Strain Name:

B6;129S2-Il6tm1Kopf/J

Stock Number:

002254

Availability:

Repository- Live
These interleukin 6 (IL6) mutant mice show defects in responses to various viruses and in inflammatory responses to tissue damage or infection.

Description

Strain Information

Former Names B6;129S6-Il6tm1Kopf    (Changed: 15-DEC-04 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
GenerationF?+33 (30-APR-08)
 
Donating Investigator Manfred Kopf,   Basel Institute for Immunology

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the targeted mutation are viable and fertile. No gene product (mRNA) is detected by RT-PCR analysis of lipopolysaccharide (LPS) challenged macrophages. Bioassay and enzyme-linked immunosorbent assay (ELISA) analysis of serum from LPS-challenged homozygotes reveals no detectable protein activity. These interleukin 6 (IL6) mutant mice show defects in responses to various viruses and in inflammatory responses to tissue damage or infection.

Of note, IL6-mutant mice may be available on different genetic backgrounds including mixed B6;129S2 (Stock No. 002254), C57BL/6J (Stock No. 002650), and BALB/cByJ (Stock No. 001026).

Development
The interleukin 6 targeted mutation was created by Manfred Kopf and Georges Kohler (Max Planck Institut Fur Immunbiologie, Freiburg Germany). A targeting vector was designed to place a neomycin resistance cassette into the first coding exon (exon 2) of the targeted gene. This construct was electroporated into 129S2/SvPas-derived D3 embryonic stem (ES) cells. Heterozygotes were intercrossed to generate homozygotes.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Il6tm1Kopf allele
002650   B6.129S2-Il6tm1Kopf/J
View Strains carrying   Il6tm1Kopf     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Il6tm1Kopf/Il6tm1Kopf

        involves: 129/Sv * C57BL/6
  • immune system phenotype
  • abnormal T cell differentiation (MGI Ref ID J:17360)
    • thymocytes are consistently reduced by 20-40%
  • abnormal serum amyloid protein physiology (MGI Ref ID J:17360)
    • 100-fold reduction in SAA production by the liver in response to turpentine injection or listeria infection
  • decreased T cell number (MGI Ref ID J:17360)
    • T cells are reduced in the periphery by 20-40%
  • defective cytotoxic T cell cytolysis (MGI Ref ID J:17360)
    • cytolytic activity of CD8 T cells to vaccinia virus infected cells is reduced 3-10 fold
  • increased susceptibility to bacterial infection (MGI Ref ID J:17360)
    • 10 to 100 fold increase in bacterial titers in the liver and spleen of mice infected with Listeria
  • increased susceptibility to viral infection (MGI Ref ID J:17360)
    • viral titers are 10-1000 fold higher in the ovaries and lungs of vaccinia virus infected mice
  • hematopoietic system phenotype
  • abnormal T cell differentiation (MGI Ref ID J:17360)
    • thymocytes are consistently reduced by 20-40%
  • decreased T cell number (MGI Ref ID J:17360)
    • T cells are reduced in the periphery by 20-40%

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Il6tm1Kopf/Il6tm1Kopf

        B6.129S2-Il6tm1Kopf/J
  • immune system phenotype
  • abnormal interleukin-6 secretion (MGI Ref ID J:109359)
    • intraperitoneal administration of LPS does not induce production of Il6 in the livers of mutants compared to wild-type where expression is increase
  • decreased interferon-gamma secretion (MGI Ref ID J:123351)
    • after restimulation of spleen cells with keyhole limpet hemocyanin one week following immunization of mutant mice, reduced interferon gamma production is observed
  • increased interleukin-4 secretion (MGI Ref ID J:123351)
    • after restimulation of spleen cells with keyhole limpet hemocyanin one week following immunization of mutant mice, enhanced Il-4 secretion is observed
  • homeostasis/metabolism phenotype
  • abnormal glucose homeostasis (MGI Ref ID J:109359)
    • inhibition of hepatic glucose production by ICV infusion of insulin is attenuated
    • inhibition of hepatic glucose production assessed by a euglycemic hyperinsulinemic clamp is also attenuated
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Immunological Defects

Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
CD Antigens, Antigen Receptors, and Histocompatibility Markers (genes regulating susceptibility to infectious disease and endotoxin)
Growth Factors/Receptors/Cytokines
Immunodeficiency
Inflammation
Intracellular Signaling Molecules
Lymphoid Tissue Defects

Internal/Organ Research
Lymphoid Tissue Defects
Wound Healing (delayed/impaired)

Research Tools
Cancer Research
Immunology and Inflammation Research (genes regulating susceptibility to infectious disease and endotoxin)

Il6tm1Kopf related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information

