Strain Name:

B6.129S2-Ltatm1Dch/J

Stock Number:

002258

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain 129S2 via D3 ES cell line
GenerationN?+10F14 (05-DEC-07)
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Appearance
black
Related Genotype: a/a

Description
Mice homozygous Ltatm1Dch targeted mutation are viable and fertile. Homozygous mutant mice show abnormal development of peripheral lymphoid organs with no detectable popliteal, inguinal, para-aortic, mesenteric, axillary, or cervical lymph nodes, and no detectable Peyer's patches. Morphological changes in the spleen white pulp were accompanied by alterations in T and B cell content. CD4+ and CD8+ T cells counts in peripheral blood are normal but there is a four-fold increase in B cells. Neutrophil, monocyte, and platelet counts are normal. The thymus contains normal numbers of CD4+CD8+, CD4+, CD8+, and CD4-CD8- T cells. Splenic T cells develop normal MHC class I and class II-restricted allocytotoxic responses. Also known as tumor necrosis factor beta, Tnfb.

Development
The targeting strategy resulted in the elemination of exon 3 (4 exons total) and the introduction of a stop codon in exon 2. The predominant 1.5 and 1.8 kb Lta transcripts are missing and a major 3 kb transcript consistent with the structure of the targeted gene is present. 129 derived D3 ES cells were used for the targeting. The Ltatm1Dch targeted mutation was backcrossed to the C57BL/6J inbred strain for 5 generations (N5) prior to establishing a homozygous colony. Backcrossing is continuing to N10.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ltatm1Dch allele
002257   B6;129S2-Ltatm1Dch/J
View Strains carrying   Ltatm1Dch     (1 strain)

Strains carrying other alleles of Lta
005108   B6.129P2-Ltb/Tnf/Ltatm1Dvk/J
005579   C57BL/6J-Ltahlb382/J
View Strains carrying other alleles of Lta     (2 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Ltatm1Dch/Ltatm1Dch

        B6.129S2-Ltatm1Dch
  • immune system phenotype
  • abnormal immune serum protein physiology (MGI Ref ID J:80616)
    • abnormal cytokine secretion (MGI Ref ID J:95222)
      • chemokine expression is essentially absent
      • no Ifn-gamma produced in nasal-associated lymphoid tissue but it is found in the spleen
    • decreased IgG level (MGI Ref ID J:80616)
      • defecient IgG antibody production
    • increased IgM level (MGI Ref ID J:80616)
      • 2-fold increased IgM
  • abnormal mucosa-associated lymphoid tissue morphology (MGI Ref ID J:80616)
    • nasal-associated lymphoid tissue poorly developed and hypocellular
  • absent Peyer's patches (MGI Ref ID J:80616)
    • not grossly detectable
  • absent spleen germinal center (MGI Ref ID J:80616)
  • absent spleen marginal zone (MGI Ref ID J:80616)
  • decreased spleen white pulp amount (MGI Ref ID J:80616)
  • increased leukocyte cell number (MGI Ref ID J:80616)
    • 2- to 3- fold increased leukocyte count in spleen, blood, and peritoneal cavity
  • hematopoietic system phenotype
  • absent spleen germinal center (MGI Ref ID J:80616)
  • absent spleen marginal zone (MGI Ref ID J:80616)
  • decreased spleen white pulp amount (MGI Ref ID J:80616)
  • increased leukocyte cell number (MGI Ref ID J:80616)
    • 2- to 3- fold increased leukocyte count in spleen, blood, and peritoneal cavity

Ltatm1Dch/Ltatm1Dch

        B6.129S2-Ltatm1Dch/J
  • immune system phenotype
  • abnormal lymph organ development (MGI Ref ID J:73100)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ltatm1Dch/Ltatm1Dch

