Strain Name:

B6.129-Apoetm1Unc Ldlrtm1Her/J

Stock Number:

002246

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain 129P2 via E14TG2a ES cell line and 129S7 via AB1 ES cell line (+Hprt-bm2)
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Apoetm1Unc and Ldlrtm1Hertargeted mutations on a normal chow diet show cholesterol levels corresponding to those seen in the Apoetm1Unc targeted mutant strain. The lipoprotein pattern in homozygous mice also resembles that seen in the Apoetm1Unc targeted mutant strain (VLDL & chylomicron remnants). The double targeted mice have a marked increase in both APOB48 and APOB100. In addition, APOAIV is increased.

Development
This double mutant was made by mating the B6.129P2-Apoetm1Unc mutant strain (Stock number 002052) at backcross generation B6N10 and the B6.129S7-Ldlrtm1Her mutant strain (Stock number 002207) at backcross generation B6N10.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Apoetm1Unc     (11 strains)

View Strains carrying   Ldlrtm1Her     (13 strains)

Strains carrying other alleles of Apoe
008525   B6.Cg-Tg(Cyp21a1-Apoe)619Fet/J
View Strains carrying other alleles of Apoe     (1 strain)

Strains carrying other alleles of Ldlr
005061   C57BL/6J-LdlrHlb301/J
View Strains carrying other alleles of Ldlr     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Apoetm1Unc/Apoetm1Unc Ldlrtm1Her/Ldlrtm1Her

        involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
  • cardiovascular system phenotype
  • abnormal impulse conducting system conduction (MGI Ref ID J:95598)
    • abnormal ST interval (MGI Ref ID J:95598)
      • elevated STU segment as a result of induced hypoxia
      • noticeable at 16% oxygen concentration
      • ECG is corrected by 10 minutes after restoration of normal oxygen
      • hypoxia response unaffected by treatment with a thrombin inhibitor
  • altered response to myocardial infarction (MGI Ref ID J:95598)
    • mice treated with a thrombin inhibitor display lower Troponin-T levels and fewer fibrinogen + cells than untreated mice 48 hours after hypoxia
    • decreased infarction size (MGI Ref ID J:95598)
      • in mice treated with a thrombin inhibitor 48 hours after hypoxia
      • infarctions are irregular in shape and subendocardial or intramural
  • atherosclerotic lesions (MGI Ref ID J:95598)
    • two out of 8 hypoxic hearts show thrombosis as well as atherosclerotic plaques
  • homeostasis/metabolism phenotype
  • altered response to myocardial infarction (MGI Ref ID J:95598)
    • mice treated with a thrombin inhibitor display lower Troponin-T levels and fewer fibrinogen + cells than untreated mice 48 hours after hypoxia
    • decreased infarction size (MGI Ref ID J:95598)
      • in mice treated with a thrombin inhibitor 48 hours after hypoxia
      • infarctions are irregular in shape and subendocardial or intramural
  • thrombosis (MGI Ref ID J:95598)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Behavioral and Learning Defects
Neurodegeneration

Apoetm1Unc related

Cardiovascular Research
Atherosclerosis
Hypercholesterolemia

Mouse/Human Gene Homologs
Alzheimer's
hyperlipoproteinemia, type III

Ldlrtm1Her related

Cardiovascular Research
Atherosclerosis
Hypercholesterolemia

Metabolism Research
Lipid Metabolism

Mouse/Human Gene Homologs
hypercholesterolemia, familial

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Apoetm1Unc
Allele Name targeted mutation 1, University of North Carolina
Allele Type Targeted (knock-out)
Common Name(s) APOE KO; AopE(-); ApoE-KO; Apoetm1Un; apoE-; apoE0; epsilon-;
Mutation Made By Nobuyo Maeda,   Univ of North Carolina at Chapel Hill
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Apoe, apolipoprotein E
Chromosome 7
Gene Common Name(s) AD2; AI255918; LDLCQ5; LPG; MGC1571; expressed sequence AI255918;
Molecular Note Insertion of a neomycin resistance cassette deleted part of exon 3 and part of intron 3 of the Apoe gene. Plasma from homozygous mutant mice gave no detectable immunoprecipitate by the Ouchterlony double immunodiffusion test using a rabbit antibody to rat APOE. [MGI Ref ID J:1050]
 
Allele Symbol Ldlrtm1Her
Allele Name targeted mutation 1, Joachim Herz
Allele Type Targeted (knock-out)
Common Name(s) LDLR KO; LDLR-; LDLr0; LDLrKO; Ldlrtm1Her;
Mutation Made By Joachim Herz,   Univ of Texas Southwest Med Ctr Dallas
Strain of Origin129S7/SvEvBrd-Hprt1<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt1<+>
Gene Symbol and Name Ldlr, low density lipoprotein receptor
Chromosome 9
Gene Common Name(s) FH; FHC; LDLCQ2; LDLRA;
General Note When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)
Molecular Note Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. [MGI Ref ID J:37394]

Genotyping

Genotyping Information

Genotyping Protocols

Apoetm1Unc, Standard PCR
Ldlr tm1Her, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Ishibashi S; Herz J; Maeda N; Goldstein JL; Brown MS. 1994. The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A 91(10):4431-5. [PubMed: 8183926]  [MGI Ref ID J:18138]

Additional References

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. [PubMed: 8349823]  [MGI Ref ID J:37394]

Piedrahita JA; Zhang SH; Hagaman JR; Oliver PM; Maeda N. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A 89(10):4471-5. [PubMed: 1584779]  [MGI Ref ID J:1050]

Apoetm1Unc related

't Hoen PA; Van der Lans CA; Van Eck M; Bijsterbosch MK; Van Berkel TJ; Twisk J. 2003. Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes. Circ Res 93(3):262-9. [PubMed: 12829615]  [MGI Ref ID J:115676]

A-Gonzalez N; Bensinger SJ; Hong C; Beceiro S; Bradley MN; Zelcer N; Deniz J; Ramirez C; Diaz M; Gallardo G; de Galarreta CR; Salazar J; Lopez F; Edwards P; Parks J; Andujar M; Tontonoz P; Castrillo A. 2009. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31(2):245-58. [PubMed: 19646905]  [MGI Ref ID J:151872]

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. [PubMed: 10727439]  [MGI Ref ID J:61147]

Adachi H; Fujiwara Y; Kondo T; Nishikawa T; Ogawa R; Matsumura T; Ishii N; Nagai R; Miyata K; Tabata M; Motoshima H; Furukawa N; Tsuruzoe K; Kawashima J; Takeya M; Yamashita S; Koh GY; Nagy A; Suda T; Oike Y; Araki E. 2009. Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. Biochem Biophys Res Commun 379(4):806-11. [PubMed: 19094966]  [MGI Ref ID J:145171]

Agrawal S; Febbraio M; Podrez E; Cathcart MK; Stark GR; Chisolm GM. 2007. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115(23):2939-47. [PubMed: 17533179]  [MGI Ref ID J:137115]

Ahluwalia N; Lin AY; Tager AM; Pruitt IE; Anderson TJ; Kristo F; Shen D; Cruz AR; Aikawa M; Luster AD; Gerszten RE. 2007. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol 179(1):691-7. [PubMed: 17579092]  [MGI Ref ID J:143153]

Aihara K; Azuma H; Akaike M; Ikeda Y; Sata M; Takamori N; Yagi S; Iwase T; Sumitomo Y; Kawano H; Yamada T; Fukuda T; Matsumoto T; Sekine K; Sato T; Nakamichi Y; Yamamoto Y; Yoshimura K; Watanabe T; Nakamura T; Oomizu A; Tsukada M; Hayashi H; Sudo T; KatoS; Matsumoto T. 2007. Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice. J Clin Invest 117(6):1514-26. [PubMed: 17549254]  [MGI Ref ID J:122173]

Aikawa E; Nahrendorf M; Sosnovik D; Lok VM; Jaffer FA; Aikawa M; Weissleder R. 2007. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115(3):377-86. [PubMed: 17224478]  [MGI Ref ID J:130156]

Alexander MR; Knowles JW; Nishikimi T; Maeda N. 2003. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 23(6):1077-82. [PubMed: 12702516]  [MGI Ref ID J:103054]

Ali K; Middleton M; Pure E; Rader DJ. 2005. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ Res 97(9):922-7. [PubMed: 16179587]  [MGI Ref ID J:114634]

Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM. 2004. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24(3):445-50. [PubMed: 14707037]  [MGI Ref ID J:102062]

Amar S; Wu SC; Madan M. 2009. Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications. J Immunol 182(3):1584-92. [PubMed: 19155507]  [MGI Ref ID J:144322]

Amigo L; Quinones V; Mardones P; Zanlungo S; Miquel JF; Nervi F; Rigotti A. 2000. Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet. Gastroenterology 118(4):772-9. [PubMed: 10734029]  [MGI Ref ID J:107676]

An G; Miwa T; Song WL; Lawson JA; Rader DJ; Zhang Y; Song WC. 2009. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol 46(8-9):1702-9. [PubMed: 19297024]  [MGI Ref ID J:148359]

Anderson DR; Tsutsui JM; Xie F; Radio SJ; Porter TR. 2007. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res 73(3):597-606. [PubMed: 17196951]  [MGI Ref ID J:119533]

Anderson R; Barnes JC; Bliss TV; Cain DP; Cambon K; Davies HA; Errington ML; Fellows LA; Gray RA; Hoh T; Stewart M; Large CH; Higgins GA. 1998. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse. Neuroscience 85(1):93-110. [PubMed: 9607706]  [MGI Ref ID J:118390]

Anderson R; Higgins GA. 1997. Absence of central cholinergic deficits in ApoE knockout mice. Psychopharmacology (Berl) 132(2):135-44. [PubMed: 9266610]  [MGI Ref ID J:127860]

Andersson IJ; Jiang YY; Davidge ST. 2009. Maternal stress and development of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring. Am J Physiol Regul Integr Comp Physiol 296(3):R663-71. [PubMed: 19129374]  [MGI Ref ID J:145701]

Ando Y; Shimizugawa T; Takeshita S; Ono M; Shimamura M; Koishi R; Furukawa H. 2003. A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res 44(6):1216-23. [PubMed: 12671033]  [MGI Ref ID J:84022]

Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. [PubMed: 15485633]  [MGI Ref ID J:93917]

Aprahamian T; Bonegio R; Rizzo J; Perlman H; Lefer DJ; Rifkin IR; Walsh K. 2006. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol 177(5):3028-34. [PubMed: 16920939]  [MGI Ref ID J:139547]

Aprahamian T; Bonegio RG; Richez C; Yasuda K; Chiang LK; Sato K; Walsh K; Rifkin IR. 2009. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182(1):340-6. [PubMed: 19109165]  [MGI Ref ID J:142895]

Aprahamian T; Rifkin I; Bonegio R; Hugel B; Freyssinet JM; Sato K; Castellot JJ Jr; Walsh K. 2004. Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease. J Exp Med 199(8):1121-31. [PubMed: 15096538]  [MGI Ref ID J:91058]

Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. [PubMed: 18029445]  [MGI Ref ID J:133332]

Auger A; Truong TQ; Rhainds D; Lapointe J; Letarte F; Brissette L. 2001. Low and high density lipoprotein metabolism in primary cultures of hepatic cells from normal and apolipoprotein E knockout mice. Eur J Biochem 268(8):2322-30. [PubMed: 11298750]  [MGI Ref ID J:115588]

Azuma K; Ichimura K; Mita T; Nakayama S; Jin WL; Hirose T; Fujitani Y; Sumiyoshi K; Shimada K; Daida H; Sakai T; Mitsumata M; Kawamori R; Watada H. 2009. Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta. Biochem Biophys Res Commun 380(3):620-6. [PubMed: 19285011]  [MGI Ref ID J:147062]

Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. [PubMed: 16380543]  [MGI Ref ID J:121507]

Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. [PubMed: 16888235]  [MGI Ref ID J:128048]

Bales KR; Liu F; Wu S; Lin S; Koger D; DeLong C; Hansen JC; Sullivan PM; Paul SM. 2009. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. J Neurosci 29(21):6771-9. [PubMed: 19474305]  [MGI Ref ID J:149522]

Bales KR; Verina T; Cummins DJ; Du Y; Dodel RC; Saura J; Fishman CE; DeLong CA; Piccardo P; Petegnief V; Ghetti B; Paul SM. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 96(26):15233-8. [PubMed: 10611368]  [MGI Ref ID J:59078]

Bales KR; Verina T; Dodel RC; Du Y; Altstiel L; Bender M; Hyslop P; Johnstone EM; Little SP; Cummins DJ; Piccardo P; Ghetti B; Paul SM. 1997. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [letter] [see comments] Nat Genet 17(3):263-4. [PubMed: 9354781]  [MGI Ref ID J:43845]

Barile GR; Pachydaki SI; Tari SR; Lee SE; Donmoyer CM; Ma W; Rong LL; Buciarelli LG; Wendt T; Horig H; Hudson BI; Qu W; Weinberg AD; Yan SF; Schmidt AM. 2005. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci 46(8):2916-24. [PubMed: 16043866]  [MGI Ref ID J:103714]

Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. [PubMed: 17329566]  [MGI Ref ID J:123530]

Barry-Lane PA; Patterson C; van der Merwe M; Hu Z; Holland SM; Yeh ET; Runge MS. 2001. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest 108(10):1513-22. [PubMed: 11714743]  [MGI Ref ID J:111638]

Barton M; Haudenschild CC; d'Uscio LV; Shaw S; Munter K; Luscher TF. 1998. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 95(24):14367-72. [PubMed: 9826706]  [MGI Ref ID J:51282]

Bates KA; Fonte J; Robertson TA; Martins RN; Harvey AR. 2002. Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein. Neuroscience 113(4):785-96. [PubMed: 12182886]  [MGI Ref ID J:120711]

Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3(4):247-56. [PubMed: 16581002]  [MGI Ref ID J:129654]

Bechtholt AJ; Smith R; Raber J; Cunningham CL. 2004. Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) mice. Pharmacol Biochem Behav 77(4):783-92. [PubMed: 15099924]  [MGI Ref ID J:102259]

Beckers L; Heeneman S; Wang L; Burkly L; Rousch M; Davidson N; Gijbels M; de Winther M; Daemen M; Lutgens E. 2007. Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages. J Pathol 212(4):420-8. [PubMed: 17573667]  [MGI Ref ID J:122864]

Bengtsson E; To F; Hakansson K; Grubb A; Branen L; Nilsson J; Jovinge S. 2005. Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(10):2151-6. [PubMed: 16051881]  [MGI Ref ID J:114346]

Bennett BJ; Scatena M; Kirk EA; Rattazzi M; Varon RM; Averill M; Schwartz SM; Giachelli CM; Rosenfeld ME. 2006. Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arterioscler Thromb Vasc Biol 26(9):2117-24. [PubMed: 16840715]  [MGI Ref ID J:128053]

Bentzon JF; Sondergaard CS; Kassem M; Falk E. 2007. Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice. Circulation 116(18):2053-61. [PubMed: 17938286]  [MGI Ref ID J:142997]

Berbee JF; van der Hoogt CC; Sundararaman D; Havekes LM; Rensen PC. 2005. Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL. J Lipid Res 46(2):297-306. [PubMed: 15576844]  [MGI Ref ID J:96691]

Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. [PubMed: 17435771]  [MGI Ref ID J:121807]

Bhattacharjee PS; Neumann DM; Stark D; Thompson HW; Hill JM. 2006. Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular model. Curr Eye Res 31(9):703-8. [PubMed: 16966142]  [MGI Ref ID J:119878]

Biswas SK; Newby DE; Rahman I; Megson IL. 2005. Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice. Biochem Biophys Res Commun 338(3):1368-73. [PubMed: 16263083]  [MGI Ref ID J:103465]

Bjorkbacka H; Kunjathoor VV; Moore KJ; Koehn S; Ordija CM; Lee MA; Means T; Halmen K; Luster AD; Golenbock DT; Freeman MW. 2004. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 10(4):416-21. [PubMed: 15034566]  [MGI Ref ID J:90091]

Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. [PubMed: 18272520]  [MGI Ref ID J:136523]

Bobkova D; Honsova E; Kovar J; Poledne R. 2004. Effect of diets on lipoprotein concentrations in heterozygous apolipoprotein E-deficient mice. Physiol Res 53(6):635-43. [PubMed: 15588132]  [MGI Ref ID J:102284]

Bobryshev YV; Babaev VR; Lord RS; Watanabe T. 1999. Ultrastructural identification of cells with dendritic cell appearance in atherosclerotic aorta of apolipoprotein E deficient mice J Submicrosc Cytol Pathol 31(4):527-31. [PubMed: 10685393]  [MGI Ref ID J:60456]

Bodary PF; Shen Y; Vargas FB; Bi X; Ostenso KA; Gu S; Shayman JA; Eitzman DT. 2005. Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency Circulation 111(5):629-32. [PubMed: 15668341]  [MGI Ref ID J:108541]

Boesten LS; Zadelaar AS; van Nieuwkoop A; Hu L; Jonkers J; van de Water B; Gijbels MJ; van der Made I; de Winther MP; Havekes LM; van Vlijmen BJ. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20(7):953-5. [PubMed: 16585057]  [MGI Ref ID J:111494]

Boisvert WA; Black AS; Curtiss LK. 1999. ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. Arterioscler Thromb Vasc Biol 19(3):525-30. [PubMed: 10073953]  [MGI Ref ID J:55595]

Boord JB; Maeda K; Makowski L; Babaev VR; Fazio S; Linton MF; Hotamisligil GS. 2002. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22(10):1686-91. [PubMed: 12377750]  [MGI Ref ID J:103224]

Boord JB; Maeda K; Makowski L; Babaev VR; Fazio S; Linton MF; Hotamisligil GS. 2004. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110(11):1492-8. [PubMed: 15353487]  [MGI Ref ID J:102223]

Boring L; Gosling J; Cleary M; Charo IF. 1998. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394(6696):894-7. [PubMed: 9732872]  [MGI Ref ID J:111471]

Bour A; Grootendorst J; Vogel E; Kelche C; Dodart JC; Bales K; Moreau PH; Sullivan PM; Mathis C. 2008. Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. Behav Brain Res 193(2):174-82. [PubMed: 18572260]  [MGI Ref ID J:139186]

Bourdillon MC; Poston RN; Covacho C; Chignier E; Bricca G; McGregor JL. 2000. ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol 20(12):2630-5. [PubMed: 11116064]  [MGI Ref ID J:103384]

Bowes AJ; Khan MI; Shi Y; Robertson L; Werstuck GH. 2009. Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis. Am J Pathol 174(1):330-42. [PubMed: 19095952]  [MGI Ref ID J:144211]

Bradley MN; Hong C; Chen M; Joseph SB; Wilpitz DC; Wang X; Lusis AJ; Collins A; Hseuh WA; Collins JL; Tangirala RK; Tontonoz P. 2007. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest 117(8):2337-46. [PubMed: 17657314]  [MGI Ref ID J:123957]

Branen L; Hovgaard L; Nitulescu M; Bengtsson E; Nilsson J; Jovinge S. 2004. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 24(11):2137-42. [PubMed: 15345516]  [MGI Ref ID J:103699]

Braunersreuther V; Zernecke A; Arnaud C; Liehn EA; Steffens S; Shagdarsuren E; Bidzhekov K; Burger F; Pelli G; Luckow B; Mach F; Weber C. 2007. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol 27(2):373-9. [PubMed: 17138939]  [MGI Ref ID J:128063]

Brecht WJ; Harris FM; Chang S; Tesseur I; Yu GQ; Xu Q; Dee Fish J; Wyss-Coray T; Buttini M; Mucke L; Mahley RW; Huang Y. 2004. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci 24(10):2527-34. [PubMed: 15014128]  [MGI Ref ID J:90126]

Bro S; Borup R; Andersen CB; Moeller F; Olgaard K; Nielsen LB. 2006. Uremia-specific effects in the arterial media during development of uremic atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(3):570-5. [PubMed: 16373611]  [MGI Ref ID J:127966]

Broedl UC; Maugeais C; Millar JS; Jin W; Moore RE; Fuki IV; Marchadier D; Glick JM; Rader DJ. 2004. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94(12):1554-61. [PubMed: 15117821]  [MGI Ref ID J:100064]

Brown MD; Jin L; Jien ML; Matsumoto AH; Helm GA; Lusis AJ; Frank JS; Shi W. 2004. Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility. J Lipid Res 45(6):1155-61. [PubMed: 15105414]  [MGI Ref ID J:89769]

Bruemmer D; Collins AR; Noh G; Wang W; Territo M; Arias-Magallona S; Fishbein MC; Blaschke F; Kintscher U; Graf K; Law RE; Hsueh WA. 2003. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 112(9):1318-31. [PubMed: 14597759]  [MGI Ref ID J:86531]

Burgos JS; Ramirez C; Sastre I; Alfaro JM; Valdivieso F. 2005. Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender. J Virol 79(3):1605-12. [PubMed: 15650186]  [MGI Ref ID J:95551]

Burleigh ME; Babaev VR; Oates JA; Harris RC; Gautam S; Riendeau D; Marnett LJ; Morrow JD; Fazio S; Linton MF. 2002. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation 105(15):1816-23. [PubMed: 11956125]  [MGI Ref ID J:103220]

Burleigh ME; Babaev VR; Yancey PG; Major AS; McCaleb JL; Oates JA; Morrow JD; Fazio S; Linton MF. 2005. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J Mol Cell Cardiol 39(3):443-52. [PubMed: 16040051]  [MGI Ref ID J:103979]

Burnett MS; Gaydos CA; Madico GE; Glad SM; Paigen B; Quinn TC; Epstein SE. 2001. Atherosclerosis in apoE knockout mice infected with multiple pathogens. J Infect Dis 183(2):226-231. [PubMed: 11120928]  [MGI Ref ID J:66879]

Burton CA; Patel S; Mundt S; Hassing H; Zhang D; Hermanowski-Vosatka A; Wright SD; Chao YS; Detmers PA; Sparrow CP. 2002. Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice. Biochem Biophys Res Commun 294(1):88-94. [PubMed: 12054745]  [MGI Ref ID J:77028]

Buttini M; Orth M; Bellosta S; Akeefe H; Pitas RE; Wyss-Coray T; Mucke L; Mahley RW. 1999. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci 19(12):4867-80. [PubMed: 10366621]  [MGI Ref ID J:55835]

Buttini M; Yu GQ; Shockley K; Huang Y; Jones B; Masliah E; Mallory M; Yeo T; Longo FM; Mucke L. 2002. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci 22(24):10539-48. [PubMed: 12486146]  [MGI Ref ID J:129689]

Buzello M; Tornig J; Faulhaber J; Ehmke H; Ritz E; Amann K. 2003. The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia. J Am Soc Nephrol 14(2):311-6. [PubMed: 12538731]  [MGI Ref ID J:103173]

Cabana VG; Feng N; Reardon CA; Lukens J; Webb NR; de Beer FC; Getz GS. 2004. Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res 45(2):317-25. [PubMed: 14595002]  [MGI Ref ID J:121045]

Cain WJ; Millar JS; Himebauch AS; Tietge UJ; Maugeais C; Usher D; Rader DJ. 2005. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. J Lipid Res 46(12):2681-91. [PubMed: 16150825]  [MGI Ref ID J:106146]

Cakir Y; Yang Z; Knight CA; Pompilius M; Westbrook D; Bailey SM; Pinkerton KE; Ballinger SW. 2007. Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis. Free Radic Biol Med 43(9):1279-88. [PubMed: 17893041]  [MGI Ref ID J:125300]

Caligiuri G; Groyer E; Khallou-Laschet J; Al Haj Zen A; Sainz J; Urbain D; Gaston AT; Lemitre M; Nicoletti A; Lafont A. 2005. Reduced immunoregulatory CD31+ T cells in the blood of atherosclerotic mice with plaque thrombosis. Arterioscler Thromb Vasc Biol 25(8):1659-64. [PubMed: 15933243]  [MGI Ref ID J:114337]

Caligiuri G; Levy B; Pernow J; Thoren P; Hansson GK. 1999. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci U S A 96(12):6920-4. [PubMed: 10359814]  [MGI Ref ID J:55973]

Caligiuri G; Nicoletti A; Poirier B; Hansson GK. 2002. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109(6):745-53. [PubMed: 11901183]  [MGI Ref ID J:75627]

Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 9(1-2):10-7. [PubMed: 12765335]  [MGI Ref ID J:105858]

Calleja L; Paris MA; Paul A; Vilella E; Joven J; Jimenez A; Beltran G; Uceda M; Maeda N; Osada J. 1999. Low-cholesterol and high-fat diets reduce atherosclerotic lesion development in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 19(10):2368-75. [PubMed: 10521366]  [MGI Ref ID J:59716]

Cambon K; Davies HA; Stewart MG. 2000. Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice. Neuroscience 97(4):685-92. [PubMed: 10842013]  [MGI Ref ID J:118049]

Canault M; Peiretti F; Poggi M; Mueller C; Kopp F; Bonardo B; Bastelica D; Nicolay A; Alessi MC; Nalbone G. 2008. Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha. J Pathol 214(5):574-83. [PubMed: 18247429]  [MGI Ref ID J:133510]

Cao RY; Adams MA; Habenicht AJ; Funk CD. 2007. Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. Prostaglandins Other Lipid Mediat 84(1-2):34-42. [PubMed: 17643886]  [MGI Ref ID J:129321]

Carlson GA; Borchelt DR; Dake A; Turner S; Danielson V; Coffin JD; Eckman C; Meiners J; Nilsen SP; Younkin SG; Hsiao KK. 1997. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 6(11):1951-9. [PubMed: 9302276]  [MGI Ref ID J:43446]

Cassis LA; Gupte M; Thayer S; Zhang X; Charnigo R; Howatt DA; Rateri DL; Daugherty A. 2009. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 296(5):H1660-5. [PubMed: 19252100]  [MGI Ref ID J:150893]

Castellani LW; Nguyen CN; Charugundla S; Weinstein MM; Doan CX; Blaner WS; Wongsiriroj N; Lusis AJ. 2008. Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance. J Biol Chem 283(17):11633-44. [PubMed: 18160395]  [MGI Ref ID J:136532]

Catanozi S; Rocha JC; Passarelli M; Guzzo ML; Alves C; Furukawa LN; Nunes VS; Nakandakare ER; Heimann JC; Quintao EC. 2003. Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice. J Lipid Res 44(4):727-32. [PubMed: 12562870]  [MGI Ref ID J:120709]

Chamberlain J; Francis S; Brookes Z; Shaw G; Graham D; Alp NJ; Dower S; Crossman DC. 2009. Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE 4(4):e5073. [PubMed: 19347044]  [MGI Ref ID J:148173]

Champagne D; Dupuy JB; Rochford J; Poirier J. 2002. Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task. Neuroscience 114(3):641-54. [PubMed: 12220566]  [MGI Ref ID J:120203]

Chang JD; Sukhova GK; Libby P; Schvartz E; Lichtenstein AH; Field SJ; Kennedy C; Madhavarapu S; Luo J; Wu D; Cantley LC. 2007. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A 104(19):8077-82. [PubMed: 17483449]  [MGI Ref ID J:121582]

Chang S; Zhang SH; Maeda N; Borensztajn J. 1994. Hepatic clearance of chylomicron remnants in mice lacking apoprotein E. Biochim Biophys Acta 1215(1-2):205-8. [PubMed: 7948005]  [MGI Ref ID J:21599]

Chen J; Kuhlencordt PJ; Astern J; Gyurko R; Huang PL. 2001. Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation 104(20):2391-4. [PubMed: 11705813]  [MGI Ref ID J:103382]

Chen WY; Cheng BC; Jiang MJ; Hsieh MY; Chang MS. 2006. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(9):2090-5. [PubMed: 16778121]  [MGI Ref ID J:127995]

Chen Y; Zhu J; Lum PY; Yang X; Pinto S; MacNeil DJ; Zhang C; Lamb J; Edwards S; Sieberts SK; Leonardson A; Castellini LW; Wang S; Champy MF; Zhang B; Emilsson V; Doss S; Ghazalpour A; Horvath S; Drake TA; Lusis AJ; Schadt EE. 2008. Variations in DNA elucidate molecular networks that cause disease. Nature 452(7186):429-35. [PubMed: 18344982]  [MGI Ref ID J:134171]

Chen Z; Fitzgerald RL; Li G; Davidson NO; Schonfeld G. 2004. Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45(1):155-63. [PubMed: 13130124]  [MGI Ref ID J:87974]

Chen Z; Fitzgerald RL; Saffitz JE; Semenkovich CF; Schonfeld G. 2003. Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arterioscler Thromb Vasc Biol 23(4):668-74. [PubMed: 12615667]  [MGI Ref ID J:103058]

Cheng C; Tempel D; van Haperen R; de Boer HC; Segers D; Huisman M; van Zonneveld AJ; Leenen PJ; van der Steen A; Serruys PW; de Crom R; Krams R. 2007. Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest 117(3):616-26. [PubMed: 17304353]  [MGI Ref ID J:120778]

Chereshnev I; Trogan E; Omerhodzic S; Itskovich V; Aguinaldo JG; Fayad ZA; Fisher EA; Reis ED. 2003. Mouse model of heterotopic aortic arch transplantation. J Surg Res 111(2):171-6. [PubMed: 12850459]  [MGI Ref ID J:118962]

Choi J; Forster MJ; McDonald SR; Weintraub ST; Carroll CA; Gracy RW. 2004. Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. Free Radic Biol Med 36(9):1155-62. [PubMed: 15082069]  [MGI Ref ID J:91069]

Choy K; Beck K; Png FY; Wu BJ; Leichtweis SB; Thomas SR; Hou JY; Croft KD; Mori TA; Stocker R. 2005. Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol 25(8):1684-90. [PubMed: 15961704]  [MGI Ref ID J:114329]

Christman MA nd; Goetz DJ; Dickerson E; McCall KD; Lewis CJ; Benencia F; Silver MJ; Kohn LD; Malgor R. 2008. Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol 294(6):H2864-70. [PubMed: 18456733]  [MGI Ref ID J:136708]

Chu A; Ordonez ET; Hellerstein MK. 2006. Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA. Am J Physiol Cell Physiol 291(5):C1014-21. [PubMed: 16774990]  [MGI Ref ID J:119869]

Chuah MI; Getchell ML. 1999. Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice. Neuroreport 10(9):1919-24. [PubMed: 10501533]  [MGI Ref ID J:59464]

Chun HJ; Ali ZA; Kojima Y; Kundu RK; Sheikh AY; Agrawal R; Zheng L; Leeper NJ; Pearl NE; Patterson AJ; Anderson JP; Tsao PS; Lenardo MJ; Ashley EA; Quertermous T. 2008. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 118(10):3343-54. [PubMed: 18769630]  [MGI Ref ID J:141167]

Clarke MC; Figg N; Maguire JJ; Davenport AP; Goddard M; Littlewood TD; Bennett MR. 2006. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med 12(9):1075-80. [PubMed: 16892061]  [MGI Ref ID J:115051]

Clarke MC; Littlewood TD; Figg N; Maguire JJ; Davenport AP; Goddard M; Bennett MR. 2008. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res 102(12):1529-38. [PubMed: 18497329]  [MGI Ref ID J:151378]

Claudel T; Leibowitz MD; Fievet C; Tailleux A; Wagner B; Repa JJ; Torpier G; Lobaccaro JM; Paterniti JR; Mangelsdorf DJ; Heyman RA; Auwerx J. 2001. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci U S A 98(5):2610-5. [PubMed: 11226287]  [MGI Ref ID J:67869]

Clee SM; Bissada N; Miao F; Miao L; Marais AD; Henderson HE; Steures P; McManus J; McManus B; LeBoeuf RC; Kastelein JJ; Hayden MR. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis J Lipid Res 41(4):521-31. [PubMed: 10744772]  [MGI Ref ID J:61561]

Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. [PubMed: 10620617]  [MGI Ref ID J:59249]

Combadiere C; Potteaux S; Gao JL; Esposito B; Casanova S; Lee EJ; Debre P; Tedgui A; Murphy PM; Mallat Z. 2003. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Circulation 107(7):1009-16. [PubMed: 12600915]  [MGI Ref ID J:103047]

Conde-Knape K; Bensadoun A; Sobel JH; Cohn JS; Shachter NS. 2002. Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase. J Lipid Res 43(12):2136-45. [PubMed: 12454276]  [MGI Ref ID J:80689]

Corey LM; Baker C; Luchtel DL. 2006. Heart-rate variability in the apolipoprotein E knockout transgenic mouse following exposure to Seattle particulate matter. J Toxicol Environ Health A 69(10):953-65. [PubMed: 16728373]  [MGI Ref ID J:136496]