Allele Symbol Il6tm1Kopf
Allele Name targeted mutation 1, Manfred Kopf
Allele Type Targeted (knock-out)
Common Name(s) IL-6 KO; IL-6-; Il6-; Il6tm1Koe; Il6tm1Kopf;
Mutation Made By Manfred Kopf,   Basel Institute for Immunology
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Il6, interleukin 6
Chromosome 5
Gene Common Name(s) BSF2; HGF; HSF; IFNB2; IL-6; ILg6; Il-6;
Molecular Note A neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice. [MGI Ref ID J:17360]

Genotyping

Genotyping Information

Genotyping Protocols

Il6tm1Kopf, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Kopf M; Baumann H; Freer G; Freudenberg M; Lamers M; Kishimoto T; Zinkernagel R; Bluethmann H; Kohler G. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368(6469):339-42. [PubMed: 8127368]  [MGI Ref ID J:17360]

Additional References

Cole N; Krockenberger M; Bao S; Beagley KW; Husband AJ; Willcox M. 2001. Effects of Exogenous Interleukin-6 during Pseudomonas aeruginosa Corneal Infection. Infect Immun 69(6):4116-9. [PubMed: 11349084]  [MGI Ref ID J:69543]

Gallucci RM; Simeonova PP; Matheson JM; Kommineni C; Guriel JL; Sugawara T; Luster MI. 2000. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice FASEB J 14(15):2525-31. [PubMed: 11099471]  [MGI Ref ID J:66089]

Hilbert DM; Kopf M; Mock BA; Kohler G; Rudikoff S. 1995. Interleukin 6 is essential for in vivo development of B lineage neoplasms. J Exp Med 182(1):243-8. [PubMed: 7790819]  [MGI Ref ID J:26249]

Lin T; Bost KL. 2004. STAT3 activation in macrophages following infection with Salmonella. Biochem Biophys Res Commun 321(4):828-34. [PubMed: 15358102]  [MGI Ref ID J:91740]

Wang Q; Fang CH; Hasselgren PO. 2001. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol 281(3):R1013-23. [PubMed: 11507020]  [MGI Ref ID J:71507]

van der Poll T; Keogh CV; Guirao X; Buurman WA; Kopf M; Lowry SF. 1997. Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis 176(2):439-44. [PubMed: 9237710]  [MGI Ref ID J:41791]

Il6tm1Kopf related

Ancrile B; Lim KH; Counter CM. 2007. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev 21(14):1714-9. [PubMed: 17639077]  [MGI Ref ID J:123152]

Angeli V; Faveeuw C; Delerive P; Fontaine J; Barriera Y; Franchimont N; Staels B; Capron M; Trottein F. 2001. Schistosoma mansoni induces the synthesis of IL-6 in pulmonary microvascular endothelial cells: role of IL-6 in the control of lung eosinophilia during infection. Eur J Immunol 31(9):2751-61. [PubMed: 11536174]  [MGI Ref ID J:71675]

Anguita J; Rincon M; Samanta S; Barthold SW; Flavell RA; Fikrig E. 1998. Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis. J Infect Dis 178(5):1512-5. [PubMed: 9780277]  [MGI Ref ID J:51191]

Armario A; Hernandez J; Bluethmann H; Hidalgo J. 1998. IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6. J Neuroimmunol 92(1-2):160-9. [PubMed: 9916891]  [MGI Ref ID J:53626]

Arsenijevic D; Clavel S; Sanchis D; Plamondon J; Huang Q; Ricquier D; Rouger L; Richard D. 2007. Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance. J Neuroimmunol 186(1-2):121-32. [PubMed: 17467814]  [MGI Ref ID J:124552]

Bai Y; Liu R; Huang D; La Cava A; Tang YY; Iwakura Y; Campagnolo DI; Vollmer TL; Ransohoff RM; Shi FD. 2008. CCL2 recruitment of IL-6-producing CD11b(+) monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. Eur J Immunol 38(7):1877-88. [PubMed: 18581322]  [MGI Ref ID J:137386]

Baltgalvis KA; Berger FG; Pena MM; Davis JM; Muga SJ; Carson JA. 2008. Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294(2):R393-401. [PubMed: 18056981]  [MGI Ref ID J:130429]

Banaiee N; Kincaid EZ; Buchwald U; Jacobs WR Jr; Ernst JD. 2006. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol 176(5):3019-27. [PubMed: 16493060]  [MGI Ref ID J:129417]

Bao S; Husband AJ; Beagley KW. 1999. B1 B cell numbers and antibodies against phosphorylcholine and LPS are increased in IL-6 gene knockout mice. Cell Immunol 198(2):139-42. [PubMed: 10648128]  [MGI Ref ID J:60275]