        involves: 129S2/SvPas * C57BL/6
  • life span-post-weaning/aging
  • abnormal induced morbidity/mortality (MGI Ref ID J:109621)
    • in response to LPS and D-GalN administration, percentage of severely moribund mice is 0 at 7 hours; 3/7 mice are severely moribund at 8 hours
  • immune system phenotype
  • abnormal class switch recombination (MGI Ref ID J:109621)
    • 19 days after immunization with OVA, mice display an isotype switch to IgG from IgM that is several fold decreased compared to wild-type
  • abnormal humoral immune response (MGI Ref ID J:39746)
    • in response to stimulation with sheep red blood cells (SRBC), mice fail to produce anti-SRBC IgG at day 6 and only produce a negligible amount by day 15 unlike wild-type mice
  • abnormal leukocyte cell number (MGI Ref ID J:17976)
    • decreased T cell number (MGI Ref ID J:17976)
      • in the spleen
    • increased leukocyte cell number (MGI Ref ID J:17976)
      • nearly 3 fold increase
      • neutrophil, monocyte, platelet counts normal
      • increased B cell number (MGI Ref ID J:17976)
        • 4 fold increase in B cell numbers
        • 30% increase in IgM positive and B220 positive B lymphocytes
  • abnormal lymph node morphology (MGI Ref ID J:17976)
    • lack para-aortic lymph nodes
    • abnormal axillary lymph node morphology (MGI Ref ID J:17976)
      • absent
    • abnormal cervical lymph node morphology (MGI Ref ID J:17976)
      • absent
    • abnormal inguinal lymph node morphology (MGI Ref ID J:17976)
      • absent
    • abnormal lymph node primary follicle (MGI Ref ID J:109621)
      • only occasional BP-3 cells are found in some lymphoid follicles
    • abnormal popliteal lymph node morphology (MGI Ref ID J:17976)
      • absent
    • absent mesenteric lymph nodes (MGI Ref ID J:17976)
      • mice lack mesenteric and cervical lymph nodes
  • abnormal spleen morphology (MGI Ref ID J:17976)
    • mice exhibit extensive disorganization
    • abnormal spleen periarteriolar lymphoid sheath morphology (MGI Ref ID J:17976)
    • absent spleen marginal zone (MGI Ref ID J:17976)
      • loss of a distinct marginal zone
    • decreased spleen white pulp amount (MGI Ref ID J:109621)
      • percentage of splenic white pulp is lower than in wild-type, Ltb nulls and Ltatm1.1Sned but higher than Ltb, Ltbr or Ltb/Tnf/Lta knockouts
  • absent Peyer's patches (MGI Ref ID J:17976)
    • not grossly detectable
  • decreased interferon-gamma secretion (MGI Ref ID J:109621)
    • in culture, OVA-specific Ifng production from purified CD4+ T cells is decreased 2-fold compared to Ltatm1.1Sned
  • decreased tumor necrosis factor secretion (MGI Ref ID J:109621)
    • in response to LPS, mice demonstrate a 10-fold decrease in production of TNF compared to wild-type or Lta
    • both bone marrow derived macrophages and neutrophils fail to produce normal levels of TNF when stimulated
  • hematopoietic system phenotype
  • abnormal class switch recombination (MGI Ref ID J:109621)
    • 19 days after immunization with OVA, mice display an isotype switch to IgG from IgM that is several fold decreased compared to wild-type
  • abnormal leukocyte cell number (MGI Ref ID J:17976)
    • decreased T cell number (MGI Ref ID J:17976)
      • in the spleen
    • increased leukocyte cell number (MGI Ref ID J:17976)
      • nearly 3 fold increase
      • neutrophil, monocyte, platelet counts normal
      • increased B cell number (MGI Ref ID J:17976)
        • 4 fold increase in B cell numbers
        • 30% increase in IgM positive and B220 positive B lymphocytes
  • abnormal spleen morphology (MGI Ref ID J:17976)
    • mice exhibit extensive disorganization
    • abnormal spleen periarteriolar lymphoid sheath morphology (MGI Ref ID J:17976)
    • absent spleen marginal zone (MGI Ref ID J:17976)
      • loss of a distinct marginal zone
    • decreased spleen white pulp amount (MGI Ref ID J:109621)
      • percentage of splenic white pulp is lower than in wild-type, Ltb nulls and Ltatm1.1Sned but higher than Ltb, Ltbr or Ltb/Tnf/Lta knockouts
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ltatm1Dch related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information

Allele Symbol Ltatm1Dch
Allele Name targeted mutation 1, David D Chaplin
Allele Type Targeted (knock-out)
Common Name(s) LT-; LT-alpha-; LTalpha-;
Mutation Made By David Chaplin,   University of Alabama at Birmingham
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Lta, lymphotoxin A
Chromosome 17
Gene Common Name(s) LT; LT-[a]; LT-alpha; LT[a]; LTalpha; Ltx; TNF beta; TNF-beta; TNFB; TNFSF1; Tnfb; Tnfsf1b; heart, lung and blood 382; hlb382; lymphotoxin; lymphotoxin alpha; tumor necrosis factor beta;
Molecular Note A neomycin resistance cassette replaced a small portion of exon 2, all of exon 3, and a small portion of exon 4. [MGI Ref ID J:110548] [MGI Ref ID J:17976] [MGI Ref ID J:95222]

Genotyping

Genotyping Information

Genotyping Protocols

Ltatm1Dch, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

De Togni P; Goellner J; Ruddle NH; Streeter PR; Fick A; Mariathasan S; Smith SC; Carlson R; Shornick LP; Strauss-Schoenberger J; Russell JH; Karr R; Chaplin DD. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin [see comments] Science 264(5159):703-7. [PubMed: 8171322]  [MGI Ref ID J:17976]