Cozen AE; Moriwaki H; Kremen M; DeYoung MB; Dichek HL; Slezicki KI; Young SG; Veniant M; Dichek DA. 2004. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 109(17):2129-35. [PubMed: 15096455]  [MGI Ref ID J:102208]

Crauwels HM; Van Hove CE; Holvoet P; Herman AG; Bult H. 2003. Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI. Cardiovasc Res 59(1):189-99. [PubMed: 12829190]  [MGI Ref ID J:132535]

Crisby M; Rahman SM; Sylven C; Winblad B; Schultzberg M. 2004. Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice. Implications for Alzheimer's disease and stroke. Neurosci Lett 369(2):87-92. [PubMed: 15450674]  [MGI Ref ID J:107524]

Cuff CA; Kothapalli D; Azonobi I; Chun S; Zhang Y; Belkin R; Yeh C; Secreto A; Assoian RK; Rader DJ; Pure E. 2001. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest 108(7):1031-40. [PubMed: 11581304]  [MGI Ref ID J:72315]

Curfs DM; Lutgens E; Gijbels MJ; Kockx MM; Daemen MJ; van Schooten FJ. 2004. Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice. Am J Pathol 164(1):101-8. [PubMed: 14695324]  [MGI Ref ID J:88500]

Cyrus T; Pratico D; Zhao L; Witztum JL; Rader DJ; Rokach J; FitzGerald GA; Funk CD. 2001. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation 103(18):2277-82. [PubMed: 11342477]  [MGI Ref ID J:103392]

Cyrus T; Witztum JL; Rader DJ; Tangirala R; Fazio S; Linton MF; Funk CD. 1999. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice [see comments] J Clin Invest 103(11):1597-604. [PubMed: 10359569]  [MGI Ref ID J:55714]

Czapiga M; Colton CA. 2003. Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. J Neuroimmunol 134(1-2):44-51. [PubMed: 12507771]  [MGI Ref ID J:105895]

Dai J; Li W; Chang L; Zhang Z; Tang C; Wang N; Zhu Y; Wang X. 2006. Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radic Biol Med 41(10):1566-77. [PubMed: 17045925]  [MGI Ref ID J:114515]

Dai J; Wang X; Feng J; Kong W; Xu Q; Shen X; Wang X. 2008. Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages. FEBS Lett 582(28):3893-8. [PubMed: 18976655]  [MGI Ref ID J:143777]

Dansky HM; Charlton SA; Barlow CB; Tamminen M; Smith JD; Frank JS; Breslow JL. 1999. Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. J Clin Invest 104(1):31-9. [PubMed: 10393696]  [MGI Ref ID J:115306]

Dansky HM; Charlton SA; Sikes JL; Heath SC; Simantov R; Levin LF; Shu P; Moore KJ; Breslow JL; Smith JD. 1999. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(8):1960-8. [PubMed: 10446078]  [MGI Ref ID J:57355]

Daugherty A; Manning MW; Cassis LA. 2000. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105(11):1605-12. [PubMed: 10841519]  [MGI Ref ID J:112053]

Daugherty A; Pure E; Delfel-Butteiger D; Chen S; Leferovich J ; Roselaar SE ; Rader DJ. 1997. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest 100(6):1575-80. [PubMed: 9294126]  [MGI Ref ID J:43047]

Davenport P; Tipping PG. 2003. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 163(3):1117-25. [PubMed: 12937153]  [MGI Ref ID J:85172]

Davis HR Jr; Hoos LM; Tetzloff G; Maguire M; Zhu LJ; Graziano MP; Altmann SW. 2007. Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice. Arterioscler Thromb Vasc Biol 27(4):841-9. [PubMed: 17218600]  [MGI Ref ID J:135062]

Dawson TC; Kuziel WA; Osahar TA; Maeda N. 1999. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 143(1):205-11. [PubMed: 10208497]  [MGI Ref ID J:84393]

De Sarno P; Jope RS. 1998. Phosphoinositide hydrolysis activated by muscarinic or glutamatergic, but not adrenergic, receptors is impaired in ApoE-deficient mice and by hydrogen peroxide and peroxynitrite. Exp Neurol 152(1):123-8. [PubMed: 9682019]  [MGI Ref ID J:106374]

DeMattos RB; Cirrito JR; Parsadanian M; May PC; O'Dell MA; Taylor JW; Harmony JA; Aronow BJ; Bales KR; Paul SM; Holtzman DM. 2004. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 41(2):193-202. [PubMed: 14741101]  [MGI Ref ID J:107702]

Deeb RS; Shen H; Gamss C; Gavrilova T; Summers BD; Kraemer R; Hao G; Gross SS; Laine M; Maeda N; Hajjar DP; Upmacis RK. 2006. Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. Am J Pathol 168(1):349-62. [PubMed: 16400036]  [MGI Ref ID J:104432]

Deguchi JO; Aikawa E; Libby P; Vachon JR; Inada M; Krane SM; Whittaker P; Aikawa M. 2005. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation 112(17):2708-15. [PubMed: 16230484]  [MGI Ref ID J:116828]

Deguchi JO; Aikawa M; Tung CH; Aikawa E; Kim DE; Ntziachristos V; Weissleder R; Libby P. 2006. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation 114(1):55-62. [PubMed: 16801460]  [MGI Ref ID J:122883]

Dekker RJ; van Thienen JV; Rohlena J; de Jager SC; Elderkamp YW; Seppen J; de Vries CJ; Biessen EA; van Berkel TJ; Pannekoek H; Horrevoets AJ. 2005. Endothelial KLF2 Links Local Arterial Shear Stress Levels to the Expression of Vascular Tone-Regulating Genes. Am J Pathol 167(2):609-18. [PubMed: 16049344]  [MGI Ref ID J:99941]

Desurmont C; Caillaud JM; Emmanuel F; Benoit P; Fruchart JC; Castro G; Branellec D; Heard JM; Duverger N. 2000. Complete atherosclerosis regression after human ApoE gene transfer in ApoE-Deficient/Nude mice Arterioscler Thromb Vasc Biol 20(2):435-42. [PubMed: 10669641]  [MGI Ref ID J:60479]

Detmers PA; Hernandez M; Mudgett J; Hassing H; Burton C; Mundt S; Chun S; Fletcher D; Card DJ; Lisnock J; Weikel R; Bergstrom JD; Shevell DE; Hermanowski-Vosatka A; Sparrow CP; Chao YS; Rader DJ; Wright SD; Pure E. 2000. Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice J Immunol 165(6):3430-5. [PubMed: 10975863]  [MGI Ref ID J:64566]

Dever GJ; Benson R; Wainwright CL; Kennedy S; Spickett CM. 2008. Phospholipid chlorohydrin induces leukocyte adhesion to ApoE(-/-) mouse arteries via upregulation of P-selectin. Free Radic Biol Med 44(3):452-63. [PubMed: 18005671]  [MGI Ref ID J:130122]

Devlin CM; Leventhal AR; Kuriakose G; Schuchman EH; Williams KJ; Tabas I. 2008. Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol 28(10):1723-30. [PubMed: 18669882]  [MGI Ref ID J:148825]

Diez-Juan A; Andres V. 2001. The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis. FASEB J 15(11):1989-95. [PubMed: 11532979]  [MGI Ref ID J:120150]

Dimayuga PC; Zhao X; Yano J; Chyu KY. 2006. Changes in immune responses to oxidized LDL epitopes during aging in hypercholesterolemic apoE(-/-) mice. Am J Physiol Regul Integr Comp Physiol 291(6):R1644-50. [PubMed: 16825416]  [MGI Ref ID J:115800]

Dithmar S; Curcio CA; Le NA; Brown S; Grossniklaus HE. 2000. Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci 41(8):2035-42. [PubMed: 10892840]  [MGI Ref ID J:63155]

Ditiatkovski M; Toh BH; Bobik A. 2006. GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2337-44. [PubMed: 16873730]  [MGI Ref ID J:128049]

Do GM; Kwon EY; Kim HJ; Jeon SM; Ha TY; Park T; Choi MS. 2008. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem Biophys Res Commun 374(1):55-9. [PubMed: 18611391]  [MGI Ref ID J:139370]

Dodart JC; Bales KR; Johnstone EM; Little SP; Paul SM. 2002. Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Res 955(1-2):191-9. [PubMed: 12419536]  [MGI Ref ID J:80485]

Dodart JC; Mathis C; Bales KR; Paul SM; Ungerer A. 2000. Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene Neuroreport 11(3):603-7. [PubMed: 10718322]  [MGI Ref ID J:61265]

Dolev I; Michaelson DM. 2004. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade. Proc Natl Acad Sci U S A 101(38):13909-14. [PubMed: 15365176]  [MGI Ref ID J:92619]

Doorenbos C; Tsaih SW; Sheehan S; Ishimori N; Navis G; Churchill G; Dipetrillo K; Korstanje R. 2008. Quantitative Trait Loci for Urinary Albumin in Crosses Between C57BL/6J and A/J Inbred Mice in the Presence and Absence of Apoe. Genetics 179(1):693-9. [PubMed: 18493081]  [MGI Ref ID J:135073]

Drosatos K; Sanoudou D; Kypreos KE; Kardassis D; Zannis VI. 2007. A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice. J Biol Chem 282(27):19556-64. [PubMed: 17456467]  [MGI Ref ID J:123576]

Duan RS; Chen Z; Dou YC; Concha Quezada H; Nennesmo I; Adem A; Winblad B; Zhu J. 2006. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Exp Neurol 202(2):373-80. [PubMed: 16919271]  [MGI Ref ID J:144674]

Dworschak M; d'Uscio LV; Breukelmann D; Hannon JD. 2005. Increased tolerance to hypoxic metabolic inhibition and reoxygenation of cardiomyocytes from apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 289(1):H160-7. [PubMed: 15734885]  [MGI Ref ID J:99888]

Eitzman DT; Westrick RJ; Shen Y; Bodary PF; Gu S; Manning SL; Dobies SL; Ginsburg D. 2005. Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation 111(14):1822-5. [PubMed: 15809370]  [MGI Ref ID J:109686]

Eitzman DT; Westrick RJ; Xu Z; Tyson J; Ginsburg D. 2000. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood 96(13):4212-5. [PubMed: 11110693]  [MGI Ref ID J:106740]

Elhage R; Arnal JF; Pieraggi MT; Duverger N; Fievet C; Faye JC; Bayard F. 1997. 17 beta-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 17(11):2679-84. [PubMed: 9409242]  [MGI Ref ID J:81001]

Elhage R; Clamens S; Reardon-Alulis C; Getz GS; Fievet C; Maret A; Arnal JF; Bayard F. 2000. Loss of atheroprotective effect of estradiol in immunodeficient mice. Endocrinology 141(1):462-5. [PubMed: 10614672]  [MGI Ref ID J:59156]

Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. [PubMed: 15579444]  [MGI Ref ID J:94976]

Elhage R; Gourdy P; Jawien J; Brouchet L; Castano C; Fievet C; Hansson GK; Arnal JF; Bayard F. 2005. The Atheroprotective Effect of 17{beta}-Estradiol Depends on Complex Interactions in Adaptive Immunity. Am J Pathol 167(1):267-74. [PubMed: 15972970]  [MGI Ref ID J:99377]

Elhage R; Jawien J; Rudling M; Ljunggren HG; Takeda K; Akira S; Bayard F; Hansson GK. 2003. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc Res 59(1):234-40. [PubMed: 12829194]  [MGI Ref ID J:102800]

Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun 74(11):6100-7. [PubMed: 16966414]  [MGI Ref ID J:113552]

Everett AW; Ernst EJ. 2004. Increased quantal size in transmission at slow but not fast neuromuscular synapses of apolipoprotein E deficient mice. Exp Neurol 185(2):290-6. [PubMed: 14736510]  [MGI Ref ID J:87833]

Ezra Y; Oron L; Moskovich L; Roses AD; Beni SM; Shohami E; Michaelson DM. 2003. Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury. Neuroscience 121(2):315-25. [PubMed: 14521991]  [MGI Ref ID J:132283]

Fagan AM; Holtzman DM; Munson G; Mathur T; Schneider D; Chang LK; Getz GS; Reardon CA; Lukens J; Shah JA; LaDu MJ. 1999. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 274(42):30001-7. [PubMed: 10514484]  [MGI Ref ID J:58019]

Fagan AM; Murphy BA; Patel SN; Kilbridge JF; Mobley WC; Bu G; Holtzman DM. 1998. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol 151(2):314-25. [PubMed: 9628766]  [MGI Ref ID J:48287]

Fagan AM; Watson M; Parsadanian M; Bales KR; Paul SM; Holtzman DM. 2002. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 9(3):305-18. [PubMed: 11950276]  [MGI Ref ID J:127846]

Fan D; Yancey PG; Qiu S; Ding L; Weeber EJ; Linton MF; Fazio S. 2008. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry 47(6):1631-9. [PubMed: 18197702]  [MGI Ref ID J:132491]

Fan YY; Ramos KS; Chapkin RS. 2001. Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr 131(6):1675-81. [PubMed: 11385052]  [MGI Ref ID J:69821]

Farese RVJr; Veniant MM; Cham CM; Flynn LM; Pierotti V; Loring JF; Traber M; Ruland S; Stokowski RS; Huszar D; Young SG. 1996. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A 93(13):6393-8. [PubMed: 8692825]  [MGI Ref ID J:33830]

Fazio S; Babaev VR; Burleigh ME; Major AS; Hasty AH; Linton MF. 2002. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res 43(10):1602-9. [PubMed: 12364544]  [MGI Ref ID J:79439]

Febbraio M; Podrez EA; Smith JD; Hajjar DP; Hazen SL; Hoff HF; Sharma K; Silverstein RL. 2000. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice [see comments] J Clin Invest 105(8):1049-56. [PubMed: 10772649]  [MGI Ref ID J:61672]

Feng X; Li H; Rumbin AA; Wang X; La Cava A; Brechtelsbauer K; Castellani LW; Witztum JL; Lusis AJ; Tsao BP. 2007. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res 48(4):794-805. [PubMed: 17259598]  [MGI Ref ID J:121671]

Fernandez-Hernando C; Ackah E; Yu J; Suarez Y; Murata T; Iwakiri Y; Prendergast J; Miao RQ; Birnbaum MJ; Sessa WC. 2007. Loss of akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab 6(6):446-57. [PubMed: 18054314]  [MGI Ref ID J:130443]

Fernandez-Hernando C; Yu J; Suarez Y; Rahner C; Davalos A; Lasuncion MA; Sessa WC. 2009. Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab 10(1):48-54. [PubMed: 19583953]  [MGI Ref ID J:152421]

Ferre N; Martinez-Clemente M; Lopez-Parra M; Gonzalez-Periz A; Horrillo R; Planaguma A; Camps J; Joven J; Tres A; Guardiola F; Bataller R; Arroyo V; Claria J. 2009. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol 296(3):G553-62. [PubMed: 19136384]  [MGI Ref ID J:146541]

Foo SY; Heller ER; Wykrzykowska J; Sullivan CJ; Manning-Tobin JJ; Moore KJ; Gerszten RE; Rosenzweig A. 2009. Vascular effects of a low-carbohydrate high-protein diet. Proc Natl Acad Sci U S A 106(36):15418-23. [PubMed: 19706393]  [MGI Ref ID J:153097]

Forte TM; Subbanagounder G; Berliner JA; Blanche PJ; Clermont AO; Jia Z; Oda MN; Krauss RM; Bielicki JK. 2002. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res 43(3):477-85. [PubMed: 11893784]  [MGI Ref ID J:75568]

Foteinos G; Hu Y; Xiao Q; Metzler B; Xu Q. 2008. Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation 117(14):1856-63. [PubMed: 18378610]  [MGI Ref ID J:153300]

Fougerat A; Gayral S; Gourdy P; Schambourg A; Ruckle T; Schwarz MK; Rommel C; Hirsch E; Arnal JF; Salles JP; Perret B; Breton-Douillon M; Wymann MP; Laffargue M. 2008. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 117(10):1310-7. [PubMed: 18268153]  [MGI Ref ID J:148451]

Frank PG; Lee H; Park DS; Tandon NN; Scherer PE; Lisanti MP. 2004. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 24(1):98-105. [PubMed: 14563650]  [MGI Ref ID J:101788]

Friedrich EB; Clever YP; Wassmann S; Werner N; Bohm M; Nickenig G. 2006. Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II. Biochem Biophys Res Commun 349(3):883-9. [PubMed: 16962068]  [MGI Ref ID J:113091]

Fryer JD; Simmons K; Parsadanian M; Bales KR; Paul SM; Sullivan PM; Holtzman DM. 2005. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci 25(11):2803-10. [PubMed: 15772340]  [MGI Ref ID J:98636]

Fryer JD; Taylor JW; DeMattos RB; Bales KR; Paul SM; Parsadanian M; Holtzman DM. 2003. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci 23(21):7889-96. [PubMed: 12944519]  [MGI Ref ID J:85307]

Fu T; Borensztajn J. 2006. Simvastatin causes the formation of cholesterol-rich remnants in mice lacking apoE. Biochem Biophys Res Commun 341(4):1172-6. [PubMed: 16460674]  [MGI Ref ID J:105757]

Fu T; Kozarsky KF; Borensztajn J. 2003. Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice. J Biol Chem 278(52):52559-63. [PubMed: 14570884]  [MGI Ref ID J:87086]

Fukumoto Y; Deguchi JO; Libby P; Rabkin-Aikawa E; Sakata Y; Chin MT; Hill CC; Lawler PR; Varo N; Schoen FJ; Krane SM; Aikawa M. 2004. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation 110(14):1953-9. [PubMed: 15451791]  [MGI Ref ID J:146712]

Fullerton SM; Shirman GA; Strittmatter WJ; Matthew WD. 2001. Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. Exp Neurol 169(1):13-22. [PubMed: 11312553]  [MGI Ref ID J:69455]

Fullerton SM; Strittmatter WJ; Matthew WD. 1998. Peripheral sensory nerve defects in apolipoprotein E knockout mice. Exp Neurol 153(1):156-63. [PubMed: 9743578]  [MGI Ref ID J:106368]

Furbee JW Jr; Francone O; Parks JS. 2002. In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. J Lipid Res 43(3):428-37. [PubMed: 11893779]  [MGI Ref ID J:75567]

Furbee JW Jr; Sawyer JK; Parks JS. 2002. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice. J Biol Chem 277(5):3511-9. [PubMed: 11719520]  [MGI Ref ID J:74315]

Galkina E; Harry BL; Ludwig A; Liehn EA; Sanders JM; Bruce A; Weber C; Ley K. 2007. CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall. Circulation 116(16):1801-11. [PubMed: 17909108]  [MGI Ref ID J:139833]

Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. [PubMed: 16682495]  [MGI Ref ID J:124135]

Gallardo G; Schluter OM; Sudhof TC. 2008. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nat Neurosci 11(3):301-8. [PubMed: 18297066]  [MGI Ref ID J:131733]

Gao J; Katagiri H; Ishigaki Y; Yamada T; Ogihara T; Imai J; Uno K; Hasegawa Y; Kanzaki M; Yamamoto TT; Ishibashi S; Oka Y. 2007. Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. Diabetes 56(1):24-33. [PubMed: 17192461]  [MGI Ref ID J:121950]

Gareus R; Kotsaki E; Xanthoulea S; van der Made I; Gijbels MJ; Kardakaris R; Polykratis A; Kollias G; de Winther MP; Pasparakis M. 2008. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 8(5):372-83. [PubMed: 19046569]  [MGI Ref ID J:143751]

Gates AC; Bernal-Mizrachi C; Chinault SL; Feng C; Schneider JG; Coleman T; Malone JP; Townsend RR; Chakravarthy MV; Semenkovich CF. 2007. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metab 6(6):497-505. [PubMed: 18054318]  [MGI Ref ID J:130440]

Gavrila D; Li WG; McCormick ML; Thomas M; Daugherty A; Cassis LA; Miller FJ Jr; Oberley LW; Dellsperger KC; Weintraub NL. 2005. Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1671-7. [PubMed: 15933246]  [MGI Ref ID J:114336]

Georgopoulos S; McKee A; Kan HY; Zannis VI. 2002. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry 41(30):9293-301. [PubMed: 12135350]  [MGI Ref ID J:78003]

Ghazalpour A; Doss S; Zhang B; Wang S; Plaisier C; Castellanos R; Brozell A; Schadt EE; Drake TA; Lusis AJ; Horvath S. 2006. Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet 2(8):e130. [PubMed: 16934000]  [MGI Ref ID J:115983]

Glaros EN; Kim WS; Quinn CM; Jessup W; Rye KA; Garner B. 2008. Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. J Lipid Res 49(2):324-31. [PubMed: 17978313]  [MGI Ref ID J:131877]

Glaros EN; Kim WS; Rye KA; Shayman JA; Garner B. 2008. Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice. J Lipid Res 49(8):1677-81. [PubMed: 18467744]  [MGI Ref ID J:138447]

Godschalk RW; Albrecht C; Curfs DM; Schins RP; Bartsch H; van Schooten FJ; Nair J. 2007. Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice. Mutat Res 621(1-2):87-94. [PubMed: 17418875]  [MGI Ref ID J:123175]

Goldstein LB; Vitek MP; Dawson H; Bullman S. 2000. Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. Neuroscience 99(4):705-10. [PubMed: 10974433]  [MGI Ref ID J:119167]

Gonzalez-Navarro H; Nong Z; Amar MJ; Shamburek RD; Najib-Fruchart J; Paigen BJ; Brewer HB Jr; Santamarina-Fojo S. 2004. The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. J Biol Chem 279(44):45312-21. [PubMed: 15304509]  [MGI Ref ID J:94495]

Goodrum JF; Bouldin TW; Zhang SH; Maeda N; Popko B. 1995. Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem 64(1):408-16. [PubMed: 7798939]  [MGI Ref ID J:22362]

Gough PJ; Gomez IG; Wille PT; Raines EW. 2006. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest 116(1):59-69. [PubMed: 16374516]  [MGI Ref ID J:105266]

Gourdy P; Schambourg A; Filipe C; Douin-Echinard V; Garmy-Susini B; Calippe B; Terce F; Bayard F; Arnal JF. 2007. Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 27(10):2214-21. [PubMed: 17690314]  [MGI Ref ID J:134877]

Grainger DJ; Reckless J; McKilligin E. 2004. Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol 173(10):6366-75. [PubMed: 15528376]  [MGI Ref ID J:94282]

Grootendorst J; Bour A; Vogel E; Kelche C; Sullivan PM; Dodart JC; Bales K; Mathis C. 2005. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav Brain Res 159(1):1-14. [PubMed: 15794991]  [MGI Ref ID J:97643]

Gross S; Tilly P; Hentsch D; Vonesch JL; Fabre JE. 2007. Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors. J Exp Med 204(2):311-20. [PubMed: 17242161]  [MGI Ref ID J:125376]

Guo GL; Santamarina-Fojo S; Akiyama TE; Amar MJ; Paigen BJ; Brewer B Jr; Gonzalez FJ. 2006. Effects of FXR in foam-cell formation and atherosclerosis development. Biochim Biophys Acta 1761(12):1401-9. [PubMed: 17110163]  [MGI Ref ID J:118172]

Guo Y; Zhang C; Du X; Nair U; Yoo TJ. 2005. Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice. Hear Res 208(1-2):54-67. [PubMed: 16051453]  [MGI Ref ID J:101576]

Guo Z; Mitchell-Raymundo F; Yang H; Ikeno Y; Nelson J; Diaz V; Richardson A; Reddick R. 2002. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev 123(8):1121-31. [PubMed: 12044962]  [MGI Ref ID J:76930]

Guo Z; Ran Q; Roberts LJ nd; Zhou L; Richardson A; Sharan C; Wu D; Yang H. 2008. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med 44(3):343-52. [PubMed: 18215741]  [MGI Ref ID J:130157]

Hafezi-Moghadam A; Thomas KL; Wagner DD. 2007. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol 292(4):C1256-62. [PubMed: 16870825]  [MGI Ref ID J:125887]

Haghighat A; Weiss D; Whalin MK; Cowan DP; Taylor WR. 2007. Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice. Circulation 115(15):2049-54. [PubMed: 17404156]  [MGI Ref ID J:135370]

Han SH; Chung SY. 2000. Marked hippocampal neuronal damage without motor deficits after mild concussive-like brain injury in apolipoprotein E-deficient mice Ann N Y Acad Sci 903:357-65. [PubMed: 10818526]  [MGI Ref ID J:62422]

Han X; Cheng H; Fryer JD; Fagan AM; Holtzman DM. 2003. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. J Biol Chem 278(10):8043-51. [PubMed: 12501252]  [MGI Ref ID J:131491]

Han X; Holtzman DM; McKeel DW Jr. 2001. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 77(4):1168-80. [PubMed: 11359882]  [MGI Ref ID J:69528]

Hanniman EA; Lambert G; McCarthy TC; Sinal CJ. 2005. Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J Lipid Res 46(12):2595-604. [PubMed: 16186601]  [MGI Ref ID J:106149]

Hansmann G; Wagner RA; Schellong S; Perez VA; Urashima T; Wang L; Sheikh AY; Suen RS; Stewart DJ; Rabinovitch M. 2007. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation 115(10):1275-84. [PubMed: 17339547]  [MGI Ref ID J:132327]

Hansmann G; de Jesus Perez VA; Alastalo TP; Alvira CM; Guignabert C; Bekker JM; Schellong S; Urashima T; Wang L; Morrell NW; Rabinovitch M. 2008. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 118(5):1846-57. [PubMed: 18382765]  [MGI Ref ID J:136168]

Hao M; Head WS; Gunawardana SC; Hasty AH; Piston DW. 2007. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes 56(9):2328-38. [PubMed: 17575085]  [MGI Ref ID J:126584]

Harja E; Bu DX; Hudson BI; Chang JS; Shen X; Hallam K; Kalea AZ; Lu Y; Rosario RH; Oruganti S; Nikolla Z; Belov D; Lalla E; Ramasamy R; Yan SF; Schmidt AM. 2008. Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice. J Clin Invest 118(1):183-94. [PubMed: 18079965]  [MGI Ref ID J:130844]

Harja E; Bucciarelli LG; Lu Y; Stern DM; Zou YS; Schmidt AM; Yan SF. 2004. Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation. Circ Res 94(3):333-9. [PubMed: 14670837]  [MGI Ref ID J:96665]

Harja E; Chang JS; Lu Y; Leitges M; Zou YS; Schmidt AM; Yan SF. 2009. Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J 23(4):1081-91. [PubMed: 19036858]  [MGI Ref ID J:147225]

Harrington SC; Simari RD; Conover CA. 2007. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 100(12):1696-702. [PubMed: 17510462]  [MGI Ref ID J:137790]

Harris FM; Brecht WJ; Xu Q; Mahley RW; Huang Y. 2004. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem 279(43):44795-801. [PubMed: 15322121]  [MGI Ref ID J:93984]

Harry BL; Sanders JM; Feaver RE; Lansey M; Deem TL; Zarbock A; Bruce AC; Pryor AW; Gelfand BD; Blackman BR; Schwartz MA; Ley K. 2008. Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 28(11):2003-8. [PubMed: 18688018]  [MGI Ref ID J:148824]

Hartley CJ; Reddy AK; Madala S; Martin-McNulty B; Vergona R; Sullivan ME; Halks-Miller M; Taffet GE; Michael LH; Entman ML; Wang YX. 2000. Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol Heart Circ Physiol 279(5):H2326-34. [PubMed: 11045969]  [MGI Ref ID J:108154]

Hartman RE; Laurer H; Longhi L; Bales KR; Paul SM; McIntosh TK; Holtzman DM. 2002. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci 22(23):10083-7. [PubMed: 12451108]  [MGI Ref ID J:133058]

Hartman RE; Wozniak DF; Nardi A; Olney JW; Sartorius L; Holtzman DM. 2001. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp Neurol 170(2):326-44. [PubMed: 11476599]  [MGI Ref ID J:71062]

Hashimoto T; Kihara M; Imai N; Yoshida S; Shimoyamada H; Yasuzaki H; Ishida J; Toya Y; Kiuchi Y; Hirawa N; Tamura K; Yazawa T; Kitamura H; Fukamizu A; Umemura S. 2007. Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 171(5):1705-12. [PubMed: 17884970]  [MGI Ref ID J:126802]

Hatcher JP; Virley D; Hadingham SJ; Roberts J; Hunter AJ; Parsons AA. 2002. The behavioural effect of middle cerebral artery occlusion on apolipoprotein-E deficient mice. Behav Brain Res 131(1-2):139-49. [PubMed: 11844581]  [MGI Ref ID J:96228]

Hemdahl AL; Falk E; Thoren P; Hansson GK. 2004. Thrombin inhibitor reduces myocardial infarction in apoE-/- x LDLR-/- mice. Am J Physiol Heart Circ Physiol 287(2):H872-7. [PubMed: 15031124]  [MGI Ref ID J:95598]

Hermanowski-Vosatka A; Balkovec JM; Cheng K; Chen HY; Hernandez M; Koo GC; Le Grand CB; Li Z; Metzger JM; Mundt SS; Noonan H; Nunes CN; Olson SH; Pikounis B; Ren N; Robertson N; Schaeffer JM; Shah K; Springer MS; Strack AM; Strowski M; Wu K; Wu T; Xiao J; Zhang BB; Wright SD; Thieringer R. 2005. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 202(4):517-27. [PubMed: 16103409]  [MGI Ref ID J:100504]

Hernandez-Vargas P; Ortiz-Munoz G; Lopez-Franco O; Suzuki Y; Gallego-Delgado J; Sanjuan G; Lazaro A; Lopez-Parra V; Ortega L; Egido J; Gomez-Guerrero C. 2006. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice. Circ Res 99(11):1188-96. [PubMed: 17053192]  [MGI Ref ID J:129087]

Hirasawa H; Tanaka S; Sakai A; Tsutsui M; Shimokawa H; Miyata H; Moriwaki S; Niida S; Ito M; Nakamura T. 2007. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res 22(7):1020-30. [PubMed: 17388726]  [MGI Ref ID J:137540]

Hirsch-Reinshagen V; Zhou S; Burgess BL; Bernier L; McIsaac SA; Chan JY; Tansley GH; Cohn JS; Hayden MR; Wellington CL. 2004. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279(39):41197-207. [PubMed: 15269218]  [MGI Ref ID J:93331]

Hirschfield GM; Gallimore JR; Kahan MC; Hutchinson WL; Sabin CA; Benson GM; Dhillon AP; Tennent GA; Pepys MB. 2005. Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 102(23):8309-14. [PubMed: 15919817]  [MGI Ref ID J:99730]

Hodgin JB; Knowles JW; Kim HS; Smithies O; Maeda N. 2002. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J Clin Invest 109(4):541-8. [PubMed: 11854327]  [MGI Ref ID J:74702]

Hofmann MA; Lalla E; Lu Y; Gleason MR; Wolf BM; Tanji N; Ferran LJ Jr; Kohl B; Rao V; Kisiel W; Stern DM; Schmidt AM. 2001. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest 107(6):675-83. [PubMed: 11254667]  [MGI Ref ID J:120549]

Hofmann SM; Perez-Tilve D; Greer TM; Coburn BA; Grant E; Basford JE; Tschop MH; Hui DY. 2008. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes 57(1):5-12. [PubMed: 17914034]  [MGI Ref ID J:132417]

Holm TM; Braun A; Trigatti BL; Brugnara C; Sakamoto M; Krieger M; Andrews NC. 2002. Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood 99(5):1817-24. [PubMed: 11861300]  [MGI Ref ID J:75090]

Holtzman DM; Bales KR; Tenkova T; Fagan AM; Parsadanian M; Sartorius LJ; Mackey B; Olney J; McKeel D; Wozniak D; Paul SM. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 97(6):2892-7. [PubMed: 10694577]  [MGI Ref ID J:61176]

Holtzman DM; Bales KR; Wu S; Bhat P; Parsadanian M; Fagan AM; Chang LK; Sun Y; Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 103(6):R15-R21. [PubMed: 10079115]  [MGI Ref ID J:53613]

Holtzman DM; Fagan AM; Mackey B; Tenkova T; Sartorius L; Paul SM; Bales K; Ashe KH; Irizarry MC; Hyman BT. 2000. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 47(6):739-47. [PubMed: 10852539]  [MGI Ref ID J:113061]

Holvoet P; Danloy S; Deridder E; Lox M; Bernar H; Dhoest A; Collen D. 1998. Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice. J Clin Invest 102(2):379-85. [PubMed: 9664079]  [MGI Ref ID J:115147]