Basu S; Hodgson G; Zhang HH; Katz M; Quilici C; Dunn AR. 2000. 'Emergency' granulopoiesis in G-CSF-deficient mice in response to candida albicans infection Blood 95(12):3725-33. [PubMed: 10845903]  [MGI Ref ID J:63085]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Bernad A; Kopf M; Kulbacki R; Weich N; Koehler G; Gutierrez-Ramos JC. 1994. Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1(9):725-31. [PubMed: 7895162]  [MGI Ref ID J:126683]

Bethin KE; Vogt SK; Muglia LJ. 2000. Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation. Proc Natl Acad Sci U S A 97(16):9317-22. [PubMed: 10922080]  [MGI Ref ID J:126698]

Bleier JI; Pillarisetty VG; Shah AB; DeMatteo RP. 2004. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J Immunol 172(12):7408-16. [PubMed: 15187118]  [MGI Ref ID J:90835]

Blindenbacher A; Wang X; Langer I; Savino R; Terracciano L; Heim MH. 2003. Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology 38(3):674-82. [PubMed: 12939594]  [MGI Ref ID J:105919]

Boe A; Baiocchi M; Carbonatto M; Papoian R; Serlupi-Crescenzi O. 1999. Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis. Cytokine 11(12):1057-64. [PubMed: 10623431]  [MGI Ref ID J:102632]

Boelen A; Maas MA; Lowik CW; Platvoet MC; Wiersinga WM. 1996. Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome. Endocrinology 137(12):5250-4. [PubMed: 8940342]  [MGI Ref ID J:37227]

Boesen EI; Pollock DM. 2007. Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice. Am J Physiol Heart Circ Physiol 293(3):H1745-9. [PubMed: 17557918]  [MGI Ref ID J:126152]

Bopst M; Haas C; Car B; Eugster HP. 1998. The combined inactivation of tumor necrosis factor and interleukin-6 prevents induction of the major acute phase proteins by endotoxin. Eur J Immunol 28(12):4130-7. [PubMed: 9862349]  [MGI Ref ID J:77684]

Brewer JA; Bethin KE; Schaefer ML; Muglia LM; Vogt SK; Weninger SC; Majzoub JA; Muglia LJ. 2003. Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. Stress 6(2):121-5. [PubMed: 12775331]  [MGI Ref ID J:97729]

Bromander AK; Ekman L; Kopf M; Nedrud JG; Lycke NY. 1996. IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection. J Immunol 156(11):4290-7. [PubMed: 8666800]  [MGI Ref ID J:110823]

Butterweck V; Prinz S; Schwaninger M. 2003. The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice. Behav Brain Res 144(1-2):49-56. [PubMed: 12946594]  [MGI Ref ID J:96218]

Cafferty WB; Gardiner NJ; Das P; Qiu J; McMahon SB; Thompson SW. 2004. Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J Neurosci 24(18):4432-43. [PubMed: 15128857]  [MGI Ref ID J:96878]

Carrasco J; Hernandez J; Bluethmann H; Hidalgo J. 1998. Interleukin-6 and tumor necrosis factor-alpha type 1 receptor deficient mice reveal a role of IL-6 and TNF-alpha on brain metallothionein-I and -III regulation. Brain Res Mol Brain Res 57(2):221-34. [PubMed: 9675420]  [MGI Ref ID J:48525]

Cenci E; Mencacci A; Casagrande A; Mosci P; Bistoni F; Romani L. 2001. Impaired antifungal effector activity but not inflammatory cell recruitment in interleukin-6-deficient mice with invasive pulmonary aspergillosis. J Infect Dis 184(5):610-7. [PubMed: 11494166]  [MGI Ref ID J:120152]

Chen Q; Fisher DT; Clancy KA; Gauguet JM; Wang WC; Unger E; Rose-John S; von Andrian UH; Baumann H; Evans SS. 2006. Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism. Nat Immunol 7(12):1299-1308. [PubMed: 17086187]  [MGI Ref ID J:116128]

Chida D; Imaki T; Suda T; Iwakura Y. 2005. Involvement of corticotropin-releasing hormone- and interleukin (IL)-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha. Endocrinology 146(12):5496-502. [PubMed: 16141396]  [MGI Ref ID J:129687]

Chida D; Iwakura Y. 2007. Peripheral TNFalpha, but not peripheral IL-1, requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response. Biochem Biophys Res Commun 364(4):765-70. [PubMed: 17967442]  [MGI Ref ID J:128436]

Chida D; Osaka T; Hashimoto O; Iwakura Y. 2006. Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice. Diabetes 55(4):971-7. [PubMed: 16567518]  [MGI Ref ID J:108607]