Additional References

Jang MH; Kweon MN; Iwatani K; Yamamoto M; Terahara K; Sasakawa C; Suzuki T; Nochi T; Yokota Y; Rennert PD; Hiroi T; Tamagawa H; Iijima H; Kunisawa J; Yuki Y; Kiyono H. 2004. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A 101(16):6110-5. [PubMed: 15071180]  [MGI Ref ID J:89586]

Kather A; Chantakru S; He H; Minhas K; Foster R; Markert UR; Pfeffer K; Croy BA. 2003. Neither lymphotoxin alpha nor lymphotoxin beta receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant mouse uterus. Immunology 108(3):338-45. [PubMed: 12603600]  [MGI Ref ID J:82424]

Moyron-Quiroz JE; Rangel-Moreno J; Kusser K; Hartson L; Sprague F; Goodrich S; Woodland DL; Lund FE; Randall TD. 2004. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med 10(9):927-34. [PubMed: 15311275]  [MGI Ref ID J:92841]

Schreyer SA; Vick CM; LeBoeuf RC. 2002. Loss of Lymphotoxin-alpha but Not Tumor Necrosis Factor-alpha Reduces Atherosclerosis in Mice. J Biol Chem 277(14):12364-8. [PubMed: 11809756]  [MGI Ref ID J:75788]

Ltatm1Dch related

Abe K; Yarovinsky FO; Murakami T; Shakhov AN; Tumanov AV; Ito D; Drutskaya LN; Pfeffer K; Kuprash DV; Komschlies KL; Nedospasov SA. 2003. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood 101(4):1477-83. [PubMed: 12560241]  [MGI Ref ID J:115537]

Alexopoulou L; Pasparakis M; Kollias G. 1998. Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function. J Exp Med 188(4):745-54. [PubMed: 9705956]  [MGI Ref ID J:110953]

Alimzhanov MB; Kuprash DV; Kosco-Vilbois MH; Luz A; Turetskaya RL ; Tarakhovsky A ; Rajewsky K ; Nedospasov SA ; Pfeffer K. 1997. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94(17):9302-7. [PubMed: 9256477]  [MGI Ref ID J:42508]

Anders RA; Subudhi SK; Wang J; Pfeffer K; Fu YX. 2005. Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol 175(2):1295-300. [PubMed: 16002734]  [MGI Ref ID J:100756]

Ansel KM; Ngo VN; Hyman PL; Luther SA; Forster R; Sedgwick JD; Browning JL; Lipp M; Cyster JG. 2000. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406(6793):309-14. [PubMed: 10917533]  [MGI Ref ID J:78282]

Aya K; Alhawagri M; Hagen-Stapleton A; Kitaura H; Kanagawa O; Veis Novack D. 2005. NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis. J Clin Invest 115(7):1848-54. [PubMed: 15937549]  [MGI Ref ID J:99806]

Beilhack A; Schulz S; Baker J; Beilhack GF; Nishimura R; Baker EM; Landan G; Herman EI; Butcher EC; Contag CH; Negrin RS. 2008. Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood 111(5):2919-28. [PubMed: 17989315]  [MGI Ref ID J:131612]

Berger DP; Naniche D; Crowley MT; Koni PA; Flavell RA; Oldstone MB. 1999. Lymphotoxin-beta-deficient mice show defective antiviral immunity. Virology 260(1):136-47. [PubMed: 10405365]  [MGI Ref ID J:102625]

Bopst M; Garcia I; Guler R; Olleros ML; Rulicke T; Muller M; Wyss S; Frei K; Le Hir M; Eugster HP. 2001. Differential effects of TNF and LTalpha in the host defense against M. bovis BCG. Eur J Immunol 31(6):1935-43. [PubMed: 11433391]  [MGI Ref ID J:115600]

Brown GR; Lee EL; El-Hayek J; Kintner K; Luck C. 2005. IL-12-independent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease. J Immunol 174(8):4688-95. [PubMed: 15814693]  [MGI Ref ID J:109999]

Chin RK; Lo JC; Kim O; Blink SE; Christiansen PA; Peterson P; Wang Y; Ware C; Fu YX. 2003. Lymphotoxin pathway directs thymic Aire expression. Nat Immunol 4(11):1121-7. [PubMed: 14517552]  [MGI Ref ID J:86259]

Chin RK; Zhu M; Christiansen PA; Liu W; Ware C; Peltonen L; Zhang X; Guo L; Han S; Zheng B; Fu YX. 2006. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol 177(1):290-7. [PubMed: 16785524]  [MGI Ref ID J:134431]

Ching S; He L; Lai W; Quan N. 2005. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav Immun 19(2):127-37. [PubMed: 15664785]  [MGI Ref ID J:105351]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056]  [MGI Ref ID J:111051]

