Strain Name:

B6.129P2-Il4tm1Cgn/J

Stock Number:

002253

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Availability:

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Mice homozygous for the Il4tm1Cgn knock-out have a reduced ability to produce Th2-derived cytokines.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129P2 via E14TG2a ES cell line
GenerationN12F46 (11-DEC-13)
Generation Definitions

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the Il4tm1Cgn targeted mutation are viable and fertile. T and B cell development is normal but IgGl and IgE levels and the ability of homozygous mutant mice to produce Th2-derived cytokines are significantly reduced.

Development
A targeting vector containing neomycin resistance and Herpes simplex virus thymidine kinase genes was used to disrupt Il4 exon 1. The construct was electroporated into 129P2/OlaHsd-derived E14-1 embryonic stem cells. The donating investigator reports that correctly targeted ES cells were injected into C57BL/6 blastocysts and the resulting chimeric animals were crossed to C57BL/6 mice (see SNP note below).

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be C57BL/6N. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il4tm1Cgn allele
005879   D1Lac.Cg-Il4tm1Cgn/J
002574   NOD.129P2(B6)-Il4tm1Cgn/Dvs
004222   NOD.129P2(B6)-Il4tm1Cgn/DvsJ
004291   NOD.Cg-Il10tm1Cgn Il4tm1Cgn/DvsJ
View Strains carrying   Il4tm1Cgn     (4 strains)

Strains carrying other alleles of Il4
002496   BALB/c-Il4tm2Nnt/J
004190   C.129-Il4tm1Lky/J
015859   C.129P2(Cg)-Il4/Il13tm1.1Lky/J
003480   C.129S2(B6)-Il4tm1Gru/J
002518   C57BL/6-Il4tm1Nnt/J
002230   C57BL/6J-Tg(LckIl4)1315Dbl/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
View Strains carrying other alleles of Il4     (7 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il4tm1Cgn/Il4tm1Cgn

        B6.129P2-Il4tm1Cgn/J
  • immune system phenotype
  • *normal* immune system phenotype
    • dendritic function is normal   (MGI Ref ID J:160119)
    • survival time of cardiac allografts (BALB/c origin) is similar to wild-type mice, unlike in Ifng or Il10 null mice   (MGI Ref ID J:44346)
  • integument phenotype
  • abnormal skin physiology
    • despite normal dendritic function, mice whose backs are shaved and painted with Alexa 647-labeled ovalbumin accumulate fewer Alexa647+CD11c+ cells in draining lymph nodes compared with similarly treated wild-type mice indicating increased barrier function   (MGI Ref ID J:160119)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Il4tm1Cgn/Il4tm1Cgn

        B6.Cg-Il4tm1Cgn
  • immune system phenotype
  • abnormal T-helper 2 physiology
    • homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization   (MGI Ref ID J:89095)
    • eosinophil infiltration is impaired in response to schistosome egg immunization   (MGI Ref ID J:89095)
  • abnormal humoral immune response
    • IgG1 response to immunization with the protein antigen OVA is severely impaired   (MGI Ref ID J:89095)
  • hematopoietic system phenotype
  • abnormal T-helper 2 physiology
    • homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization   (MGI Ref ID J:89095)
    • eosinophil infiltration is impaired in response to schistosome egg immunization   (MGI Ref ID J:89095)

Il4tm1Cgn/Il4tm1Cgn

        involves: 129P2/OlaHsd * NOD
  • immune system phenotype
  • abnormal cytokine secretion
    • CD4+ T cells from deficient animals show a strongly reduced ability to produce Il5 after anti-TCR stimulation compared to wild-type cells   (MGI Ref ID J:85924)
  • decreased IgG1 level
    • CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization   (MGI Ref ID J:85924)
  • hematopoietic system phenotype
  • decreased IgG1 level
    • CD4+ T cells from deficient animals show a reduction in circulating IgG1 in the absence of deliberate immunization   (MGI Ref ID J:85924)