Chida Y; Sudo N; Motomura Y; Kubo C. 2004. Electric foot-shock stress drives TNF-alpha production in the liver of IL-6-deficient mice. Neuroimmunomodulation 11(6):419-24. [PubMed: 15467358]  [MGI Ref ID J:105444]

Ching S; He L; Lai W; Quan N. 2005. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav Immun 19(2):127-37. [PubMed: 15664785]  [MGI Ref ID J:105351]

Chong DY; Boehlke CS; Zheng QD; Zhang L; Han Y; Zacks DN. 2008. Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 49(7):3193-200. [PubMed: 18378582]  [MGI Ref ID J:136895]

Coles B; Fielding CA; Rose-John S; Scheller J; Jones SA; O'Donnell VB. 2007. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. Am J Pathol 171(1):315-25. [PubMed: 17591976]  [MGI Ref ID J:122823]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318]  [MGI Ref ID J:117889]

Dann SM; Spehlmann ME; Hammond DC; Iimura M; Hase K; Choi LJ; Hanson E; Eckmann L. 2008. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol 180(10):6816-26. [PubMed: 18453602]  [MGI Ref ID J:134871]

Dedera DA; Urashima M; Chauhan D; LeBrun DP; Bronson RT; Anderson KC. 1996. Interleukin-6 is required for pristane-induced plasma cell hyperplasia in mice. Br J Haematol 94(1):53-6. [PubMed: 8757508]  [MGI Ref ID J:34203]

Deng C; Goluszko E; Tuzun E; Yang H; Christadoss P. 2002. Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 production. J Immunol 169(2):1077-83. [PubMed: 12097416]  [MGI Ref ID J:123833]

Denkinger CM; Denkinger MD; Forsthuber TG. 2007. Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation. Cell Immunol 246(1):46-54. [PubMed: 17601518]  [MGI Ref ID J:123551]

Denzel A; Maus UA; Rodriguez Gomez M; Moll C; Niedermeier M; Winter C; Maus R; Hollingshead S; Briles DE; Kunz-Schughart LA; Talke Y; Mack M. 2008. Basophils enhance immunological memory responses. Nat Immunol 9(7):733-42. [PubMed: 18516038]  [MGI Ref ID J:137679]

Di Gregorio GB; Hensley L; Lu T; Ranganathan G; Kern PA. 2004. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol Endocrinol Metab 287(1):E182-7. [PubMed: 15191885]  [MGI Ref ID J:95403]

Diao H; Kohanawa M. 2005. Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production. Infect Immun 73(6):3745-8. [PubMed: 15908405]  [MGI Ref ID J:99141]

Dube PH; Handley SA; Lewis J; Miller VL. 2004. Protective role of interleukin-6 during Yersinia enterocolitica infection is mediated through the modulation of inflammatory cytokines. Infect Immun 72(6):3561-70. [PubMed: 15155665]  [MGI Ref ID J:90264]

El Kasmi KC; Holst J; Coffre M; Mielke L; de Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG Jr; Alexander W; Vignali DA; Watowich SS; Ernst M; Hilton DJ; Murray PJ. 2006. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8. [PubMed: 17114459]  [MGI Ref ID J:140695]

Elhage R; Clamens S; Besnard S; Mallat Z; Tedgui A; Arnal J; Maret A; Bayard F. 2001. Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17beta-estradiol in apolipoprotein E-deficient mice. Atherosclerosis 156(2):315-20. [PubMed: 11395027]  [MGI Ref ID J:81146]

Ellingsgaard H; Ehses JA; Hammar EB; Van Lommel L; Quintens R; Martens G; Kerr-Conte J; Pattou F; Berney T; Pipeleers D; Halban PA; Schuit FC; Donath MY. 2008. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A 105(35):13163-8. [PubMed: 18719127]  [MGI Ref ID J:139138]

Eriksson U; Kurrer MO; Schmitz N; Marsch SC; Fontana A; Eugster HP; Kopf M. 2003. Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3. Circulation 107(2):320-5. [PubMed: 12538435]  [MGI Ref ID J:103083]

Ernst M; Najdovska M; Grail D; Lundgren-May T; Buchert M; Tye H; Matthews VB; Armes J; Bhathal PS; Hughes NR; Marcusson EG; Karras JG; Na S; Sedgwick JD; Hertzog PJ; Jenkins BJ. 2008. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest 118(5):1727-38. [PubMed: 18431520]  [MGI Ref ID J:135184]