De Trez C; Schneider K; Potter K; Droin N; Fulton J; Norris PS; Ha SW; Fu YX; Murphy T; Murphy KM; Pfeffer K; Benedict CA; Ware CF. 2008. The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J Immunol 180(1):238-48. [PubMed: 18097025]  [MGI Ref ID J:130896]

Douni E; Kollias G. 1998. A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R. J Exp Med 188(7):1343-52. [PubMed: 9763613]  [MGI Ref ID J:114744]

Eberl G; Littman DR. 2004. Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells. Science 305(5681):248-51. [PubMed: 15247480]  [MGI Ref ID J:91566]

Ehlers S; Holscher C; Scheu S; Tertilt C; Hehlgans T; Suwinski J; Endres R; Pfeffer K. 2003. The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. J Immunol 170(10):5210-8. [PubMed: 12734369]  [MGI Ref ID J:109995]

Elewaut D; Brossay L; Santee SM; Naidenko OV; Burdin N; De Winter H; Matsuda J; Ware CF; Cheroutre H; Kronenberg M. 2000. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol 165(2):671-9. [PubMed: 10878339]  [MGI Ref ID J:106601]

Engwerda CR; Ato M; Stager S; Alexander CE; Stanley AC; Kaye PM. 2004. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection. Am J Pathol 165(6):2123-33. [PubMed: 15579454]  [MGI Ref ID J:94946]

Ericsson A; Kotarsky K; Svensson M; Sigvardsson M; Agace W. 2006. Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors. J Immunol 176(6):3642-51. [PubMed: 16517733]  [MGI Ref ID J:129504]

Finke D; Acha-Orbea H; Mattis A; Lipp M; Kraehenbuhl J. 2002. CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5. Immunity 17(3):363-73. [PubMed: 12354388]  [MGI Ref ID J:111436]

Fu YX; Huang G; Matsumoto M; Molina H; Chaplin DD. 1997. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc Natl Acad Sci U S A 94(11):5739-43. [PubMed: 9159143]  [MGI Ref ID J:78647]

Fu YX; Huang G; Wang Y; Chaplin DD. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 187(7):1009-18. [PubMed: 9529317]  [MGI Ref ID J:118756]

Fu YX; Huang G; Wang Y; Chaplin DD. 2000. Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation. J Immunol 164(5):2508-14. [PubMed: 10679088]  [MGI Ref ID J:126988]

Fu YX; Molina H; Matsumoto M; Huang G; Min J; Chaplin DD. 1997. Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses. J Exp Med 185(12):2111-20. [PubMed: 9182683]  [MGI Ref ID J:41079]

Fukuyama S; Hiroi T; Yokota Y; Rennert PD; Yanagita M; Kinoshita N; Terawaki S; Shikina T; Yamamoto M; Kurono Y; Kiyono H. 2002. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity 17(1):31-40. [PubMed: 12150889]  [MGI Ref ID J:78101]

Furtado GC; Marinkovic T; Martin AP; Garin A; Hoch B; Hubner W; Chen BK; Genden E; Skobe M; Lira SA. 2007. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proc Natl Acad Sci U S A 104(12):5026-31. [PubMed: 17360402]  [MGI Ref ID J:120088]

Futterer A; Mink K; Luz A; Kosco-Vilbois MH; Pfeffer K. 1998. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9(1):59-70. [PubMed: 9697836]  [MGI Ref ID J:48837]

Gajewska BU; Alvarez D; Vidric M; Goncharova S; Stampfli MR; Coyle AJ; Gutierrez-Ramos JC; Jordana M. 2001. Generation of experimental allergic airways inflammation in the absence of draining lymph nodes. J Clin Invest 108(4):577-83. [PubMed: 11518731]  [MGI Ref ID J:118404]

Goluszko E; Hjelmstrom P; Deng C; Poussin MA; Ruddle NH; Christadoss P. 2001. Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis. J Neuroimmunol 113(1):109-18. [PubMed: 11137582]  [MGI Ref ID J:102964]

Hamada H; Hiroi T; Nishiyama Y; Takahashi H; Masunaga Y; Hachimura S; Kaminogawa S; Takahashi-Iwanaga H; Iwanaga T; Kiyono H; Yamamoto H; Ishikawa H. 2002. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol 168(1):57-64. [PubMed: 11751946]  [MGI Ref ID J:73436]

Harmsen A; Kusser K; Hartson L; Tighe M; Sunshine MJ; Sedgwick JD; Choi Y; Littman DR; Randall TD. 2002. Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent. J Immunol 168(3):986-90. [PubMed: 11801629]  [MGI Ref ID J:111963]

Heikenwalder M; Prinz M; Zeller N; Lang KS; Junt T; Rossi S; Tumanov A; Schmidt H; Priller J; Flatz L; Rulicke T; Macpherson AJ; Hollander GA; Nedospasov SA; Aguzzi A. 2008. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am J Pathol 172(6):1555-70. [PubMed: 18483211]  [MGI Ref ID J:136357]