Il4tm1Cgn/Il4tm1Cgn

        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • abnormal cytokine secretion
    • conA stimulated spleen cells from homozygotes secrete ~800-fold less Il4 than control cells   (MGI Ref ID J:704)
  • decreased IgE level
    • there were no dectectable levels of IgE in 5 of 6 mice compared to controls, which all had dectectable levels   (MGI Ref ID J:704)
    • after infection with a nematode, 6-week old animals have almost undetectable IgE levels compared to controls which show about 50-fold increase in levels after infection   (MGI Ref ID J:704)
  • decreased IgG1 level
    • homozygotes have about 1/6 the level of IgG1 of wild-type at 6 weeks   (MGI Ref ID J:704)
    • in response to immunization with chicken globulin, antibodies produced by mutants are ~40-50% IgG1, while wild-type mice produce >95% IgG1-specific antibodies   (MGI Ref ID J:704)
  • granulomatous inflammation
    • upon infection with Schistosoma mansoni eggs, primary granuloma formation and volume is equivalent to wild-type   (MGI Ref ID J:113543)
    • volumes of secondary granulomas after second exposure with parasite eggs are reduced by ~50% compared to wild-type   (MGI Ref ID J:113543)
  • hematopoietic system phenotype
  • decreased IgE level
    • there were no dectectable levels of IgE in 5 of 6 mice compared to controls, which all had dectectable levels   (MGI Ref ID J:704)
    • after infection with a nematode, 6-week old animals have almost undetectable IgE levels compared to controls which show about 50-fold increase in levels after infection   (MGI Ref ID J:704)
  • decreased IgG1 level
    • homozygotes have about 1/6 the level of IgG1 of wild-type at 6 weeks   (MGI Ref ID J:704)
    • in response to immunization with chicken globulin, antibodies produced by mutants are ~40-50% IgG1, while wild-type mice produce >95% IgG1-specific antibodies   (MGI Ref ID J:704)

Il4tm1Cgn/Il4tm1Cgn

        MRL.129P2-Il4tm1Cgn
  • immune system phenotype
  • lacrimal gland inflammation
    • dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells   (MGI Ref ID J:132514)
    • predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 12% of infiltrate   (MGI Ref ID J:132514)
    • B cells are more abundant in infiltrates (30%) than in MRL.Cg- Il4tm1Cgn Faslpr mice   (MGI Ref ID J:132514)
  • vision/eye phenotype
  • lacrimal gland inflammation
    • dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells   (MGI Ref ID J:132514)
    • predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 12% of infiltrate   (MGI Ref ID J:132514)
    • B cells are more abundant in infiltrates (30%) than in MRL.Cg- Il4tm1Cgn Faslpr mice   (MGI Ref ID J:132514)
  • endocrine/exocrine gland phenotype
  • lacrimal gland inflammation
    • dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells   (MGI Ref ID J:132514)
    • predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 12% of infiltrate   (MGI Ref ID J:132514)
    • B cells are more abundant in infiltrates (30%) than in MRL.Cg- Il4tm1Cgn Faslpr mice   (MGI Ref ID J:132514)

Il4tm1Cgn/Il4tm1Cgn

        involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp
  • immune system phenotype
  • decreased IgE level
    • at 3 months of age relative to wild-type controls   (MGI Ref ID J:39600)
  • decreased IgG1 level
    • at 3 and 7-8 months of age relative to wild-type controls   (MGI Ref ID J:39600)
  • hematopoietic system phenotype
  • decreased IgE level
    • at 3 months of age relative to wild-type controls   (MGI Ref ID J:39600)
  • decreased IgG1 level
    • at 3 and 7-8 months of age relative to wild-type controls   (MGI Ref ID J:39600)

Il4tm1Cgn/Il4tm1Cgn

        involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss
  • homeostasis/metabolism phenotype
  • abnormal physiological response to xenobiotic
    • abnormal IgG responses to HgCL2 exposure   (MGI Ref ID J:119207)
    • however, mercury induced increases in autoantibodies are similar to controls   (MGI Ref ID J:119207)
  • immune system phenotype
  • decreased IgG1 level
    • following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice   (MGI Ref ID J:119207)
  • increased IgG2a level
    • following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice   (MGI Ref ID J:119207)
  • hematopoietic system phenotype
  • decreased IgG1 level
    • following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice   (MGI Ref ID J:119207)
  • increased IgG2a level
    • following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice   (MGI Ref ID J:119207)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Il4tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il4tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (knock-out)
Common Name(s) IL-4 KO; IL-4-; IL-4KO; IL-4T-; IL4-; IL4tm1cgn129; IL4T;
Mutation Made ByDr. Ralf Kuhn,   University of Cologne
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Il4, interleukin 4
Chromosome 11
Gene Common Name(s) BCGF-1; BCGF1; BSF-1; BSF1; IL-4; Il-4; Il4e12;
Molecular Note A translational stop codon and a neomycin resistance gene were inserted into the first exon of the gene. [MGI Ref ID J:704]