Eugster HP; Frei K; Winkler F; Koedel U; Pfister W; Lassmann H; Fontana A. 2001. Superantigen overcomes resistance of IL-6-deficient mice towards MOG-induced EAE by a TNFR1 controlled pathway. Eur J Immunol 31(8):2302-12. [PubMed: 11477542]  [MGI Ref ID J:71157]

Evans R; Shultz LD; Dranoff G; Fuller JA; Kamdar SJ. 1998. CSF-1 regulation of Il6 gene expression by murine macrophages: a pivotal role for GM-CSF. J Leukoc Biol 64(6):810-6. [PubMed: 9850165]  [MGI Ref ID J:51325]

Faldt J; Wernstedt I; Fitzgerald SM; Wallenius K; Bergstrom G; Jansson JO. 2004. Reduced exercise endurance in interleukin-6-deficient mice. Endocrinology 145(6):2680-6. [PubMed: 14988384]  [MGI Ref ID J:105633]

Fehervari Z; Sakaguchi S. 2004. Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells. Int Immunol 16(12):1769-80. [PubMed: 15520045]  [MGI Ref ID J:94004]

Fenton RR; Molesworth-Kenyon S; Oakes JE; Lausch RN. 2002. Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci 43(3):737-43. [PubMed: 11867592]  [MGI Ref ID J:119135]

Fielding CA; McLoughlin RM; McLeod L; Colmont CS; Najdovska M; Grail D; Ernst M; Jones SA; Topley N; Jenkins BJ. 2008. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. J Immunol 181(3):2189-95. [PubMed: 18641358]  [MGI Ref ID J:139226]

Fuchs M; Hilfiker A; Kaminski K; Hilfiker-Kleiner D; Guener Z; Klein G; Podewski E; Schieffer B; Rose-John S; Drexler H. 2003. Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction. FASEB J 17(14):2118-20. [PubMed: 12958147]  [MGI Ref ID J:118479]

Fujimaki H; Kurokawa Y; Yamamoto S; Satoh M. 2006. Distinct requirements for interleukin-6 in airway inflammation induced by diesel exhaust in mice. Immunopharmacol Immunotoxicol 28(4):703-14. [PubMed: 17190745]  [MGI Ref ID J:136469]

Gabay C; Gigley J; Sipe J; Arend WP; Fantuzzi G. 2001. Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase protein in vivo. Eur J Immunol 31(2):490-9. [PubMed: 11180114]  [MGI Ref ID J:134201]

Gallucci RM; Lee EG; Tomasek JJ. 2006. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol 126(3):561-8. [PubMed: 16397521]  [MGI Ref ID J:106773]

Gallucci RM; Simeonova PP; Matheson JM; Kommineni C; Guriel JL; Sugawara T; Luster MI. 2000. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice FASEB J 14(15):2525-31. [PubMed: 11099471]  [MGI Ref ID J:66089]

Gao W; Pereira MA. 2002. Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi. Int J Parasitol 32(2):167-70. [PubMed: 11812493]  [MGI Ref ID J:106201]

Goodwill MH; Lawrence DA; Seegal RF. 2007. Polychlorinated biphenyls induce proinflammatory cytokine release and dopaminergic dysfunction: protection in interleukin-6 knockout mice. J Neuroimmunol 183(1-2):125-32. [PubMed: 17229471]  [MGI Ref ID J:124502]

Gowen BB; Hoopes JD; Wong MH; Jung KH; Isakson KC; Alexopoulou L; Flavell RA; Sidwell RW. 2006. TLR3 deletion limits mortality and disease severity due to Phlebovirus infection. J Immunol 177(9):6301-7. [PubMed: 17056560]  [MGI Ref ID J:140514]

Hams E; Colmont CS; Dioszeghy V; Hammond VJ; Fielding CA; Williams AS; Tanaka M; Miyajima A; Taylor PR; Topley N; Jones SA. 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. J Immunol 181(3):2174-80. [PubMed: 18641356]  [MGI Ref ID J:139227]

Hata H; Sakaguchi N; Yoshitomi H; Iwakura Y; Sekikawa K; Azuma Y; Kanai C; Moriizumi E; Nomura T; Nakamura T; Sakaguchi S. 2004. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114(4):582-8. [PubMed: 15314695]  [MGI Ref ID J:92002]

Hilbert DM; Kopf M; Mock BA; Kohler G; Rudikoff S. 1995. Interleukin 6 is essential for in vivo development of B lineage neoplasms. J Exp Med 182(1):243-8. [PubMed: 7790819]  [MGI Ref ID J:26249]

Hirota K; Hashimoto M; Yoshitomi H; Tanaka S; Nomura T; Yamaguchi T; Iwakura Y; Sakaguchi N; Sakaguchi S. 2007. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 204(1):41-7. [PubMed: 17227914]  [MGI Ref ID J:125290]