Homeister JW; Daugherty A; Lowe JB. 2004. Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 24(10):1897-903. [PubMed: 15308551]  [MGI Ref ID J:102212]

Hopkins PC; Huang Y; McGuire JG; Pitas RE. 2002. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J Lipid Res 43(11):1881-9. [PubMed: 12401887]  [MGI Ref ID J:123999]

Horsburgh K; Kelly S; McCulloch J; Higgins GA; Roses AD; Nicoll JA. 1999. Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia. Neuroreport 10(4):837-41. [PubMed: 10208557]  [MGI Ref ID J:54423]

Horsburgh K; McCulloch J; Nilsen M; Roses AD; Nicoll JA. 2000. Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia. Eur J Neurosci 12(12):4309-17. [PubMed: 11122341]  [MGI Ref ID J:129722]

Hoshii Y; Kawano H; Cui D; Takeda T; Gondo T; Takahashi M; Kogishi K ; Higuchi K ; Ishihara T. 1997. Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice. Am J Pathol 151(4):911-7. [PubMed: 9327723]  [MGI Ref ID J:43190]

Huang M; Pang X; Karalis K; Theoharides TC. 2003. Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Cardiovasc Res 59(1):241-9. [PubMed: 12829195]  [MGI Ref ID J:102798]

Huang MS; Lu J; Ivanov Y; Sage AP; Tseng W; Demer LL; Tintut Y. 2008. Hyperlipidemia impairs osteoanabolic effects of PTH. J Bone Miner Res 23(10):1672-9. [PubMed: 18505371]  [MGI Ref ID J:153411]

Huang Y; Liu XQ; Rall SC Jr; Taylor JM; von Eckardstein A; Assmann G; Mahley RW. 1998. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem 273(41):26388-93. [PubMed: 9756870]  [MGI Ref ID J:115206]

Huang Y; Rall SC Jr; Mahley RW. 1997. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol 17(11):2817-24. [PubMed: 9409260]  [MGI Ref ID J:45728]

Huang ZH; Reardon CA; Mazzone T. 2006. Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. Diabetes 55(12):3394-402. [PubMed: 17130485]  [MGI Ref ID J:121013]

Huber SA; Sakkinen P; Conze D; Hardin N; Tracy R. 1999. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol 19(10):2364-7. [PubMed: 10521365]  [MGI Ref ID J:103386]

Hudson BI; Bucciarelli LG; Wendt T; Sakaguchi T; Lalla E; Qu W; Lu Y; Lee L; Stern DM; Naka Y; Ramasamy R; Yan SD; Yan SF; D'Agati V; Schmidt AM. 2003. Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys 419(1):80-8. [PubMed: 14568011]  [MGI Ref ID J:86419]

Huo Y; Schober A; Forlow SB; Smith DF; Hyman MC; Jung S; Littman DR; Weber C; Ley K. 2003. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9(1):61-7. [PubMed: 12483207]  [MGI Ref ID J:81164]

Hyvarinen K; Tuomainen AM; Laitinen S; Bykov IL; Tormakangas L; Lindros K; Kakela R; Alfthan G; Salminen I; Jauhiainen M; Kovanen PT; Leinonen M; Saikku P; Pussinen PJ. 2009. Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect Immun 77(8):3442-9. [PubMed: 19451238]  [MGI Ref ID J:151250]

Igbavboa U; Avdulov NA; Chochina SV; Wood WG. 1997. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69(4):1661-7. [PubMed: 9326295]  [MGI Ref ID J:43043]

Ihara Y; Egashira K; Nakano K; Ohtani K; Kubo M; Koga J; Iwai M; Horiuchi M; Gang Z; Yamagishi S; Sunagawa K. 2007. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol 43(4):455-64. [PubMed: 17761193]  [MGI Ref ID J:126372]

Imai Y; Shindo T; Maemura K; Sata M; Saito Y; Kurihara Y; Akishita M; Osuga J; Ishibashi S; Tobe K; Morita H; Oh-hashi Y; Suzuki T; Maekawa H; Kangawa K; Minamino N; Yazaki Y; Nagai R; Kurihara H. 2002. Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression. Arterioscler Thromb Vasc Biol 22(8):1310-5. [PubMed: 12171793]  [MGI Ref ID J:103212]

Inoue K; Arai Y; Kurihara H; Kita T; Sawamura T. 2005. Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res 97(2):176-84. [PubMed: 15961718]  [MGI Ref ID J:111393]

Isenberg JS; Hyodo F; Pappan LK; Abu-Asab M; Tsokos M; Krishna MC; Frazier WA; Roberts DD. 2007. Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. Arterioscler Thromb Vasc Biol 27(12):2582-8. [PubMed: 17916772]  [MGI Ref ID J:147523]

Ishibashi S; Perrey S; Chen Z; Osuga Ji; Shimada M; Ohashi K; Harada K; Yazaki Y; Yamada N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem 271(37):22422-7. [PubMed: 8798405]  [MGI Ref ID J:35377]

Ishida T; Choi SY; Kundu RK; Spin J; Yamashita T; Hirata K; Kojima Y; Yokoyama M; Cooper AD; Quertermous T. 2004. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 279(43):45085-92. [PubMed: 15304490]  [MGI Ref ID J:93987]

Ishigaki Y; Oikawa S; Suzuki T; Usui S; Magoori K; Kim DH; Suzuki H; Sasaki J; Sasano H; Okazaki M; Toyota T; Saito T; Yamamoto TT. 2000. Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice J Biol Chem 275(40):31269-73. [PubMed: 10903326]  [MGI Ref ID J:65016]

Ishimori N; Iwabuchi K; Fujii S; Watano K; Iwabuchi C; Ato M; Chiba H; Tanaka S; Kitabatake A; Onoe K. 2001. Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice. J Leukoc Biol 69(5):732-40. [PubMed: 11358981]  [MGI Ref ID J:69647]

Isoda K; Sawada S; Ishigami N; Matsuki T; Miyazaki K; Kusuhara M; Iwakura Y; Ohsuzu F. 2004. Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24(6):1068-73. [PubMed: 15059807]  [MGI Ref ID J:102337]

Ivanovski O; Szumilak D; Nguyen-Khoa T; Ruellan N; Phan O; Lacour B; Descamps-Latscha B; Drueke TB; Massy ZA. 2005. The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice. Kidney Int 67(6):2288-94. [PubMed: 15882270]  [MGI Ref ID J:110116]

Iwai M; Chen R; Li Z; Shiuchi T; Suzuki J; Ide A; Tsuda M; Okumura M; Min LJ; Mogi M; Horiuchi M. 2005. Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. Circulation 112(11):1636-43. [PubMed: 16145000]  [MGI Ref ID J:116799]

Jawien J; Gajda M; Olszanecki R; Korbut R. 2007. BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol 58(3):583-8. [PubMed: 17928652]  [MGI Ref ID J:130080]

Ji Y; Gong Y; Gan W; Beach T; Holtzman DM; Wisniewski T. 2003. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience 122(2):305-15. [PubMed: 14614898]  [MGI Ref ID J:126171]

Jiang XC; Beyer TP; Li Z; Liu J; Quan W; Schmidt RJ; Zhang Y; Bensch WR; Eacho PI; Cao G. 2003. Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression. J Biol Chem 278(49):49072-8. [PubMed: 12947111]  [MGI Ref ID J:86766]

Jiang XC; Tall AR; Qin S; Lin M; Schneider M; Lalanne F; Deckert V; Desrumaux C; Athias A; Witztum JL; Lagrost L. 2002. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem 277(35):31850-6. [PubMed: 12105225]  [MGI Ref ID J:120468]

Johansson ME; Hagg U; Wikstrom J; Wickman A; Bergstrom G; Gan LM. 2005. Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE-/- mice. Clin Sci (Lond) 108(6):531-8. [PubMed: 15675896]  [MGI Ref ID J:109794]

Johnstone SR; Ross J; Rizzo MJ; Straub AC; Lampe PD; Leitinger N; Isakson BE. 2009. Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation. Am J Pathol 175(2):916-24. [PubMed: 19608875]  [MGI Ref ID J:150954]

Joseph SB; McKilligin E; Pei L; Watson MA; Collins AR; Laffitte BA; Chen M; Noh G; Goodman J; Hagger GN; Tran J; Tippin TK; Wang X; Lusis AJ; Hsueh WA; Law RE; Collins JL; Willson TM; Tontonoz P. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99(11):7604-9. [PubMed: 12032330]  [MGI Ref ID J:76860]

Joyce CW; Amar MJ; Lambert G; Vaisman BL; Paigen B; Najib-Fruchart J; Hoyt RF Jr; Neufeld ED; Remaley AT; Fredrickson DS; Brewer HB Jr; Santamarina-Fojo S. 2002. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci U S A 99(1):407-12. [PubMed: 11752403]  [MGI Ref ID J:73704]

Karackattu SL; Picard MH; Krieger M. 2005. Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 25(4):803-8. [PubMed: 15692099]  [MGI Ref ID J:110023]

Karackattu SL; Trigatti B; Krieger M. 2006. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 26(3):548-54. [PubMed: 16397139]  [MGI Ref ID J:127979]

Karagiannides I; Abdou R; Tzortzopoulou A; Voshol PJ; Kypreos KE. 2008. Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice. FEBS J 275(19):4796-809. [PubMed: 18754772]  [MGI Ref ID J:142460]

Karra R; Vemullapalli S; Dong C; Herderick EE; Song X; Slosek K; Nevins JR; West M; Goldschmidt-Clermont PJ; Seo D. 2005. Molecular evidence for arterial repair in atherosclerosis. Proc Natl Acad Sci U S A 102(46):16789-94. [PubMed: 16275914]  [MGI Ref ID J:103741]

Kauser K; da Cunha V; Fitch R; Mallari C; Rubanyi GM. 2000. Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 278(5):H1679-85. [PubMed: 10775149]  [MGI Ref ID J:62352]

Keller JN; Lauderback CM; Butterfield DA; Kindy MS; Yu J; Markesbery WR. 2000. Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice. J Neurochem 74(4):1579-86. [PubMed: 10737615]  [MGI Ref ID J:61167]

Khallou-Laschet J; Caligiuri G; Groyer E; Tupin E; Gaston AT; Poirier B; Kronenberg M; Cohen JL; Klatzmann D; Kaveri SV; Nicoletti A. 2006. The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease. Arterioscler Thromb Vasc Biol 26(2):353-8. [PubMed: 16322528]  [MGI Ref ID J:127968]

Kim E; Tolhurst AT; Qin LY; Chen XY; Febbraio M; Cho S. 2008. CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury. J Neurosci 28(18):4661-70. [PubMed: 18448643]  [MGI Ref ID J:134972]

Kindy MS; Rader DJ. 1998. Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice [see comments] Am J Pathol 152(5):1387-95. [PubMed: 9588907]  [MGI Ref ID J:47401]

King VL; Cassis LA; Daugherty A. 2007. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am J Pathol 171(6):2040-7. [PubMed: 18055554]  [MGI Ref ID J:128948]

Kirii H; Niwa T; Yamada Y; Wada H; Saito K; Iwakura Y; Asano M; Moriwaki H; Seishima M. 2003. Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 23(4):656-60. [PubMed: 12615675]  [MGI Ref ID J:103057]

Kirk EA; Heinecke JW; LeBoeuf RC. 2001. Iron overload diminishes atherosclerosis in apoE-deficient mice. J Clin Invest 107(12):1545-53. [PubMed: 11413162]  [MGI Ref ID J:70613]

Kisucka J; Chauhan AK; Zhao BQ; Patten IS; Yesilaltay A; Krieger M; Wagner DD. 2009. Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. Blood 113(23):6015-22. [PubMed: 19349621]  [MGI Ref ID J:149496]

Kitayama J; Faraci FM; Lentz SR; Heistad DD. 2007. Cerebral vascular dysfunction during hypercholesterolemia. Stroke 38(7):2136-41. [PubMed: 17525390]  [MGI Ref ID J:148665]

Klement H; St Croix B; Milsom C; May L; Guo Q; Yu JL; Klement P; Rak J. 2007. Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy. Am J Pathol 171(4):1342-51. [PubMed: 17823292]  [MGI Ref ID J:125516]

Knaapen AM; Curfs DM; Pachen DM; Gottschalk RW; de Winther MP; Daemen MJ; Van Schooten FJ. 2007. The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis. Mutat Res 621(1-2):31-41. [PubMed: 17376491]  [MGI Ref ID J:123179]

Knowles JW; Reddick RL; Jennette JC; Shesely EG; Smithies O; Maeda N. 2000. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest 105(4):451-8. [PubMed: 10683374]  [MGI Ref ID J:60670]

Ko KW; Corry DB; Brayton CF; Paul A; Chan L. 2009. Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun 384(1):93-9. [PubMed: 19393222]  [MGI Ref ID J:150604]

Ko KW; Paul A; Ma K; Li L; Chan L. 2005. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 46(12):2586-94. [PubMed: 16199802]  [MGI Ref ID J:106132]

Koistinaho M; Kettunen MI; Holtzman DM; Kauppinen RA; Higgins LS; Koistinaho J. 2002. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Stroke 33(7):1905-10. [PubMed: 12105373]  [MGI Ref ID J:133156]

Koistinaho M; Lin S; Wu X; Esterman M; Koger D; Hanson J; Higgs R; Liu F; Malkani S; Bales KR; Paul SM. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 10(7):719-26. [PubMed: 15195085]  [MGI Ref ID J:91799]

Kotti T; Head DD; McKenna CE; Russell DW. 2008. Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proc Natl Acad Sci U S A 105(32):11394-9. [PubMed: 18685105]  [MGI Ref ID J:140342]

Kraemer R; Baker PJ; Kent KC; Ye Y; Han JJ; Tejada R; Silane M; Upmacis R; Deeb R; Chen Y; Levine DM; Hempstead B. 2005. Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. Circulation 112(23):3644-53. [PubMed: 16330706]  [MGI Ref ID J:116881]

Krebs P; Scandella E; Bolinger B; Engeler D; Miller S; Ludewig B. 2007. Chronic immune reactivity against persisting microbial antigen in the vasculature exacerbates atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol 27(10):2206-13. [PubMed: 17656668]  [MGI Ref ID J:134893]

Kremen M; Krishnan R; Emery I; Hu JH; Slezicki KI; Wu A; Qian K; Du L; Plawman A; Stempien-Otero A; Dichek DA. 2008. Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice. Proc Natl Acad Sci U S A 105(44):17109-14. [PubMed: 18957535]  [MGI Ref ID J:144061]

Krohn R; Raffetseder U; Bot I; Zernecke A; Shagdarsuren E; Liehn EA; van Santbrink PJ; Nelson PJ; Biessen EA; Mertens PR; Weber C. 2007. Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice. Circulation 116(16):1812-20. [PubMed: 17893273]  [MGI Ref ID J:139837]

Krzywkowski P; Ghribi O; Gagne J; Chabot C; Kar S; Rochford J; Massicotte G; Poirier J. 1999. Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice. Neuroscience 92(4):1273-86. [PubMed: 10426483]  [MGI Ref ID J:110875]

Kudchodkar B; Jones H; Simecka J; Dory L. 2008. Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice. Clin Immunol 128(3):435-41. [PubMed: 18595776]  [MGI Ref ID J:138706]

Kuhlencordt PJ; Chen J; Han F; Astern J; Huang PL. 2001. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103(25):3099-104. [PubMed: 11425775]  [MGI Ref ID J:103350]

Kuhlencordt PJ; Gyurko R; Han F; Scherrer-Crosbie M; Aretz TH; Hajjar R; Picard MH; Huang PL. 2001. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104(4):448-54. [PubMed: 11468208]  [MGI Ref ID J:103306]

Kunieda T; Minamino T; Nishi J; Tateno K; Oyama T; Katsuno T; Miyauchi H; Orimo M; Okada S; Takamura M; Nagai T; Kaneko S; Komuro I. 2006. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114(9):953-60. [PubMed: 16908765]  [MGI Ref ID J:125247]

Kunjathoor VV; Chiu DS; O'Brien KD; LeBoeuf RC. 2002. Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 22(3):462-8. [PubMed: 11884291]  [MGI Ref ID J:103309]

Kypreos KE. 2008. ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia. Biochemistry 47(39):10491-502. [PubMed: 18767813]  [MGI Ref ID J:141173]

Kypreos KE; Li X; van Dijk KW; Havekes LM; Zannis VI. 2003. Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype. Biochemistry 42(33):9841-53. [PubMed: 12924933]  [MGI Ref ID J:115687]

Kypreos KE; Zannis VI. 2006. LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice. J Lipid Res 47(3):521-9. [PubMed: 16339113]  [MGI Ref ID J:107556]

Kypreos KE; Zannis VI. 2007. Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. Biochem J 403(2):359-67. [PubMed: 17206937]  [MGI Ref ID J:121679]

Lambert G; Sakai N; Vaisman BL; Neufeld EB; Marteyn B; Chan CC; Paigen B; Lupia E; Thomas A; Striker LJ; Blanchette-Mackie J; Csako G; Brady JN; Costello R; Striker GE; Remaley AT; Brewer HB Jr; Santamarina-Fojo S. 2001. Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice. J Biol Chem 276(18):15090-8. [PubMed: 11278414]  [MGI Ref ID J:69299]

Landsman L; Bar-On L; Zernecke A; Kim KW; Krauthgamer R; Shagdarsuren E; Lira SA; Weissman IL; Weber C; Jung S. 2009. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 113(4):963-72. [PubMed: 18971423]  [MGI Ref ID J:145036]

Langheinrich AC; Michniewicz A; Sedding DG; Walker G; Beighley PE; Rau WS; Bohle RM; Ritman EL. 2006. Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice. Arterioscler Thromb Vasc Biol 26(2):347-52. [PubMed: 16293797]  [MGI Ref ID J:127960]

Laskowitz DT; Lee DM; Schmechel D; Staats HF. 2000. Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res 41(4):613-20. [PubMed: 10744782]  [MGI Ref ID J:61564]

Laufs U; Wassmann S; Czech T; Munzel T; Eisenhauer M; Bohm M; Nickenig G. 2005. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 25(4):809-14. [PubMed: 15692095]  [MGI Ref ID J:110022]

Law A; Gauthier S; Quirion R. 2003. Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice. Neurobiol Aging 24(1):187-90. [PubMed: 12493565]  [MGI Ref ID J:119319]

Layne MD; Patel A; Chen YH; Rebel VI; Carvajal IM; Pellacani A; Ith B; Zhao D; Schreiber BM; Yet SF; Lee ME; Storch J; Perrella MA. 2001. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15(14):2733-5. [PubMed: 11606480]  [MGI Ref ID J:73162]

Le Lay S; Kurzchalia TV. 2005. Getting rid of caveolins: phenotypes of caveolin-deficient animals. Biochim Biophys Acta 1746(3):322-33. [PubMed: 16019085]  [MGI Ref ID J:104846]

Lee EC; Desai U; Gololobov G; Hong S; Feng X; Yu XC; Gay J; Wilganowski N; Gao C; Du LL; Chen J; Hu Y; Zhao S; Kirkpatrick L; Schneider M; Zambrowicz BP; Landes G; Powell DR; Sonnenburg WK. 2009. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem 284(20):13735-45. [PubMed: 19318355]  [MGI Ref ID J:149912]

Lee HT; Chiu LL; Lee TS; Tsai HL; Chau LY. 2003. Dietary iron restriction increases plaque stability in apolipoprotein-e-deficient mice. J Biomed Sci 10(5):510-7. [PubMed: 12928591]  [MGI Ref ID J:103069]

Lee K; Saidel GM; Penn MS. 2008. Permeability change of arterial endothelium is an age-dependent function of lesion size in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol 295(6):H2273-9. [PubMed: 18835923]  [MGI Ref ID J:143304]

Lee SJ; Grosskopf I; Choi SY; Cooper AD. 2004. Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158->Cys), and E3-Leiden. J Lipid Res 45(12):2199-210. [PubMed: 15466367]  [MGI Ref ID J:94176]

Lee TS; Shiao MS; Pan CC; Chau LY. 1999. Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. Circulation 99(9):1222-9. [PubMed: 10069791]  [MGI Ref ID J:103204]

Lee TS; Yen HC; Pan CC; Chau LY. 1999. The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(3):734-42. [PubMed: 10073981]  [MGI Ref ID J:53839]

Leidenfrost JE; Khan MF; Boc KP; Villa BR; Collins ET; Parks WC; Abendschein DR; Choi ET. 2003. A model of primary atherosclerosis and post-angioplasty restenosis in mice. Am J Pathol 163(2):773-8. [PubMed: 12875996]  [MGI Ref ID J:113609]

Leighty RE; Nilsson LN; Potter H; Costa DA; Low MA; Bales KR; Paul SM; Arendash GW. 2004. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition. Behav Brain Res 153(1):107-21. [PubMed: 15219712]  [MGI Ref ID J:91238]

Lemaitre V; Soloway PD; D'Armiento J. 2003. Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1. Circulation 107(2):333-8. [PubMed: 12538437]  [MGI Ref ID J:103082]

Levi O; Dolev I; Belinson H; Michaelson DM. 2007. Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation. J Neurochem 103(3):1031-40. [PubMed: 17666042]  [MGI Ref ID J:126660]

Levi O; Jongen-Relo AL; Feldon J; Roses AD; Michaelson DM. 2003. ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol Dis 13(3):273-82. [PubMed: 12901842]  [MGI Ref ID J:131475]

Levi O; Lutjohann D; Devir A; von Bergmann K; Hartmann T; Michaelson DM. 2005. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. J Neurochem 95(4):987-97. [PubMed: 16190879]  [MGI Ref ID J:102888]

Levi O; Michaelson DM. 2007. Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice. J Neurochem 100(1):202-10. [PubMed: 17074063]  [MGI Ref ID J:118697]

Levy AP; Levy JE; Kalet-Litman S; Miller-Lotan R; Levy NS; Asaf R; Guetta J; Yang C; Purushothaman KR; Fuster V; Moreno PR. 2007. Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque. Arterioscler Thromb Vasc Biol 27(1):134-40. [PubMed: 17068284]  [MGI Ref ID J:134942]

Lewis P; Stefanovic N; Pete J; Calkin AC; Giunti S; Thallas-Bonke V; Jandeleit-Dahm KA; Allen TJ; Kola I; Cooper ME; de Haan JB. 2007. Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice. Circulation 115(16):2178-87. [PubMed: 17420349]  [MGI Ref ID J:135907]

Li G; Sanders JM; Bevard MH; Sun Z; Chumley JW; Galkina EV; Ley K; Sarembock IJ. 2008. CD40 Ligand Promotes Mac-1 Expression, Leukocyte Recruitment, and Neointima Formation after Vascular Injury. Am J Pathol 172(4):1141-52. [PubMed: 18349125]  [MGI Ref ID J:133345]

Li G; Sanders JM; Phan ET; Ley K; Sarembock IJ. 2005. Arterial macrophages and regenerating endothelial cells express p-selectin in atherosclerosis-prone apolipoprotein e-deficient mice. Am J Pathol 167(6):1511-8. [PubMed: 16314466]  [MGI Ref ID J:103660]

Li Q; Li Y; Zhang Z; Gilbert TR; Matsumoto AH; Dobrin SE; Shi W. 2008. Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Stroke 39(1):166-73. [PubMed: 18048852]  [MGI Ref ID J:129301]

Li XA; Guo L; Dressman JL; Asmis R; Smart EJ. 2005. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem 280(19):19087-96. [PubMed: 15749707]  [MGI Ref ID J:99934]

Li Z; Park TS; Li Y; Pan X; Iqbal J; Lu D; Tang W; Yu L; Goldberg IJ; Hussain MM; Jiang XC. 2009. Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol. Biochim Biophys Acta 1791(4):297-306. [PubMed: 19416652]  [MGI Ref ID J:148766]

Liao D; Tan H; Hui R; Li Z; Jiang X; Gaubatz J; Yang F; Durante W; Chan L; Schafer AI; Pownall HJ; Yang X; Wang H. 2006. Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res 99(6):598-606. [PubMed: 16931800]  [MGI Ref ID J:125063]

Lim HY; Rutkowski JM; Helft J; Reddy ST; Swartz MA; Randolph GJ; Angeli V. 2009. Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration. Am J Pathol 175(3):1328-37. [PubMed: 19679879]  [MGI Ref ID J:152800]

Liu C; Wang Q; Guo H; Xia M; Yuan Q; Hu Y; Zhu H; Hou M; Ma J; Tang Z; Ling W. 2008. Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr 138(2):311-5. [PubMed: 18203897]  [MGI Ref ID J:133409]

Liu P; Yu YR; Spencer JA; Johnson AE; Vallanat CT; Fong AM; Patterson C; Patel DD. 2008. CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. Arterioscler Thromb Vasc Biol 28(2):243-50. [PubMed: 18079406]  [MGI Ref ID J:147667]

Liuba P; Karnani P; Pesonen E; Paakkari I; Forslid A; Johansson L; Persson K; Wadstrom T; Laurini R. 2000. Endothelial dysfunction after repeated Chlamydia pneumoniae infection in apolipoprotein E-knockout mice. Circulation 102(9):1039-44. [PubMed: 10961970]  [MGI Ref ID J:103191]

Lizarbe TR; Tarin C; Gomez M; Lavin B; Aracil E; Orte LM; Zaragoza C. 2009. Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN. Am J Pathol :. [PubMed: 19779140]  [MGI Ref ID J:152751]

Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. [PubMed: 18160459]  [MGI Ref ID J:133453]

Lowbeer C; Forsberg AM; Tokuno S; Hemdahl AL; Gustafsson SA; Valen G. 2004. Cardiac troponin T content in heart and skeletal muscle and in blood samples from ApoE/LDL receptor double knockout mice. Clin Chim Acta 344(1-2):73-8. [PubMed: 15149873]  [MGI Ref ID J:105262]

Luchtefeld M; Schunkert H; Stoll M; Selle T; Lorier R; Grote K; Sagebiel C; Jagavelu K; Tietge UJ; Assmus U; Streetz K; Hengstenberg C; Fischer M; Mayer B; Maresso K; El Mokhtari NE; Schreiber S; Muller W; Bavendiek U; Grothusen C; Drexler H; Trautwein C; Broeckel U; Schieffer B. 2007. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J Exp Med 204(8):1935-44. [PubMed: 17664290]  [MGI Ref ID J:125950]

Ludewig B; Freigang S; Jaggi M; Kurrer MO; Pei YC; Vlk L; Odermatt B; Zinkernagel RM; Hengartner H. 2000. Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model Proc Natl Acad Sci U S A 97(23):12752-7. [PubMed: 11050173]  [MGI Ref ID J:65803]

Ludewig B; Jaggi M; Dumrese T; Brduscha-Riem K; Odermatt B; Hengartner H; Zinkernagel RM. 2001. Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses. J Immunol 166(5):3369-76. [PubMed: 11207293]  [MGI Ref ID J:126478]

Lund G; Andersson L; Lauria M; Lindholm M; Fraga MF; Villar-Garea A; Ballestar E; Esteller M; Zaina S. 2004. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem 279(28):29147-54. [PubMed: 15131116]  [MGI Ref ID J:91688]

Lutgens E; Faber B; Schapira K; Evelo CT; van Haaften R; Heeneman S; Cleutjens KB; Bijnens AP; Beckers L; Porter JG; Mackay CR; Rennert P; Bailly V; Jarpe M; Dolinski B; Koteliansky V; de Fougerolles T; Daemen MJ. 2005. Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. Circulation 111(25):3443-52. [PubMed: 15967845]  [MGI Ref ID J:114617]

Lutgens E; Gorelik L; Daemen MJ; de Muinck ED; Grewal IS; Koteliansky VE; Flavell RA. 1999. Requirement for CD154 in the progression of atherosclerosis. Nat Med 5(11):1313-6. [PubMed: 10546000]  [MGI Ref ID J:124002]

Lutgens E; Lutgens SP; Faber BC; Heeneman S; Gijbels MM; de Winther MP; Frederik P; van der Made I; Daugherty A; Sijbers AM; Fisher A; Long CJ; Saftig P; Black D; Daemen MJ; Cleutjens KB. 2006. Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 113(1):98-107. [PubMed: 16365196]  [MGI Ref ID J:121514]

Lutgens SP; Kisters N; Lutgens E; van Haaften RI; Evelo CT; de Winther MP; Saftig P; Daemen MJ; Heeneman S; Cleutjens KB. 2006. Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic. J Pathol 210(3):334-43. [PubMed: 16972305]  [MGI Ref ID J:115163]

Luttun A; Lupu F; Storkebaum E; Hoylaerts MF; Moons L; Crawley J; Bono F; Poole AR; Tipping P; Herbert JM; Collen D; Carmeliet P. 2002. Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 22(3):499-505. [PubMed: 11884297]  [MGI Ref ID J:102938]

Ma Y; Malbon CC; Williams DL; Thorngate FE. 2008. Altered gene expression in early atherosclerosis is blocked by low level apolipoprotein E. PLoS ONE 3(6):e2503. [PubMed: 18560564]  [MGI Ref ID J:137210]

Ma Z; Choudhury A; Kang SA; Monestier M; Cohen PL; Eisenberg RA. 2008. Accelerated atherosclerosis in ApoE deficient lupus mouse models. Clin Immunol 127(2):168-75. [PubMed: 18325838]  [MGI Ref ID J:133606]

Madan M; Amar S. 2008. Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS ONE 3(9):e3204. [PubMed: 18787704]  [MGI Ref ID J:143937]

Magoori K; Kang MJ; Ito MR; Kakuuchi H; Ioka RX; Kamataki A; Kim DH; Asaba H; Iwasaki S; Takei YA; Sasaki M; Usui S; Okazaki M; Takahashi S; Ono M; Nose M; Sakai J; Fujino T; Yamamoto TT. 2003. Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. J Biol Chem 278(13):11331-6. [PubMed: 12509421]  [MGI Ref ID J:82582]

Maguire JJ; Wiley KE; Kuc RE; Stoneman VE; Bennett MR; Davenport AP. 2006. Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin. Exp Biol Med (Maywood) 231(6):806-12. [PubMed: 16741003]  [MGI Ref ID J:135718]

Maitra U; Davis S; Reilly CM; Li L. 2009. Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol 182(9):5763-9. [PubMed: 19380824]  [MGI Ref ID J:147704]

Major AS; Dove DE; Ishiguro H; Su YR; Brown AM; Liu L; Carter KJ; Linton MF; Fazio S. 2001. Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice. Arterioscler Thromb Vasc Biol 21(11):1790-5. [PubMed: 11701467]  [MGI Ref ID J:107390]

Makowski L; Boord JB; Maeda K; Babaev VR; Uysal KT; Morgan MA; Parker RA; Suttles J; Fazio S; Hotamisligil GS; Linton MF. 2001. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 7(6):699-705. [PubMed: 11385507]  [MGI Ref ID J:69989]

Mallat Z; Gojova A; Marchiol-Fournigault C; Esposito B; Kamate C; Merval R; Fradelizi D; Tedgui A. 2001. Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 89(10):930-4. [PubMed: 11701621]  [MGI Ref ID J:115410]

Malloy SI; Altenburg MK; Knouff C; Lanningham-Foster L; Parks JS; Maeda N. 2004. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol 24(1):91-7. [PubMed: 12969990]  [MGI Ref ID J:146721]

Manelli AM; Bulfinch LC; Sullivan PM; LaDu MJ. 2007. Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. Neurobiol Aging 28(8):1139-47. [PubMed: 16837105]  [MGI Ref ID J:123898]

Manka D; Collins RG; Ley K; Beaudet AL; Sarembock IJ. 2001. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice. Circulation 103(7):1000-5. [PubMed: 11181476]  [MGI Ref ID J:103301]

Marneros AG; Keene DR; Hansen U; Fukai N; Moulton K; Goletz PL; Moiseyev G; Pawlyk BS; Halfter W; Dong S; Shibata M; Li T; Crouch RK; Bruckner P; Olsen BR. 2004. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J 23(1):89-99. [PubMed: 14685281]  [MGI Ref ID J:87454]

Martens GW; Arikan MC; Lee J; Ren F; Vallerskog T; Kornfeld H. 2008. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun 76(8):3464-72. [PubMed: 18505807]  [MGI Ref ID J:139394]

Martinez-Miguel P; Raoch V; Zaragoza C; Valdivielso JM; Rodriguez-Puyol M; Rodriguez-Puyol D; Lopez-Ongil S. 2009. Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins. J Lipid Res 50(3):364-75. [PubMed: 18997155]  [MGI Ref ID J:149087]

