Strain Name: |
C3H/HeSnJ-Ctnna2cdf/J |
|---|---|
Stock Number: |
002235 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
C3H/HeSnJ-Catna2cdf/J (Changed: 02-JUN-05
) |
|
C3H/HeSnJ-cdf/+ (Changed: 15-DEC-04
) | |
| Genes & Alleles | Ctnna2; Ctnna2cdf; Pde6b; Pde6brd1; |
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation +10N6F4+N1 Appearance
agouti
Related Genotype: A/AImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Strain Description
Cerebellar deficient folia (cdf) is a recessive mutation which maps to chromosome 6. Homozygotes display a constant side-to-side wobble in their gait that is apparent as early as 2 weeks of age. Additionally, they often hold their tails off the surface or arch them over their heads while moving. Smaller size is detectable in homozygotes by two weeks of age, at weaning they weigh approximately 25% less than littermate controls, and as adults they weigh, on average, 50% less. These mutants live a normal life span (one-and-a-half to two years on the C3H/HeJ background), but homozygous males rarely breed and homozygous females are poor mothers requiring transfer of litters to foster mothers.The cdf mutation causes a hypoplastic and dysmorphic cerebellum. On the C3H/HeJ background, homozygotes have only 7 cerebellar folia rather than the 10 present in wildtype, and the folia pattern is abnormal. Their vermis is one-third smaller than wildtype in rostro-caudal length and the ventral vermis contains concentric mineral deposits. Ectopic Purkinje cells (mostly zebrin II-negative) are in the deep core of the cerebellum between the cerebellar nuclei, in the granular cell layer, and in the intralobular white matter. BrdU analysis indicates that these ectopic Purkinje cells, like Pukinje cells in wildtype mice, are generated during embryonic days 11-13. The overall number of Purkinje cells in homozygotes is relatively normal. The Perkinje cell defect appears to result from a failure in dispersion of the zebrin II-negative subpopulation. (Cook et al., 1997; Beierbach et al., 2001.)
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Ctnna2cdf | ||
|---|---|---|---|
| Allele Name | cerebellar deficient folia | ||
| Common Name(s) | cdf; | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Ctnna2, catenin (cadherin associated protein), alpha 2 | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AI481747; CAP-R; CAPR; CTNR; Catna; Catna2; DKFZp686H02198; alpha N-catenin; alpha catenin 2; alpha(N)-catenin; alpha-catenin (cadherin-associated protein); catenin alpha 2; cdf; cerebellar deficient folia; cerebellar hypoplasia; chp; expressed sequence AI481747; | ||
| Molecular Note | This mutation was discovered in a mouse colony in 1985 at The Jackson Laboratory. The phenotype has been attributed to a deletion of ~150 kb that includes the 3' UTR and sequences encoding the last 96 amino acids of the gene. [J:77488] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
| Allele | Control | |
|---|---|---|
| Ctnna2cdf | Untyped from the colony | |
| Considerations for Choosing Controls | ||
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
Strains carrying other alleles of Pde6b
004297 B6.CXB1-Pde6brd10/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J View Strains carrying other alleles of Pde6b (8 strains)
Ctnna2cdf related
Pde6brd1 relatedDevelopmental Biology Research
Neurodevelopmental Defects
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects (Purkinje cell defect)
Neurodevelopmental Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
| Strain Name: | C3H/HeSnJ-Ctnna2cdf/J |
| Stock Number: | 002235 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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