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Ramsay AJ; Husband AJ; Ramshaw IA; Bao S; Matthaei KI; Koehler G; Kopf M. 1994. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 264(5158):561-3. [PubMed: 8160012]  [MGI Ref ID J:17860]

Reil JC; Gilles S; Zahler S; Brandl A; Drexler H; Hultner L; Matrisian LM; Welsch U; Becker BF. 2007. Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts. J Mol Cell Cardiol 42(1):133-41. [PubMed: 17101148]  [MGI Ref ID J:119661]

Remick DG; Bolgos G; Copeland S; Siddiqui J. 2005. Role of interleukin-6 in mortality from and physiologic response to sepsis. Infect Immun 73(5):2751-7. [PubMed: 15845478]  [MGI Ref ID J:97611]

Ren X; Hogaboam C; Carpenter A; Colletti L. 2003. Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. J Clin Invest 112(9):1407-18. [PubMed: 14597766]  [MGI Ref ID J:118475]

Rodriguez Mdel C; Bernad A; Aracil M. 2004. Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support. Blood 103(9):3349-54. [PubMed: 14701687]  [MGI Ref ID J:90289]

Rosenbaum JT; Kievit P; Han YB; Park JM; Planck SR. 1998. Interleukin-6 does not mediate endotoxin-induced uveitis in mice: studies in gene deletion animals. Invest Ophthalmol Vis Sci 39(1):64-9. [PubMed: 9430546]  [MGI Ref ID J:45408]

Saito H; Patterson C; Hu Z; Runge MS; Tipnis U; Sinha M; Papaconstantinou J. 2000. Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia. Am J Physiol Heart Circ Physiol 279(5):H2241-8. [PubMed: 11045959]  [MGI Ref ID J:108274]

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Samoilova EB; Horton JL; Hilliard B; Liu TS; Chen Y. 1998. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 161(12):6480-6. [PubMed: 9862671]  [MGI Ref ID J:110811]

Sanders CJ; Moore DA rd; Williams IR; Gewirtz AT. 2008. Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol 180(11):7184-92. [PubMed: 18490717]  [MGI Ref ID J:136347]

Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. [PubMed: 16717113]  [MGI Ref ID J:124381]

Schieffer B; Selle T; Hilfiker A; Hilfiker-Kleiner D; Grote K; Tietge UJ; Trautwein C; Luchtefeld M; Schmittkamp C; Heeneman S; Daemen MJ; Drexler H. 2004. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation 110(22):3493-500. [PubMed: 15557373]  [MGI Ref ID J:103918]

Schmidt C; Hocherl K; Bucher M. 2007. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 292(5):F1479-89. [PubMed: 17229673]  [MGI Ref ID J:121446]

Serrano AL; Baeza-Raja B; Perdiguero E; Jardi M; Munoz-Canoves P. 2008. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab 7(1):33-44. [PubMed: 18177723]  [MGI Ref ID J:131016]

Siebert H; Bruck W. 2003. The role of cytokines and adhesion molecules in axon degeneration after peripheral nerve axotomy: a study in different knockout mice. Brain Res 960(1-2):152-6. [PubMed: 12505667]  [MGI Ref ID J:107780]

Siewert E; Dietrich CG; Lammert F; Heinrich PC; Matern S; Gartung C; Geier A. 2004. Interleukin-6 regulates hepatic transporters during acute-phase response. Biochem Biophys Res Commun 322(1):232-8. [PubMed: 15313196]  [MGI Ref ID J:113760]

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Sims NA; Jenkins BJ; Quinn JM; Nakamura A; Glatt M; Gillespie MT; Ernst M; Martin TJ. 2004. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. J Clin Invest 113(3):379-89. [PubMed: 14755335]  [MGI Ref ID J:87612]

Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. [PubMed: 11035735]  [MGI Ref ID J:133107]

Sparkman NL; Buchanan JB; Heyen JR; Chen J; Beverly JL; Johnson RW. 2006. Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci 26(42):10709-16. [PubMed: 17050710]  [MGI Ref ID J:113436]

Sporri R; Joller N; Albers U; Hilbi H; Oxenius A. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J Immunol 176(10):6162-71. [PubMed: 16670325]  [MGI Ref ID J:131762]

Sprando RL; Pestka J; Collins TF; Rorie J; O'Donnell M; Hinton D; Chirtel S. 1999. The effect of vomitoxin (Deoxnivalenol) on testicular morphology, testicular spermatid counts and epididymal sperm counts in IL-6KO [B6129-IL6 [TmlKopf] (IL-6 gene deficient)] and WT [B6129F2 (wild type to B6129-IL6 with an intact IL-6 gene)] mice. Food Chem Toxicol 37(11):1073-9. [PubMed: 10566878]  [MGI Ref ID J:59653]