Heikenwalder M; Zeller N; Seeger H; Prinz M; Klohn PC; Schwarz P; Ruddle NH; Weissmann C; Aguzzi A. 2005. Chronic lymphocytic inflammation specifies the organ tropism of prions. Science 307(5712):1107-10. [PubMed: 15661974]  [MGI Ref ID J:96344]

Iizuka K; Chaplin DD; Wang Y; Wu Q; Pegg LE; Yokoyama WM; Fu YX. 1999. Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci U S A 96(11):6336-40. [PubMed: 10339588]  [MGI Ref ID J:55470]

Ito D; Back TC; Shakhov AN; Wiltrout RH; Nedospasov SA. 1999. Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment. J Immunol 163(5):2809-15. [PubMed: 10453025]  [MGI Ref ID J:57087]

Itoh M; Miyamoto K; Ooga T; Iwahashi K; Takeuchi Y. 1999. Spontaneous accumulation of eosinophils and macrophages throughout the stroma of the epididymis and vas deferens in alymphoplasia (aly) mutant mice: I. A histological study. Am J Reprod Immunol 42(4):246-53. [PubMed: 10580607]  [MGI Ref ID J:59868]

Jang MH; Kweon MN; Iwatani K; Yamamoto M; Terahara K; Sasakawa C; Suzuki T; Nochi T; Yokota Y; Rennert PD; Hiroi T; Tamagawa H; Iijima H; Kunisawa J; Yuki Y; Kiyono H. 2004. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A 101(16):6110-5. [PubMed: 15071180]  [MGI Ref ID J:89586]

Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. [PubMed: 12093872]  [MGI Ref ID J:132920]

Kajiura F; Sun S; Nomura T; Izumi K; Ueno T; Bando Y; Kuroda N; Han H; Li Y; Matsushima A; Takahama Y; Sakaguchi S; Mitani T; Matsumoto M. 2004. NF-kappaB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol 172(4):2067-75. [PubMed: 14764671]  [MGI Ref ID J:87993]

Kang HS; Blink SE; Chin RK; Lee Y; Kim O; Weinstock J; Waldschmidt T; Conrad D; Chen B; Solway J; Sperling AI; Fu YX. 2003. Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation. J Exp Med 198(11):1643-52. [PubMed: 14638845]  [MGI Ref ID J:86810]

Kang HS; Chin RK; Wang Y; Yu P; Wang J; Newell KA; Fu YX. 2002. Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat Immunol 3(6):576-82. [PubMed: 12006975]  [MGI Ref ID J:76773]

Kather A; Chantakru S; He H; Minhas K; Foster R; Markert UR; Pfeffer K; Croy BA. 2003. Neither lymphotoxin alpha nor lymphotoxin beta receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant mouse uterus. Immunology 108(3):338-45. [PubMed: 12603600]  [MGI Ref ID J:82424]

Klonowski KD; Marzo AL; Williams KJ; Lee SJ; Pham QM; Lefrancois L. 2006. CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen. J Immunol 177(10):6738-46. [PubMed: 17082587]  [MGI Ref ID J:140494]

Koni PA; Flavell RA. 1998. A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta. J Exp Med 187(12):1977-83. [PubMed: 9625757]  [MGI Ref ID J:110881]

Koni PA; Sacca R; Lawton P; Browning JL; Ruddle NH; Flavell RA. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 6(4):491-500. [PubMed: 9133428]  [MGI Ref ID J:39746]

Kranich J; Krautler NJ; Heinen E; Polymenidou M; Bridel C; Schildknecht A; Huber C; Kosco-Vilbois MH; Zinkernagel R; Miele G; Aguzzi A. 2008. Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8. J Exp Med 205(6):1293-302. [PubMed: 18490487]  [MGI Ref ID J:137077]

Kuprash DV; Alimzhanov MB; Tumanov AV; Anderson AO; Pfeffer K; Nedospasov SA. 1999. TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J Immunol 163(12):6575-80. [PubMed: 10586051]  [MGI Ref ID J:58981]

Kuprash DV; Alimzhanov MB; Tumanov AV; Grivennikov SI; Shakhov AN; Drutskaya LN; Marino MW; Turetskaya RL; Anderson AO; Rajewsky K; Pfeffer K; Nedospasov SA. 2002. Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol Cell Biol 22(24):8626-34. [PubMed: 12446781]  [MGI Ref ID J:80616]

Kwa SF; Beverley P; Smith AL. 2006. Peyer's patches are required for the induction of rapid Th1 responses in the gut and mesenteric lymph nodes during an enteric infection. J Immunol 176(12):7533-41. [PubMed: 16751400]  [MGI Ref ID J:132354]