Massaro D; Massaro GD. 2008. Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function. Am J Physiol Lung Cell Mol Physiol 294(5):L991-7. [PubMed: 18344414]  [MGI Ref ID J:136630]

Massberg S; Brand K; Gruner S; Page S; Muller E; Muller I; Bergmeier W; Richter T; Lorenz M; Konrad I; Nieswandt B; Gawaz M. 2002. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med 196(7):887-96. [PubMed: 12370251]  [MGI Ref ID J:112015]

Massberg S; Gruner S; Konrad I; Garcia Arguinzonis MI; Eigenthaler M; Hemler K; Kersting J; Schulz C; Muller I; Besta F; Nieswandt B; Heinzmann U; Walter U; Gawaz M. 2004. Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice. Blood 103(1):136-42. [PubMed: 12933589]  [MGI Ref ID J:87218]

Massberg S; Schurzinger K; Lorenz M; Konrad I; Schulz C; Plesnila N; Kennerknecht E; Rudelius M; Sauer S; Braun S; Kremmer E; Emambokus NR; Frampton J; Gawaz M. 2005. Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. Circulation 112(8):1180-8. [PubMed: 16103235]  [MGI Ref ID J:116803]

Massy ZA; Ivanovski O; Nguyen-Khoa T; Angulo J; Szumilak D; Mothu N; Phan O; Daudon M; Lacour B; Drueke TB; Muntzel MS. 2005. Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice. J Am Soc Nephrol 16(1):109-16. [PubMed: 15563564]  [MGI Ref ID J:110084]

Mato M; Ookawara S; Mashiko T; Sakamoto A; Mato TK; Maeda N; Kodama T. 1999. Regional difference of lipid distribution in brain of apolipoprotein E deficient mice. Anat Rec 256(2):165-76. [PubMed: 10486514]  [MGI Ref ID J:57869]

Matsui Y; Rittling SR; Okamoto H; Inobe M; Jia N; Shimizu T; Akino M; Sugawara T; Morimoto J; Kimura C; Kon S; Denhardt D; Kitabatake A; Uede T. 2003. Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23(6):1029-34. [PubMed: 12730087]  [MGI Ref ID J:103051]

Matsumoto T; D'uscio LV; Eguchi D; Akiyama M; Smith LA; Katusic ZS. 2003. Protective effect of chronic vitamin C treatment on endothelial function of apolipoprotein E-deficient mouse carotid artery. J Pharmacol Exp Ther 306(1):103-8. [PubMed: 12660308]  [MGI Ref ID J:124738]

Matsushima Y; Hayashi S; Tachibana M. 1999. Spontaneously hyperlipidemic (SHL) mice: Japanese wild mice with apolipoprotein E deficiency. Mamm Genome 10(4):352-7. [PubMed: 10087291]  [MGI Ref ID J:54051]

Matter CM; Ma L; von Lukowicz T; Meier P; Lohmann C; Zhang D; Kilic U; Hofmann E; Ha SW; Hersberger M; Hermann DM; Luscher TF. 2006. Increased balloon-induced inflammation, proliferation, and neointima formation in apolipoprotein E (ApoE) knockout mice. Stroke 37(10):2625-32. [PubMed: 16946151]  [MGI Ref ID J:135932]

Matthews RT; Beal MF. 1996. Increased 3-nitrotyrosine in brains of Apo E-deficient mice. Brain Res 718(1-2):181-4. [PubMed: 8773783]  [MGI Ref ID J:33429]

Maugeais C; Tietge UJ; Tsukamoto K; Glick JM; Rader DJ. 2000. Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice. J Lipid Res 41(10):1673-9. [PubMed: 11013310]  [MGI Ref ID J:120029]

Mayr M; Zampetaki A; Sidibe A; Mayr U; Yin X; De Souza AI; Chung YL; Madhu B; Quax PH; Hu Y; Griffiths JR; Xu Q. 2008. Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Circ Res 102(9):1046-56. [PubMed: 18388323]  [MGI Ref ID J:149025]

McDaniel B; Sheng H; Warner DS; Hedlund LW; Benveniste H. 2001. Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. Neuroimage 14(6):1244-55. [PubMed: 11707081]  [MGI Ref ID J:103030]

McGillicuddy CJ; Carrier MJ; Weinberg PD. 2001. Distribution of lipid deposits around aortic branches of mice lacking LDL receptors and apolipoprotein E. Arterioscler Thromb Vasc Biol 21(7):1220-5. [PubMed: 11451755]  [MGI Ref ID J:103203]

Mencarelli A; Renga B; Distrutti E; Fiorucci S. 2009. Antiatherosclerotic effect of farnesoid X receptor. Am J Physiol Heart Circ Physiol 296(2):H272-81. [PubMed: 19028791]  [MGI Ref ID J:146332]

Mercer J; Figg N; Stoneman V; Braganza D; Bennett MR. 2005. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circ Res 96(6):667-74. [PubMed: 15746445]  [MGI Ref ID J:107632]

Merched AJ; Chan L. 2004. Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis. Circulation 110(25):3830-41. [PubMed: 15596565]  [MGI Ref ID J:112845]

Merhi-Soussi F; Kwak BR; Magne D; Chadjichristos C; Berti M; Pelli G; James RW; Mach F; Gabay C. 2005. Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice. Cardiovasc Res 66(3):583-93. [PubMed: 15914123]  [MGI Ref ID J:132570]

Merkel M; Velez-Carrasco W; Hudgins LC; Breslow JL. 2001. Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A 98(23):13294-9. [PubMed: 11606787]  [MGI Ref ID J:72580]

Mezdour H; Jones R; Dengremont C; Castro G; Maeda N. 1997. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 272(21):13570-5. [PubMed: 9153204]  [MGI Ref ID J:40434]

Miao J; Vitek MP; Xu F; Previti ML; Davis J; Van Nostrand WE. 2005. Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci 25(27):6271-7. [PubMed: 16000616]  [MGI Ref ID J:99430]

Michelsen KS; Wong MH; Shah PK; Zhang W; Yano J; Doherty TM; Akira S; Rajavashisth TB; Arditi M. 2004. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 101(29):10679-84. [PubMed: 15249654]  [MGI Ref ID J:91481]

Mihara K; Spansier M; Rooseboom M; Smit MJ; Dokter W. 2007. Functional replacement of murine CXCR2 by its human homologue in the development of atherosclerosis in LDLR knockout mice. Biol Pharm Bull 30(7):1231-6. [PubMed: 17603159]  [MGI Ref ID J:124372]

Mikael LG; Wang XL; Wu Q; Jiang H; Maclean KN; Rozen R. 2009. Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Mol Genet Metab 98(1-2):187-94. [PubMed: 19560954]  [MGI Ref ID J:152562]

Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283(10):6449-58. [PubMed: 18175806]  [MGI Ref ID J:133757]

Miriyala S; Gongora Nieto MC; Mingone C; Smith D; Dikalov S; Harrison DG; Jo H. 2006. Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation 113(24):2818-25. [PubMed: 16769910]  [MGI Ref ID J:122442]

Mishima T; Iwabuchi K; Fujii S; Tanaka SY; Ogura H; Watano-Miyata K; Ishimori N; Andoh Y; Nakai Y; Iwabuchi C; Ato M; Kitabatake A; Tsutsui H; Onoe K. 2008. Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice. Int J Mol Med 21(2):181-7. [PubMed: 18204784]  [MGI Ref ID J:149040]

Mitchell C; Mignon A; Guidotti JE; Besnard S; Fabre M; Duverger N; Parlier D; Tedgui A; Kahn A; Gilgenkrantz H. 2000. Therapeutic liver repopulation in a mouse model of hypercholesterolemia Hum Mol Genet 9(11):1597-602. [PubMed: 10861286]  [MGI Ref ID J:63199]

Miura Y; Chiba T; Tomita I; Koizumi H; Miura S; Umegaki K; Hara Y; Ikeda M; Tomita T. 2001. Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J Nutr 131(1):27-32. [PubMed: 11208934]  [MGI Ref ID J:66898]

Miyamoto T; Yumoto H; Takahashi Y; Davey M; Gibson FC rd; Genco CA. 2006. Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun 74(2):1376-80. [PubMed: 16428788]  [MGI Ref ID J:105066]

Moazed TC; Campbell LA; Rosenfeld ME; Grayston JT; Kuo CC. 1999. Chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. J Infect Dis 180(1):238-41. [PubMed: 10353889]  [MGI Ref ID J:120562]

Moghadasian MH; McManus BM; Nguyen LB; Shefer S; Nadji M; Godin DV; Green TJ; Hill J; Yang Y; Scudamore CH; Frohlich JJ. 2001. Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans. FASEB J 15(14):2623-30. [PubMed: 11726538]  [MGI Ref ID J:73202]

Moghadasian MH; Nguyen LB; Shefer S; McManus BM; Frohlich JJ. 1999. Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: effects of dietary cholesterol and phytosterols. Lab Invest 79(3):355-64. [PubMed: 10092072]  [MGI Ref ID J:120513]

Molenaar TJ; Twisk J; de Haas SA; Peterse N; Vogelaar BJ; van Leeuwen SH; Michon IN; van Berkel TJ; Kuiper J; Biessen EA. 2003. P-selectin as a candidate target in atherosclerosis. Biochem Pharmacol 66(5):859-66. [PubMed: 12948867]  [MGI Ref ID J:115693]

Montine TJ; Montine KS; Olson SJ; Graham DG; Roberts LJ 2nd; Morrow JD; Linton MF; Fazio S; Swift LL. 1999. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Exp Neurol 158(1):234-41. [PubMed: 10448437]  [MGI Ref ID J:56409]

Moore KJ; Kunjathoor VV; Koehn SL; Manning JJ; Tseng AA; Silver JM; McKee M; Freeman MW. 2005. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest 115(8):2192-201. [PubMed: 16075060]  [MGI Ref ID J:100226]

Moore ZW; Hui DY. 2005. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. J Lipid Res 46(10):2083-90. [PubMed: 16061951]  [MGI Ref ID J:104724]

Moos MP; John N; Grabner R; Nossmann S; Gunther B; Vollandt R; Funk CD; Kaiser B; Habenicht AJ. 2005. The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(11):2386-91. [PubMed: 16179593]  [MGI Ref ID J:116852]

Moriwaki H; Stempien-Otero A; Kremen M; Cozen AE; Dichek DA. 2004. Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice. Circ Res 95(6):637-44. [PubMed: 15297377]  [MGI Ref ID J:101486]

Mortimer BC; Beveridge DJ; Martins IJ; Redgrave TG. 1995. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. J Biol Chem 270(48):28767-76. [PubMed: 7499399]  [MGI Ref ID J:29909]

Nachtigal M; Ghaffar A; Mayer EP. 2008. Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient mice. Am J Pathol 172(1):247-55. [PubMed: 18156214]  [MGI Ref ID J:130923]

Nagarajan S; Burris RL; Stewart BW; Wilkerson JE; Badger TM. 2008. Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression. J Nutr 138(2):332-7. [PubMed: 18203900]  [MGI Ref ID J:133406]

Naiki Y; Sorrentino R; Wong MH; Michelsen KS; Shimada K; Chen S; Yilmaz A; Slepenkin A; Schroder NW; Crother TR; Bulut Y; Doherty TM; Bradley M; Shaposhnik Z; Peterson EM; Tontonoz P; Shah PK; Arditi M. 2008. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol 181(10):7176-85. [PubMed: 18981139]  [MGI Ref ID J:140936]

Nakai Y; Iwabuchi K; Fujii S; Ishimori N; Dashtsoodol N; Watano K; Mishima T; Iwabuchi C; Tanaka S; Bezbradica JS; Nakayama T; Taniguchi M; Miyake S; Yamamura T; Kitabatake A; Joyce S; Van Kaer L; Onoe K. 2004. Natural killer T cells accelerate atherogenesis in mice. Blood 104(7):2051-9. [PubMed: 15113755]  [MGI Ref ID J:93754]

Nakamuta M; Taniguchi S; Ishida BY; Kobayashi K; Chan L. 1998. Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: role of apoB mRNA editing in lipoprotein phenotype expression. Arterioscler Thromb Vasc Biol 18(5):747-55. [PubMed: 9598833]  [MGI Ref ID J:48202]

Nakata Y; Maeda N. 2002. Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic Acid. Circulation 105(12):1485-90. [PubMed: 11914259]  [MGI Ref ID J:103232]

Nashed B; Yeganeh B; HayGlass KT; Moghadasian MH. 2005. Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice. J Nutr 135(10):2438-44. [PubMed: 16177209]  [MGI Ref ID J:106647]

Nathan BP; Nisar R; Short J; Randall S; Grissom E; Griffin G; Switzer PV; Struble RG. 2005. Delayed olfactory nerve regeneration in ApoE-deficient mice. Brain Res 1041(1):87-94. [PubMed: 15804503]  [MGI Ref ID J:97427]

Nathan BP; Yost J; Litherland MT; Struble RG; Switzer PV. 2004. Olfactory function in apoE knockout mice. Behav Brain Res 150(1-2):1-7. [PubMed: 15033273]  [MGI Ref ID J:89344]

Naura AS; Hans CP; Zerfaoui M; Errami Y; Ju J; Kim H; Matrougui K; Kim JG; Boulares AH. 2009. High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors. Lab Invest 89(11):1243-51. [PubMed: 19752857]  [MGI Ref ID J:153736]

Ng DS; Maguire GF; Wylie J; Ravandi A; Xuan W; Ahmed Z; Eskandarian M; Kuksis A; Connelly PW. 2002. Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis. J Biol Chem 277(14):11715-20. [PubMed: 11809774]  [MGI Ref ID J:124830]

Nguyen AD; Itoh S; Jeney V; Yanagisawa H; Fujimoto M; Ushio-Fukai M; Fukai T. 2004. Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ Res 95(11):1067-74. [PubMed: 15528465]  [MGI Ref ID J:103848]

Nicoletti A; Kaveri S; Caligiuri G; Bariety J; Hansson GK. 1998. Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice. J Clin Invest 102(5):910-8. [PubMed: 9727059]  [MGI Ref ID J:49660]

Niebauer J; Maxwell AJ; Lin PS; Wang D; Tsao PS; Cooke JP. 2003. NOS inhibition accelerates atherogenesis: reversal by exercise. Am J Physiol Heart Circ Physiol 285(2):H535-40. [PubMed: 12598230]  [MGI Ref ID J:84828]

Nilsson LN; Arendash GW; Leighty RE; Costa DA; Low MA; Garcia MF; Cracciolo JR; Rojiani A; Wu X; Bales KR; Paul SM; Potter H. 2004. Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiol Aging 25(9):1153-67. [PubMed: 15312961]  [MGI Ref ID J:102326]

Nofer JR; Brodde M; Herminghaus G; Seedorf U; Assmann G; Kehrel BE. 2006. Normal platelet reactivity in apolipoprotein E (apo E)-deficient mouse. Platelets 17(7):498-500. [PubMed: 17074727]  [MGI Ref ID J:136476]

Nong Z; Gonzalez-Navarro H; Amar M; Freeman L; Knapper C; Neufeld EB; Paigen BJ; Hoyt RF; Fruchart-Najib J; Santamarina-Fojo S. 2003. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. J Clin Invest 112(3):367-78. [PubMed: 12897204]  [MGI Ref ID J:84922]

Nwosu I; Gairhe S; Struble RG; Nathan BP. 2008. Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulb. Neurosci Lett 441(3):282-5. [PubMed: 18621483]  [MGI Ref ID J:138855]

O'Brien KD; McDonald TO; Kunjathoor V; Eng K; Knopp EA; Lewis K; Lopez R; Kirk EA; Chait A; Wight TN; deBeer FC; LeBoeuf RC. 2005. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 25(4):785-90. [PubMed: 15692094]  [MGI Ref ID J:110024]

Ohashi M; Runge MS; Faraci FM; Heistad DD. 2006. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2331-6. [PubMed: 16873728]  [MGI Ref ID J:128050]

Ohkubo N; Lee YD; Morishima A; Terashima T; Kikkawa S; Tohyama M; Sakanaka M; Tanaka J; Maeda N; Vitek MP; Mitsuda N. 2003. Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. FASEB J 17(2):295-7. [PubMed: 12490540]  [MGI Ref ID J:110630]

Ohman MK; Shen Y; Obimba CI; Wright AP; Warnock M; Lawrence DA; Eitzman DT. 2008. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 117(6):798-805. [PubMed: 18212290]  [MGI Ref ID J:145083]

Ohsawa I; Nishimaki K; Murakami Y; Suzuki Y; Ishikawa M; Ohta S. 2008. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci 28(24):6239-49. [PubMed: 18550766]  [MGI Ref ID J:137374]

Ohsawa I; Nishimaki K; Yamagata K; Ishikawa M; Ohta S. 2008. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 377(4):1195-8. [PubMed: 18996093]  [MGI Ref ID J:143175]

Okamoto Y; Folco EJ; Minami M; Wara AK; Feinberg MW; Sukhova GK; Colvin RA; Kihara S; Funahashi T; Luster AD; Libby P. 2008. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res 102(2):218-25. [PubMed: 17991878]  [MGI Ref ID J:145595]

Okazaki H; Igarashi M; Nishi M; Sekiya M; Tajima M; Takase S; Takanashi M; Ohta K; Tamura Y; Okazaki S; Yahagi N; Ohashi K; Amemiya-Kudo M; Nakagawa Y; Nagai R; Kadowaki T; Osuga J; Ishibashi S. 2008. Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages. J Biol Chem 283(48):33357-64. [PubMed: 18782767]  [MGI Ref ID J:143389]

Olofsson PS; Soderstrom LA; Wagsater D; Sheikine Y; Ocaya P; Lang F; Rabu C; Chen L; Rudling M; Aukrust P; Hedin U; Paulsson-Berne G; Sirsjo A; Hansson GK. 2008. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117(10):1292-301. [PubMed: 18285570]  [MGI Ref ID J:148448]

Ong JM; Zorapapel NC; Aoki AM; Brown DJ; Nesburn AB; Rich KA; Kenney CM. 2003. Impaired electroretinogram (ERG) response in apolipoprotein E-deficient mice. Curr Eye Res 27(1):15-24. [PubMed: 12868005]  [MGI Ref ID J:84688]

Ong JM; Zorapapel NC; Rich KA; Wagstaff RE; Lambert RW; Rosenberg SE; Moghaddas F; Pirouzmanesh A; Aoki AM; Kenney MC. 2001. Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice. Invest Ophthalmol Vis Sci 42(8):1891-900. [PubMed: 11431458]  [MGI Ref ID J:70245]

Ophir G; Meilin S; Efrati M; Chapman J; Karussis D; Roses A; Michaelson DM. 2003. Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. Neurobiol Dis 12(1):56-64. [PubMed: 12609489]  [MGI Ref ID J:126223]

Osada N; Kosuge Y; Kihara T; Ishige K; Ito Y. 2009. Apolipoprotein E-deficient mice are more vulnerable to ER stress after transient forebrain ischemia. Neurochem Int 54(7):403-9. [PubMed: 19428781]  [MGI Ref ID J:150590]

Ostos MA; Recalde D; Zakin MM; Scott-Algara D. 2002. Implication of natural killer T cells in atherosclerosis development during a LPS-induced chronic inflammation. FEBS Lett 519(1-3):23-9. [PubMed: 12023012]  [MGI Ref ID J:109189]

Osuga J; Yagyu H; Ohashi K; Harada K; Yazaki Y; Yamada N; Ishibashi S. 1997. Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1. Biochem Biophys Res Commun 236(2):375-8. [PubMed: 9240444]  [MGI Ref ID J:41982]

Oumouna-Benachour K; Hans CP; Suzuki Y; Naura A; Datta R; Belmadani S; Fallon K; Woods C; Boulares AH. 2007. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation 115(18):2442-50. [PubMed: 17438151]  [MGI Ref ID J:137119]

Ovchinnikova O; Robertson AK; Wagsater D; Folco EJ; Hyry M; Myllyharju J; Eriksson P; Libby P; Hansson GK. 2009. T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice. Am J Pathol 174(2):693-700. [PubMed: 19131590]  [MGI Ref ID J:144195]

Owiny JR; Strandberg JD. 2000. Cholesterol granulomas in mice deficient in apolipoprotein E Contemp Topics 39(6):57-58.  [MGI Ref ID J:66450]

Ozaki M; Kawashima S; Yamashita T; Hirase T; Namiki M; Inoue N; Hirata K; Yasui H; Sakurai H; Yoshida Y; Masada M; Yokoyama M. 2002. Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest 110(3):331-40. [PubMed: 12163452]  [MGI Ref ID J:118410]

Paszty C; Maeda N; Verstuyft J; Rubin EM. 1994. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest 94(2):899-903. [PubMed: 8040345]  [MGI Ref ID J:111180]

Patel S; Thelander EM; Hernandez M; Montenegro J; Hassing H; Burton C; Mundt S; Hermanowski-Vosatka A; Wright SD; Chao YS; Detmers PA. 2001. ApoE(-/-) mice develop atherosclerosis in the absence of complement component C5. Biochem Biophys Res Commun 286(1):164-70. [PubMed: 11485323]  [MGI Ref ID J:71193]

Patrick CB; Krzywkowski P; Ramassamy C; Poirier J; Rapoport SI; Murphy EJ. 2000. Phospholipase A2 activity is decreased selectively in the hippocampus of aged apolipoprotein E deficient mice. Neurosci Lett 288(3):211-4. [PubMed: 10889345]  [MGI Ref ID J:108022]

Paul A; Chang BH; Li L; Yechoor VK; Chan L. 2008. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res 102(12):1492-501. [PubMed: 18483409]  [MGI Ref ID J:151382]

Paul A; Ko KW; Li L; Yechoor V; McCrory MA; Szalai AJ; Chan L. 2004. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 109(5):647-55. [PubMed: 14744975]  [MGI Ref ID J:127913]

Paulsson G; Zhou X; Tornquist E; Hansson GK. 2000. Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(1):10-7. [PubMed: 10634795]  [MGI Ref ID J:60057]

Peluzio MC; Miguel E Jr; Drumond TC; Cesar GC; Santiago HC; Teixeira MM; Vieira EC; Arantes RM; Alvarez-Leite JI. 2003. Monocyte chemoattractant protein-1 involvement in the alpha-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice. Br J Nutr 90(1):3-11. [PubMed: 12844369]  [MGI Ref ID J:106130]

Perrella MA; Pellacani A; Layne MD; Patel A; Zhao D; Schreiber BM; Storch J; Feinberg MW; Hsieh CM; Haber E; Lee ME. 2001. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15(10):1774-6. [PubMed: 11481226]  [MGI Ref ID J:70693]

Persson L; Boren J; Nicoletti A; Hansson GK; Pekna M. 2005. Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement system. Clin Exp Immunol 142(3):441-5. [PubMed: 16297155]  [MGI Ref ID J:107602]

Persson L; Boren J; Robertson AK; Wallenius V; Hansson GK; Pekna M. 2004. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 24(6):1062-7. [PubMed: 15059809]  [MGI Ref ID J:102339]

Petit-Turcotte C; Aumont N; Blain JF; Poirier J. 2007. Apolipoprotein E receptors and amyloid expression are modulated in an apolipoprotein E-dependent fashion in response to hippocampal deafferentation in rodent. Neuroscience 150(1):58-63. [PubMed: 17935896]  [MGI Ref ID J:130789]

Petrovan RJ; Yuan Y; Curtiss LK. 2008. Expression of the Lystbeige mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice. J Lipid Res 49(2):429-37. [PubMed: 17982137]  [MGI Ref ID J:131876]

Pfankuch T; Rizk A; Olsen R; Poage C; Raber J. 2005. Role of circulating androgen levels in effects of apoE4 on cognitive function. Brain Res 1053(1-2):88-96. [PubMed: 16054121]  [MGI Ref ID J:100285]

Piedrahita JA; Zhang SH; Hagaman JR; Oliver PM; Maeda N. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A 89(10):4471-5. [PubMed: 1584779]  [MGI Ref ID J:1050]

Podrez EA; Byzova TV; Febbraio M; Salomon RG; Ma Y; Valiyaveettil M; Poliakov E; Sun M; Finton PJ; Curtis BR; Chen J; Zhang R; Silverstein RL; Hazen SL. 2007. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 13(9):1086-95. [PubMed: 17721545]  [MGI Ref ID J:125153]

Poeckel D; Zemski Berry KA; Murphy RC; Funk CD. 2009. Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in apoe knock-out mice. J Biol Chem 284(31):21077-89. [PubMed: 19509298]  [MGI Ref ID J:153174]

Pola R; Gaetani E; Flex A; Aprahamian T; Proia AS; Bosch-Marce M; Smith RC; Pola P. 2003. Peripheral nerve ischemia: apolipoprotein E deficiency results in impaired functional recovery and reduction of associated intraneural angiogenic response. Exp Neurol 184(1):264-73. [PubMed: 14637097]  [MGI Ref ID J:118461]

Ponnuswamy P; Ostermeier E; Schrottle A; Chen J; Huang PL; Ertl G; Nieswandt B; Kuhlencordt PJ. 2009. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174(6):2400-10. [PubMed: 19465644]  [MGI Ref ID J:148912]

Popko B; Goodrum JF; Bouldin TW; Zhang SH; Maeda N. 1993. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J Neurochem 60(3):1155-8. [PubMed: 8436967]  [MGI Ref ID J:115371]

Pratico D; Cyrus T; Li H; FitzGerald GA. 2000. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis Blood 96(12):3823-6. [PubMed: 11090066]  [MGI Ref ID J:66258]

Pratico D; Rokach J; Tangirala RK. 1999. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. J Neurochem 73(2):736-41. [PubMed: 10428071]  [MGI Ref ID J:111985]

Proctor BM; Ren J; Chen Z; Schneider JG; Coleman T; Lupu TS; Semenkovich CF; Muslin AJ. 2007. Grb2 is required for atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol 27(6):1361-7. [PubMed: 17363695]  [MGI Ref ID J:134913]

Puolivali J; Pradier L; Riekkinen P Jr. 2000. Impaired recovery of noradrenaline levels in apolipoprotein E-deficient mice after N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine lesion Neuroscience 95(2):353-8. [PubMed: 10658614]  [MGI Ref ID J:60513]

Qiao JH; Tripathi J; Mishra NK; Cai Y; Tripathi S; Wang XP; Imes S ; Fishbein MC ; Clinton SK ; Libby P ; Lusis AJ ; Rajavashisth TB. 1997. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 150(5):1687-99. [PubMed: 9137093]  [MGI Ref ID J:40136]

Qiao X; Cummins DJ; Paul SM. 2001. Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse. Eur J Neurosci 14(3):474-82. [PubMed: 11553297]  [MGI Ref ID J:128174]

Qin Z; Itoh S; Jeney V; Ushio-Fukai M; Fukai T. 2006. Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress. FASEB J 20(2):334-6. [PubMed: 16371425]  [MGI Ref ID J:105736]

Qureshi AA; Salser WA; Parmar R; Emeson EE. 2001. Novel tocotrienols of rice bran inhibit atherosclerotic lesions in C57BL/6 ApoE-deficient mice. J Nutr 131(10):2606-18. [PubMed: 11584079]  [MGI Ref ID J:72067]

Raber J; Akana SF; Bhatnagar S; Dallman MF; Wong D; Mucke L. 2000. Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations. J Neurosci 20(5):2064-71. [PubMed: 10684907]  [MGI Ref ID J:60585]

Raber J; Bongers G; LeFevour A; Buttini M; Mucke L. 2002. Androgens protect against apolipoprotein E4-induced cognitive deficits. J Neurosci 22(12):5204-9. [PubMed: 12077215]  [MGI Ref ID J:109059]

Raber J; Wong D; Buttini M; Orth M; Bellosta S; Pitas RE; Mahley RW; Mucke L. 1998. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A 95(18):10914-9. [PubMed: 9724804]  [MGI Ref ID J:100975]

Raber J; Wong D; Yu GQ; Buttini M; Mahley RW; Pitas RE; Mucke L. 2000. Apolipoprotein E and cognitive performance. Nature 404(6776):352-4. [PubMed: 10746713]  [MGI Ref ID J:129695]

Rahaman SO; Lennon DJ; Febbraio M; Podrez EA; Hazen SL; Silverstein RL. 2006. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab 4(3):211-21. [PubMed: 16950138]  [MGI Ref ID J:129743]

Rahman A; Akterin S; Flores-Morales A; Crisby M; Kivipelto M; Schultzberg M; Cedazo-Minguez A. 2005. High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice. FEBS Lett 579(28):6411-6. [PubMed: 16288750]  [MGI Ref ID J:103774]

Rahman SM; Van Dam AM; Schultzberg M; Crisby M. 2005. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. J Neuroimmunol 169(1-2):59-67. [PubMed: 16198427]  [MGI Ref ID J:106397]

Raj T; Kanellakis P; Pomilio G; Jennings G; Bobik A; Agrotis A. 2006. Inhibition of fibroblast growth factor receptor signaling attenuates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(8):1845-51. [PubMed: 16709940]  [MGI Ref ID J:127978]

Ramassamy C; Averill D; Beffert U; Theroux L; Lussier-Cacan S; Cohn JS; Christen Y; Schoofs A; Davignon J; Poirier J. 2000. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain. Neurobiol Dis 7(1):23-37. [PubMed: 10671320]  [MGI Ref ID J:60765]

Ramassamy C; Krzywkowski P; Averill D; Lussier-Cacan S; Theroux L; Christen Y; Davignon J; Poirier J. 2001. Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain. Brain Res Mol Brain Res 86(1-2):76-83. [PubMed: 11165374]  [MGI Ref ID J:67204]

Ramos CL; Huo Y; Jung U; Ghosh S; Manka DR; Sarembock IJ; Ley K. 1999. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 84(11):1237-44. [PubMed: 10364560]  [MGI Ref ID J:55953]

Rattazzi M; Bennett BJ; Bea F; Kirk EA; Ricks JL; Speer M; Schwartz SM; Giachelli CM; Rosenfeld ME. 2005. Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Arterioscler Thromb Vasc Biol 25(7):1420-5. [PubMed: 15845913]  [MGI Ref ID J:114224]

Rayner K; Chen YX; McNulty M; Simard T; Zhao X; Wells DJ; de Belleroche J; O'Brien ER. 2008. Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A. Circ Res 103(2):133-41. [PubMed: 18566345]  [MGI Ref ID J:151372]

Reardon CA; Blachowicz L; White T; Cabana V; Wang Y; Lukens J; Bluestone J; Getz GS. 2001. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21(6):1011-6. [PubMed: 11397712]  [MGI Ref ID J:103188]

Reardon CA; Miller ER; Blachowicz L; Lukens J; Binder CJ; Witztum JL; Getz GS. 2004. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. J Lipid Res 45(7):1347-54. [PubMed: 15102879]  [MGI Ref ID J:90652]

Reddick RL; Zhang SH; Maeda N. 1994. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression [published erratum appears in Arterioscler Thromb 1994 May;14(5):839] Arterioscler Thromb 14(1):141-7. [PubMed: 8274470]  [MGI Ref ID J:28538]

Reddy ST; Nguyen JT; Grijalva V; Hough G; Hama S; Navab M; Fogelman AM. 2004. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Arterioscler Thromb Vasc Biol 24(9):1676-81. [PubMed: 15242861]  [MGI Ref ID J:102220]

Reeve JL; Stenson-Cox C; O'Doherty A; Porn-Ares I; Ares M; O'Brien T; Samali A. 2007. OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas. Biochem Biophys Res Commun 356(3):681-6. [PubMed: 17374365]  [MGI Ref ID J:121476]

Reich EE; Montine KS; Gross MD; Roberts LJ nd; Swift LL; Morrow JD; Montine TJ. 2001. Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. J Neurosci 21(16):5993-9. [PubMed: 11487622]  [MGI Ref ID J:123803]

Reifenberg K; Lehr HA; Baskal D; Wiese E; Schaefer SC; Black S; Samols D; Torzewski M; Lackner KJ; Husmann M; Blettner M; Bhakdi S. 2005. Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer? Arterioscler Thromb Vasc Biol 25(8):1641-6. [PubMed: 15920030]  [MGI Ref ID J:114340]

Reis ED; Roque M; Dansky H; Fallon JT; Badimon JJ; Cordon-Cardo C; Shiff SJ; Fisher EA. 2000. Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice Proc Natl Acad Sci U S A 97(23):12764-9. [PubMed: 11027305]  [MGI Ref ID J:65802]

