Description

Strain Information

Former Names DDY/Jcl    (Changed: 15-DEC-04 ) DDY/JclSeyFrk    (Changed: 15-DEC-04 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse H2 Haplotype s Generation ?+F57 (11-MAR-13) Generation Definitions

Appearance
albino
Related Genotype: a/a Tyr^c/Tyr^c

Description
The inbred strain DDY was developed from the outbred "dd"; a stock originally bred in Germany and transferred to Japan before 1920. The strain name ddY stands for Deutschland, Denken, and Yoken. In Japan, ddY is used as a general purpose mouse; it is not known if traits attributed to ddY in the literature are found in the inbred DDY/JclSidSeyFrkJ. DDY/JclSidSeyFrkJ shares a 75% genetic homology (personal communication, Dr. Wayne Frankel) with the epilepsy model EL/SuzSeyFrkJ (Stock No. 001956). DDY does not develop spontaneous seizures and may be used a genetic control for EL/SuzSeyFrkJ.

Development
The inbred strain DDY was developed from the outbred "dd" originally bred in Germany and transferred to Japan before 1920. The strain name ddY stands for Deutschland, Denken, and Yoken. The stock was maintained first at the National Institute of Health (Yoken) and then, at the Institute of Infectious Diseases of Tokyo University (Denken). Mice of the DDY/Jcl strain were purchased from CLEA Japan by Dr. Robert Green in the 1980s, when he was a member of the laboratory of Dr. Richard Sidman (Sid). Green gave breeder pairs to Dr. Thomas Seyfried (Sey), at Boston College, who maintained them by random colony breeding (avoiding sib matings) for an indeterminate number of years. Dr. Wayne Frankel (Frk), a researcher at The Jackson Laboratory, received mice from Dr. Seyfried and maintained them by sib mating; the strain has been inbred by Dr. Frankel for more than 30 generations.

Related Strains

DDY Strains

002814

DDY/EFrkJ

View DDY Strains     (1 strain)

Strains carrying   Disc1^del allele

001137	129P1/ReJ
000690	129P3/J
001198	129P4/RrRkJ
002448	129S1/SvImJ
002064	129T2/SvEms
002065	129T2/SvEmsJ
000691	129X1/SvJ
002282	BTBR T+ Itpr3tf/J
001800	FVB/NJ
000676	LP/J
000686	SJL/J
000689	SWR/J

View Strains carrying   Disc1^del     (12 strains)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: DDY

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Schizophrenia 9; SCZD9   (DISC1) Schizophrenia; SCZD   (DISC1)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Epilepsy
      control strain for El/SuzSeyFrk

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Disc1del
Allele Name		deletion
Allele Type		Spontaneous
Common Name(s)		Disc1129S6; Disc1delta6;
Strain of Origin		various
Gene Symbol and Name		Disc1, disrupted in schizophrenia 1
Chromosome		8
Gene Common Name(s)		C1orf136; SCZD9;
General Note		This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note		A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Frankel WN; Valenzuela A; Lutz CM; Johnson EW; Dietrich WF; Coffin JM. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6(12):830-8. [PubMed: 8747920]  [MGI Ref ID J:30433]

Wang H; Burdette LJ; Frankel WN; Masukawa LM. 1997. Paroxysmal discharges in the EL mouse, a genetic model of epilepsy. Brain Res 760(1-2):266-71. [PubMed: 9237545]  [MGI Ref ID J:41700]

Disc1^del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. [PubMed: 16751659]  [MGI Ref ID J:111837]

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :.  [MGI Ref ID J:118317]

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. [PubMed: 16484369]  [MGI Ref ID J:107244]

Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. [PubMed: 21903668]  [MGI Ref ID J:177560]

Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. [PubMed: 23563120]  [MGI Ref ID J:195189]

Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826]  [MGI Ref ID J:185685]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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