Laouar A; Haridas V; Vargas D; Zhinan X; Chaplin D; van Lier RA; Manjunath N. 2005. CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat Immunol 6(7):698-706. [PubMed: 15937486]  [MGI Ref ID J:99148]

Liepinsh DJ; Grivennikov SI; Klarmann KD; Lagarkova MA; Drutskaya MS; Lockett SJ; Tessarollo L; McAuliffe M; Keller JR; Kuprash DV; Nedospasov SA. 2006. Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Mol Cell Biol 26(11):4214-25. [PubMed: 16705172]  [MGI Ref ID J:109621]

Lin X; Ma X; Rodriguez M; Feng X; Zoecklein L; Fu YX; Roos RP. 2003. Membrane lymphotoxin is required for resistance to Theiler's virus infection. Int Immunol 15(8):955-62. [PubMed: 12882833]  [MGI Ref ID J:84938]

Lo JC; Chin RK; Lee Y; Kang HS; Wang Y; Weinstock JV; Banks T; Ware CF; Franzoso G; Fu YX. 2003. Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clin Invest 112(10):1495-505. [PubMed: 14617751]  [MGI Ref ID J:113397]

Lo JC; Wang Y; Tumanov AV; Bamji M; Yao Z; Reardon CA; Getz GS; Fu YX. 2007. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316(5822):285-8. [PubMed: 17431181]  [MGI Ref ID J:120962]

Lorenz RG; Chaplin DD; McDonald KG; McDonough JS; Newberry RD. 2003. Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin beta Receptor, and TNF Receptor I Function. J Immunol 170(11):5475-82. [PubMed: 12759424]  [MGI Ref ID J:83455]

Lund FE; Partida-Sanchez S; Lee BO; Kusser KL; Hartson L; Hogan RJ; Woodland DL; Randall TD. 2002. Lymphotoxin-alpha-Deficient Mice Make Delayed, But Effective, T and B Cell Responses to Influenza. J Immunol 169(9):5236-43. [PubMed: 12391242]  [MGI Ref ID J:79758]

Luther SA; Lopez T; Bai W; Hanahan D; Cyster JG. 2000. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12(5):471-81. [PubMed: 10843380]  [MGI Ref ID J:110548]

Macpherson AJ; Gatto D; Sainsbury E; Harriman GR; Hengartner H; Zinkernagel RM. 2000. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288(5474):2222-6. [PubMed: 10864873]  [MGI Ref ID J:63088]

Mandik-Nayak L; Huang G; Sheehan KC; Erikson J; Chaplin DD. 2001. Signaling Through TNF Receptor p55 in TNF-alpha-Deficient Mice Alters the CXCL13/CCL19/CCL21 Ratio in the Spleen and Induces Maturation and Migration of Anergic B Cells into the B Cell Follicle. J Immunol 167(4):1920-8. [PubMed: 11489971]  [MGI Ref ID J:70819]

Mariathasan S; Matsumoto M; Baranyay F; Nahm MH; Kanagawa O; Chaplin DD. 1995. Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration. J Inflamm 45(1):72-8. [PubMed: 7583355]  [MGI Ref ID J:29136]

Matsumoto M; Fu YX; Molina H; Chaplin DD. 1997. Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. Immunol Rev 156:137-44. [PubMed: 9176705]  [MGI Ref ID J:40209]

Matsumoto M; Fu YX; Molina H; Huang G; Kim J; Thomas DA; Nahm MH; Chaplin DD. 1997. Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. J Exp Med 186(12):1997-2004. [PubMed: 9396768]  [MGI Ref ID J:44877]

Matsumoto M; Iwamasa K; Rennert PD; Yamada T; Suzuki R; Matsushima A ; Okabe M ; Fujita S ; Yokoyama M. 1999. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J Immunol 163(3):1584-91. [PubMed: 10415063]  [MGI Ref ID J:56996]

Matsumoto M; Lo SF; Carruthers CJ; Min J; Mariathasan S; Huang G; Plas DR; Martin SM; Geha RS; Nahm MH; Chaplin DD. 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature 382(6590):462-6. [PubMed: 8684487]  [MGI Ref ID J:34433]

Matsumoto M; Mariathasan S; Nahm MH; Baranyay F; Peschon JJ; Chaplin DD. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271(5253):1289-91. [PubMed: 8638112]  [MGI Ref ID J:63530]

McDonald KG; McDonough JS; Newberry RD. 2005. Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles. J Immunol 174(9):5720-8. [PubMed: 15843574]  [MGI Ref ID J:98463]

McDonald KG; McDonough JS; Wang C; Kucharzik T; Williams IR; Newberry RD. 2007. CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles. Am J Pathol 170(4):1229-40. [PubMed: 17392163]  [MGI Ref ID J:120122]

Meier D; Bornmann C; Chappaz S; Schmutz S; Otten LA; Ceredig R; Acha-Orbea H; Finke D. 2007. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity 26(5):643-54. [PubMed: 17521585]  [MGI Ref ID J:123554]