Rekhter M; Staschke K; Estridge T; Rutherford P; Jackson N; Gifford-Moore D; Foxworthy P; Reidy C; Huang XD; Kalbfleisch M; Hui K; Kuo MS; Gilmour R; Vlahos CJ. 2008. Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation. Biochem Biophys Res Commun 367(3):642-8. [PubMed: 18190779]  [MGI Ref ID J:131296]

Rizk-Jackson A; Robertson J; Raber J. 2008. Tfm-AR modulates the effects of ApoE4 on cognition. J Neurochem 105(1):63-7. [PubMed: 18039320]  [MGI Ref ID J:135450]

Robertson AK; Rudling M; Zhou X; Gorelik L; Flavell RA; Hansson GK. 2003. Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. J Clin Invest 112(9):1342-50. [PubMed: 14568988]  [MGI Ref ID J:86532]

Robertson J; Curley J; Kaye J; Quinn J; Pfankuch T; Raber J. 2005. apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice. Neurobiol Aging 26(5):637-43. [PubMed: 15708438]  [MGI Ref ID J:101973]

Robertson TA; Dutton NS; Martins RN; Taddei K; Papadimitriou JM. 2000. Comparison of astrocytic and myocytic metabolic dysregulation in apolipoprotein E deficient and human apolipoprotein E transgenic mice. Neuroscience 98(2):353-9. [PubMed: 10854768]  [MGI Ref ID J:119594]

Rocha VZ; Folco EJ; Sukhova G; Shimizu K; Gotsman I; Vernon AH; Libby P. 2008. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 103(5):467-76. [PubMed: 18658050]  [MGI Ref ID J:152646]

Roselaar SE; Kakkanathu PX; Daugherty A. 1996. Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice. Decreasing density with disease progression. Arterioscler Thromb Vasc Biol 16(8):1013-8. [PubMed: 8696940]  [MGI Ref ID J:111962]

Rosenfeld ME; Polinsky P; Virmani R; Kauser K; Rubanyi G; Schwartz SM. 2000. Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse. Arterioscler Thromb Vasc Biol 20(12):2587-92. [PubMed: 11116057]  [MGI Ref ID J:102940]

Rossignol P; Luttun A; Martin-Ventura JL; Lupu F; Carmeliet P; Collen D; Angles-Cano E; Lijnen HR. 2006. Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques. J Thromb Haemost 4(3):664-70. [PubMed: 16460449]  [MGI Ref ID J:135792]

Rouis M; Adamy C; Duverger N; Lesnik P; Horellou P; Moreau M; Emmanuel F; Caillaud JM; Laplaud PM; Dachet C; Chapman MJ. 1999. Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice. Circulation 100(5):533-40. [PubMed: 10430768]  [MGI Ref ID J:57414]

Rozenberg O; Rosenblat M; Coleman R; Shih DM; Aviram M. 2003. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Radic Biol Med 34(6):774-84. [PubMed: 12633754]  [MGI Ref ID J:82696]

Rozenberg O; Shiner M; Aviram M; Hayek T. 2008. Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties. Free Radic Biol Med 44(11):1951-9. [PubMed: 18358245]  [MGI Ref ID J:136069]

Ruby MA; Nomura DK; Hudak CS; Mangravite LM; Chiu S; Casida JE; Krauss RM. 2008. Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proc Natl Acad Sci U S A 105(38):14561-6. [PubMed: 18794527]  [MGI Ref ID J:142587]

Saederup N; Chan L; Lira SA; Charo IF. 2008. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation 117(13):1642-8. [PubMed: 18165355]  [MGI Ref ID J:153310]

Sales VL; Sukhova GK; Lopez-Ilasaca MA; Libby P; Dzau VJ; Pratt RE. 2005. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 112(21):3328-36. [PubMed: 16286588]  [MGI Ref ID J:116912]

Samyn H; Moerland M; van Gent T; van Haperen R; van Tol A; de Crom R. 2009. Reduction of HDL levels lowers plasma PLTP and affects its distribution among lipoproteins in mice. Biochim Biophys Acta 1791(8):790-6. [PubMed: 19422933]  [MGI Ref ID J:153479]

Satoh K; Nigro P; Matoba T; O'Dell MR; Cui Z; Shi X; Mohan A; Yan C; Abe J; Illig KA; Berk BC. 2009. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 15(6):649-56. [PubMed: 19430489]  [MGI Ref ID J:151171]

Schapira K; Lutgens E; de Fougerolles A; Sprague A; Roemen A; Gardner H; Koteliansky V; Daemen M; Heeneman S. 2005. Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice. Arterioscler Thromb Vasc Biol 25(9):1917-24. [PubMed: 15976328]  [MGI Ref ID J:114326]

Schieffer B; Selle T; Hilfiker A; Hilfiker-Kleiner D; Grote K; Tietge UJ; Trautwein C; Luchtefeld M; Schmittkamp C; Heeneman S; Daemen MJ; Drexler H. 2004. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation 110(22):3493-500. [PubMed: 15557373]  [MGI Ref ID J:103918]

Schilling AF; Schinke T; Munch C; Gebauer M; Niemeier A; Priemel M; Streichert T; Rueger JM; Amling M. 2005. Increased bone formation in mice lacking apolipoprotein E. J Bone Miner Res 20(2):274-82. [PubMed: 15647822]  [MGI Ref ID J:111209]

Schneider DJ; Hayes M; Wadsworth M; Taatjes H; Rincon M; Taatjes DJ; Sobel BE. 2004. Attenuation of neointimal vascular smooth muscle cellularity in atheroma by plasminogen activator inhibitor type 1 (PAI-1). J Histochem Cytochem 52(8):1091-9. [PubMed: 15258185]  [MGI Ref ID J:136411]

Schneider JG; Finck BN; Ren J; Standley KN; Takagi M; Maclean KH; Bernal-Mizrachi C; Muslin AJ; Kastan MB; Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 4(5):377-89. [PubMed: 17084711]  [MGI Ref ID J:129761]

Schober A; Zernecke A; Liehn EA; von Hundelshausen P; Knarren S; Kuziel WA; Weber C. 2004. Crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets. Circ Res 95(11):1125-33. [PubMed: 15528472]  [MGI Ref ID J:103847]

Schober JM; Chen N; Grzeszkiewicz TM; Jovanovic I; Emeson EE; Ugarova TP; Ye RD; Lau LF; Lam SC. 2002. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 99(12):4457-65. [PubMed: 12036876]  [MGI Ref ID J:77053]

Schreyer SA; Vick C; Lystig TC; Mystkowski P; LeBoeuf RC. 2002. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab 282(1):E207-14. [PubMed: 11739102]  [MGI Ref ID J:75609]

Schroder K; Vecchione C; Jung O; Schreiber JG; Shiri-Sverdlov R; van Gorp PJ; Busse R; Brandes RP. 2006. Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet. Free Radic Biol Med 41(9):1353-60. [PubMed: 17023262]  [MGI Ref ID J:114514]

Schulte S; Sukhova GK; Libby P. 2008. Genetically programmed biases in Th1 and th2 immune responses modulate atherogenesis. Am J Pathol 172(6):1500-8. [PubMed: 18467709]  [MGI Ref ID J:136186]

Schwedler SB; Amann K; Wernicke K; Krebs A; Nauck M; Wanner C; Potempa LA; Galle J. 2005. Native C-reactive protein increases whereas modified C-reactive protein reduces atherosclerosis in apolipoprotein E-knockout mice. Circulation 112(7):1016-23. [PubMed: 16087790]  [MGI Ref ID J:116864]

Secchiero P; Candido R; Corallini F; Zacchigna S; Toffoli B; Rimondi E; Fabris B; Giacca M; Zauli G. 2006. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation 114(14):1522-30. [PubMed: 17000905]  [MGI Ref ID J:126407]

Secchiero P; Corallini F; Pandolfi A; Consoli A; Candido R; Fabris B; Celeghini C; Capitani S; Zauli G. 2006. An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction. Am J Pathol 169(6):2236-44. [PubMed: 17148684]  [MGI Ref ID J:116226]

Seitz A; Gourevitch D; Zhang XM; Clark L; Chen P; Kragol M; Levenkova N; Rux J; Samulewicz S; Heber-Katz E. 2005. Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts. Hum Mol Genet 14(18):2661-70. [PubMed: 16091415]  [MGI Ref ID J:103504]

Sekiya M; Osuga J; Nagashima S; Ohshiro T; Igarashi M; Okazaki H; Takahashi M; Tazoe F; Wada T; Ohta K; Takanashi M; Kumagai M; Nishi M; Takase S; Yahagi N; Yagyu H; Ohashi K; Nagai R; Kadowaki T; Furukawa Y; Ishibashi S. 2009. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab 10(3):219-28. [PubMed: 19723498]  [MGI Ref ID J:152385]

Sentman ML; Brannstrom T; Westerlund S; Laukkanen MO; Yla-Herttuala S; Basu S; Marklund SL. 2001. Extracellular superoxide dismutase deficiency and atherosclerosis in mice. Arterioscler Thromb Vasc Biol 21(9):1477-82. [PubMed: 11557675]  [MGI Ref ID J:103233]

Shamshiev AT; Ampenberger F; Ernst B; Rohrer L; Marsland BJ; Kopf M. 2007. Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity. J Exp Med 204(2):441-52. [PubMed: 17296788]  [MGI Ref ID J:125366]

Shea TB; Rogers E; Ashline D; Ortiz D; Sheu MS. 2002. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic Biol Med 33(8):1115-20. [PubMed: 12374623]  [MGI Ref ID J:118781]

Shi W; Pei H; Fischer JJ; James JC; Angle JF; Matsumoto AH; Helm GA; Sarembock IJ. 2004. Neointimal formation in two apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility. J Lipid Res 45(11):2008-14. [PubMed: 15314103]  [MGI Ref ID J:94175]

Shi W; Wang X; Wong J; Hedrick CC; Wong H; Castellani LW; Lusis AJ. 2004. Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice. Biochem Biophys Res Commun 317(1):223-9. [PubMed: 15047172]  [MGI Ref ID J:88891]

Shih DM; Xia YR; Wang XP; Miller E; Castellani LW; Subbanagounder G; Cheroutre H; Faull KF; Berliner JA; Witztum JL; Lusis AJ. 2000. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem 275(23):17527-35. [PubMed: 10748217]  [MGI Ref ID J:62750]

Shih DM; Xia YR; Wang XP; Wang SS; Bourquard N; Fogelman AM; Lusis AJ; Reddy ST. 2007. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res 100(8):1200-7. [PubMed: 17379834]  [MGI Ref ID J:135375]

Shinohara M; Yamashita T; Tawa H; Takeda M; Sasaki N; Takaya T; Toh R; Takeuchi A; Ohigashi T; Shinohara K; Kawashima S; Yokoyama M; Hirata K; Momose A. 2008. Atherosclerotic plaque imaging using phase-contrast X-ray computed tomography. Am J Physiol Heart Circ Physiol 294(2):H1094-100. [PubMed: 18083896]  [MGI Ref ID J:132318]

Singaraja RR; Fievet C; Castro G; James ER; Hennuyer N; Clee SM; Bissada N; Choy JC; Fruchart JC; McManus BM; Staels B; Hayden MR. 2002. Increased ABCA1 activity protects against atherosclerosis. J Clin Invest 110(1):35-42. [PubMed: 12093886]  [MGI Ref ID J:77473]

Sjoland H; Eitzman DT; Gordon D; Westrick R; Nabel EG; Ginsburg D. 2000. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 20(3):846-52. [PubMed: 10712412]  [MGI Ref ID J:61287]

Smith R; Petersen A; Bates GP; Brundin P; Li JY. 2005. Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction. Neurobiol Dis 20(3):673-84. [PubMed: 15967669]  [MGI Ref ID J:104634]

Smook ML; van Leeuwen M; Heeringa P; Damoiseaux JG; Theunissen R; Daemen MJ; Lutgens E; Cohen Tervaert JW. 2008. Anti-oxLDL antibody isotype levels, as potential markers for progressive atherosclerosis in APOE and APOECD40L mice. Clin Exp Immunol 154(2):264-9. [PubMed: 18778362]  [MGI Ref ID J:142416]

Sobel BE; Schneider DJ; Lee YH; Pratley RE. 2006. Insulin resistance increases PAI-1 in the heart. Biochem Biophys Res Commun 346(1):102-7. [PubMed: 16750510]  [MGI Ref ID J:110785]

Solca C; Pandit B; Yu H; Tint GS; Patel SB. 2007. Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. Mol Genet Metab 91(1):7-14. [PubMed: 17197219]  [MGI Ref ID J:121454]

Sommerville LJ; Kelemen SE; Autieri MV. 2008. Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice. Arterioscler Thromb Vasc Biol 28(1):47-53. [PubMed: 17991871]  [MGI Ref ID J:147519]

Soro-Paavonen A; Watson AM; Li J; Paavonen K; Koitka A; Calkin AC; Barit D; Coughlan MT; Drew BG; Lancaster GI; Thomas M; Forbes JM; Nawroth PP; Bierhaus A; Cooper ME; Jandeleit-Dahm KA. 2008. Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes. Diabetes 57(9):2461-9. [PubMed: 18511846]  [MGI Ref ID J:141808]

Staprans I; Pan XM; Rapp JH; Grunfeld C; Feingold KR. 2000. Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(3):708-14. [PubMed: 10712395]  [MGI Ref ID J:103278]

Stevens HY; Melchior B; Bell KS; Yun S; Yeh JC; Frangos JA. 2008. PECAM-1 is a critical mediator of atherosclerosis. Dis Model Mech 1(2-3):175-81. [PubMed: 19048083]  [MGI Ref ID J:142083]

Stoneman V; Braganza D; Figg N; Mercer J; Lang R; Goddard M; Bennett M. 2007. Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ Res 100(6):884-93. [PubMed: 17322176]  [MGI Ref ID J:133717]

Strom A; Olin AI; Aspberg A; Hultgardh-Nilsson A. 2006. Fibulin-2 is present in murine vascular lesions and is important for smooth muscle cell migration. Cardiovasc Res 69(3):755-63. [PubMed: 16409997]  [MGI Ref ID J:105710]

Su YR; Dove DE; Major AS; Hasty AH; Boone B; Linton MF; Fazio S. 2005. Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation 111(18):2373-81. [PubMed: 15851589]  [MGI Ref ID J:111648]

Su Z; Li Y; James JC; Matsumoto AH; Helm GA; Lusis AJ; Shi W. 2006. Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Hum Mol Genet 15(10):1650-8. [PubMed: 16595606]  [MGI Ref ID J:108422]

Su Z; Li Y; James JC; McDuffie M; Matsumoto AH; Helm GA; Weber JL; Lusis AJ; Shi W. 2006. Quantitative Trait Locus Analysis of Atherosclerosis in an Intercross Between C57BL/6 and C3H Mice Carrying the Mutant Apolipoprotein E Gene. Genetics 172(3):1799-807. [PubMed: 16387874]  [MGI Ref ID J:106521]

Suarna C; Wu BJ; Choy K; Mori T; Croft K; Cynshi O; Stocker R. 2006. Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency. Free Radic Biol Med 41(5):722-30. [PubMed: 16895792]  [MGI Ref ID J:111987]

Subbarao K; Jala VR; Mathis S; Suttles J; Zacharias W; Ahamed J; Ali H; Tseng MT; Haribabu B. 2004. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol 24(2):369-75. [PubMed: 14656734]  [MGI Ref ID J:102012]

Sugita M; Sugita H; Kaneki M. 2007. Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 27(6):1390-5. [PubMed: 17363690]  [MGI Ref ID J:135085]

Sukhova GK; Wang B; Libby P; Pan JH; Zhang Y; Grubb A; Fang K; Chapman HA; Shi GP. 2005. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res 96(3):368-75. [PubMed: 15653570]  [MGI Ref ID J:106879]

Sullivan PM; Mace BE; Maeda N; Schmechel DE. 2004. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience 124(4):725-33. [PubMed: 15026113]  [MGI Ref ID J:89986]

Sun Y; Wu S; Bu G; Onifade MK; Patel SN; LaDu MJ; Fagan AM; Holtzman DM. 1998. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18(9):3261-72. [PubMed: 9547235]  [MGI Ref ID J:93487]

Sussan TE; Jun J; Thimmulappa R; Bedja D; Antero M; Gabrielson KL; Polotsky VY; Biswal S. 2008. Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE 3(11):e3791. [PubMed: 19023427]  [MGI Ref ID J:143903]

Suzuki H; Kurihara Y; Takeya M; Kamada N; Kataoka M; Jishage K ; Ueda O ; Sakaguchi H ; Higashi T ; Suzuki T ; Takashima Y ; Kawabe Y ; Cynshi O ; Wada Y ; Honda M ; Kurihara H ; Aburatani H ; Doi T ; Matsumoto A ; Azuma S ; Noda T ; Toyoda Y ; Itakura H; Yazaki Y ; Kodama T ; et al. 1997. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386(6622):292-6. [PubMed: 9069289]  [MGI Ref ID J:39079]

Swirski FK; Libby P; Aikawa E; Alcaide P; Luscinskas FW; Weissleder R; Pittet MJ. 2007. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest 117(1):195-205. [PubMed: 17200719]  [MGI Ref ID J:117447]

Tabibiazar R; Wagner RA; Spin JM; Ashley EA; Narasimhan B; Rubin EM; Efron B; Tsao PS; Tibshirani R; Quertermous T. 2005. Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. Arterioscler Thromb Vasc Biol 25(2):302-8. [PubMed: 15550693]  [MGI Ref ID J:109803]

Tacke F; Alvarez D; Kaplan TJ; Jakubzick C; Spanbroek R; Llodra J; Garin A; Liu J; Mack M; van Rooijen N; Lira SA; Habenicht AJ; Randolph GJ. 2007. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 117(1):185-94. [PubMed: 17200718]  [MGI Ref ID J:117437]

Takaoka N; Campbell LA; Lee A; Rosenfeld ME; Kuo CC. 2008. Chlamydia pneumoniae infection increases adherence of mouse macrophages to mouse endothelial cells in vitro and to aortas ex vivo. Infect Immun 76(2):510-4. [PubMed: 18070891]  [MGI Ref ID J:130335]

Taketa K; Matsumura T; Yano M; Ishii N; Senokuchi T; Motoshima H; Murata Y; Kim-Mitsuyama S; Kawada T; Itabe H; Takeya M; Nishikawa T; Tsuruzoe K; Araki E. 2008. Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages. J Biol Chem 283(15):9852-62. [PubMed: 18208815]  [MGI Ref ID J:135237]

Taleb S; Romain M; Ramkhelawon B; Uyttenhove C; Pasterkamp G; Herbin O; Esposito B; Perez N; Yasukawa H; Van Snick J; Yoshimura A; Tedgui A; Mallat Z. 2009. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med 206(10):2067-77. [PubMed: 19737863]  [MGI Ref ID J:153361]

Tam SP; Ancsin JB; Tan R; Kisilevsky R. 2005. Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice. J Lipid Res 46(10):2091-101. [PubMed: 16061946]  [MGI Ref ID J:104723]

Tamura Y; Osuga J; Adachi H; Tozawa R; Takanezawa Y; Ohashi K; Yahagi N; Sekiya M; Okazaki H; Tomita S; Iizuka Y; Koizumi H; Inaba T; Yagyu H; Kamada N; Suzuki H; Shimano H; Kadowaki T; Tsujimoto M; Arai H; Yamada N; Ishibashi S. 2004. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem 279(30):30938-44. [PubMed: 15145948]  [MGI Ref ID J:91911]

Tanaka R; Miwa Y; Mou K; Tomikawa M; Eguchi N; Urade Y; Takahashi-Yanaga F; Morimoto S; Wake N; Sasaguri T. 2009. Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice. Biochem Biophys Res Commun 378(4):851-6. [PubMed: 19070593]  [MGI Ref ID J:142908]

Tang M; Cyrus T; Yao Y; Vocun L; Pratico D. 2005. Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice. Circulation 112(18):2867-74. [PubMed: 16267259]  [MGI Ref ID J:116835]

Tangirala RK; Bischoff ED; Joseph SB; Wagner BL; Walczak R; Laffitte BA; Daige CL; Thomas D; Heyman RA; Mangelsdorf DJ; Wang X; Lusis AJ; Tontonoz P; Schulman IG. 2002. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A 99(18):11896-901. [PubMed: 12193651]  [MGI Ref ID J:125452]

Taniyama Y; Fuse H; Satomi T; Tozawa R; Yasuhara Y; Shimakawa K; Shibata S; Hattori M; Nakata M; Taketomi S. 2005. Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun 330(1):104-10. [PubMed: 15781238]  [MGI Ref ID J:97471]

Tchantchou F; Graves M; Shea TB. 2006. Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: modulation by apolipoprotein E-deficiency. Nutr Neurosci 9(1-2):17-24. [PubMed: 16910166]  [MGI Ref ID J:135845]

Tenger C; Zhou X. 2003. Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell. Immunology 109(3):392-7. [PubMed: 12807485]  [MGI Ref ID J:84130]

Tennert C; Teupser D; Mueller MA; Wilfert W; Renner-Muller I; Stein O; Stein Y; Sippel AE; Wolf E; Thiery J. 2007. Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice. Biochem Biophys Res Commun 361(3):574-9. [PubMed: 17669363]  [MGI Ref ID J:124271]

Terasawa Y; Ladha Z; Leonard SW; Morrow JD; Newland D; Sanan D; Packer L; Traber MG; Farese RV Jr. 2000. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E Proc Natl Acad Sci U S A 97(25):13830-4. [PubMed: 11095717]  [MGI Ref ID J:66419]

Teter B; Harris-White ME; Frautschy SA; Cole GM. 1999. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience 91(3):1009-16. [PubMed: 10391478]  [MGI Ref ID J:119607]

Teupser D; Pavlides S; Tan M; Gutierrez-Ramos JC; Kolbeck R; Breslow JL. 2004. Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A 101(51):17795-800. [PubMed: 15596719]  [MGI Ref ID J:95279]

Theilmeier G; De Geest B; Van Veldhoven PP; Stengel D; Michiels C; Lox M; Landeloos M; Chapman MJ; Ninio E; Collen D; Himpens B; Holvoet P. 2000. HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice. FASEB J 14(13):2032-9. [PubMed: 11023987]  [MGI Ref ID J:119589]

Thomas M; Gavrila D; McCormick ML; Miller FJ Jr; Daugherty A; Cassis LA; Dellsperger KC; Weintraub NL. 2006. Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation 114(5):404-13. [PubMed: 16864727]  [MGI Ref ID J:123854]

Thorngate FE; Rudel LL; Walzem RL; Williams DL. 2000. Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 20(8):1939-45. [PubMed: 10938015]  [MGI Ref ID J:130658]

Thorngate FE; Strockbine PA; Erickson SK; Williams DL. 2002. Altered adrenal gland cholesterol metabolism in the apoE-deficient mouse. J Lipid Res 43(11):1920-6. [PubMed: 12401891]  [MGI Ref ID J:123997]

Tian J; Pei H; James JC; Li Y; Matsumoto AH; Helm GA; Shi W. 2005. Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility. Biochem Biophys Res Commun 329(3):1102-7. [PubMed: 15752767]  [MGI Ref ID J:97395]

Tiebel O; Oka K; Robinson K; Sullivan M; Martinez J; Nakamuta M; Ishimura-Oka K; Chan L. 1999. Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation. Atherosclerosis 145(2):239-51. [PubMed: 10488949]  [MGI Ref ID J:59491]

Tilley RE; Pedersen B; Pawlinski R; Sato Y; Erlich JH; Shen Y; Day S; Huang Y; Eitzman DT; Boisvert WA; Curtiss LK; Fay WP; Mackman N. 2006. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler Thromb Vasc Biol 26(3):555-62. [PubMed: 16385085]  [MGI Ref ID J:127980]

Tirziu D; Moodie KL; Zhuang ZW; Singer K; Helisch A; Dunn JF; Li W; Singh J; Simons M. 2005. Delayed arteriogenesis in hypercholesterolemic mice. Circulation 112(16):2501-9. [PubMed: 16230502]  [MGI Ref ID J:116827]

Tokuno S; Hinokiyama K; Tokuno K; Lowbeer C; Hansson LO; Valen G. 2002. Spontaneous ischemic events in the brain and heart adapt the hearts of severely atherosclerotic mice to ischemia. Arterioscler Thromb Vasc Biol 22(6):995-1001. [PubMed: 12067910]  [MGI Ref ID J:102937]

Tomiyama-Hanayama M; Rakugi H; Kohara M; Mima T; Adachi Y; Ohishi M; Katsuya T; Hoshida Y; Aozasa K; Ogihara T; Nishimoto N. 2009. Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice. Am J Physiol Renal Physiol 297(3):F679-84. [PubMed: 19570877]  [MGI Ref ID J:152197]

Tordjman K; Bernal-Mizrachi C; Zemany L; Weng S; Feng C; Zhang F; Leone TC; Coleman T; Kelly DP; Semenkovich CF. 2001. PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J Clin Invest 107(8):1025-34. [PubMed: 11306606]  [MGI Ref ID J:68880]

Torzewski M; Ochsenhirt V; Kleschyov AL; Oelze M; Daiber A; Li H; Rossmann H; Tsimikas S; Reifenberg K; Cheng F; Lehr HA; Blankenberg S; Forstermann U; Munzel T; Lackner KJ. 2007. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 27(4):850-7. [PubMed: 17255533]  [MGI Ref ID J:135067]

Tous M; Ferre N; Rull A; Marsillach J; Coll B; Alonso-Villaverde C; Camps J; Joven J. 2006. Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient mice. Biochem Biophys Res Commun 340(4):1078-84. [PubMed: 16403442]  [MGI Ref ID J:105001]

Tous M; Ferre N; Vilella E; Riu F; Camps J; Joven J. 2004. Circulating blood cells modulate the atherosclerotic process in apolipoprotein E-deficient mice. Metabolism 53(1):95-100. [PubMed: 14681849]  [MGI Ref ID J:87089]

Tous M; Ribas V; Ferre N; Escola-Gil JC; Blanco-Vaca F; Alonso-Villaverde C; Coll B; Camps J; Joven J. 2005. Turpentine-induced inflammation reduces the hepatic expression of the multiple drug resistance gene, the plasma cholesterol concentration and the development of atherosclerosis in apolipoprotein E deficient mice. Biochim Biophys Acta 1733(2-3):192-8. [PubMed: 15863366]  [MGI Ref ID J:99060]

Toyama K; Wulff H; Chandy KG; Azam P; Raman G; Saito T; Fujiwara Y; Mattson DL; Das S; Melvin JE; Pratt PF; Hatoum OA; Gutterman DD; Harder DR; Miura H. 2008. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest 118(9):3025-37. [PubMed: 18688283]  [MGI Ref ID J:140971]

Trieu VN; Uckun FM. 2000. Apolipoprotein E and apolipoprotein D expression in a murine model of singlet oxygen-induced cerebral stroke. Biochem Biophys Res Commun 268(3):835-41. [PubMed: 10679292]  [MGI Ref ID J:60716]

Trigatti B; Rayburn H; Vinals M; Braun A; Miettinen H; Penman M; Hertz M; Schrenzel M; Amigo L; Rigotti A; Krieger M. 1999. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc Natl Acad Sci U S A 96(16):9322-7. [PubMed: 10430941]  [MGI Ref ID J:105226]

Tse J; Martin-McNaulty B; Halks-Miller M; Kauser K; DelVecchio V; Vergona R; Sullivan ME; Rubanyi GM. 1999. Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiol. Atherosclerosis 144(2):303-13. [PubMed: 10407491]  [MGI Ref ID J:56238]

Tupin E; Nicoletti A; Elhage R; Rudling M; Ljunggren HG; Hansson GK; Berne GP. 2004. CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med 199(3):417-22. [PubMed: 14744994]  [MGI Ref ID J:90471]

Upmacis RK; Crabtree MJ; Deeb RS; Shen H; Lane PB; Benguigui LE; Maeda N; Hajjar DP; Gross SS. 2007. Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol 293(5):H2878-87. [PubMed: 17766468]  [MGI Ref ID J:132084]

Vaessen SF; Dallinga-Thie GM; Ross CJ; Splint LJ; Castellani LW; Rensen PC; Hayden MR; Schaap FG; Kuivenhoven JA. 2009. Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels. J Lipid Res 50(5):880-4. [PubMed: 19141870]  [MGI Ref ID J:149639]

VanderLaan PA; Reardon CA; Thisted RA; Getz GS. 2009. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. J Lipid Res 50(3):376-85. [PubMed: 18957695]  [MGI Ref ID J:149089]

Vatassery GT; Quach HT; Smith WE; Kuskowski M. 2008. Deletion of apolipoprotein E gene modifies the rate of depletion of alpha tocopherol (vitamin E) from mice brains. Biochim Biophys Acta 1782(6):414-20. [PubMed: 18395016]  [MGI Ref ID J:136773]

Vatassery GT; Quach HT; Smith WE; Santacruz KS; Roy S. 2007. Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles. Biochim Biophys Acta 1772(7):797-803. [PubMed: 17560088]  [MGI Ref ID J:124803]

Veillard NR; Steffens S; Pelli G; Lu B; Kwak BR; Gerard C; Charo IF; Mach F. 2005. Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo. Circulation 112(6):870-8. [PubMed: 16061736]  [MGI Ref ID J:116866]

Vendrov AE; Hakim ZS; Madamanchi NR; Rojas M; Madamanchi C; Runge MS. 2007. Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells. Arterioscler Thromb Vasc Biol 27(12):2714-21. [PubMed: 17823367]  [MGI Ref ID J:147527]

Veniant MM; Sullivan MA; Kim SK; Ambroziak P; Chu A; Wilson MD; Hellerstein MK; Rudel LL; Walzem RL; Young SG. 2000. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 J Clin Invest 106(12):1501-10. [PubMed: 11120757]  [MGI Ref ID J:66424]

Vidal J; Bruce Verchere C; Andrikopoulos S; Wang F; Hull RL; Cnop M; Olin KL; LeBoeuf RC; O'Brien KD; Chait A; Kahn SE. 2003. The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice. Diabetologia 46(1):71-9. [PubMed: 12637985]  [MGI Ref ID J:82403]

Vikramadithyan RK; Kako Y; Chen G; Hu Y; Arikawa-Hirasawa E; Yamada Y; Goldberg IJ. 2004. Atherosclerosis in perlecan heterozygous mice. J Lipid Res 45(10):1806-12. [PubMed: 15258195]  [MGI Ref ID J:93619]

Vitek MP; Brown CM; Colton CA. 2009. APOE genotype-specific differences in the innate immune response. Neurobiol Aging 30(9):1350-60. [PubMed: 18155324]  [MGI Ref ID J:152961]

Vliegen I; Duijvestijn A; Grauls G; Herngreen S; Bruggeman C; Stassen F. 2004. Cytomegalovirus infection aggravates atherogenesis in apoE knockout mice by both local and systemic immune activation. Microbes Infect 6(1):17-24. [PubMed: 14738889]  [MGI Ref ID J:105285]

Wahrle SE; Jiang H; Parsadanian M; Kim J; Li A; Knoten A; Jain S; Hirsch-Reinshagen V; Wellington CL; Bales KR; Paul SM; Holtzman DM. 2008. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest 118(2):671-82. [PubMed: 18202749]  [MGI Ref ID J:131400]

Walker LC; Parker CA; Lipinski WJ; Callahan MJ; Carroll RT; Gandy SE ; Smith JD ; Jucker M ; Bisgaier CL. 1997. Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol 151(5):1371-7. [PubMed: 9358763]  [MGI Ref ID J:43846]

Wang H; Jiang X; Yang F; Gaubatz JW; Ma L; Magera MJ; Yang X; Berger PB; Durante W; Pownall HJ; Schafer AI. 2003. Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood 101(10):3901-7. [PubMed: 12506016]  [MGI Ref ID J:83449]

Wang J; Xian X; Huang W; Chen L; Wu L; Zhu Y; Fan J; Ross C; Hayden MR; Liu G. 2007. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice. Arterioscler Thromb Vasc Biol 27(1):197-203. [PubMed: 17038632]  [MGI Ref ID J:134943]

Wang S; Yehya N; Schadt EE; Wang H; Drake TA; Lusis AJ. 2006. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet 2(2):e15. [PubMed: 16462940]  [MGI Ref ID J:115779]

Wang SS; Schadt EE; Wang H; Wang X; Ingram-Drake L; Shi W; Drake TA; Lusis AJ. 2007. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res 101(3):e11-30. [PubMed: 17641228]  [MGI Ref ID J:140288]

Wang WJ; Baez JM; Maurer R; Dansky HM; Cohen DE. 2006. Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice. J Lipid Res 47(11):2400-7. [PubMed: 16940277]  [MGI Ref ID J:147028]

