Strain Name:

B6 x BALB/cJ-Gdf5bp-3J/J

Stock Number:

002239

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Availability:

Cryopreserved - Ready for recovery

Other products are available, see Purchasing Information for Cryopreserved Embryos

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Gdf5
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
014183   B6.Cg-Gdf5bp-4J/GrsrJ
021333   C57BL/6J-Gdf5Bp-5J/GrsrJ
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
View Strains carrying other alleles of Gdf5     (4 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Acromesomelic Dysplasia, Hunter-Thompson Type   (GDF5)
Brachydactyly, Type A1, C; BDA1C   (GDF5)
Brachydactyly, Type A2; BDA2   (GDF5)
Brachydactyly, Type C; BDC   (GDF5)
Chondrodysplasia, Grebe Type   (GDF5)
Fibular Hypoplasia and Complex Brachydactyly   (GDF5)
Multiple Synostoses Syndrome 2; SYNS2   (GDF5)
Osteoarthritis Susceptibility 5; OS5   (GDF5)
Symphalangism, Proximal, 1B; SYM1B   (GDF5)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Gdf5bp-3J/Gdf5bp-3J

        BALB/cJ
  • limbs/digits/tail phenotype
  • abnormal carpal bone morphology
    • the majority of mice display partial or complete fusion of the wrist and a combination of carpal bones including capitate/hamate bone fusions, centrale/capitate/hamate bone fusions, and/or fusion of trapezoid/centrale and capitate/hamate bones   (MGI Ref ID J:38423)
    • fused carpal bones   (MGI Ref ID J:38423)
  • abnormal digit morphology   (MGI Ref ID J:38423)
    • abnormal phalanx morphology   (MGI Ref ID J:38423)
  • abnormal patella morphology
    • medial displacement   (MGI Ref ID J:38423)
    • failed mineralization of menisci   (MGI Ref ID J:38423)
  • abnormal tarsal bone morphology
    • partial or complete fusion of tarsals (navicular/lateral/cuneiform)   (MGI Ref ID J:38423)
    • partial or complete fusion of proximal/medial phalanges, digits II-V   (MGI Ref ID J:38423)
  • skeleton phenotype
  • abnormal carpal bone morphology
    • the majority of mice display partial or complete fusion of the wrist and a combination of carpal bones including capitate/hamate bone fusions, centrale/capitate/hamate bone fusions, and/or fusion of trapezoid/centrale and capitate/hamate bones   (MGI Ref ID J:38423)
    • fused carpal bones   (MGI Ref ID J:38423)
  • abnormal metacarpal bone morphology
    • 1 of 2 metacarpo-phalangeal sesamoids of digit II may be absent or reduced in size   (MGI Ref ID J:38423)
    • there is partial or complete fusion of the metacarpal/proximal phalanx of digit V, proximal/medial phalanges of digits II-V, and metacarpo-phalangeal sesamoids of digits III and IV   (MGI Ref ID J:38423)
  • abnormal metatarsal bone morphology
    • growth plates of digits II and V are absent or reduced in size   (MGI Ref ID J:38423)
  • abnormal patella morphology
    • medial displacement   (MGI Ref ID J:38423)
    • failed mineralization of menisci   (MGI Ref ID J:38423)
  • abnormal phalanx morphology   (MGI Ref ID J:38423)
  • abnormal tarsal bone morphology
    • partial or complete fusion of tarsals (navicular/lateral/cuneiform)   (MGI Ref ID J:38423)
    • partial or complete fusion of proximal/medial phalanges, digits II-V   (MGI Ref ID J:38423)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Gdf5bp-3J related

Developmental Biology Research
Growth Defects
      Growth Defects (homozygous)
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gdf5bp-3J
Allele Name brachypodism 3 Jackson
Allele Type Spontaneous
Strain of OriginBALB/cJ
Gene Symbol and Name Gdf5, growth differentiation factor 5
Chromosome 2
Gene Common Name(s) BDA1C; BMP14; CDMP-1; CDMP1; LAP4; OS5; SYM1B; SYNS2; bp; brachypod Japan; brachypodism; brp; cartilage-derived morphogenetic protein-1;
General Note The long bones of the limbs of mutant mice are slightly shorter than controls, and the fibula is shortened proximally. The bones of the axial skeleton are unaffected.
Molecular Note A CG dinucleotide was replaced by a single base pair (T) at position 876, causing a frame shift and a translational stop at the next codon. [MGI Ref ID J:17582]

Genotyping

Genotyping Information

Genotyping Protocols

Gdf5bp-3J, Sanger sequencing


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Gdf5bp-3J related

Storm EE; Huynh TV; Copeland NG; Jenkins NA; Kingsley DM; Lee SJ. 1994. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments] Nature 368(6472):639-43. [PubMed: 8145850]  [MGI Ref ID J:17582]

Storm EE; Kingsley DM. 1996. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 122(12):3969-79. [PubMed: 9012517]  [MGI Ref ID J:38423]

Sweet HO. 1993. Remutations at The Jackson Laboratory Mouse Genome 91(4):862-65.  [MGI Ref ID J:16313]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $1600.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $2080.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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