and significance of metallothioneins in murine organs and tissues following mercury vapour exposure. Toxicol Pathol 31(5):514-23. [PubMed: 14692620]  [MGI Ref ID J:126199]

Stankovic RK; Li Z. 2006. Decreased neurofilament density in large myelinated axons of metallothionein-I, II knockout mice. Neurosci Lett 402(1-2):1-6. [PubMed: 16600496]  [MGI Ref ID J:111123]

Suemori S; Shimazawa M; Kawase K; Satoh M; Nagase H; Yamamoto T; Hara H. 2006. Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. Invest Ophthalmol Vis Sci 47(9):3975-82. [PubMed: 16936113]  [MGI Ref ID J:116275]

Vidal E; Tortosa R; Marquez M; Serafin A; Hidalgo J; Pumarola M. 2008. Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie. Brain Res 1196:140-50. [PubMed: 18221736]  [MGI Ref ID J:131897]

Waalkes MP; Liu J; Goyer RA; Diwan BA. 2004. Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: role of inclusion body formation. Cancer Res 64(21):7766-72. [PubMed: 15520181]  [MGI Ref ID J:93863]

Waalkes MP; Liu J; Kasprzak KS; Diwan BA. 2006. Hypersusceptibility to cisplatin carcinogenicity in metallothionein-I/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses. Int J Cancer 119(1):28-32. [PubMed: 16432836]  [MGI Ref ID J:108564]

Waalkes MP; Liu J; Kasprzak KS; Diwan BA. 2005. Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice. Int J Toxicol 24(4):215-20. [PubMed: 16126615]  [MGI Ref ID J:104179]

Waelput W; Broekaert D; Vandekerckhove J; Brouckaert P; Tavernier J; Libert C. 2001. A mediator role for metallothionein in tumor necrosis factor-induced lethal shock. J Exp Med 194(11):1617-24. [PubMed: 11733576]  [MGI Ref ID J:73099]

Wang WH; Li LF; Zhang BX; Lu XY. 2004. Metallothionein-null mice exhibit reduced tolerance to ultraviolet B injury in vivo. Clin Exp Dermatol 29(1):57-61. [PubMed: 14723724]  [MGI Ref ID J:101785]

Wastney ME; House WA. 2008. Development of a compartmental model of zinc kinetics in mice. J Nutr 138(11):2148-55. [PubMed: 18936212]  [MGI Ref ID J:140652]

Wesselkamper SC; McDowell SA; Medvedovic M; Dalton TP; Deshmukh HS; Sartor MA; Case LM; Henning LN; Borchers MT; Tomlinson CR; Prows DR; Leikauf GD. 2006. The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol 34(1):73-82. [PubMed: 16166738]  [MGI Ref ID J:120196]

Xie T; Tong L; McCann UD; Yuan J; Becker KG; Mechan AO; Cheadle C; Donovan DM; Ricaurte GA. 2004. Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons. J Neurosci 24(32):7043-50. [PubMed: 15306638]  [MGI Ref ID J:97267]

Zhou Z; Wang L; Song Z; Saari JT; McClain CJ; Kang YJ. 2004. Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury. Am J Pathol 164(5):1547-56. [PubMed: 15111301]  [MGI Ref ID J:89568]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Breeding & HusbandryThe Mt1tm1Bri Mt2tm1Bri strain is maintained by mating homozygous siblings. Homozygous mice may be ordered. Expected coat color from breeding:White Bellied Agouti
Mating SystemHomozygote x Homozygote         (Female x Male)
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $90.10Female or MaleHomozygous for Mt1tm1Bri, Homozygous for Mt2tm1Bri
Pairs /Price*Pair Genotype
$180.20Homozygous for Mt1tm1Bri, Homozygous for Mt2tm1Bri x Homozygous for Mt1tm1Bri, Homozygous for Mt2tm1Bri
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $117.20Female or MaleHomozygous for Mt1tm1Bri, Homozygous for Mt2tm1Bri
Pairs /Price*Pair Genotype
$234.30Homozygous for Mt1tm1Bri, Homozygous for Mt2tm1Bri x Homozygous for Mt1tm1Bri, Homozygous for Mt2tm1Bri
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Control
   002448 129S1/SvImJ (approximate)
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use


General Terms and Conditions


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phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

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In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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