Wang YX; Halks-Miller M; Vergona R; Sullivan ME; Fitch R; Mallari C; Martin-McNulty B; da Cunha V; Freay A; Rubanyi GM; Kauser K. 2000. Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 278(2):H428-34. [PubMed: 10666072]  [MGI Ref ID J:60364]

Wang Z; Liu B; Wang P; Dong X; Fernandez-Hernando C; Li Z; Hla T; Li Z; Claffey K; Smith JD; Wu D. 2008. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest 118(1):195-204. [PubMed: 18079968]  [MGI Ref ID J:130826]

Wassmann S; Czech T; van Eickels M; Fleming I; Bohm M; Nickenig G. 2004. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation 110(19):3062-7. [PubMed: 15277329]  [MGI Ref ID J:103721]

Wassmann S; Werner N; Czech T; Nickenig G. 2006. Improvement of endothelial function by systemic transfusion of vascular progenitor cells. Circ Res 99(8):e74-83. [PubMed: 16990568]  [MGI Ref ID J:126502]

Welch CL; Sun Y; Arey BJ; Lemaitre V; Sharma N; Ishibashi M; Sayers S; Li R; Gorelik A; Pleskac N; Collins-Fletcher K; Yasuda Y; Bromme D; D'Armiento JM; Ogletree ML; Tall AR. 2007. Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice. Circulation 116(21):2444-52. [PubMed: 17984379]  [MGI Ref ID J:142987]

Wen M; Segerer S; Dantas M; Brown PA; Hudkins KL; Goodpaster T; Kirk E; LeBoeuf RC; Alpers CE. 2002. Renal injury in apolipoprotein E-deficient mice. Lab Invest 82(8):999-1006. [PubMed: 12177238]  [MGI Ref ID J:125978]

Westerterp M; Berbee JF; Pires NM; van Mierlo GJ; Kleemann R; Romijn JA; Havekes LM; Rensen PC. 2007. Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. Circulation 116(19):2173-81. [PubMed: 17967778]  [MGI Ref ID J:142992]

Westrick RJ; Bodary PF; Xu Z; Shen YC; Broze GJ; Eitzman DT. 2001. Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice. Circulation 103(25):3044-6. [PubMed: 11425765]  [MGI Ref ID J:103352]

Whitman SC; Ravisankar P; Daugherty A. 2002. Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma. Circ Res 90(2):E34-8. [PubMed: 11834721]  [MGI Ref ID J:109710]

Willner EL; Tow B; Buhman KK; Wilson M; Sanan DA; Rudel LL; Farese RV Jr. 2003. Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 100(3):1262-7. [PubMed: 12538880]  [MGI Ref ID J:81836]

Wilson KM; McCaw RB; Leo L; Arning E; Lhotak S; Bottiglieri T; Austin RC; Lentz SR. 2007. Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 27(1):233-40. [PubMed: 17082485]  [MGI Ref ID J:147558]

Wilson PG; Thompson JC; Webb NR; de Beer FC; King VL; Tannock LR. 2008. Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner. Am J Pathol 173(6):1902-10. [PubMed: 18974302]  [MGI Ref ID J:143924]

Witting PK; Pettersson K; Ostlund-Lindqvist AM; Westerlund C; Eriksson AW; Stocker R. 1999. Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice. FASEB J 13(6):667-75. [PubMed: 10094927]  [MGI Ref ID J:54037]

Wolfsgruber W; Feil S; Brummer S; Kuppinger O; Hofmann F; Feil R. 2003. A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. Proc Natl Acad Sci U S A 100(23):13519-24. [PubMed: 14597716]  [MGI Ref ID J:128779]

Wong CW; Christen T; Roth I; Chadjichristos CE; Derouette JP; Foglia BF; Chanson M; Goodenough DA; Kwak BR. 2006. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med 12(8):950-4. [PubMed: 16862155]  [MGI Ref ID J:111966]

Woollett LA; Osono Y; Herz J; Dietschy JM. 1995. Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse. Proc Natl Acad Sci U S A 92(26):12500-4. [PubMed: 8618929]  [MGI Ref ID J:30297]

Wright SD; Burton C; Hernandez M; Hassing H; Montenegro J; Mundt S; Patel S; Card DJ; Hermanowski-Vosatka A; Bergstrom JD; Sparrow CP; Detmers PA; Chao YS. 2000. Infectious agents are not necessary for murine atherogenesis. J Exp Med 191(8):1437-42. [PubMed: 10770809]  [MGI Ref ID J:61722]

Wu BJ; Kathir K; Witting PK; Beck K; Choy K; Li C; Croft KD; Mori TA; Tanous D; Adams MR; Lau AK; Stocker R. 2006. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med 203(4):1117-27. [PubMed: 16606673]  [MGI Ref ID J:123780]

Wu D; Sharan C; Yang H; Goodwin JS; Zhou L; Grabowski GA; Du H; Guo Z. 2007. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res 48(12):2571-8. [PubMed: 17720994]  [MGI Ref ID J:129977]

Wu D; Yang H; Xiang W; Zhou L; Shi M; Julies G; Laplante JM; Ballard BR; Guo Z. 2005. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46(7):1380-7. [PubMed: 15863839]  [MGI Ref ID J:100500]

Wu JH; Goswami R; Cai X; Exum ST; Huang X; Zhang L; Brian L; Premont RT; Peppel K; Freedman NJ. 2006. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. J Biol Chem 281(49):37758-72. [PubMed: 17018529]  [MGI Ref ID J:117638]

Wuttge DM; Eriksson P; Sirsjo A; Hansson GK; Stemme S. 2001. Expression of interleukin-15 in mouse and human atherosclerotic lesions. Am J Pathol 159(2):417-23. [PubMed: 11485899]  [MGI Ref ID J:70860]

Xian X; Ding Y; Zhang L; Wang Y; McNutt MA; Ross C; Hayden MR; Deng X; Liu G. 2009. Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice. Biochem Biophys Res Commun 385(4):563-9. [PubMed: 19481534]  [MGI Ref ID J:151434]

Xiao N; Yin M; Zhang L; Qu X; Du H; Sun X; Mao L; Ren G; Zhang C; Geng Y; An L; Pan J. 2009. Tumor necrosis factor-alpha deficiency retards early fatty-streak lesion by influencing the expression of inflammatory factors in apoE-null mice. Mol Genet Metab 96(4):239-44. [PubMed: 19157944]  [MGI Ref ID J:146902]

Xie C; Burns DK; Turley SD; Dietschy JM. 2000. Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased. J Neuropathol Exp Neurol 59(12):1106-17. [PubMed: 11138930]  [MGI Ref ID J:104996]

Xu F; Ji J; Li L; Chen R; Hu WC. 2007. Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse. Biochem Biophys Res Commun 352(3):681-8. [PubMed: 17141183]  [MGI Ref ID J:116614]

Xu PT; Schmechel D; Rothrock-Christian T; Burkhart DS; Qiu HL; Popko B; Sullivan P; Maeda N; Saunders AM; Roses AD; Gilbert JR. 1996. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis 3(3):229-45. [PubMed: 8980023]  [MGI Ref ID J:109197]

Yagyu H; Ishibashi S; Chen Z; Osuga J; Okazaki M; Perrey S; Kitamine T; Shimada M; Ohashi K; Harada K; Shionoiri F; Yahagi N; Gotoda T; Yazaki Y; Yamada N. 1999. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 40(9):1677-85. [PubMed: 10484615]  [MGI Ref ID J:57257]

Yagyu H; Kitamine T; Osuga J; Tozawa R; Chen Z; Kaji Y; Oka T; Perrey S; Tamura Y; Ohashi K; Okazaki H; Yahagi N; Shionoiri F; Iizuka Y; Harada K; Shimano H; Yamashita H; Gotoda T; Yamada N; Ishibashi S. 2000. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem 275(28):21324-30. [PubMed: 10777503]  [MGI Ref ID J:63468]

Yamauchi T; Kamon J; Waki H; Imai Y; Shimozawa N; Hioki K; Uchida S; Ito Y; Takakuwa K; Matsui J; Takata M; Eto K; Terauchi Y; Komeda K; Tsunoda M; Murakami K; Ohnishi Y; Naitoh T; Yamamura K; Ueyama Y; Froguel P; Kimura S; Nagai R; Kadowaki T. 2003. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278(4):2461-8. [PubMed: 12431986]  [MGI Ref ID J:81727]

Yancey PG; Jerome WG; Yu H; Griffin EE; Cox BE; Babaev VR; Fazio S; Linton MF. 2007. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res 48(5):1140-9. [PubMed: 17299204]  [MGI Ref ID J:121848]

Yang H; Roberts LJ; Shi MJ; Zhou LC; Ballard BR; Richardson A; Guo ZM. 2004. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res 95(11):1075-81. [PubMed: 15528470]  [MGI Ref ID J:103561]

Yang J; Sato K; Aprahamian T; Brown NJ; Hutcheson J; Bialik A; Perlman H; Walsh K. 2004. Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24(8):1466-73. [PubMed: 15178561]  [MGI Ref ID J:102307]

Yao J; Petanceska SS; Montine TJ; Holtzman DM; Schmidt SD; Parker CA; Callahan MJ; Lipinski WJ; Bisgaier CL; Turner BA; Nixon RA; Martins RN; Ouimet C; Smith JD; Davies P; Laska E; Ehrlich ME; Walker LC; Mathews PM; Gandy S. 2004. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. J Neurochem 90(4):1011-8. [PubMed: 15287908]  [MGI Ref ID J:107867]

Yet SF; Layne MD; Liu X; Chen YH; Ith B; Sibinga NE; Perrella MA. 2003. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J 17(12):1759-61. [PubMed: 12958201]  [MGI Ref ID J:85417]

Yi X; Maeda N. 2006. alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes 55(8):2238-44. [PubMed: 16873686]  [MGI Ref ID J:116519]

Yoshimatsu M; Terasaki Y; Sakashita N; Kiyota E; Sato H; van der Laan LJ; Takeya M. 2004. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. Int J Exp Pathol 85(6):335-43. [PubMed: 15566430]  [MGI Ref ID J:104609]

Yoshimura K; Aoki H; Ikeda Y; Fujii K; Akiyama N; Furutani A; Hoshii Y; Tanaka N; Ricci R; Ishihara T; Esato K; Hamano K; Matsuzaki M. 2005. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 11(12):1330-8. [PubMed: 16311603]  [MGI Ref ID J:104132]

Young CG; Knight CA; Vickers KC; Westbrook D; Madamanchi NR; Runge MS; Ischiropoulos H; Ballinger SW. 2005. Differential effects of exercise on aortic mitochondria. Am J Physiol Heart Circ Physiol 288(4):H1683-9. [PubMed: 15550530]  [MGI Ref ID J:97385]

Yu H; Zhang W; Yancey PG; Koury MJ; Zhang Y; Fazio S; Linton MF. 2006. Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice. Arterioscler Thromb Vasc Biol 26(1):150-6. [PubMed: 16269665]  [MGI Ref ID J:127962]

Yu KC; David C; Kadambi S; Stahl A; Hirata K; Ishida T; Quertermous T; Cooper AD; Choi SY. 2004. Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. J Lipid Res 45(9):1614-23. [PubMed: 15175355]  [MGI Ref ID J:93268]

Yu KC; Jiang Y; Chen W; Cooper AD. 2000. Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E J Lipid Res 41(11):1715-27. [PubMed: 11060341]  [MGI Ref ID J:65695]

Yuan Z; Miyoshi T; Bao Y; Sheehan JP; Matsumoto AH; Shi W. 2009. Microarray analysis of gene expression in mouse aorta reveals role of the calcium signaling pathway in control of atherosclerosis susceptibility. Am J Physiol Heart Circ Physiol 296(5):H1336-43. [PubMed: 19304945]  [MGI Ref ID J:150880]

Yuan Z; Pei H; Roberts DJ; Zhang Z; Rowlan JS; Matsumoto AH; Shi W. 2009. Quantitative trait locus analysis of neointimal formation in an intercross between C57BL/6 and C3H/HeJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet 2(3):220-228. [PubMed: 19718279]  [MGI Ref ID J:153521]

Yuan Z; Su Z; Miyoshi T; Rowlan JS; Shi W. 2008. Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice. Mol Genet Genomics 280(5):375-83. [PubMed: 18704499]  [MGI Ref ID J:153398]

Zaina S; Pettersson L; Ahren B; Branen L; Hassan AB; Lindholm M; Mattsson R; Thyberg J; Nilsson J. 2002. Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model. J Biol Chem 277(6):4505-11. [PubMed: 11726660]  [MGI Ref ID J:74530]

Zernecke A; Bot I; Djalali-Talab Y; Shagdarsuren E; Bidzhekov K; Meiler S; Krohn R; Schober A; Sperandio M; Soehnlein O; Bornemann J; Tacke F; Biessen EA; Weber C. 2008. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102(2):209-17. [PubMed: 17991882]  [MGI Ref ID J:145593]

Zernecke A; Liehn EA; Fraemohs L; von Hundelshausen P; Koenen RR; Corada M; Dejana E; Weber C. 2006. Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 26(2):e10-3. [PubMed: 16306427]  [MGI Ref ID J:127969]

Zernecke A; Liehn EA; Gao JL; Kuziel WA; Murphy PM; Weber C. 2006. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. Blood 107(11):4240-3. [PubMed: 16467202]  [MGI Ref ID J:128843]

Zernecke A; Schober A; Bot I; von Hundelshausen P; Liehn EA; Mopps B; Mericskay M; Gierschik P; Biessen EA; Weber C. 2005. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res 96(7):784-91. [PubMed: 15761195]  [MGI Ref ID J:137758]

Zhang L; Peppel K; Sivashanmugam P; Orman ES; Brian L; Exum ST; Freedman NJ. 2007. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arterioscler Thromb Vasc Biol 27(5):1087-94. [PubMed: 17442899]  [MGI Ref ID J:128059]

Zhang S; Picard MH; Vasile E; Zhu Y; Raffai RL; Weisgraber KH; Krieger M. 2005. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111(25):3457-64. [PubMed: 15967843]  [MGI Ref ID J:114611]

Zhang SH; Reddick RL; Burkey B; Maeda N. 1994. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest 94(3):937-45. [PubMed: 8083379]  [MGI Ref ID J:20459]

Zhang SH; Reddick RL; Piedrahita JA; Maeda N. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258(5081):468-71. [PubMed: 1411543]  [MGI Ref ID J:16573]

Zhang W; Yancey PG; Su YR; Babaev VR; Zhang Y; Fazio S; Linton MF. 2003. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 108(18):2258-63. [PubMed: 14581413]  [MGI Ref ID J:103014]

Zhang WJ; Bird KE; McMillen TS; LeBoeuf RC; Hagen TM; Frei B. 2008. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117(3):421-8. [PubMed: 18158360]  [MGI Ref ID J:145089]

Zhao L; Pratico D; Rader DJ; Funk CD. 2005. 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway. Prostaglandins Other Lipid Mediat 78(1-4):185-93. [PubMed: 16303615]  [MGI Ref ID J:112785]

Zhou J; Lhotak S; Hilditch BA; Austin RC. 2005. Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 111(14):1814-21. [PubMed: 15809369]  [MGI Ref ID J:109687]

Zhou X; Hansson GK. 1999. Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice. Scand J Immunol 50(1):25-30. [PubMed: 10404048]  [MGI Ref ID J:56605]

Zhou X; Paulsson G; Stemme S; Hansson GK. 1998. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest 101(8):1717-25. [PubMed: 9541503]  [MGI Ref ID J:47027]

Zhou X; Robertson AK; Rudling M; Parini P; Hansson GK. 2005. Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ Res 96(4):427-34. [PubMed: 15662027]  [MGI Ref ID J:106869]

Zhou X; Stemme S; Hansson GK. 1996. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice [see comments] Am J Pathol 149(2):359-66. [PubMed: 8701976]  [MGI Ref ID J:34435]

Zhou Y; Cheshire A; Howell LA; Ryan DH; Harris RB. 1999. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain Res Bull 49(3):173-9. [PubMed: 10435780]  [MGI Ref ID J:110915]

Zhu B; Kuhel DG; Witte DP; Hui DY. 2000. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice Am J Pathol 157(6):1839-48. [PubMed: 11106557]  [MGI Ref ID J:66130]

d'Uscio LV; Baker TA; Mantilla CB; Smith L; Weiler D; Sieck GC; Katusic ZS. 2001. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21(6):1017-22. [PubMed: 11397713]  [MGI Ref ID J:103189]

d'Uscio LV; Katusic ZS. 2006. Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 290(6):H2466-71. [PubMed: 16428344]  [MGI Ref ID J:111845]

d'Uscio LV; Smith LA; Katusic ZS. 2001. Hypercholesterolemia impairs endothelium-dependent relaxations in common carotid arteries of apolipoprotein e-deficient mice. Stroke 32(11):2658-64. [PubMed: 11692031]  [MGI Ref ID J:104001]

van Haperen R; de Waard M; van Deel E; Mees B; Kutryk M; van Aken T; Hamming J; Grosveld F; Duncker DJ; de Crom R. 2002. Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide. J Biol Chem 277(50):48803-7. [PubMed: 12364322]  [MGI Ref ID J:80701]

van Meer P; Pfankuch T; Raber J. 2007. Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice. J Neurochem 103(1):124-30. [PubMed: 17573822]  [MGI Ref ID J:128042]

von Dehn G; von Dehn O; Volker W; Langer C; Weinbauer GF; Behre HM; Nieschlag E; Assmann G; von Eckardstein A. 2001. Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Horm Metab Res 33(2):110-4. [PubMed: 11294492]  [MGI Ref ID J:68906]

Ldlrtm1Her related

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. [PubMed: 10727439]  [MGI Ref ID J:61147]

Afek A; Keren G; Harats D; George J. 2001. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice. Exp Mol Pathol 71(1):63-72. [PubMed: 11502098]  [MGI Ref ID J:106255]

Ait-Oufella H; Kinugawa K; Zoll J; Simon T; Boddaert J; Heeneman S; Blanc-Brude O; Barateau V; Potteaux S; Merval R; Esposito B; Teissier E; Daemen MJ; Leseche G; Boulanger C; Tedgui A; Mallat Z. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115(16):2168-77. [PubMed: 17420351]  [MGI Ref ID J:135906]

Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. [PubMed: 16462800]  [MGI Ref ID J:105800]

Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. [PubMed: 16299001]  [MGI Ref ID J:107322]

Altenburg M; Arbones-Mainar J; Johnson L; Wilder J; Maeda N. 2008. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol 28(6):1104-10. [PubMed: 18369154]  [MGI Ref ID J:149026]

Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. [PubMed: 15485633]  [MGI Ref ID J:93917]

Arai S; Shelton JM; Chen M; Bradley MN; Castrillo A; Bookout AL; Mak PA; Edwards PA; Mangelsdorf DJ; Tontonoz P; Miyazaki T. 2005. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 1(3):201-13. [PubMed: 16054063]  [MGI Ref ID J:129845]

Aslanian AM; Chapman HA; Charo IF. 2005. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 25(3):628-32. [PubMed: 15591216]  [MGI Ref ID J:110061]

Aslanian AM; Charo IF. 2006. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation 114(6):583-90. [PubMed: 16880330]  [MGI Ref ID J:123851]

Azhar S; Luo Y; Medicherla S; Reaven E. 1999. Upregulation of selective cholesteryl ester uptake pathway in mice with deletion of low-density lipoprotein receptor function. J Cell Physiol 180(2):190-202. [PubMed: 10395289]  [MGI Ref ID J:56099]

Babaev VR; Chew JD; Ding L; Davis S; Breyer MD; Breyer RM; Oates JA; Fazio S; Linton MF. 2008. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab 8(6):492-501. [PubMed: 19041765]  [MGI Ref ID J:144376]

Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. [PubMed: 16380543]  [MGI Ref ID J:121507]

Babaev VR; Ishiguro H; Ding L; Yancey PG; Dove DE; Kovacs WJ; Semenkovich CF; Fazio S; Linton MF. 2007. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 116(12):1404-12. [PubMed: 17724261]  [MGI Ref ID J:139843]

Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238]  [MGI Ref ID J:114332]

Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. [PubMed: 16888235]  [MGI Ref ID J:128048]

Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. [PubMed: 17329566]  [MGI Ref ID J:123530]

Basso F; Amar MJ; Wagner EM; Vaisman B; Paigen B; Santamarina-Fojo S; Remaley AT. 2006. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochem Biophys Res Commun 351(2):398-404. [PubMed: 17070501]  [MGI Ref ID J:116554]

Basso F; Freeman LA; Ko C; Joyce C; Amar MJ; Shamburek RD; Tansey T; Thomas F; Wu J; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2007. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res 48(1):114-26. [PubMed: 17060690]  [MGI Ref ID J:117682]

Bavendiek U; Zirlik A; LaClair S; MacFarlane L; Libby P; Schonbeck U. 2005. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol 25(6):1244-9. [PubMed: 15746436]  [MGI Ref ID J:114293]

Bell TA rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. [PubMed: 17431188]  [MGI Ref ID J:134910]

Bernal-Mizrachi C; Weng S; Feng C; Finck BN; Knutsen RH; Leone TC; Coleman T; Mecham RP; Kelly DP; Semenkovich CF. 2003. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 9(8):1069-75. [PubMed: 12847522]  [MGI Ref ID J:84844]

Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. [PubMed: 17435771]  [MGI Ref ID J:121807]

Bhasin KK; van Nas A; Martin LJ; Davis RC; Devaskar SU; Lusis AJ. 2009. Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes 58(3):559-66. [PubMed: 19073773]  [MGI Ref ID J:146932]

Bhatia VK; Yun S; Leung V; Grimsditch DC; Benson GM; Botto MB; Boyle JJ; Haskard DO. 2007. Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 170(1):416-26. [PubMed: 17200212]  [MGI Ref ID J:117210]

Billon-Gales A; Fontaine C; Filipe C; Douin-Echinard V; Fouque MJ; Flouriot G; Gourdy P; Lenfant F; Laurell H; Krust A; Chambon P; Arnal JF. 2009. The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci U S A 106(6):2053-8. [PubMed: 19188600]  [MGI Ref ID J:144952]

Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809]  [MGI Ref ID J:118092]

Binder CJ; Horkko S; Dewan A; Chang MK; Kieu EP; Goodyear CS; Shaw PX; Palinski W; Witztum JL; Silverman GJ. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 9(6):736-43. [PubMed: 12740573]  [MGI Ref ID J:83726]

Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. [PubMed: 18272520]  [MGI Ref ID J:136523]

Boisvert WA; Rose DM; Johnson KA; Fuentes ME; Lira SA; Curtiss LK; Terkeltaub RA. 2006. Up-regulated expression of the CXCR2 Ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol 168(4):1385-95. [PubMed: 16565511]  [MGI Ref ID J:107325]

Boisvert WA; Santiago R; Curtiss LK; Terkeltaub RA. 1998. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 101(2):353-63. [PubMed: 9435307]  [MGI Ref ID J:45392]

Bostrom MA; Boyanovsky BB; Jordan CT; Wadsworth MP; Taatjes DJ; de Beer FC; Webb NR. 2007. Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice. Arterioscler Thromb Vasc Biol 27(3):600-6. [PubMed: 17204667]  [MGI Ref ID J:149057]

Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. [PubMed: 12690199]  [MGI Ref ID J:82871]

Boucher P; Li WP; Matz RL; Takayama Y; Auwerx J; Anderson RG; Herz J. 2007. LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS ONE 2(5):e448. [PubMed: 17505534]  [MGI Ref ID J:129347]

Bovenschen N; Mertens K; Hu L; Havekes LM; van Vlijmen BJ. 2005. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 106(3):906-12. [PubMed: 15840700]  [MGI Ref ID J:117317]

Boyanovsky BB; van der Westhuyzen DR; Webb NR. 2005. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem 280(38):32746-52. [PubMed: 16040605]  [MGI Ref ID J:102157]

Bretillon L; Acar N; Seeliger MW; Santos M; Maire MA; Juaneda P; Martine L; Gregoire S; Joffre C; Bron AM; Creuzot-Garcher C. 2008. ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina. Invest Ophthalmol Vis Sci 49(4):1307-14. [PubMed: 18385042]  [MGI Ref ID J:136142]

Broedl UC; Maugeais C; Millar JS; Jin W; Moore RE; Fuki IV; Marchadier D; Glick JM; Rader DJ. 2004. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94(12):1554-61. [PubMed: 15117821]  [MGI Ref ID J:100064]

Brown JM; Bell TA rd; Alger HM; Sawyer JK; Smith TL; Kelley K; Shah R; Wilson MD; Davis MA; Lee RG; Graham MJ; Crooke RM; Rudel LL. 2008. Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J Biol Chem 283(16):10522-34. [PubMed: 18281279]  [MGI Ref ID J:136556]

Buga GM; Frank JS; Mottino GA; Hakhamian A; Narasimha A; Watson AD; Yekta B; Navab M; Reddy ST; Anantharamaiah GM; Fogelman AM. 2008. D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet. J Lipid Res 49(1):192-205. [PubMed: 17925450]  [MGI Ref ID J:130095]

Buga GM; Frank JS; Mottino GA; Hendizadeh M; Hakhamian A; Tillisch JH; Reddy ST; Navab M; Anantharamaiah GM; Ignarro LJ; Fogelman AM. 2006. D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet. J Lipid Res 47(10):2148-60. [PubMed: 16835442]  [MGI Ref ID J:116493]

Buono C; Binder CJ; Stavrakis G; Witztum JL; Glimcher LH; Lichtman AH. 2005. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A 102(5):1596-601. [PubMed: 15665085]  [MGI Ref ID J:96110]

Buono C; Come CE; Stavrakis G; Maguire GF; Connelly PW; Lichtman AH. 2003. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 23(3):454-60. [PubMed: 12615659]  [MGI Ref ID J:103072]

Buono C; Come CE; Witztum JL; Maguire GF; Connelly PW; Carroll M; Lichtman AH. 2002. Influence of C3 deficiency on atherosclerosis. Circulation 105(25):3025-31. [PubMed: 12081998]  [MGI Ref ID J:103349]

Burleigh ME; Babaev VR; Oates JA; Harris RC; Gautam S; Riendeau D; Marnett LJ; Morrow JD; Fazio S; Linton MF. 2002. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation 105(15):1816-23. [PubMed: 11956125]  [MGI Ref ID J:103220]

Cain WJ; Millar JS; Himebauch AS; Tietge UJ; Maugeais C; Usher D; Rader DJ. 2005. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. J Lipid Res 46(12):2681-91. [PubMed: 16150825]  [MGI Ref ID J:106146]

Calara F; Silvestre M; Casanada F; Yuan N; Napoli C; Palinski W. 2001. Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice. J Pathol 195(2):257-63. [PubMed: 11592107]  [MGI Ref ID J:71794]

Caligiuri G; Levy B; Pernow J; Thoren P; Hansson GK. 1999. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci U S A 96(12):6920-4. [PubMed: 10359814]  [MGI Ref ID J:55973]

Cao D; Fukuchi K; Wan H; Kim H; Li L. 2006. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiol Aging 27(11):1632-43. [PubMed: 16236385]  [MGI Ref ID J:114480]

Carpenter B; Lin Y; Stoll S; Raffai RL; McCuskey R; Wang R. 2005. VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development 132(14):3293-303. [PubMed: 15944181]  [MGI Ref ID J:100427]

Casquero AC; Berti JA; Salerno AG; Bighetti EJ; Cazita PM; Ketelhuth DF; Gidlund M; Oliveira HC. 2006. Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice. J Lipid Res 47(7):1526-34. [PubMed: 16603720]  [MGI Ref ID J:112057]

Cassis LA; Gupte M; Thayer S; Zhang X; Charnigo R; Howatt DA; Rateri DL; Daugherty A. 2009. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 296(5):H1660-5. [PubMed: 19252100]  [MGI Ref ID J:150893]

Cassis LA; Rateri DL; Lu H; Daugherty A. 2007. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol 27(2):380-6. [PubMed: 17158350]  [MGI Ref ID J:130546]

Castellani LW; Chang JJ; Wang X; Lusis AJ; Reynolds WF. 2006. Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males. J Lipid Res 47(7):1366-77. [PubMed: 16639078]  [MGI Ref ID J:112085]

Catanozi S; Rocha JC; Passarelli M; Guzzo ML; Alves C; Furukawa LN; Nunes VS; Nakandakare ER; Heimann JC; Quintao EC. 2003. Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice. J Lipid Res 44(4):727-32. [PubMed: 12562870]  [MGI Ref ID J:120709]

Cazita PM; Berti JA; Aoki C; Gidlund M; Harada LM; Nunes VS; Quintao EC; Oliveira HC. 2003. Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice. J Lipid Res 44(1):33-40. [PubMed: 12518020]  [MGI Ref ID J:120685]

Chadjichristos CE; Matter CM; Roth I; Sutter E; Pelli G; Luscher TF; Chanson M; Kwak BR. 2006. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation 113(24):2835-43. [PubMed: 16769907]  [MGI Ref ID J:122443]

Chan JC; Piper DE; Cao Q; Liu D; King C; Wang W; Tang J; Liu Q; Higbee J; Xia Z; Di Y; Shetterly S; Arimura Z; Salomonis H; Romanow WG; Thibault ST; Zhang R; Cao P; Yang XP; Yu T; Lu M; Retter MW; Kwon G; Henne K; Pan O; Tsai MM; Fuchslocher B; Yang E; Zhou L; Lee KJ; Daris M; Sheng J; Wang Y; Shen WD; Yeh WC; Emery M; Walker NP; Shan B; Schwarz M; Jackson SM. 2009. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A 106(24):9820-5. [PubMed: 19443683]  [MGI Ref ID J:150005]

Chen CT; Ma DW; Kim JH; Mount HT; Bazinet RP. 2008. The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations. J Lipid Res 49(1):147-52. [PubMed: 17932396]  [MGI Ref ID J:130078]

Chen Z; Fitzgerald RL; Li G; Davidson NO; Schonfeld G. 2004. Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45(1):155-63. [PubMed: 13130124]  [MGI Ref ID J:87974]

Choi JH; Nam KH; Kim J; Baek MW; Park JE; Park HY; Kwon HJ; Kwon OS; Kim DY; Oh GT. 2005. Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(11):2404-9. [PubMed: 16141407]  [MGI Ref ID J:116800]

Christoffersen C; Jauhiainen M; Moser M; Porse B; Ehnholm C; Boesl M; Dahlback B; Nielsen LB. 2008. Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J Biol Chem 283(4):1839-47. [PubMed: 18006500]  [MGI Ref ID J:130647]

Coenen KR; Gruen ML; Chait A; Hasty AH. 2007. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes 56(3):564-73. [PubMed: 17327423]  [MGI Ref ID J:122029]

Coenen KR; Gruen ML; Lee-Young RS; Puglisi MJ; Wasserman DH; Hasty AH. 2009. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia 52(2):318-28. [PubMed: 19052722]  [MGI Ref ID J:144370]

Coenen KR; Hasty AH. 2007. Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice. Am J Physiol Endocrinol Metab 293(2):E492-9. [PubMed: 17566116]  [MGI Ref ID J:123342]

Cybulsky MI; Iiyama K; Li H; Zhu S; Chen M; Iiyama M; Davis V; Gutierrez-Ramos JC; Connelly PW; Milstone DS. 2001. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 107(10):1255-62. [PubMed: 11375415]  [MGI Ref ID J:69597]

Cyrus T; Tang LX; Rokach J; FitzGerald GA; Pratico D. 2001. Lipid peroxidation and platelet activation in murine atherosclerosis. Circulation 104(16):1940-5. [PubMed: 11602498]  [MGI Ref ID J:103216]

Dandapat A; Hu CP; Chen J; Liu Y; Khan JA; Remeo F; Carey RM; Hermonat PL; Mehta JL. 2008. Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque. Biochem Biophys Res Commun 366(4):871-7. [PubMed: 18037370]  [MGI Ref ID J:130186]

Davies MR; Lund RJ; Mathew S; Hruska KA. 2005. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol 16(4):917-28. [PubMed: 15743994]  [MGI Ref ID J:110048]

Day SM; Reeve JL; Pedersen B; Farris DM; Myers DD; Im M; Wakefield TW; Mackman N; Fay WP. 2005. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood 105(1):192-8. [PubMed: 15339841]  [MGI Ref ID J:96377]

Deane R; Sagare A; Hamm K; Parisi M; Lane S; Finn MB; Holtzman DM; Zlokovic BV. 2008. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 118(12):4002-13. [PubMed: 19033669]  [MGI Ref ID J:144730]