Stager S; Maroof A; Zubairi S; Sanos SL; Kopf M; Kaye PM. 2006. Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. Eur J Immunol 36(7):1764-71. [PubMed: 16791879]  [MGI Ref ID J:115789]

Stahel PF; Shohami E; Younis FM; Kariya K; Otto VI; Lenzlinger PM; Grosjean MB; Eugster HP; Trentz O; Kossmann T; Morganti-Kossmann MC. 2000. Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J Cereb Blood Flow Metab 20(2):369-80. [PubMed: 10698075]  [MGI Ref ID J:61314]

Sugiura S; Lahav R; Han J; Kou SY; Banner LR; de Pablo F; Patterson PH. 2000. Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro. Eur J Neurosci 12(2):457-66. [PubMed: 10712626]  [MGI Ref ID J:89814]

Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. [PubMed: 17546038]  [MGI Ref ID J:125116]

Sun J; Sukhova GK; Yang M; Wolters PJ; MacFarlane LA; Libby P; Sun C; Zhang Y; Liu J; Ennis TL; Knispel R; Xiong W; Thompson RW; Baxter BT; Shi GP. 2007. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 117(11):3359-68. [PubMed: 17932568]  [MGI Ref ID J:127400]

Suzuki M; Sugimoto Y; Ohsaki Y; Ueno M; Kato S; Kitamura Y; Hosokawa H; Davies JP; Ioannou YA; Vanier MT; Ohno K; Ninomiya H. 2007. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. J Neurosci 27(8):1879-91. [PubMed: 17314284]  [MGI Ref ID J:118352]

Swartz KR; Liu F; Sewell D; Schochet T; Campbell I; Sandor M; Fabry Z. 2001. Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Res 896(1-2):86-95. [PubMed: 11277977]  [MGI Ref ID J:68649]

Swiergiel AH; Dunn AJ. 2006. Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male mice. Behav Brain Res 171(1):94-108. [PubMed: 16677721]  [MGI Ref ID J:108975]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Tebbutt NC; Giraud AS; Inglese M; Jenkins B; Waring P; Clay FJ; Malki S; Alderman BM; Grail D; Hollande F; Heath JK; Ernst M. 2002. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 8(10):1089-97. [PubMed: 12219085]  [MGI Ref ID J:79073]

Tissieres P; Dunn-Siegrist I; Schappi M; Elson G; Comte R; Nobre V; Pugin J. 2008. Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria. Blood 111(4):2122-31. [PubMed: 18056837]  [MGI Ref ID J:131315]

Turnbull AV; Prehar S; Kennedy AR; Little RA; Hopkins SJ. 2003. Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology 144(5):1894-906. [PubMed: 12697697]  [MGI Ref ID J:115710]

Ueda N; Kuki H; Kamimura D; Sawa S; Seino K; Tashiro T; Fushuku K; Taniguchi M; Hirano T; Murakami M. 2006. CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4. Int Immunol 18(9):1397-404. [PubMed: 16914507]  [MGI Ref ID J:113387]

Uematsu S; Fujimoto K; Jang MH; Yang BG; Jung YJ; Nishiyama M; Sato S; Tsujimura T; Yamamoto M; Yokota Y; Kiyono H; Miyasaka M; Ishii KJ; Akira S. 2008. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 9(7):769-76. [PubMed: 18516037]  [MGI Ref ID J:137710]

Vallieres L; Rivest S. 1999. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia. Endocrinology 140(9):3890-903. [PubMed: 10465257]  [MGI Ref ID J:110676]

Van Lenten BJ; Wagner AC; Navab M; Fogelman AM. 2001. Oxidized phospholipids induce changes in hepatic paraoxonase and ApoJ but not monocyte chemoattractant protein-1 via interleukin-6. J Biol Chem 276(3):1923-9. [PubMed: 11034996]  [MGI Ref ID J:67047]

Venihaki M; Dikkes P; Carrigan A; Karalis KP. 2001. Corticotropin-releasing hormone regulates IL-6 expression during inflammation. J Clin Invest 108(8):1159-66. [PubMed: 11602623]  [MGI Ref ID J:72196]

Vivien L; Benoist C; Mathis D. 2001. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol 13(6):763-8. [PubMed: 11369703]  [MGI Ref ID J:69776]

Walker F; Zhang HH; Matthews V; Weinstock J; Nice EC; Ernst M; Rose-John S; Burgess AW. 2008. IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood 111(8):3978-85. [PubMed: 18156493]  [MGI Ref ID J:134366]