Genotyping

Genotyping Information

Genotyping Protocols

Il4tm1Cgn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Kuhn R; Rajewsky K; Muller W. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254(5032):707-10. [PubMed: 1948049]  [MGI Ref ID J:704]

Additional References

Dohi T; Fujihashi K; Kiyono H; Elson CO; McGhee JR. 2000. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119(3):724-33. [PubMed: 10982767]  [MGI Ref ID J:64230]

Hadeiba H; Corry DB; Locksley RM. 2000. Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system. J Immunol 164(9):4933-40. [PubMed: 10779804]  [MGI Ref ID J:61706]

Hayakawa Y; Berzins SP; Crowe NY; Godfrey DI; Smyth MJ. 2004. Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors. (Retraction Nature Immunol 2006;7:890) Nat Immunol 5(6):590-6. [PubMed: 15122252]  [MGI Ref ID J:90639]

Jaruga B; Hong F; Sun R; Radaeva S; Gao B. 2003. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 171(6):3233-44. [PubMed: 12960353]  [MGI Ref ID J:85386]

Le Moine A; Flamand V; de Lavareille A; Paulart F; Buonocore S; Vanderhaeghen ML; Nagy N; Habran C; Kiss R; Abramowicz D; Goldman M. 2002. Hypereosinophilic syndrome induced by neonatal immunization against MHC class II alloantigen: critical role of IL-4. Eur J Immunol 32(1):174-81. [PubMed: 11754358]  [MGI Ref ID J:73934]

Metwali A; Blum AM; Li J; Elliott DE; Weinstock JV. 2000. IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis. FASEB J 14(7):948-54. [PubMed: 10783149]  [MGI Ref ID J:61805]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Turner J; Frank AA; Brooks JV; Gonzalez-Juarrero M; Orme IM. 2001. The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4. Exp Gerontol 36(3):537-45. [PubMed: 11250124]  [MGI Ref ID J:68120]

Il4tm1Cgn related

Aguirre SA; Perryman LE; Davis WC; McGuire TC. 1998. IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: analysis of CD4+alpha beta+IFN-gamma+ and CD4+alpha beta+IL-4+ lymphocytes in gut-associated lymphoid tissue during resolution of infection. J Immunol 161(4):1891-900. [PubMed: 9712058]  [MGI Ref ID J:49699]

Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712]  [MGI Ref ID J:115475]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669]  [MGI Ref ID J:91913]

Babayan SA; Read AF; Lawrence RA; Bain O; Allen JE. 2010. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy. PLoS Biol 8(10):e1000525. [PubMed: 20976099]  [MGI Ref ID J:167364]

Bachmann MF; Schorle H; Kuhn R; Muller W; Hengartner H; Zinkernagel RM; Horak I. 1995. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J Virol 69(8):4842-6. [PubMed: 7609051]  [MGI Ref ID J:26861]

Bagley J; Sawada T; Wu Y; Iacomini J. 2000. A critical role for interleukin 4 in activating alloreactive CD4 T cells. Nat Immunol 1(3):257-61. [PubMed: 10973285]  [MGI Ref ID J:118019]

Bancroft AJ; Artis D; Donaldson DD; Sypek JP; Grencis RK. 2000. Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent. Eur J Immunol 30(7):2083-91. [PubMed: 10940898]  [MGI Ref ID J:63513]

Bancroft AJ; McKenzie AN; Grencis RK. 1998. A critical role for IL-13 in resistance to intestinal nematode infection. J Immunol 160(7):3453-61. [PubMed: 9531306]  [MGI Ref ID J:111618]

Beal AM; Ramos-Hernandez N; Riling CR; Nowelsky EA; Oliver PM. 2011. TGF-beta induces the expression of the adaptor Ndfip1 to silence IL-4 production during iT(reg) cell differentiation. Nat Immunol 13(1):77-85. [PubMed: 22080920]  [MGI Ref ID J:179003]

Bediako Y; Bian Y; Zhang H; Cho H; Stein PL; Wang CR. 2012. SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells. J Immunol 189(10):4787-96. [PubMed: 23041566]  [MGI Ref ID J:190592]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Belghith M; Bluestone JA; Barriot S; Megret J; Bach JF; Chatenoud L. 2003. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9(9):1202-8. [PubMed: 12937416]  [MGI Ref ID J:85362]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756]  [MGI Ref ID J:118003]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826]  [MGI Ref ID J:26221]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845]  [MGI Ref ID J:115204]

Bezbradica JS; Gordy LE; Stanic AK; Dragovic S; Hill T; Hawiger J; Unutmaz D; Van Kaer L; Joyce S. 2006. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity 25(3):487-97. [PubMed: 16949316]  [MGI Ref ID J:113451]

