Strain Name: |
STOCK a Tyrp1b shmy/J |
|---|---|
Stock Number: |
002238 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Tyrp1; Tyrp1b; a; shmy; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation F14 Appearance
nonagouti brown
Related Genotype: a/a Tyrp1b/Tyrp1bStrain Description
Shimmy homozygotes can generally be identified by 12-14 days of age by a hesitant, wobbly gait with swaying hindquarters and slightly smaller overall body size as compared with unaffected littermates. There can be a delay in the opening of the eyes such that one or both remain closed until 15 to 20 days of age.Strain Development
The shimmy mutation (shmy) arose spontaneously in 1991 in a non-inbred strain bearing sks. sks arose spontaneously in A/J and was crossed to B6C3Fe-a/a before sibling mating for several generations with selection for a and Tyrp1b. shmy arose in this stock when it was at F7 and presented in a male, which did not breed, and a female which bred successfully with an unaffected sibling. This strain was maintained via sibling mating primarily homozygous females with heterozygous males and in 1994 embryos were cryopreserved from matings of heterozygous and homozygous females at generation F13 and beyond with heterozygous males at generation F15.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tyrp1b | ||
|---|---|---|---|
| Allele Name | brown | ||
| Strain of Origin | C57BL | ||
| Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein; | ||
| General Note | Tyrp1b, brown, recessive. This type mutant of the brown locus is an old mutation of the mouse fancy. The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much 14C-tyrosine as normal (J:12173). | ||
| Molecular Note | A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [J:44435] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Symbol | shmy | ||
| Allele Name | shimmy | ||
| Strain of Origin | STOCK sks | ||
Colony Maintenance
| Breeding & Husbandry | Males homozygous for shimmy do not breed, but are not sterile. Many, but not all, homozygous females are fertile and do breed. Thus, this strain can be maintained by breeding homozygous or heterozygous females with heterozygous males. |
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Related Strains
Strains carrying Tyrp1b allele
000004 ABP/LeJ 000571 B6.Cg-Whrnwi Tyrp1b/+ +/J 000027 B6.D-Tyrp1b m/J 000265 MY/HuLeJ 001045 SI/Col Tyrp1b Dnahc11iv/J 000064 STOCK a Tyrp1b Sisi/J 001432 STOCK a/a Tyrp1b sks/Tyrp1b +/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J 001101 STOCK T(3;4)5Rk Tyrp1b/J 000274 TSJ/LeJ View Strains carrying Tyrp1b (10 strains)
000068 C57BL/6J-Tyrp1b-J/J 000093 C57BL/6J-Tyrp1b-cJ/J 000671 DBA/2J 003588 LT/SvEi 006252 LT/SvEiJ 002142 STOCK 11R30m/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
005133 B10.D1-H2q/SgJ-shmy2J/J
Research Applications
This mouse can be used to support research in many areas including:Tyrp1b related
shmy relatedDermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
oculocutaneous albinism type III
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | STOCK a Tyrp1b shmy/J |
| Stock Number: | 002238 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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