Wallenius V; Wallenius K; Ahren B; Rudling M; Carlsten H; Dickson SL; Ohlsson C; Jansson JO. 2002. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8(1):75-9. [PubMed: 11786910]  [MGI Ref ID J:73753]

Wallenius V; Wallenius K; Hisaoka M; Sandstedt J; Ohlsson C; Kopf M; Jansson JO. 2001. Retarded liver growth in interleukin-6-deficient and tumor necrosis factor receptor-1-deficient mice. Endocrinology 142(7):2953-60. [PubMed: 11416016]  [MGI Ref ID J:71930]

Wang J; Homer RJ; Chen Q; Elias JA. 2000. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. J Immunol 165(7):4051-61. [PubMed: 11034416]  [MGI Ref ID J:118443]

Wang Q; Fang CH; Hasselgren PO. 2001. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol 281(3):R1013-23. [PubMed: 11507020]  [MGI Ref ID J:71507]

Wang T; Town T; Alexopoulou L; Anderson JF; Fikrig E; Flavell RA. 2004. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 10(12):1366-73. [PubMed: 15558055]  [MGI Ref ID J:99595]

Wang XP; Schunck M; Kallen KJ; Neumann C; Trautwein C; Rose-John S; Proksch E. 2004. The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J Invest Dermatol 123(1):124-31. [PubMed: 15191552]  [MGI Ref ID J:90509]

Warren GL; Hulderman T; Jensen N; McKinstry M; Mishra M; Luster MI; Simeonova PP. 2002. Physiological role of tumor necrosis factor alpha in traumatic muscle injury. FASEB J 16(12):1630-2. [PubMed: 12207010]  [MGI Ref ID J:119897]

Weigmann B; Lehr HA; Yancopoulos G; Valenzuela D; Murphy A; Stevens S; Schmidt J; Galle PR; Rose-John S; Neurath MF. 2008. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med 205(9):2099-110. [PubMed: 18710929]  [MGI Ref ID J:138976]

Weinmann P; Scharffetter-Kochanek K; Forlow SB; Peters T; Walzog B. 2003. A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient mice. Blood 101(2):739-46. [PubMed: 12393639]  [MGI Ref ID J:115556]

Weissenberger J; Loeffler S; Kappeler A; Kopf M; Lukes A; Afanasieva TA; Aguzzi A; Weis J. 2004. IL-6 is required for glioma development in a mouse model. Oncogene 23(19):3308-16. [PubMed: 15064729]  [MGI Ref ID J:89585]

Wernstedt I; Olsson B; Jernas M; Paglialunga S; Carlsson LM; Smith U; Cianflone K; Wallenius K; Wallenius V. 2006. Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-)) mice. Endocrinology 147(6):2690-5. [PubMed: 16513824]  [MGI Ref ID J:129659]

Westberg JA; Serlachius M; Lankila P; Andersson LC. 2007. Hypoxic preconditioning induces elevated expression of stanniocalcin-1 in the heart. Am J Physiol Heart Circ Physiol 293(3):H1766-71. [PubMed: 17573464]  [MGI Ref ID J:126148]

Wong PK; Egan PJ; Croker BA; O'Donnell K; Sims NA; Drake S; Kiu H; McManus EJ; Alexander WS; Roberts AW; Wicks IP. 2006. SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest 116(6):1571-81. [PubMed: 16710471]  [MGI Ref ID J:110372]

Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. [PubMed: 17646407]  [MGI Ref ID J:125952]

Wuestefeld T; Klein C; Streetz KL; Betz U; Lauber J; Buer J; Manns MP; Muller W; Trautwein C. 2003. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 278(13):11281-8. [PubMed: 12509437]  [MGI Ref ID J:91064]

Xing Z; Gauldie J; Cox G; Baumann H; Jordana M; Lei XF; Achong MK. 1998. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 101(2):311-20. [PubMed: 9435302]  [MGI Ref ID J:118763]

Yang R; Han X; Uchiyama T; Watkins SK; Yaguchi A; Delude RL; Fink MP. 2003. IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol 285(3):G621-9. [PubMed: 12773301]  [MGI Ref ID J:85434]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThis strain is maintained by mating homozygous siblings. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $93.20Female or MaleHomozygous for Il6tm1Kopf
Pairs /Price*Pair Genotype
$186.40Homozygous for Il6tm1Kopf x Homozygous for Il6tm1Kopf
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $121.20Female or MaleHomozygous for Il6tm1Kopf
Pairs /Price*Pair Genotype
$242.40Homozygous for Il6tm1Kopf x Homozygous for Il6tm1Kopf
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International -