Deevska GM; Rozenova KA; Giltiay NV; Chambers MA; White J; Boyanovsky BB; Wei J; Daugherty A; Smart EJ; Reid MB; Merrill AH Jr; Nikolova-Karakashian M. 2009. Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. J Biol Chem 284(13):8359-68. [PubMed: 19074137]  [MGI Ref ID J:148558]

Degrace P; Moindrot B; Mohamed I; Gresti J; Du ZY; Chardigny JM; Sebedio JL; Clouet P. 2006. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. J Lipid Res 47(12):2647-55. [PubMed: 16957181]  [MGI Ref ID J:117203]

Devlin CM; Kuriakose G; Hirsch E; Tabas I. 2002. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size. Proc Natl Acad Sci U S A 99(9):6280-5. [PubMed: 11983917]  [MGI Ref ID J:76336]

Devlin CM; Leventhal AR; Kuriakose G; Schuchman EH; Williams KJ; Tabas I. 2008. Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol 28(10):1723-30. [PubMed: 18669882]  [MGI Ref ID J:148825]

Dichek HL; Agrawal N; El Andaloussi N; Qian K. 2006. Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology. Am J Physiol Endocrinol Metab 290(5):E908-15. [PubMed: 16368783]  [MGI Ref ID J:108412]

Dichek HL; Johnson SM; Akeefe H; Lo GT; Sage E; Yap CE; Mahley RW. 2001. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J Lipid Res 42(2):201-10. [PubMed: 11181749]  [MGI Ref ID J:68351]

Dichek HL; Qian K; Agrawal N. 2004. Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis. Arterioscler Thromb Vasc Biol 24(9):1696-702. [PubMed: 15205216]  [MGI Ref ID J:134693]

Dichek HL; Qian K; Agrawal N. 2004. The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient 'apoB-48-only' and 'apoB-100-only' mice. J Lipid Res 45(3):551-60. [PubMed: 14679168]  [MGI Ref ID J:88634]

Dullens SP; Mensink RP; Bragt MC; Kies AK; Plat J. 2008. Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice. J Lipid Res 49(4):790-6. [PubMed: 18162663]  [MGI Ref ID J:133589]

Dupasquier CM; Dibrov E; Kneesh AL; Cheung PK; Lee KG; Alexander HK; Yeganeh BK; Moghadasian MH; Pierce GN. 2007. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Am J Physiol Heart Circ Physiol 293(4):H2394-402. [PubMed: 17616740]  [MGI Ref ID J:126120]

Egan KM; Lawson JA; Fries S; Koller B; Rader DJ; Smyth EM; Fitzgerald GA. 2004. COX-2-derived prostacyclin confers atheroprotection on female mice. Science 306(5703):1954-7. [PubMed: 15550624]  [MGI Ref ID J:105640]

Elder GA; Cho JY; English DF; Franciosi S; Schmeidler J; Sosa MA; Gasperi RD; Fisher EA; Mathews PM; Haroutunian V; Buxbaum JD. 2007. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor. J Neurochem 102(4):1220-31. [PubMed: 17472705]  [MGI Ref ID J:124132]

Elder GA; Ragnauth A; Dorr N; Franciosi S; Schmeidler J; Haroutunian V; Buxbaum JD. 2008. Increased locomotor activity in mice lacking the low-density lipoprotein receptor. Behav Brain Res 191(2):256-265. [PubMed: 18466986]  [MGI Ref ID J:135078]

Erickson RP; Bhattacharyya A; Hunter RJ; Heidenreich RA; Cherrington NJ. 2005. Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet. Am J Physiol Gastrointest Liver Physiol 289(2):G300-7. [PubMed: 15790756]  [MGI Ref ID J:100351]

Erickson RP; Kiela M; Garver WS; Krishnan K; Heidenreich RA. 2001. Cholesterol signaling at the endoplasmic reticulum occurs in npc1(-/-) but not in npc1(-/-), LDLR(-/-) mice. Biochem Biophys Res Commun 284(2):326-30. [PubMed: 11394880]  [MGI Ref ID J:69915]

Eriksson EE; Xie X; Werr J; Thoren P; Lindbom L. 2001. Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins. FASEB J 15(7):1149-57. [PubMed: 11344083]  [MGI Ref ID J:120455]

Eriksson EE; Xie X; Werr J; Thoren P; Lindbom L. 2001. Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J Exp Med 194(2):205-18. [PubMed: 11457895]  [MGI Ref ID J:118726]

Espirito Santo SM; Pires NM; Boesten LS; Gerritsen G; Bovenschen N; van Dijk KW; Jukema JW; Princen HM; Bensadoun A; Li WP; Herz J; Havekes LM; van Vlijmen BJ. 2004. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood 103(10):3777-82. [PubMed: 14739216]  [MGI Ref ID J:90547]

Estrada-Smith D; Collins AR; Wang X; Crockett C; Castellani L; Lusis AJ; Davis RC. 2006. Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice. Diabetes 55(8):2265-71. [PubMed: 16873689]  [MGI Ref ID J:116503]

Fazio S; Babaev VR; Burleigh ME; Major AS; Hasty AH; Linton MF. 2002. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res 43(10):1602-9. [PubMed: 12364544]  [MGI Ref ID J:79439]

Fazio S; Hasty AH; Carter KJ; Murray AB; Price JO; Linton MF. 1997. Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse. J Lipid Res 38(2):391-400. [PubMed: 9162757]  [MGI Ref ID J:38840]

Forte TM; Subbanagounder G; Berliner JA; Blanche PJ; Clermont AO; Jia Z; Oda MN; Krauss RM; Bielicki JK. 2002. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res 43(3):477-85. [PubMed: 11893784]  [MGI Ref ID J:75568]

Fougerat A; Gayral S; Gourdy P; Schambourg A; Ruckle T; Schwarz MK; Rommel C; Hirsch E; Arnal JF; Salles JP; Perret B; Breton-Douillon M; Wymann MP; Laffargue M. 2008. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 117(10):1310-7. [PubMed: 18268153]  [MGI Ref ID J:148451]

Franco C; Hou G; Ahmad PJ; Fu EY; Koh L; Vogel WF; Bendeck MP. 2008. Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice. Circ Res 102(10):1202-11. [PubMed: 18451340]  [MGI Ref ID J:149015]

Francone OL; Royer L; Boucher G; Haghpassand M; Freeman A; Brees D; Aiello RJ. 2005. Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages. Arterioscler Thromb Vasc Biol 25(6):1198-205. [PubMed: 15831807]  [MGI Ref ID J:114227]

Freeman L; Amar MJ; Shamburek R; Paigen B; Brewer HB Jr; Santamarina-Fojo S; Gonzalez-Navarro H. 2007. Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice. J Lipid Res 48(1):104-13. [PubMed: 17071916]  [MGI Ref ID J:117481]

Fryer JD; Demattos RB; McCormick LM; O'Dell MA; Spinner ML; Bales KR; Paul SM; Sullivan PM; Parsadanian M; Bu G; Holtzman DM. 2005. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J Biol Chem 280(27):25754-9. [PubMed: 15888448]  [MGI Ref ID J:100836]

Furbee JW Jr; Francone O; Parks JS. 2001. Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT. J Lipid Res 42(10):1626-35. [PubMed: 11590219]  [MGI Ref ID J:124250]

Furbee JW Jr; Francone O; Parks JS. 2002. In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. J Lipid Res 43(3):428-37. [PubMed: 11893779]  [MGI Ref ID J:75567]

Furbee JW Jr; Sawyer JK; Parks JS. 2002. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice. J Biol Chem 277(5):3511-9. [PubMed: 11719520]  [MGI Ref ID J:74315]

George J; Afek A; Shaish A; Levkovitz H; Bloom N; Cyrus T; Zhao L; Funk CD; Sigal E; Harats D. 2001. 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circulation 104(14):1646-50. [PubMed: 11581143]  [MGI Ref ID J:86385]

George J; Shoenfeld Y; Harats D. 1999. The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis. J Autoimmun 13(1):57-60. [PubMed: 10441168]  [MGI Ref ID J:56653]

German DC; Quintero EM; Liang C; Xie C; Dietschy JM. 2001. Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor. Neuroscience 105(4):999-1005. [PubMed: 11530237]  [MGI Ref ID J:126474]

Ghazalpour A; Wang X; Lusis AJ; Mehrabian M. 2006. Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice. Genetics 173(2):943-51. [PubMed: 16624897]  [MGI Ref ID J:109792]

Ghesquiere SA; Gijbels MJ; Anthonsen M; van Gorp PJ; van der Made I; Johansen B; Hofker MH; de Winther MP. 2005. Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition. J Lipid Res 46(2):201-10. [PubMed: 15576846]  [MGI Ref ID J:136941]

Girod WG; Jones SP; Sieber N; Aw TY; Lefer DJ. 1999. Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 19(11):2776-81. [PubMed: 10559025]  [MGI Ref ID J:129258]

Gitlin JM; Homeister JW; Bulgrien J; Counselman J; Curtiss LK; Lowe JB; Boisvert WA. 2009. Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice. Am J Pathol 174(1):343-50. [PubMed: 19056851]  [MGI Ref ID J:144237]

Goldberg IJ; Hu Y; Noh HL; Wei J; Huggins LA; Rackmill MG; Hamai H; Reid BN; Blaner WS; Huang LS. 2008. Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes. Diabetes 57(6):1674-82. [PubMed: 18346984]  [MGI Ref ID J:136922]

Gonon AT; Bulhak A; Broijersen A; Pernow J. 2005. Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. Br J Pharmacol 144(6):860-6. [PubMed: 15685207]  [MGI Ref ID J:110052]

Grainger DJ; Reckless J; McKilligin E. 2004. Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol 173(10):6366-75. [PubMed: 15528376]  [MGI Ref ID J:94282]

Gu L; Okada Y; Clinton SK; Gerard C; Sukhova GK; Libby P; Rollins BJ. 1998. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 2(2):275-81. [PubMed: 9734366]  [MGI Ref ID J:75837]

Han CY; Subramanian S; Chan CK; Omer M; Chiba T; Wight TN; Chait A. 2007. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 56(9):2260-73. [PubMed: 17563062]  [MGI Ref ID J:126587]

Han S; Liang CP; DeVries-Seimon T; Ranalletta M; Welch CL; Collins-Fletcher K; Accili D; Tabas I; Tall AR. 2006. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab 3(4):257-66. [PubMed: 16581003]  [MGI Ref ID J:129653]

Han S; Liang CP; Westerterp M; Senokuchi T; Welch CL; Wang Q; Matsumoto M; Accili D; Tall AR. 2009. Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest 119(4):1029-41. [PubMed: 19273907]  [MGI Ref ID J:149755]

Harada-Shiba M; Takagi A; Marutsuka K; Moriguchi S; Yagyu H; Ishibashi S; Asada Y; Yokoyama S. 2004. Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo. Circ Res 95(9):945-52. [PubMed: 15472122]  [MGI Ref ID J:102291]

Harats D; Shaish A; George J; Mulkins M; Kurihara H; Levkovitz H; Sigal E. 2000. Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 20(9):2100-5. [PubMed: 10978255]  [MGI Ref ID J:127953]

Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241]  [MGI Ref ID J:149005]

Hartvigsen K; Binder CJ; Hansen LF; Rafia A; Juliano J; Horkko S; Steinberg D; Palinski W; Witztum JL; Li AC. 2007. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol 27(4):878-85. [PubMed: 17255537]  [MGI Ref ID J:148155]

Hasty AH; Shimano H; Osuga Ji; Namatame I; Takahashi A; Yahagi N; Perrey S; Iizuka Y; Tamura Y; Amemiya-Kudo M; Yoshikawa T; Okazaki H; Ohashi K; Harada K; Matsuzaka T; Sone H; Gotoda T; Nagai R; Ishibashi S; Yamada N. 2001. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276(40):37402-8. [PubMed: 11445560]  [MGI Ref ID J:72027]

Hauer AD; Uyttenhove C; de Vos P; Stroobant V; Renauld JC; van Berkel TJ; van Snick J; Kuiper J. 2005. Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis. Circulation 112(7):1054-62. [PubMed: 16103256]  [MGI Ref ID J:117550]

Heinonen SE; Leppanen P; Kholova I; Lumivuori H; Hakkinen SK; Bosch F; Laakso M; Yla-Herttuala S. 2007. Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia. Circ Res 101(10):1058-67. [PubMed: 17872464]  [MGI Ref ID J:141333]

Hemdahl AL; Falk E; Thoren P; Hansson GK. 2004. Thrombin inhibitor reduces myocardial infarction in apoE-/- x LDLR-/- mice. Am J Physiol Heart Circ Physiol 287(2):H872-7. [PubMed: 15031124]  [MGI Ref ID J:95598]

Henninger DD; Gerritsen ME; Granger DN. 1997. Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. Circ Res 81(2):274-81. [PubMed: 9242189]  [MGI Ref ID J:42527]

Herijgers N; Van Eck M; Korporaal SJ; Hoogerbrugge PM; Van Berkel TJ. 2000. Relative importance of the LDL receptor and scavenger receptor class B in the beta-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages J Lipid Res 41(7):1163-71. [PubMed: 10884299]  [MGI Ref ID J:63449]

Herijgers N; de Winther MP; Van Eck M; Havekes LM; Hofker MH; Hoogerbrugge PM; Van Berkel TJ. 2000. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice J Lipid Res 41(9):1402-9. [PubMed: 10974047]  [MGI Ref ID J:64891]

Herz J; Qiu SQ; Oesterle A; DeSilva HV; Shafi S; Havel RJ. 1995. Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor. Proc Natl Acad Sci U S A 92(10):4611-5. [PubMed: 7753850]  [MGI Ref ID J:25195]

Hime NJ; Black AS; Bulgrien JJ; Curtiss LK. 2008. Leukocyte-derived hepatic lipase increases HDL and decreases en face aortic atherosclerosis in LDLr-/- mice expressing CETP. J Lipid Res 49(10):2113-23. [PubMed: 18599739]  [MGI Ref ID J:140426]

Hockings PD; Roberts T; Galloway GJ; Reid DG; Harris DA; Vidgeon-Hart M; Groot PH; Suckling KE; Benson GM. 2002. Repeated three-dimensional magnetic resonance imaging of atherosclerosis development in innominate arteries of low-density lipoprotein receptor-knockout mice. Circulation 106(13):1716-21. [PubMed: 12270868]  [MGI Ref ID J:103222]

Hoekstra M; Stitzinger M; van Wanrooij EJ; Michon IN; Kruijt JK; Kamphorst J; Van Eck M; Vreugdenhil E; Van Berkel TJ; Kuiper J. 2006. Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet. J Lipid Res 47(10):2198-207. [PubMed: 16885566]  [MGI Ref ID J:116502]

Holdt LM; Thiery J; Breslow JL; Teupser D. 2008. Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice. Arterioscler Thromb Vasc Biol 28(6):1097-103. [PubMed: 18356551]  [MGI Ref ID J:149028]

Hu L; Boesten LS; May P; Herz J; Bovenschen N; Huisman MV; Berbee JF; Havekes LM; van Vlijmen BJ; Tamsma JT. 2006. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol 26(12):2710-5. [PubMed: 17038633]  [MGI Ref ID J:129557]

Hu L; van der Hoogt CC; Espirito Santo SM; Out R; Kypreos KE; van Vlijmen BJ; Van Berkel TJ; Romijn JA; Havekes LM; van Dijk KW; Rensen PC. 2008. The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI. J Lipid Res 49(7):1553-61. [PubMed: 18367731]  [MGI Ref ID J:138462]

Huang F; Thompson JC; Wilson PG; Aung HH; Rutledge JC; Tannock LR. 2008. Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development. J Lipid Res 49(3):521-30. [PubMed: 18033753]  [MGI Ref ID J:133289]

Huang Y; Liu XQ; Rall SC Jr; Taylor JM; von Eckardstein A; Assmann G; Mahley RW. 1998. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem 273(41):26388-93. [PubMed: 9756870]  [MGI Ref ID J:115206]

Huang Y; Rall SC Jr; Mahley RW. 1997. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol 17(11):2817-24. [PubMed: 9409260]  [MGI Ref ID J:45728]

Huszar D; Varban ML; Rinninger F; Feeley R; Arai T; Fairchild-Huntress V; Donovan MJ; Tall AR. 2000. Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol 20(4):1068-73. [PubMed: 10764675]  [MGI Ref ID J:62371]

Igbavboa U; Avdulov NA; Chochina SV; Wood WG. 1997. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69(4):1661-7. [PubMed: 9326295]  [MGI Ref ID J:43043]

Iqbal J; Rudel LL; Hussain MM. 2008. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem 283(29):19967-80. [PubMed: 18502767]  [MGI Ref ID J:138737]

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. [PubMed: 8349823]  [MGI Ref ID J:37394]

Ishibashi S; Goldstein JL; Brown MS; Herz J; Burns DK. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 93(5):1885-93. [PubMed: 8182121]  [MGI Ref ID J:77012]

Ishibashi S; Hammer RE; Herz J. 1994. Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. J Biol Chem 269(45):27803-6. [PubMed: 7961705]  [MGI Ref ID J:21380]

Ishibashi S; Perrey S; Chen Z; Osuga Ji; Shimada M; Ohashi K; Harada K; Yazaki Y; Yamada N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem 271(37):22422-7. [PubMed: 8798405]  [MGI Ref ID J:35377]

Ishikawa K; Sugawara D; Wang Xp; Suzuki K; Itabe H; Maruyama Y; Lusis AJ. 2001. Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ Res 88(5):506-12. [PubMed: 11249874]  [MGI Ref ID J:115392]

Iwaki T; Donahue DL; Castellino FJ. 2007. High levels of LDL-cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice. J Thromb Haemost 5(3):624-6. [PubMed: 17155952]  [MGI Ref ID J:135942]

Iwaki T; Sandoval-Cooper MJ; Brechmann M; Ploplis VA; Castellino FJ. 2006. A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood 107(10):3883-91. [PubMed: 16434491]  [MGI Ref ID J:132734]

Jagavelu K; Tietge UJ; Gaestel M; Drexler H; Schieffer B; Bavendiek U. 2007. Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice. Circ Res 101(11):1104-12. [PubMed: 17885219]  [MGI Ref ID J:142788]

Jeong Ts; Schissel SL; Tabas I; Pownall HJ; Tall AR; Jiang X. 1998. Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J Clin Invest 101(4):905-12. [PubMed: 9466986]  [MGI Ref ID J:46009]

Jiang XC; Qin S; Qiao C; Kawano K; Lin M; Skold A; Xiao X; Tall AR. 2001. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med 7(7):847-52. [PubMed: 11433351]  [MGI Ref ID J:70250]

Jiang XC; Tall AR; Qin S; Lin M; Schneider M; Lalanne F; Deckert V; Desrumaux C; Athias A; Witztum JL; Lagrost L. 2002. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem 277(35):31850-6. [PubMed: 12105225]  [MGI Ref ID J:120468]

Johansson F; Kramer F; Barnhart S; Kanter JE; Vaisar T; Merrill RD; Geng L; Oka K; Chan L; Chait A; Heinecke JW; Bornfeldt KE. 2008. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci U S A 105(6):2082-7. [PubMed: 18252823]  [MGI Ref ID J:143961]

Jones C; Garuti R; Michaely P; Li WP; Maeda N; Cohen JC; Herz J; Hobbs HH. 2007. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. J Clin Invest 117(1):165-74. [PubMed: 17200716]  [MGI Ref ID J:117439]

Jones C; Hammer RE; Li WP; Cohen JC; Hobbs HH; Herz J. 2003. Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem 278(31):29024-30. [PubMed: 12746448]  [MGI Ref ID J:84694]

Jong MC; Dahlmans VE; van Gorp PJ; van Dijk KW; Breuer ML; Hofker MH; Havekes LM. 1996. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. J Clin Invest 98(10):2259-67. [PubMed: 8941642]  [MGI Ref ID J:65146]

Joseph SB; McKilligin E; Pei L; Watson MA; Collins AR; Laffitte BA; Chen M; Noh G; Goodman J; Hagger GN; Tran J; Tippin TK; Wang X; Lusis AJ; Hsueh WA; Law RE; Collins JL; Willson TM; Tontonoz P. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99(11):7604-9. [PubMed: 12032330]  [MGI Ref ID J:76860]

Joyce CW; Wagner EM; Basso F; Amar MJ; Freeman LA; Shamburek RD; Knapper CL; Syed J; Wu J; Vaisman BL; Fruchart-Najib J; Billings EM; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2006. ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. J Biol Chem 281(44):33053-65. [PubMed: 16928680]  [MGI Ref ID J:117282]

Kanters E; Gijbels MJ; van der Made I; Vergouwe MN; Heeringa P; Kraal G; Hofker MH; de Winther MP. 2004. Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype. Blood 103(3):934-40. [PubMed: 14512319]  [MGI Ref ID J:87639]

Kanters E; Pasparakis M; Gijbels MJ; Vergouwe MN; Partouns-Hendriks I; Fijneman RJ; Clausen BE; Forster I; Kockx MM; Rajewsky K; Kraal G; Hofker MH; de Winther MP. 2003. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest 112(8):1176-85. [PubMed: 14561702]  [MGI Ref ID J:86163]

Karagiannides I; Abdou R; Tzortzopoulou A; Voshol PJ; Kypreos KE. 2008. Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice. FEBS J 275(19):4796-809. [PubMed: 18754772]  [MGI Ref ID J:142460]

Kawashiri Ma; Zhang Y; Usher D; Reilly M; Pure E; Rader DJ. 2001. Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice. J Lipid Res 42(6):943-50. [PubMed: 11369802]  [MGI Ref ID J:69834]

Keren P; George J; Shaish A; Levkovitz H; Janakovic Z; Afek A; Goldberg I; Kopolovic J; Keren G; Harats D. 2000. Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. Diabetes 49(6):1064-9. [PubMed: 10866061]  [MGI Ref ID J:62295]

King LM; Francomano CA. 2001. Characterization of a human gene encoding nucleosomal binding protein nsbp1. Genomics 71(2):163-73. [PubMed: 11161810]  [MGI Ref ID J:67578]

King VL; Cassis LA; Daugherty A. 2007. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am J Pathol 171(6):2040-7. [PubMed: 18055554]  [MGI Ref ID J:128948]

King VL; Szilvassy SJ; Daugherty A. 2002. Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice. Arterioscler Thromb Vasc Biol 22(3):456-61. [PubMed: 11884290]  [MGI Ref ID J:103308]

King VL; Szilvassy SJ; Daugherty A. 2002. Interleukin-4 deficiency promotes gallstone formation. J Lipid Res 43(5):768-71. [PubMed: 11971948]  [MGI Ref ID J:76258]

Kitamoto S; Sukhova GK; Sun J; Yang M; Libby P; Love V; Duramad P; Sun C; Zhang Y; Yang X; Peters C; Shi GP. 2007. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation 115(15):2065-75. [PubMed: 17404153]  [MGI Ref ID J:135371]

Knouff C; Briand O; Lestavel S; Clavey V; Altenburg M; Maeda N. 2004. Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor. Biochim Biophys Acta 1684(1-3):8-17. [PubMed: 15450205]  [MGI Ref ID J:92554]

Ko KW; Paul A; Ma K; Li L; Chan L. 2005. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 46(12):2586-94. [PubMed: 16199802]  [MGI Ref ID J:106132]

Kobayashi K; Oka K; Forte T; Ishida B; Teng B; Ishimura-Oka K; Nakamuta M; Chan L. 1996. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J Biol Chem 271(12):6852-60. [PubMed: 8636110]  [MGI Ref ID J:32102]

Kovacs A; Tornvall P; Nilsson R; Tegner J; Hamsten A; Bjorkegren J. 2007. Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proc Natl Acad Sci U S A 104(34):13768-73. [PubMed: 17702862]  [MGI Ref ID J:124095]

Kozarsky KF; Donahee MH; Glick JM; Krieger M; Rader DJ. 2000. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol 20(3):721-7. [PubMed: 10712397]  [MGI Ref ID J:61288]

Kraemer FB; Shen WJ; Patel S; Osuga J; Ishibashi S; Azhar S. 2007. The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. Am J Physiol Endocrinol Metab 292(2):E408-12. [PubMed: 16985254]  [MGI Ref ID J:143674]

Kubo N; Boisvert WA; Ballantyne CM; Curtiss LK. 2000. Leukocyte CD11b expression is not essential for the development of atherosclerosis in mice J Lipid Res 41(7):1060-6. [PubMed: 10884286]  [MGI Ref ID J:63447]

Kulinski A; Rustaeus S; Vance JE. 2002. Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation. J Biol Chem 277(35):31516-25. [PubMed: 12072432]  [MGI Ref ID J:78774]

Kumar AP; Piedrafita FJ; Reynolds WF. 2004. Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. J Biol Chem 279(9):8300-15. [PubMed: 14668325]  [MGI Ref ID J:130052]

Kunjathoor VV; Chiu DS; O'Brien KD; LeBoeuf RC. 2002. Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 22(3):462-8. [PubMed: 11884291]  [MGI Ref ID J:103309]

Kwak BR; Veillard N; Pelli G; Mulhaupt F; James RW; Chanson M; Mach F. 2003. Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation 107(7):1033-9. [PubMed: 12600918]  [MGI Ref ID J:103052]

Kypreos KE; Li X; van Dijk KW; Havekes LM; Zannis VI. 2003. Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype. Biochemistry 42(33):9841-53. [PubMed: 12924933]  [MGI Ref ID J:115687]

Kypreos KE; Zannis VI. 2006. LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice. J Lipid Res 47(3):521-9. [PubMed: 16339113]  [MGI Ref ID J:107556]

Lagace TA; Curtis DE; Garuti R; McNutt MC; Park SW; Prather HB; Anderson NN; Ho YK; Hammer RE; Horton JD. 2006. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice. J Clin Invest 116(11):2995-3005. [PubMed: 17080197]  [MGI Ref ID J:114949]

Lai CF; Seshadri V; Huang K; Shao JS; Cai J; Vattikuti R; Schumacher A; Loewy AP; Denhardt DT; Rittling SR; Towler DA. 2006. An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. Circ Res 98(12):1479-89. [PubMed: 16709900]  [MGI Ref ID J:122625]

Lambert G; Jarnoux AL; Pineau T; Pape O; Chetiveaux M; Laboisse C; Krempf M; Costet P. 2006. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology 147(10):4985-95. [PubMed: 16794006]  [MGI Ref ID J:129548]

Lamharzi N; Renard CB; Kramer F; Pennathur S; Heinecke JW; Chait A; Bornfeldt KE. 2004. Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL. Diabetes 53(12):3217-25. [PubMed: 15561953]  [MGI Ref ID J:94609]

Langheinrich AC; Michniewicz A; Sedding DG; Walker G; Beighley PE; Rau WS; Bohle RM; Ritman EL. 2006. Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice. Arterioscler Thromb Vasc Biol 26(2):347-52. [PubMed: 16293797]  [MGI Ref ID J:127960]

Larsson SL; Skogsberg J; Bjorkegren J. 2004. The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver. J Biol Chem 279(2):831-6. [PubMed: 14583618]  [MGI Ref ID J:124544]

Laurila A; Cole SP; Merat S; Obonyo M; Palinski W; Fierer J; Witztum JL. 2001. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arterioscler Thromb Vasc Biol 21(6):991-6. [PubMed: 11397709]  [MGI Ref ID J:103300]

Lee CH; Chawla A; Urbiztondo N; Liao D; Boisvert WA; Evans RM; Curtiss LK. 2003. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science 302(5644):453-7. [PubMed: 12970571]  [MGI Ref ID J:122915]

Lee EC; Desai U; Gololobov G; Hong S; Feng X; Yu XC; Gay J; Wilganowski N; Gao C; Du LL; Chen J; Hu Y; Zhao S; Kirkpatrick L; Schneider M; Zambrowicz BP; Landes G; Powell DR; Sonnenburg WK. 2009. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem 284(20):13735-45. [PubMed: 19318355]  [MGI Ref ID J:149912]

Lee RG; Kelley KL; Sawyer JK; Farese RV Jr; Parks JS; Rudel LL. 2004. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ Res 95(10):998-1004. [PubMed: 15486318]  [MGI Ref ID J:103854]

Lee RG; Shah R; Sawyer JK; Hamilton RL; Parks JS; Rudel LL. 2005. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice. J Lipid Res 46(6):1205-12. [PubMed: 15805543]  [MGI Ref ID J:128885]

Lee SJ; Grosskopf I; Choi SY; Cooper AD. 2004. Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158->Cys), and E3-Leiden. J Lipid Res 45(12):2199-210. [PubMed: 15466367]  [MGI Ref ID J:94176]

Leppanen P; Koota S; Kholova I; Koponen J; Fieber C; Eriksson U; Alitalo K; Yla-Herttuala S. 2005. Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice. Circulation 112(9):1347-52. [PubMed: 16129816]  [MGI Ref ID J:118230]

Leung VW; Yun S; Botto M; Mason JC; Malik TH; Song W; Paixao-Cavalcante D; Pickering MC; Boyle JJ; Haskard DO. 2009. Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 175(4):1757-67. [PubMed: 19729477]  [MGI Ref ID J:153060]

Li AC; Brown KK; Silvestre MJ; Willson TM; Palinski W; Glass CK. 2000. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 106(4):523-31. [PubMed: 10953027]  [MGI Ref ID J:64040]

Li L; Naples M; Song H; Yuan R; Ye F; Shafi S; Adeli K; Ng DS. 2007. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling. Am J Physiol Endocrinol Metab 293(2):E587-94. [PubMed: 17551001]  [MGI Ref ID J:123371]

Li L; Thompson PA; Kitchens RL. 2008. Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors. J Lipid Res 49(8):1782-93. [PubMed: 18497424]  [MGI Ref ID J:138430]

Li Z; Basterr MJ; Hailemariam TK; Hojjati MR; Lu S; Liu J; Liu R; Zhou H; Jiang XC. 2005. The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis. Biochim Biophys Acta 1735(2):130-4. [PubMed: 15967715]  [MGI Ref ID J:124540]

Lichtman AH; Clinton SK; Iiyama K; Connelly PW; Libby P; Cybulsky MI. 1999. Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol 19(8):1938-44. [PubMed: 10446074]  [MGI Ref ID J:129810]

Lie J; Moerland M; van Gent T; van Haperen R; Scheek L; Sadeghi-Niaraki F; de Crom R; van Tol A. 2006. Sex differences in atherosclerosis in mice with elevated phospholipid transfer protein activity are related to decreased plasma high density lipoproteins and not to increased production of triglycerides. Biochim Biophys Acta 1761(9):1070-7. [PubMed: 16935026]  [MGI Ref ID J:116584]

Lie J; de Crom R; van Gent T; van Haperen R; Scheek L; Sadeghi-Niaraki F; van Tol A. 2004. Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins. J Lipid Res 45(5):805-11. [PubMed: 14993244]  [MGI Ref ID J:89308]

Lieu HD; Withycombe SK; Walker Q; Rong JX; Walzem RL; Wong JS; Hamilton RL; Fisher EA; Young SG. 2003. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107(9):1315-21. [PubMed: 12628954]  [MGI Ref ID J:91722]

Lightle S; Tosheva R; Lee A; Queen-Baker J; Boyanovsky B; Shedlofsky S; Nikolova-Karakashian M. 2003. Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase. Arch Biochem Biophys 419(2):120-8. [PubMed: 14592455]  [MGI Ref ID J:113578]

Lillis AP; Greenlee MC; Mikhailenko I; Pizzo SV; Tenner AJ; Strickland DK; Bohlson SS. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1):364-73. [PubMed: 18566402]  [MGI Ref ID J:137404]

Lim WS; Timmins JM; Seimon TA; Sadler A; Kolodgie FD; Virmani R; Tabas I. 2008. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation 117(7):940-51. [PubMed: 18227389]  [MGI Ref ID J:145081]

Linton MF; Babaev VR; Gleaves LA; Fazio S. 1999. A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation. J Biol Chem 274(27):19204-10. [PubMed: 10383427]  [MGI Ref ID J:56080]

Liu B; Li H; Repa JJ; Turley SD; Dietschy JM. 2008. Genetic variations and treatments that affect the lifespan of the NPC1 mouse. J Lipid Res 49(3):663-9. [PubMed: 18077828]  [MGI Ref ID J:133425]

Liu B; Xie C; Richardson JA; Turley SD; Dietschy JM. 2007. Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease. J Lipid Res 48(8):1710-23. [PubMed: 17476031]  [MGI Ref ID J:123778]

Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. [PubMed: 18160459]  [MGI Ref ID J:133453]