Blackstock R; Murphy JW. 2004. Role of interleukin-4 in resistance to Cryptococcus neoformans infection. Am J Respir Cell Mol Biol 30(1):109-17. [PubMed: 12855407]  [MGI Ref ID J:95350]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Brayer JB; Cha S; Nagashima H; Yasunari U; Lindberg A; Diggs S; Martinez J; Goa J; Humphreys-Beher MG; Peck AB. 2001. IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjogren's syndrome. Scand J Immunol 54(1-2):133-40. [PubMed: 11439159]  [MGI Ref ID J:103875]

Briesemeister D; Friese C; Isern CC; Dietz E; Blankenstein T; Thoene-Reineke C; Kammertoens T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine 60(3):626-33. [PubMed: 22902947]  [MGI Ref ID J:192770]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Cole N; Hume EB; Khan S; Garthwaite L; Schubert T; Reeve V; Willcox MD. 2007. The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4. Immunol Cell Biol 85(4):333-7. [PubMed: 17389870]  [MGI Ref ID J:122715]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Cunningham AF; Fallon PG; Khan M; Vacheron S; Acha-Orbea H; MacLennan IC; McKenzie AN; Toellner KM. 2002. Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. J Immunol 169(6):2900-6. [PubMed: 12218103]  [MGI Ref ID J:120432]

D'Orazio TJ; Niederkorn JY. 1998. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160(5):2089-98. [PubMed: 9498745]  [MGI Ref ID J:111362]

Denzel A; Maus UA; Rodriguez Gomez M; Moll C; Niedermeier M; Winter C; Maus R; Hollingshead S; Briles DE; Kunz-Schughart LA; Talke Y; Mack M. 2008. Basophils enhance immunological memory responses. Nat Immunol 9(7):733-42. [PubMed: 18516038]  [MGI Ref ID J:137679]

Derecki NC; Cardani AN; Yang CH; Quinnies KM; Crihfield A; Lynch KR; Kipnis J. 2010. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207(5):1067-80. [PubMed: 20439540]  [MGI Ref ID J:160932]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Dieli F; Sireci G; Scire E; Salerno A; Bellavia A. 1999. Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice. Immunology 98(1):71-9. [PubMed: 10469236]  [MGI Ref ID J:110461]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Emson CL; Bell SE; Jones A; Wisden W; McKenzie AN. 1998. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J Exp Med 188(2):399-404. [PubMed: 9670052]  [MGI Ref ID J:112473]

Everest P; Allen J; Papakonstantinopoulou A; Mastroeni P; Roberts M ; Dougan G. 1997. Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathology. J Immunol 159(4):1820-7. [PubMed: 9257845]  [MGI Ref ID J:42104]

Fallon PG; Ballantyne SJ; Mangan NE; Barlow JL; Dasvarma A; Hewett DR; McIlgorm A; Jolin HE; McKenzie AN. 2006. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med 203(4):1105-16. [PubMed: 16606668]  [MGI Ref ID J:123748]

Fallon PG; Emson CL; Smith P; McKenzie AN. 2001. IL-13 overexpression predisposes to anaphylaxis following antigen sensitization. J Immunol 166(4):2712-6. [PubMed: 11160336]  [MGI Ref ID J:135014]

Fallon PG; Jolin HE; Smith P; Emson CL; Townsend MJ; Fallon R; Smith P; McKenzie AN. 2002. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17(1):7-17. [PubMed: 12150887]  [MGI Ref ID J:113543]

Fang M; Xie H; Dougan SK; Ploegh H; van Oudenaarden A. 2013. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol 11(7):e1001618. [PubMed: 23935453]  [MGI Ref ID J:201603]

Fousteri G; Dave A; Bot A; Juntti T; Omid S; von Herrath M. 2010. Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia 53(9):1958-70. [PubMed: 20490452]  [MGI Ref ID J:163357]

French AR; Sjolin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Karre K; Yokoyama WM. 2006. DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol 177(8):4981-90. [PubMed: 17015680]  [MGI Ref ID J:139300]

Gao J; Killedar S; Cornelius JG; Nguyen C; Cha S; Peck AB. 2006. Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun 26(2):90-103. [PubMed: 16413168]  [MGI Ref ID J:105803]

Gocheva V; Wang HW; Gadea BB; Shree T; Hunter KE; Garfall AL; Berman T; Joyce JA. 2010. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24(3):241-55. [PubMed: 20080943]  [MGI Ref ID J:156936]