Mendez-Fernandez YV; Hansen MJ; Rodriguez M; Pease LR. 2005. Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection. J Virol 79(5):3063-70. [PubMed: 15709026]  [MGI Ref ID J:96694]

Moyron-Quiroz JE; Rangel-Moreno J; Kusser K; Hartson L; Sprague F; Goodrich S; Woodland DL; Lund FE; Randall TD. 2004. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med 10(9):927-34. [PubMed: 15311275]  [MGI Ref ID J:92841]

Newberry RD; McDonough JS; McDonald KG; Lorenz RG. 2002. Postgestational lymphotoxin/lymphotoxin beta receptor interactions are essential for the presence of intestinal B lymphocytes. J Immunol 168(10):4988-97. [PubMed: 11994450]  [MGI Ref ID J:127286]

Ngo VN; Cornall RJ; Cyster JG. 2001. Splenic T zone development is B cell dependent. J Exp Med 194(11):1649-60. [PubMed: 11733579]  [MGI Ref ID J:73100]

Nolte MA; Arens R; Kraus M; van Oers MH; Kraal G; van Lier RA; Mebius RE. 2004. B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol 172(6):3620-7. [PubMed: 15004164]  [MGI Ref ID J:88620]

Oldstone MB; Race R; Thomas D; Lewicki H; Homann D; Smelt S; Holz A; Koni P; Lo D; Chesebro B; Flavell R. 2002. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. J Virol 76(9):4357-63. [PubMed: 11932402]  [MGI Ref ID J:126282]

Olleros ML; Guler R; Corazza N; Vesin D; Eugster HP; Marchal G; Chavarot P; Mueller C; Garcia I. 2002. Transmembrane TNF induces an efficient cell-mediated immunity and resistance to Mycobacterium bovis bacillus Calmette-Guerin infection in the absence of secreted TNF and lymphotoxin-alpha. J Immunol 168(7):3394-401. [PubMed: 11907097]  [MGI Ref ID J:75580]

Pasparakis M; Kousteni S; Peschon J; Kollias G. 2000. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell Immunol 201(1):33-41. [PubMed: 10805971]  [MGI Ref ID J:62236]

Plant SR; Arnett HA; Ting JP. 2005. Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination. Glia 49(1):1-14. [PubMed: 15382206]  [MGI Ref ID J:104812]

Rangel-Moreno J; Moyron-Quiroz J; Kusser K; Hartson L; Nakano H; Randall TD. 2005. Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue. J Immunol 175(8):4904-13. [PubMed: 16210592]  [MGI Ref ID J:119053]

Rebholz B; Haase I; Eckelt B; Paxian S; Flaig MJ; Ghoreschi K; Nedospasov SA; Mailhammer R; Debey-Pascher S; Schultze JL; Weindl G; Forster I; Huss R; Stratis A; Ruzicka T; Rocken M; Pfeffer K; Schmid RM; Rupec RA. 2007. Crosstalk between Keratinocytes and Adaptive Immune Cells in an IkappaBalpha Protein-Mediated Inflammatory Disease of the Skin. Immunity 27(2):296-307. [PubMed: 17692539]  [MGI Ref ID J:124343]

Rennert PD; James D; Mackay F; Browning JL; Hochman PS. 1998. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity 9(1):71-9. [PubMed: 9697837]  [MGI Ref ID J:48789]

Sacca R; Turley S; Soong L; Mellman I; Ruddle NH. 1997. Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-alpha-deficient mice. J Immunol 159(9):4252-60. [PubMed: 9379020]  [MGI Ref ID J:110671]

Sedger LM; Hou S; Osvath SR; Glaccum MB; Peschon JJ; van Rooijen N; Hyland L. 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 169(11):6193-201. [PubMed: 12444124]  [MGI Ref ID J:118778]

Shakhov AN; Lyakhov IG; Tumanov AV; Rubtsov AV; Drutskaya LN; Marino MW; Nedospasov SA. 2000. Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies. J Leukoc Biol 68(1):151-7. [PubMed: 10914503]  [MGI Ref ID J:120421]

Shimomura Y; Ogawa A; Kawada M; Sugimoto K; Mizoguchi E; Shi HN; Pillai S; Bhan AK; Mizoguchi A. 2008. A unique B2 B cell subset in the intestine. J Exp Med 205(6):1343-55. [PubMed: 18519649]  [MGI Ref ID J:137039]

Spahn TW; Fontana A; Faria AM; Slavin AJ; Eugster HP; Zhang X; Koni PA; Ruddle NH; Flavell RA; Rennert PD; Weiner HL. 2001. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur J Immunol 31(4):1278-87. [PubMed: 11298355]  [MGI Ref ID J:119455]