Lo JC; Wang Y; Tumanov AV; Bamji M; Yao Z; Reardon CA; Getz GS; Fu YX. 2007. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316(5822):285-8. [PubMed: 17431181]  [MGI Ref ID J:120962]

Loeffler B; Heeren J; Blaeser M; Radner H; Kayser D; Aydin B; Merkel M. 2007. Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor. J Lipid Res 48(2):288-98. [PubMed: 17090659]  [MGI Ref ID J:118187]

Loeper S; Asa SL; Ezzat S. 2008. Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. Cancer Res 68(10):3715-23. [PubMed: 18483254]  [MGI Ref ID J:135021]

Lowbeer C; Forsberg AM; Tokuno S; Hemdahl AL; Gustafsson SA; Valen G. 2004. Cardiac troponin T content in heart and skeletal muscle and in blood samples from ApoE/LDL receptor double knockout mice. Clin Chim Acta 344(1-2):73-8. [PubMed: 15149873]  [MGI Ref ID J:105262]

Lu H; Boustany-Kari CM; Daugherty A; Cassis LA. 2007. Angiotensin II increases adipose angiotensinogen expression. Am J Physiol Endocrinol Metab 292(5):E1280-7. [PubMed: 17213477]  [MGI Ref ID J:121237]

Lu H; Rateri DL; Feldman DL; Jr RJ; Fukamizu A; Ishida J; Oesterling EG; Cassis LA; Daugherty A. 2008. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest 118(3):984-93. [PubMed: 18274671]  [MGI Ref ID J:135297]

Ludewig B; Jaggi M; Dumrese T; Brduscha-Riem K; Odermatt B; Hengartner H; Zinkernagel RM. 2001. Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses. J Immunol 166(5):3369-76. [PubMed: 11207293]  [MGI Ref ID J:126478]

MacDonald ML; Singaraja RR; Bissada N; Ruddle P; Watts R; Karasinska JM; Gibson WT; Fievet C; Vance JE; Staels B; Hayden MR. 2008. Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. J Lipid Res 49(1):217-29. [PubMed: 17960025]  [MGI Ref ID J:130278]

MacDougall ED; Kramer F; Polinsky P; Barnhart S; Askari B; Johansson F; Varon R; Rosenfeld ME; Oka K; Chan L; Schwartz SM; Bornfeldt KE. 2006. Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice. Am J Pathol 168(6):2064-73. [PubMed: 16723719]  [MGI Ref ID J:109123]

Mach F; Sukhova GK; Michetti M; Libby P; Michetti P. 2002. Influence of Helicobacter pylori infection during atherogenesis in vivo in mice. Circ Res 90(1):E1-4. [PubMed: 11786527]  [MGI Ref ID J:109711]

Major AS; Fazio S; Linton MF. 2002. B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 22(11):1892-8. [PubMed: 12426221]  [MGI Ref ID J:103218]

Mallat Z; Gojova A; Sauzeau V; Brun V; Silvestre JS; Esposito B; Merval R; Groux H; Loirand G; Tedgui A. 2003. Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice. Circ Res 93(9):884-8. [PubMed: 14525807]  [MGI Ref ID J:115653]

Malloy SI; Altenburg MK; Knouff C; Lanningham-Foster L; Parks JS; Maeda N. 2004. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol 24(1):91-7. [PubMed: 12969990]  [MGI Ref ID J:146721]

Marsh MM; Walker VR; Curtiss LK; Banka CL. 1999. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice. J Lipid Res 40(5):893-900. [PubMed: 10224158]  [MGI Ref ID J:54588]

Martins IJ; Hone E; Chi C; Seydel U; Martins RN; Redgrave TG. 2000. Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice. J Lipid Res 41(2):205-13. [PubMed: 10681404]  [MGI Ref ID J:120545]

Masucci-Magoulas L; Goldberg IJ; Bisgaier CL; Serajuddin H; Francone OL ; Breslow JL ; Tall AR. 1997. A mouse model with features of familial combined hyperlipidemia. Science 275(5298):391-4. [PubMed: 8994037]  [MGI Ref ID J:37861]

Masucci-Magoulas L; Plump A; Jiang XC; Walsh A; Breslow JL; Tall AR. 1996. Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels. J Clin Invest 97(1):154-61. [PubMed: 8550828]  [MGI Ref ID J:111394]

Matasconi M; Parini P; Angelin B; Rudling M. 2005. Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. Biochim Biophys Acta 1736(3):221-7. [PubMed: 16185916]  [MGI Ref ID J:102525]

McCaffrey TA; Fu C; Du B; Eksinar S; Kent KC; Bush H Jr; Kreiger K; Rosengart T; Cybulsky MI; Silverman ES; Collins T. 2000. High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis [see comments] J Clin Invest 105(5):653-62. [PubMed: 10712437]  [MGI Ref ID J:60968]

McGillicuddy CJ; Carrier MJ; Weinberg PD. 2001. Distribution of lipid deposits around aortic branches of mice lacking LDL receptors and apolipoprotein E. Arterioscler Thromb Vasc Biol 21(7):1220-5. [PubMed: 11451755]  [MGI Ref ID J:103203]

McMillen TS; Heinecke JW; LeBoeuf RC. 2005. Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation 111(21):2798-804. [PubMed: 15911707]  [MGI Ref ID J:112270]

Mehrabian M; Allayee H; Wong J; Shi W; Wang XP; Shaposhnik Z; Funk CD; Lusis AJ. 2002. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 91(2):120-6. [PubMed: 12142344]  [MGI Ref ID J:109703]

Mehta JL; Sanada N; Hu CP; Chen J; Dandapat A; Sugawara F; Satoh H; Inoue K; Kawase Y; Jishage K; Suzuki H; Takeya M; Schnackenberg L; Beger R; Hermonat PL; Thomas M; Sawamura T. 2007. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res 100(11):1634-42. [PubMed: 17478727]  [MGI Ref ID J:130794]

Merat S; Casanada F; Sutphin M; Palinski W; Reaven PD. 1999. Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet. Arterioscler Thromb Vasc Biol 19(5):1223-30. [PubMed: 10323773]  [MGI Ref ID J:103205]

Merat S; Fruebis J; Sutphin M; Silvestre M; Reaven PD. 2000. Effect of aging on aortic expression of the vascular cell adhesion molecule-1 and atherosclerosis in murine models of atherosclerosis. J Gerontol A Biol Sci Med Sci 55(2):B85-94. [PubMed: 10737683]  [MGI Ref ID J:61164]

Merkel M; Velez-Carrasco W; Hudgins LC; Breslow JL. 2001. Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A 98(23):13294-9. [PubMed: 11606787]  [MGI Ref ID J:72580]

Methia N; Andre P; Denis CV; Economopoulos M; Wagner DD. 2001. Localized reduction of atherosclerosis in von Willebrand factor-deficient mice. Blood 98(5):1424-8. [PubMed: 11520791]  [MGI Ref ID J:106677]

Mihara K; Spansier M; Rooseboom M; Smit MJ; Dokter W. 2007. Functional replacement of murine CXCR2 by its human homologue in the development of atherosclerosis in LDLR knockout mice. Biol Pharm Bull 30(7):1231-6. [PubMed: 17603159]  [MGI Ref ID J:124372]

Millar JS; Maugeais C; Fuki IV; Rader DJ. 2002. Normal production rate of apolipoprotein B in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 22(6):989-94. [PubMed: 12067909]  [MGI Ref ID J:103299]

Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283(10):6449-58. [PubMed: 18175806]  [MGI Ref ID J:133757]

Moerland M; Samyn H; van Gent T; Jauhiainen M; Metso J; van Haperen R; Grosveld F; van Tol A; de Crom R. 2007. Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice. J Lipid Res 48(12):2622-31. [PubMed: 17761633]  [MGI Ref ID J:129970]

Moore RE; Navab M; Millar JS; Zimetti F; Hama S; Rothblat GH; Rader DJ. 2005. Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circ Res 97(8):763-71. [PubMed: 16151025]  [MGI Ref ID J:114636]

Mori N; Horie Y; Nimura Y; Wolf R; Granger DN. 2000. Hepatic microvascular responses to ischemia-reperfusion in low-density lipoprotein receptor knockout mice. Am J Physiol Gastrointest Liver Physiol 279(6):G1257-64. [PubMed: 11093949]  [MGI Ref ID J:108060]

Mortimer BC; Beveridge DJ; Martins IJ; Redgrave TG. 1995. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. J Biol Chem 270(48):28767-76. [PubMed: 7499399]  [MGI Ref ID J:29909]

Mulder M; Jansen PJ; Janssen BJ; van de Berg WD; van der Boom H; Havekes LM; de Kloet RE; Ramaekers FC; Blokland A. 2004. Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiol Dis 16(1):212-9. [PubMed: 15207278]  [MGI Ref ID J:120389]

Mulder M; Koopmans G; Wassink G; Al Mansouri G; Simard ML; Havekes LM; Prickaerts J; Blokland A. 2007. LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus. Neurosci Res 59(3):251-6. [PubMed: 17720268]  [MGI Ref ID J:127270]

Mullick AE; Soldau K; Kiosses WB; Bell TA rd; Tobias PS; Curtiss LK. 2008. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J Exp Med 205(2):373-83. [PubMed: 18250194]  [MGI Ref ID J:131783]

Mullick AE; Tobias PS; Curtiss LK. 2005. Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 115(11):3149-56. [PubMed: 16211093]  [MGI Ref ID J:102502]

Naik SU; Wang X; Da Silva JS; Jaye M; Macphee CH; Reilly MP; Billheimer JT; Rothblat GH; Rader DJ. 2006. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation 113(1):90-7. [PubMed: 16365197]  [MGI Ref ID J:121508]

Nakai Y; Iwabuchi K; Fujii S; Ishimori N; Dashtsoodol N; Watano K; Mishima T; Iwabuchi C; Tanaka S; Bezbradica JS; Nakayama T; Taniguchi M; Miyake S; Yamamura T; Kitabatake A; Joyce S; Van Kaer L; Onoe K. 2004. Natural killer T cells accelerate atherogenesis in mice. Blood 104(7):2051-9. [PubMed: 15113755]  [MGI Ref ID J:93754]

Nakamuta M; Taniguchi S; Ishida BY; Kobayashi K; Chan L. 1998. Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: role of apoB mRNA editing in lipoprotein phenotype expression. Arterioscler Thromb Vasc Biol 18(5):747-55. [PubMed: 9598833]  [MGI Ref ID J:48202]

Nakaya H; Summers BD; Nicholson AC; Gotto AM Jr; Hajjar DP; Han J. 2009. Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone. Am J Pathol 174(6):2007-14. [PubMed: 19435790]  [MGI Ref ID J:148764]

Nassir F; Xie Y; Patterson BW; Luo J; Davidson NO. 2004. Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor. J Lipid Res 45(9):1649-59. [PubMed: 15145984]  [MGI Ref ID J:121192]

Nathan L; Shi W; Dinh H; Mukherjee TK; Wang X; Lusis AJ; Chaudhuri G. 2001. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A 98(6):3589-93. [PubMed: 11248122]  [MGI Ref ID J:80921]

Navab M; Hama-Levy S; Van Lenten BJ; Fonarow GC; Cardinez CJ ; Castellani LW ; Brennan ML ; Lusis AJ ; Fogelman AM ; La Du BN. 1997. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio [published erratum appears in J Clin Invest 1997 Jun 15;99(12):3043] J Clin Invest 99(8):2005-19. [PubMed: 9109446]  [MGI Ref ID J:40285]

Netea MG; Demacker PN; Kullberg BJ; Boerman OC; Verschueren I; Stalenhoef AF; van der Meer JW. 1996. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J Clin Invest 97(6):1366-72. [PubMed: 8617867]  [MGI Ref ID J:31997]

Netea MG; Joosten LA; Keuter M; Wagener F; Stalenhoef AF; van der Meer JW; Kullberg BJ. 2009. Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection. PLoS ONE 4(1):e4237. [PubMed: 19156198]  [MGI Ref ID J:144972]

Ng DS; Xie C; Maguire GF; Zhu X; Ugwu F; Lam E; Connelly PW. 2004. Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance. J Biol Chem 279(9):7636-42. [PubMed: 14668345]  [MGI Ref ID J:89015]

Nofer JR; Bot M; Brodde M; Taylor PJ; Salm P; Brinkmann V; van Berkel T; Assmann G; Biessen EA. 2007. FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 115(4):501-8. [PubMed: 17242282]  [MGI Ref ID J:130151]

Nuotio-Antar AM; Hachey DL; Hasty AH. 2007. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293(6):E1517-28. [PubMed: 17878220]  [MGI Ref ID J:145108]

O'Brien KD; McDonald TO; Kunjathoor V; Eng K; Knopp EA; Lewis K; Lopez R; Kirk EA; Chait A; Wight TN; deBeer FC; LeBoeuf RC. 2005. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 25(4):785-90. [PubMed: 15692094]  [MGI Ref ID J:110024]

Okazaki H; Tazoe F; Okazaki S; Isoo N; Tsukamoto K; Sekiya M; Yahagi N; Iizuka Y; Ohashi K; Kitamine T; Tozawa R; Inaba T; Yagyu H; Okazaki M; Shimano H; Shibata N; Arai H; Nagai RZ; Kadowaki T; Osuga J; Ishibashi S. 2006. Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver. J Lipid Res 47(9):1950-8. [PubMed: 16741291]  [MGI Ref ID J:114485]

Oliveira HC; Cosso RG; Alberici LC; Maciel EN; Salerno AG; Dorighello GG; Velho JA; de Faria EC; Vercesi AE. 2005. Oxidative stress in atherosclerosis-prone mouse is due to low antioxidant capacity of mitochondria. FASEB J 19(2):278-80. [PubMed: 15569776]  [MGI Ref ID J:105088]

Orozco LD; Kapturczak MH; Barajas B; Wang X; Weinstein MM; Wong J; Deshane J; Bolisetty S; Shaposhnik Z; Shih DM; Agarwal A; Lusis AJ; Araujo JA. 2007. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res 100(12):1703-11. [PubMed: 17495224]  [MGI Ref ID J:137771]

Osono Y; Woollett LA; Herz J; Dietschy JM. 1995. Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. J Clin Invest 95(3):1124-32. [PubMed: 7883961]  [MGI Ref ID J:23579]

Osuga J; Yonemoto M; Yamada N; Shimano H; Yagyu H; Ohashi K; Harada K; Kamei T; Yazaki Y; Ishibashi S. 1998. Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E. J Clin Invest 102(2):386-94. [PubMed: 9664080]  [MGI Ref ID J:115142]

Out R; Hoekstra M; Habets K; Meurs I; de Waard V; Hildebrand RB; Wang Y; Chimini G; Kuiper J; Van Berkel TJ; Van Eck M. 2008. Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels. Arterioscler Thromb Vasc Biol 28(2):258-64. [PubMed: 18006857]  [MGI Ref ID J:147678]

Out R; Hoekstra M; Hildebrand RB; Kruit JK; Meurs I; Li Z; Kuipers F; Van Berkel TJ; Van Eck M. 2006. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2295-300. [PubMed: 16857950]  [MGI Ref ID J:128052]

Overton CD; Yancey PG; Major AS; Linton MF; Fazio S. 2007. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 100(5):670-7. [PubMed: 17303763]  [MGI Ref ID J:133698]

Paim BA; Velho JA; Castilho RF; Oliveira HC; Vercesi AE. 2008. Oxidative stress in hypercholesterolemic LDL (low-density lipoprotein) receptor knockout mice is associated with low content of mitochondrial NADP-linked substrates and is partially reversed by citrate replacement. Free Radic Biol Med 44(3):444-51. [PubMed: 17991444]  [MGI Ref ID J:130348]

Pan JH; Sukhova GK; Yang JT; Wang B; Xie T; Fu H; Zhang Y; Satoskar AR; David JR; Metz CN; Bucala R; Fang K; Simon DI; Chapman HA; Libby P; Shi GP. 2004. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 109(25):3149-53. [PubMed: 15197138]  [MGI Ref ID J:102201]

Parks BW; Gambill GP; Lusis AJ; Kabarowski JH. 2005. Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice. J Lipid Res 46(7):1405-15. [PubMed: 15834123]  [MGI Ref ID J:100498]

Parks BW; Lusis AJ; Kabarowski JH. 2006. Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 26(12):2703-9. [PubMed: 16990555]  [MGI Ref ID J:128044]

Persson L; Boren J; Nicoletti A; Hansson GK; Pekna M. 2005. Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement system. Clin Exp Immunol 142(3):441-5. [PubMed: 16297155]  [MGI Ref ID J:107602]

Persson L; Boren J; Robertson AK; Wallenius V; Hansson GK; Pekna M. 2004. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 24(6):1062-7. [PubMed: 15059809]  [MGI Ref ID J:102339]

Plat J; Beugels I; Gijbels MJ; de Winther MP; Mensink RP. 2006. Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols. J Lipid Res 47(12):2762-71. [PubMed: 16957178]  [MGI Ref ID J:117204]

Plump AS; Masucci-Magoulas L; Bruce C; Bisgaier CL; Breslow JL; Tall AR. 1999. Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler Thromb Vasc Biol 19(4):1105-10. [PubMed: 10195942]  [MGI Ref ID J:55980]

Podrez EA; Byzova TV; Febbraio M; Salomon RG; Ma Y; Valiyaveettil M; Poliakov E; Sun M; Finton PJ; Curtis BR; Chen J; Zhang R; Silverstein RL; Hazen SL. 2007. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 13(9):1086-95. [PubMed: 17721545]  [MGI Ref ID J:125153]

Potteaux S; Esposito B; van Oostrom O; Brun V; Ardouin P; Groux H; Tedgui A; Mallat Z. 2004. Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 24(8):1474-8. [PubMed: 15178562]  [MGI Ref ID J:102225]

Powell-Braxton L; Veniant M; Latvala RD; Hirano KI; Won WB; Ross J; Dybdal N; Zlot CH; Young SG; Davidson NO. 1998. A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet [see comments] Nat Med 4(8):934-8. [PubMed: 9701246]  [MGI Ref ID J:49125]

Pratico D; Cyrus T; Li H; FitzGerald GA. 2000. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis Blood 96(12):3823-6. [PubMed: 11090066]  [MGI Ref ID J:66258]

Pratico D; Rokach J; Tangirala RK. 1999. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. J Neurochem 73(2):736-41. [PubMed: 10428071]  [MGI Ref ID J:111985]

Pratico D; Tillmann C; Zhang ZB; Li H; FitzGerald GA. 2001. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc Natl Acad Sci U S A 98(6):3358-63. [PubMed: 11248083]  [MGI Ref ID J:68091]

Qian YW; Schmidt RJ; Zhang Y; Chu S; Lin A; Wang H; Wang X; Beyer TP; Bensch WR; Li W; Ehsani ME; Lu D; Konrad RJ; Eacho PI; Moller DE; Karathanasis SK; Cao G. 2007. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res 48(7):1488-98. [PubMed: 17449864]  [MGI Ref ID J:122491]

Qiu H; Gabrielsen A; Agardh HE; Wan M; Wetterholm A; Wong CH; Hedin U; Swedenborg J; Hansson GK; Samuelsson B; Paulsson-Berne G; Haeggstrom JZ. 2006. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci U S A 103(21):8161-6. [PubMed: 16698924]  [MGI Ref ID J:110208]

Quan G; Xie C; Dietschy JM; Turley SD. 2003. Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse. Brain Res Dev Brain Res 146(1-2):87-98. [PubMed: 14643015]  [MGI Ref ID J:86935]

Raikwar NS; Cho WK; Bowen RF; Deeg MA. 2006. Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism. Am J Physiol Endocrinol Metab 290(3):E463-70. [PubMed: 16219662]  [MGI Ref ID J:106052]

Rashid S; Curtis DE; Garuti R; Anderson NN; Bashmakov Y; Ho YK; Hammer RE; Moon YA; Horton JD. 2005. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A 102(15):5374-9. [PubMed: 15805190]  [MGI Ref ID J:97836]

Ratliff EP; Gutierrez A; Davis RA. 2006. Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia. J Lipid Res 47(7):1513-20. [PubMed: 16609145]  [MGI Ref ID J:112052]

Recinos A rd; Carr BK; Bartos DB; Boldogh I; Carmical JR; Belalcazar LM; Brasier AR. 2004. Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiol Genomics 19(1):131-42. [PubMed: 15238619]  [MGI Ref ID J:106239]

Reddy ST; Nguyen JT; Grijalva V; Hough G; Hama S; Navab M; Fogelman AM. 2004. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Arterioscler Thromb Vasc Biol 24(9):1676-81. [PubMed: 15242861]  [MGI Ref ID J:102220]

Reiterer G; MacDonald R; Browning JD; Morrow J; Matveev SV; Daugherty A; Smart E; Toborek M; Hennig B. 2005. Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. J Nutr 135(9):2114-8. [PubMed: 16140885]  [MGI Ref ID J:106652]

Renard CB; Kramer F; Johansson F; Lamharzi N; Tannock LR; von Herrath MG; Chait A; Bornfeldt KE. 2004. Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest 114(5):659-68. [PubMed: 15343384]  [MGI Ref ID J:92597]

Repa JJ; Li H; Frank-Cannon TC; Valasek MA; Turley SD; Tansey MG; Dietschy JM. 2007. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci 27(52):14470-80. [PubMed: 18160655]  [MGI Ref ID J:130969]

Repa JJ; Turley SD; Quan G; Dietschy JM. 2005. Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption. J Lipid Res 46(4):779-89. [PubMed: 15654122]  [MGI Ref ID J:98574]

Rogers L; Burchat S; Gage J; Hasu M; Thabet M; Wilcox L; Ramsamy TA; Whitman SC. 2008. Deficiency of invariant V alpha 14 natural killer T cells decreases atherosclerosis in LDL receptor null mice. Cardiovasc Res 78(1):167-74. [PubMed: 18192239]  [MGI Ref ID J:140276]

Romeo GR; Moulton KS; Kazlauskas A. 2007. Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res 101(4):357-67. [PubMed: 17615372]  [MGI Ref ID J:140294]

Roselaar SE; Kakkanathu PX; Daugherty A. 1996. Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice. Decreasing density with disease progression. Arterioscler Thromb Vasc Biol 16(8):1013-8. [PubMed: 8696940]  [MGI Ref ID J:111962]

Rudling M; Angelin B. 2001. Growth hormone reduces plasma cholesterol in LDL receptor-deficient mice. FASEB J 15(8):1350-6. [PubMed: 11387232]  [MGI Ref ID J:120519]

Rudolf M; Winkler B; Aherrahou Z; Doehring LC; Kaczmarek P; Schmidt-Erfurth U. 2005. Increased expression of vascular endothelial growth factor associated with accumulation of lipids in Bruch's membrane of LDL receptor knockout mice. Br J Ophthalmol 89(12):1627-30. [PubMed: 16299144]  [MGI Ref ID J:116908]

Samyn H; Moerland M; van Gent T; van Haperen R; Metso J; Grosveld F; Jauhiainen M; van Tol A; de Crom R. 2008. Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study. J Lipid Res 49(12):2504-12. [PubMed: 18711210]  [MGI Ref ID J:142969]

Sanan DA; Newland DL; Tao R; Marcovina S; Wang J; Mooser V; Hammer RE; Hobbs HH. 1998. Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a). Proc Natl Acad Sci U S A 95(8):4544-9. [PubMed: 9539774]  [MGI Ref ID J:47464]

Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354]  [MGI Ref ID J:91367]

Schiller NK; Boisvert WA; Curtiss LK. 2002. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations. Arterioscler Thromb Vasc Biol 22(8):1341-6. [PubMed: 12171798]  [MGI Ref ID J:103214]

Schmidt-Erfurth U; Rudolf M; Funk M; Hofmann-Rummelt C; Franz-Haas NS; Aherrahrou Z; Schlotzer-Schrehardt U. 2008. Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection. Invest Ophthalmol Vis Sci 49(1):390-8. [PubMed: 18172117]  [MGI Ref ID J:132498]

Schneider F; Sukhova GK; Aikawa M; Canner J; Gerdes N; Tang SM; Shi GP; Apte SS; Libby P. 2008. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation 117(7):931-9. [PubMed: 18250269]  [MGI Ref ID J:145079]

Schneider JG; Finck BN; Ren J; Standley KN; Takagi M; Maclean KH; Bernal-Mizrachi C; Muslin AJ; Kastan MB; Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 4(5):377-89. [PubMed: 17084711]  [MGI Ref ID J:129761]

Schonbeck U; Sukhova GK; Shimizu K; Mach F; Libby P. 2000. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice [see comments] Proc Natl Acad Sci U S A 97(13):7458-63. [PubMed: 10861012]  [MGI Ref ID J:63076]

Schreyer SA; Vick C; Lystig TC; Mystkowski P; LeBoeuf RC. 2002. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab 282(1):E207-14. [PubMed: 11739102]  [MGI Ref ID J:75609]

Sehayek E; Ono JG; Duncan EM; Batta AK; Salen G; Shefer S; Neguyen LB; Yang K; Lipkin M; Breslow JL. 2001. Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice. J Lipid Res 42(8):1250-6. [PubMed: 11483626]  [MGI Ref ID J:70721]

Sekiya M; Osuga J; Nagashima S; Ohshiro T; Igarashi M; Okazaki H; Takahashi M; Tazoe F; Wada T; Ohta K; Takanashi M; Kumagai M; Nishi M; Takase S; Yahagi N; Yagyu H; Ohashi K; Nagai R; Kadowaki T; Furukawa Y; Ishibashi S. 2009. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab 10(3):219-28. [PubMed: 19723498]  [MGI Ref ID J:152385]

Semenkovich CF; Coleman T; Daugherty A. 1998. Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. J Lipid Res 39(6):1141-51. [PubMed: 9643345]  [MGI Ref ID J:48030]

Senokuchi T; Liang CP; Seimon TA; Han S; Matsumoto M; Banks AS; Paik JH; DePinho RA; Accili D; Tabas I; Tall AR. 2008. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 57(11):2967-76. [PubMed: 18728232]  [MGI Ref ID J:142468]

Shaposhnik Z; Wang X; Weinstein M; Bennett BJ; Lusis AJ. 2007. Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 27(3):621-7. [PubMed: 17158354]  [MGI Ref ID J:130538]

Sharabi Y; Grossman E; Sherer Y; Shaish A; Levkovitz H; Bitzur R; Harats D. 2000. The effect of renin-angiotensin axis inhibition on early atherogenesis in LDL-receptor-deficient mice. Pathobiology 68(6):270-4. [PubMed: 11493760]  [MGI Ref ID J:71167]

Sherer Y; Shoenfeld Y; Shaish A; Levkovitz H; Bitzur R; Harats D. 2000. Suppression of atherogenesis in female low-density lipoprotein receptor knockout mice following magnesium fortification of drinking water: the importance of diet. Pathobiology 68(2):93-8. [PubMed: 10878506]  [MGI Ref ID J:63520]

Shi W; Wang X; Wong J; Hedrick CC; Wong H; Castellani LW; Lusis AJ. 2004. Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice. Biochem Biophys Res Commun 317(1):223-9. [PubMed: 15047172]  [MGI Ref ID J:88891]

Shih DM; Xia YR; Wang XP; Wang SS; Bourquard N; Fogelman AM; Lusis AJ; Reddy ST. 2007. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res 100(8):1200-7. [PubMed: 17379834]  [MGI Ref ID J:135375]

Shimada M; Ishibashi S; Inaba T; Yagyu H; Harada K; Osuga JI; Ohashi K; Yazaki Y; Yamada N. 1996. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci U S A 93(14):7242-6. [PubMed: 8692976]  [MGI Ref ID J:34082]

Singh U; Zhong S; Xiong M; Li TB; Sniderman A; Teng BB. 2004. Increased plasma non-esterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice. Clin Sci (Lond) 106(4):421-32. [PubMed: 14717654]  [MGI Ref ID J:105456]

Sjoland H; Eitzman DT; Gordon D; Westrick R; Nabel EG; Ginsburg D. 2000. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 20(3):846-52. [PubMed: 10712412]  [MGI Ref ID J:61287]

Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J. 2008. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3(11):e3771. [PubMed: 19020660]  [MGI Ref ID J:143905]

Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455]  [MGI Ref ID J:136835]

Solca C; Pandit B; Yu H; Tint GS; Patel SB. 2007. Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. Mol Genet Metab 91(1):7-14. [PubMed: 17197219]  [MGI Ref ID J:121454]

Sommerville LJ; Kelemen SE; Autieri MV. 2008. Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice. Arterioscler Thromb Vasc Biol 28(1):47-53. [PubMed: 17991871]  [MGI Ref ID J:147519]

Song H; Zhu L; Picardo CM; Maguire G; Leung V; Connelly PW; Ng DS. 2006. Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism. Am J Physiol Endocrinol Metab 290(1):E17-E25. [PubMed: 16105858]  [MGI Ref ID J:104219]

Song L; Leung C; Schindler C. 2001. Lymphocytes are important in early atherosclerosis. J Clin Invest 108(2):251-9. [PubMed: 11457878]  [MGI Ref ID J:118405]

Spady DK; Cuthbert JA; Willard MN; Meidell RS. 1998. Overexpression of cholesterol 7alpha-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. LDL transport and plasma LDL concentrations are reduced. J Biol Chem 273(1):126-32. [PubMed: 9417056]  [MGI Ref ID J:45043]

Stanic AK; Stein CM; Morgan AC; Fazio S; Linton MF; Wakeland EK; Olsen NJ; Major AS. 2006. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A 103(18):7018-23. [PubMed: 16636270]  [MGI Ref ID J:109461]

Staprans I; Pan XM; Rapp JH; Grunfeld C; Feingold KR. 2000. Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(3):708-14. [PubMed: 10712395]  [MGI Ref ID J:103278]

Steffens S; Burger F; Pelli G; Dean Y; Elson G; Kosco-Vilbois M; Chatenoud L; Mach F. 2006. Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation 114(18):1977-84. [PubMed: 17043169]  [MGI Ref ID J:127202]

Stein CS; Martins I; Davidson BL. 2000. Long-term reversal of hypercholesterolemia in low density lipoprotein receptor (LDLR)-deficient mice by adenovirus-mediated LDLR gene transfer combined with CD154 blockade J Gene Med 2(1):41-51. [PubMed: 10765504]  [MGI Ref ID J:62368]

Strom A; Olin AI; Aspberg A; Hultgardh-Nilsson A. 2006. Fibulin-2 is present in murine vascular lesions and is important for smooth muscle cell migration. Cardiovasc Res 69(3):755-63. [PubMed: 16409997]  [MGI Ref ID J:105710]

Subramanian S; Han CY; Chiba T; McMillen TS; Wang SA; Haw A rd; Kirk EA; O'Brien KD; Chait A. 2008. Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 28(4):685-91. [PubMed: 18239153]  [MGI Ref ID J:149038]

Sugiyama E; Tanaka N; Nakajima T; Kamijo Y; Yokoyama S; Li Y; Gonzalez FJ; Aoyama T. 2006. Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia. Biochem Biophys Res Commun 350(2):370-6. [PubMed: 17011521]  [MGI Ref ID J:116049]

Sukhova GK; Zhang Y; Pan JH; Wada Y; Yamamoto T; Naito M; Kodama T; Tsimikas S; Witztum JL; Lu ML; Sakara Y; Chin MT; Libby P; Shi GP. 2003. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest 111(6):897-906. [PubMed: 12639996]  [MGI Ref ID J:82520]

Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. [PubMed: 17546038]  [MGI Ref ID J:125116]

Surmi BK; Atkinson RD; Gruen ML; Coenen KR; Hasty AH. 2008. The role of macrophage leptin receptor in aortic root lesion formation. Am J Physiol Endocrinol Metab 294(3):E488-95. [PubMed: 18182468]  [MGI Ref ID J:133462]

Tacken PJ; Teusink B; Jong MC; Harats D; Havekes LM; van Dijk KW; Hofker MH. 2000. LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice J Lipid Res 41(12):2055-62. [PubMed: 11108739]  [MGI Ref ID J:66431]

Takata Y; Liu J; Yin F; Collins AR; Lyon CJ; Lee CH; Atkins AR; Downes M; Barish GD; Evans RM; Hsueh WA; Tangirala RK. 2008. PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci U S A 105(11):4277-82. [PubMed: 18337495]  [MGI Ref ID J:133474]

Taleb S; Herbin O; Ait-Oufella H; Verreth W; Gourdy P; Barateau V; Merval R; Esposito B; Clement K; Holvoet P; Tedgui A; Mallat Z. 2007. Defective leptin/leptin receptor signaling impr