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Shreiner AB; Murdock BJ; Sadighi Akha AA; Falkowski NR; Christensen PJ; White ES; Hogaboam CM; Huffnagle GB. 2012. Repeated Exposure to Aspergillus fumigatus Conidia Results in CD4+ T Cell-Dependent and -Independent Pulmonary Arterial Remodeling in a Mixed Th1/Th2/Th17 Microenvironment That Requires Interleukin-4 (IL-4) and IL-10. Infect Immun 80(1):388-97. [PubMed: 22064716]  [MGI Ref ID J:179004]

Sirak JH; Orosz CG; Roopenian DC; Wakely E; VanBuskirk AM. 1998. Cardiac allograft tolerance: failure to develop in interleukin-4-deficient mice correlates with unusual allosensitization patterns. Transplantation 65(10):1352-6. [PubMed: 9625018]  [MGI Ref ID J:47988]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye. Immunology 110(1):18-29. [PubMed: 12941137]  [MGI Ref ID J:113598]

Smith P; Mangan NE; Walsh CM; Fallon RE; McKenzie AN; van Rooijen N; Fallon PG. 2007. Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J Immunol 178(7):4557-66. [PubMed: 17372014]  [MGI Ref ID J:145137]

Sokol CL; Chu NQ; Yu S; Nish SA; Laufer TM; Medzhitov R. 2009. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 10(7):713-20. [PubMed: 19465907]  [MGI Ref ID J:150141]

Specht S; Volkmann L; Wynn T; Hoerauf A. 2004. Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis. Infect Immun 72(11):6287-93. [PubMed: 15501755]  [MGI Ref ID J:93273]

Svensson L; Arvola M; Sallstrom M; Holmdahl R; Mattsson R. 2001. The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51(1):3-7. [PubMed: 11438376]  [MGI Ref ID J:70597]

Tamura T; Igarashi O; Hino A; Yamane H; Aizawa S; Kato T; Nariuchi H. 2001. Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset. J Immunol 167(4):1962-9. [PubMed: 11489976]  [MGI Ref ID J:110880]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Tang H; Sharp GC; Peterson KE; Braley-Mullen H. 1998. Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene-disrupted mice. J Immunol 160(1):155-62. [PubMed: 9551967]  [MGI Ref ID J:46310]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Texido G; Jacobs H; Meiering M; Kuhn R; Roes J; Muller W; Gilfillan S; Fujiwara H; Kikutani H; Yoshida N; Amakawa R; Benoist C; Mathis D; Kishimoto T; Mak TW; Rajewsky K. 1996. Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants. Eur J Immunol 26(8):1966-9. [PubMed: 8765046]  [MGI Ref ID J:34589]

Thackray AM; McKenzie AN; Klein MA; Lauder A; Bujdoso R. 2004. Accelerated prion disease in the absence of interleukin-10. J Virol 78(24):13697-707. [PubMed: 15564479]  [MGI Ref ID J:94220]

Thieu VT; Nguyen ET; McCarthy BP; Bruns HA; Kapur R; Chang CH; Kaplan MH. 2007. IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol 82(2):370-9. [PubMed: 17513694]  [MGI Ref ID J:123512]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

Ueno A; Cho S; Cheng L; Wang Z; Wang B; Yang Y. 2005. Diabetes resistance/susceptibility in T cells of nonobese diabetic mice conferred by MHC and MHC-linked genes. J Immunol 175(8):5240-7. [PubMed: 16210629]  [MGI Ref ID J:119112]

Ueno A; Wang J; Cheng L; Im JS; Shi Y; Porcelli SA; Yang Y. 2008. Enhanced early expansion and maturation of semi-invariant NK T cells inhibited autoimmune pathogenesis in congenic nonobese diabetic mice. J Immunol 181(10):6789-96. [PubMed: 18981096]  [MGI Ref ID J:140949]

Urban JF Jr; Noben-Trauth N; Donaldson DD; Madden KB; Morris SC; Collins M; Finkelman FD. 1998. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8(2):255-64. [PubMed: 9492006]  [MGI Ref ID J:110429]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryExpected coat color from breeding is Black.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $195.00Female or MaleHomozygous for Il4tm1Cgn  
Price per Pair (US dollars $)Pair Genotype
$390.00Homozygous for Il4tm1Cgn x Homozygous for Il4tm1Cgn  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $253.50Female or MaleHomozygous for Il4tm1Cgn  
Price per Pair (US dollars $)Pair Genotype
$507.00Homozygous for Il4tm1Cgn x Homozygous for Il4tm1Cgn  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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