Spahn TW; Herbst H; Rennert PD; Lugering N; Maaser C; Kraft M; Fontana A; Weiner HL; Domschke W; Kucharzik T. 2002. Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches. Am J Pathol 161(6):2273-82. [PubMed: 12466141]  [MGI Ref ID J:108224]

Spahn TW; Maaser C; Eckmann L; Heidemann J; Lugering A; Newberry R; Domschke W; Herbst H; Kucharzik T. 2004. The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology 127(5):1463-73. [PubMed: 15521015]  [MGI Ref ID J:93429]

Spahn TW; Weiner HL; Rennert PD; Lugering N; Fontana A; Domschke W; Kucharzik T. 2002. Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches. Eur J Immunol 32(4):1109-13. [PubMed: 11920578]  [MGI Ref ID J:75996]

Staton TL; Habtezion A; Winslow MM; Sato T; Love PE; Butcher EC. 2006. CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat Immunol 7(5):482-8. [PubMed: 16582913]  [MGI Ref ID J:112592]

Taylor RT; Lugering A; Newell KA; Williams IR. 2004. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. J Immunol 173(12):7183-9. [PubMed: 15585839]  [MGI Ref ID J:94865]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Togbe D; de Sousa PL; Fauconnier M; Boissay V; Fick L; Scheu S; Pfeffer K; Menard R; Grau GE; Doan BT; Beloeil JC; Renia L; Hansen AM; Ball HJ; Hunt NH; Ryffel B; Quesniaux VF. 2008. Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS ONE 3(7):e2608. [PubMed: 18612394]  [MGI Ref ID J:137984]

Tumanov AV; Kuprash DV; Mach JA; Nedospasov SA; Chervonsky AV. 2004. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches. J Immunol 173(1):86-91. [PubMed: 15210762]  [MGI Ref ID J:90815]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186]  [MGI Ref ID J:133099]

Vondenhoff MF; Desanti GE; Cupedo T; Bertrand JY; Cumano A; Kraal G; Mebius RE; Golub R. 2008. Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner. J Leukoc Biol 84(1):152-61. [PubMed: 18403646]  [MGI Ref ID J:137812]

Wang J; Foster A; Chin R; Yu P; Sun Y; Wang Y; Pfeffer K; Fu YX. 2002. The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function. Eur J Immunol 32(7):1969-79. [PubMed: 12115617]  [MGI Ref ID J:115520]

Wang J; Fu YX. 2003. LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide. J Immunol 170(8):3986-93. [PubMed: 12682226]  [MGI Ref ID J:132834]

Wang Y; Wang J; Sun Y; Wu Q; Fu YX. 2001. Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells J Immunol 166(1):330-7. [PubMed: 11123309]  [MGI Ref ID J:66397]

Wolniak KL; Noelle RJ; Waldschmidt TJ. 2006. Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice. J Immunol 177(4):2072-9. [PubMed: 16887965]  [MGI Ref ID J:138400]

Wu Q; Sun Y; Wang J; Lin X; Wang Y; Pegg LE; Futterer A; Pfeffer K; Fu YX. 2001. Signal via lymphotoxin-betaR on bone marrow stromal cells is required for an early checkpoint of NK cell development. J Immunol 166(3):1684-9. [PubMed: 11160211]  [MGI Ref ID J:67101]

Wu Q; Wang Y; Wang J; Hedgeman EO; Browning JL; Fu YX. 1999. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med 190(5):629-38. [PubMed: 10477548]  [MGI Ref ID J:110887]

Ying X; Chan K; Shenoy P; Hill M; Ruddle NH. 2005. Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin. Am J Pathol 166(1):135-46. [PubMed: 15632007]  [MGI Ref ID J:95222]

Yu P; Wang Y; Chin RK; Martinez-Pomares L; Gordon S; Kosco-Vibois MH; Cyster J; Fu YX. 2002. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J Immunol 168(10):5117-23. [PubMed: 11994465]  [MGI Ref ID J:127080]

Zhou P; Hwang KW; Palucki D; Kim O; Newell KA; Fu YX; Alegre ML. 2003. Secondary lymphoid organs are important but not absolutely required for allograft responses. Am J Transplant 3(3):259-66. [PubMed: 12614279]  [MGI Ref ID J:132919]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThis strain is maintained by homozygous sibling matings. Expected coat color from breeding:Black
Mating SystemHomozygote x Homozygote         (Female x Male)
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $87.00Female or MaleHomozygous for Ltatm1Dch
Pairs /Price*Pair Genotype
$174.00Homozygous for Ltatm1Dch x Homozygous for Ltatm1Dch
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $113.10Female or MaleHomozygous for Ltatm1Dch
Pairs /Price*Pair Genotype
$226.20Homozygous for Ltatm1Dch x Homozygous for Ltatm1Dch
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

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“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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